Uncovering Earth’s virome

Nature, Journal Year: 2016, Volume and Issue: 536(7617), P. 425 - 430

Published: Aug. 16, 2016

Language: Английский

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Antibiotic resistance and persistence—Implications for human health and treatment perspectives

EMBO Reports, Journal Year: 2020, Volume and Issue: 21(12)

Published: Dec. 3, 2020

Language: Английский

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Resistance Development to Bacteriophages Occurring during Bacteriophage Therapy

Viruses, Journal Year: 2018, Volume and Issue: 10(7), P. 351 - 351

Published: June 30, 2018

Bacteriophage (phage) therapy, i.e., the use of viruses that infect bacteria as antimicrobial agents, is a promising alternative to conventional antibiotics. Indeed, resistance antibiotics has become major public health problem after decades extensive usage. However, one main questions regarding phage therapy possible rapid emergence phage-resistant bacterial variants, which could impede favourable treatment outcomes. Experimental data shown variants occurred in up 80% studies targeting intestinal milieu and 50% using sepsis models. Phage-resistant have also been observed human studies, described three out four clinical trials recorded resistance. On other hand, recent animal suggest mutations confer phage-resistance may result fitness costs resistant bacterium, which, turn, benefit host. Thus, should not be underestimated efforts made develop methodologies for monitoring preventing it. Moreover, understanding taking advantage resistance-induced pathogens potentially avenue.

Language: Английский

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Bioconjugation with Maleimides: A Useful Tool for Chemical Biology

Chemistry - A European Journal, Journal Year: 2018, Volume and Issue: 25(1), P. 43 - 59

Published: Aug. 10, 2018

Maleimide chemistry stands out in the bioconjugation toolbox by virtue of its synthetic accessibility, excellent reactivity, and practicability. The second-generation clinically approved antibody-drug conjugates (ADC) much current ADC pipeline clinical trials contain maleimide linkage. However, thiosuccinimide linkages are now known to be less robust than once thought, ergo, correlated with suboptimal pharmacodynamics, pharmacokinetics, safety profiles some constructs. Rational design novel generations maleimides maleimide-type reagents have been reported address shortcomings classical maleimides, allowing for formation bioconjugate linkages. This review highlights main strategies rational reagent that allowed irreversible bioconjugations cysteines, reversible labelling disulfide re-bridging.

Language: Английский

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Synergy between the Host Immune System and Bacteriophage Is Essential for Successful Phage Therapy against an Acute Respiratory Pathogen

Cell Host & Microbe, Journal Year: 2017, Volume and Issue: 22(1), P. 38 - 47.e4

Published: July 1, 2017

Language: Английский

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36th International Symposium on Intensive Care and Emergency Medicine

Critical Care, Journal Year: 2016, Volume and Issue: 20(S2)

Published: April 1, 2016

P001 - Sepsis impairs the capillary response within hypoxic capillaries and decreases erythrocyte oxygen-dependent ATP efflux R. M. Bateman, D. Sharpe, J. E. Jagger, C. G. Ellis P002 Lower serum immunoglobulin G2 level does not predispose to severe flu. Solé-Violán, López-Rodríguez, Herrera-Ramos, Ruíz-Hernández, L. Borderías, Horcajada, N. González-Quevedo, O. Rajas, Briones, F. Rodríguez de Castro, Gallego P003 Brain protective effects of intravenous through inhibition complement activation apoptosis in a rat model sepsis Esen, Orhun, P. Ergin Ozcan, Senturk, Ugur Yilmaz, Orhan, Arican, Kaya, Kucukerden, Giris, U. Akcan, S. Bilgic Gazioglu, Tuzun P004 Adenosine a1 receptor dysfunction is associated with leukopenia: A possible mechanism for sepsis-induced leukopenia Riff, Naamani, A. Douvdevani P005 Analysis neutrophil by hyper spectral imaging preliminary report Takegawa, H. Yoshida, T. Hirose, Yamamoto, Hagiya, Ojima, Y. Akeda, Tasaki, K. Tomono, Shimazu P006 Chemiluminescent intensity assessed eaa predicts incidence postoperative infectious complications following gastrointestinal surgery Ono, Kubo, Suda, Ueno, Ikeda P007 Serial change c1 inhibitor patients – prospective observational study Ogura, Takahashi, Kang, Nakamura, Kojima, P008 Comparison bacteremia on related biomarkers Ikeda, Izutani, Ono P009 The changes procalcitonin levels critical abdominal septic shock during blood purification Taniguchi, O P010 Validation new sensitive point care device rapid measurement Dinter, Lotz, B. Eilers, Wissmann, Lott P011 Infection primary acute respiratory tract infections C-reactive protein Meili, Schuetz P012 Do we need lower cut off? Hawa, Sharshir, Aburageila, Salahuddin P013 predictive role central nervous system extensively drug resistant bacteria V. Chantziara, Georgiou, Tsimogianni, Alexandropoulos, Vassi, Lagiou, Valta, Micha, Chinou, Michaloudis P014 Changes endotoxin activity assay after direct hemoperfusion polymyxin-b immobilized fiber Kodaira, Imaizumi P015 Diagnostic usefullness combination ICU admission De la Torre-Prados, Garcia-De Torre, Enguix-Armada, Puerto-Morlan, Perez-Valero, Garcia-Alcantara P016 Platelet function analysis utilising PFA-100 predict infection, bacteraemia, or outcome critically ill Bolton, Dudziak, Bonney, Tridente, Nee P017 Extracellular histone H3 are inversely correlated antithrombin platelet counts mortality Nicolaes, Wiewel, Schultz, Wildhagen, Horn, Schrijver, Van der Poll, Reutelingsperger P018 Il-8: this more reliable biomarker severity than CRP, Procalcitonin, E-selectin, IL-6 TNF-[alpha] Pillai, Davies, Mills, Aubrey, Morris, Williams, Evans P019 Relation between adrenomedullin short-term patients: Results from frog Gayat, Struck, Cariou, Deye, Guidet, Jabert, Launay, Legrand, Léone, Resche-Rigon, Vicaut, Vieillard-Baron, Mebazaa P020 Impact disease assessment performance heparin-binding prediction Arnold, Capan, Linder, Akesson P021 Kinetics prognostic value presepsin (sCD14) patients. pilot Popescu, Tomescu P022 CD64 performed facs accellix systems Sprung, Calderon Morales, Munteanu, Orenbuch-Harroch, Levin, Kasdan, Reiter, Volker, Himmel, Cohen, Meissonnier P023 Diagnosing 5 minutes: Nanofluidic technology pancreatic-stone (PSP/ reg) Girard, Rebeaud P024 How nanotechnology-based approaches could contribute prevention, diagnosis treatment I. Herrmann P025 Il7r transcriptional expression Delwarde, Peronnet, Cerrato, Venet, Lepape, Rimmelé, Monneret, Textoris P026 Disbalance microbial metabolites aromatic acids affects Beloborodova, Moroz, Osipov, Bedova, Sarshor, Pautova, Sergeev, Chernevskaya P027 Copeptin 10-year all-cause community Odermatt, Bolliger, Hersberger, Ottiger, Christ-Crain, Mueller, P028 Identification differential proteomic secondary hospital acquired pneumonia Sharma, Tashima, Brunialti, Machado, Assuncao, Rigato, Salomao P029 Monocyte HLA-DR community-acquired bacteremic dynamics aetiology Cajander, Rasmussen, Tina, Söderquist, Källman, Strålin P030 Soluble B- T-lymphocyte attenuator: marker Lange, Sundén-Cullberg, Magnuson, Hultgren P031 Fractal dimension: quantifying clot microstructure across spectrum P032 coagulation, (Df) rotational thromboelastometry (ROTEM) P033 fibrinolysis spectrum: use lysis index (LI60) D-Dimer concentration P034 intensive infection score promising its severity. Geest, Mohseni, Linssen, Jonge, Duran, Groeneveld P035 Challenges clinical Miller III, Lopansri, McHugh, Seldon, Burke P036 Does zero heat flux thermometry accurately identify care? Johnston, Reece-Anthony, Bond, Molokhia P037 Advancing quality (AQ) programme: Improving early identification & North West England. Mcgrath, Nsutebu P038 Prehospital transport Bank Pedersen, Pilsgaard Henriksen, Mikkelsen, Touborg Lassen P039 Vasodilatory plant extracts gel as an alternative fever Tincu, Cobilinschi, Tomescu, Z. Ghiorghiu, Macovei P040 Host hypothermic Harmon, Vught, Scicluna, Hoogendijk, Zwinderman, Cremer, Bonten, Juffermans, W. Wiersinga P041 Septic alert over SIRS criteria has impact but needs be revised Eren, Y Tekdos, Dogan, Acicbe, Hergunsel P042 Association previous prescription βblockers rate among retrospective Alsolamy, Ghamdi, Alswaidan, Alharbi, Alenezi, Arabi P043 Recognition labour ward– teaching information resources can improve knowledge Heaton, Boyce, Nolan, Dukoff-Gordon, Dean, P044 Culture negative what unique patient population? Mann Ben Yehudah P045 Organ identified administrative data Germany, 2007-2013 Fleischmann, Thomas-Rueddel, Haas, Dennler, Reinhart P046 comparison residents’ regarding; Surviving Campaign 2012 guideline Suntornlohanakul, Khwannimit P047 Effectiveness bundle outcomes Breckenridge, Puxty P048 Dose norepinephrine first 24 hours parameter evaluating effectiveness Szturz, Folwarzcny, Svancara, Kula, Sevcik P049 Norepinephrine vasopressin + shock. series 39 Caneva, Casazza, Bellazzi, Marra, Pagani, Vetere, Vanzino, Ciprandi, Preda, Boschi, Carnevale P050 Methylene blue contributory Lopez, Aguilar Arzapalo, Barradas, Escalante, Gongora, Cetina P051 Coagulation disorders DIC evaluated thromboelastometry. B Adamik, D Jakubczyk, Kübler P052 Frequency sepsis-associated coagulopathy Radford, Lee, Singer, Boyd, Fineberg, Russell P053 Assessment cancer case-control Scarlatescu, Droc, Arama P054 Thromboelastometry disseminated intravascular coagulation Müller, Straat, Zeerleder, Juffermans P055 Cessation preexisting chronic antiplatelet therapy increased rates Fuchs, Scheer, Wauschkuhn, Vollmer, Meissner, Kuhn, Hahnenkamp, Rehberg, Gründling P056 Neutrophil Traps (NETs) production under condition Hamaguchi, Shimazu, Tomono P057 ultraviolet air sterilizer unit room, Gómez-Sánchez, Heredia-Rodríguez, Álvarez-Fuente, Lorenzo-López, Gómez-Pesquera, Aragón-Camino, Liu-Zhu, Sánchez-López, Hernández-Lozano, Peláez-Jareño, Tamayo P058 Focus cohorts Germany Thomas-Rüddel, P059 “Zero CLABSI” get there? Obstacles 4 year journey our strategies overcome them experience Indian Adora, Kar, Chakraborty, Roy, Bandyopadhyay, Das P060 Novel molecular techniques venous catheter (CVC) stream (BSIs) Yehudah, Salim, Kumar, Arabi, Burger, Lephart, Toth-martin P061 Zero clabsi” Rao, Chakraborty P062 Prevention line-associated bloodstream units: An international online survey Valencia, Hammami, Blot, Vincent, Lambert P063 30 days antimicrobial efficacy non-leaching catheters Brunke, Riemann, Roschke P064 Efficacy noble metal alloy-coated prevention bacteriuria P065 Predicting urinary setting: Nimitvilai, Jintanapramote, Jarupongprapa P066 Eight-year acinetobacter spp. monobacteremia surgical medical units at university Lithuania Adukauskiene, Valanciene P067 Group group streptococcal tertiary centre Bose, Lostarakos, Carr P068 Improved detection spontaneous bacterial peritonitis uritop tm strip test inoculation culture bottles ascitic fluid Khedher, Maaoui, Ezzamouri, Salem P069 Increased risk cellulitis congestive heart failure: population based cohort Chen P070 Outcomes necrotizing fasciitis Cranendonk, P071 Botulism outbreak people who inject drugs (PWIDs) Scotland. Day, Penrice, Robertson, Godbole, Jones, Booth, Donaldson P072 Surveillance ESBL-producing enterobacteriaceae fecal carriers Kawano, Ishikura P073 Prevalence ESBL carbapenemase producing uropathogens newly opened south India Sreevidya, Brahmananda Reddy, Muraray Govind, Pratheema, Devachandran Apollo Speciality Hospital OMR, Chennai, P074 Prevalence, factors methicillin-resistant staphylococcus aureus nasal colonization Al-Dorzi, Almutairi, Alhamadi, Crizaldo Toledo, Khan, Al Raiy, P075 Multidrug-resistant Acinetobacter baumannii building construction: Is there association? Talaie P076 organisms Dutch Oers, Harts, Nieuwkoop, Vos P077 Epidemiology caused multidrug-resistant gram bacilli Boussarsar, Boutouta, Kamoun, Mezghani, Koubaji, Souissi, Riahi, P078 pathogens polyclonal IgM-enriched immunoglobulins Giamarellos-Bourboulis, Tziolos, Routsi, Katsenos, Tsangaris, Pneumatikos, Vlachogiannis, Theodorou, Prekates, Antypa, Koulouras, Kapravelos, Gogos, Antoniadou, Mandragos, Armaganidis P079 Must practice ICU? Robles Caballero, Civantos, Figueira, López P080 Mediterranean spotted diseases Silva-Pinto, Ceia, Sarmento, Santos P081 Clinical features Middle East syndrome requiring saudi unit: 31 cases Almekhlafi, Sakr P082 coronavirus Baharoon, Aldawood, Matroud, Alchin, Johani, Balkhy, P083 syndrome: Yousif, Alotabi, Alsaawi P085 Use Taqman array card diagnostics pneumonia: case Ang, MD Curran, Enoch, Navapurkar, Conway Morris P086 ‘BUNS’: investigation protocol improves management Sharvill, Astin P087 Pneumonia peritonitis: epidemiological P088 “CURB-65 score” emergency room clinicians large Patel, Kruger P089 Incidence viral mechanically ventilated O’Neal, Rhodes, Jancik P090 SAATELLITE Study: S Nosocomial (NP) MEDI4893, Human Monoclonal Antibody (mAb) Against François, Laterre, Eggimann, Torres, Sánchez, Dequin, Bassi, Chastre, Jafri P091 Risk microbiological profile nosocomial trauma Romdhane, Douira, Bousselmi, M.S. P092 Correlation percentages developed vap agents Vakalos, Avramidis P093 two ventilator surveillance Craven, Wojcik, Kefala, McCoubrey, Reilly, Paterson, Inverarity, Laurenson, Walsh P094 Lung ultrasound before fiberbronchoscopy modifications may ventilator-associated Mongodi, Bouhemad, Orlando, Stella, Via, Iotti, Braschi, Mojoli P095 Comparing accuracy predictors Haliloglu, Bilgili, Kasapoglu, Sayan, Süzer Aslan, Yalcın, Cinel P096 pRBCs transfusion percentage VAP P097 interventions Ellis, Bauchmuller, Miller, Temple P098 EVADE study: P aeruginosa MEDI3902, Bispecific Antibody, against virulence Luyt, P099 Short-term inhaled colistin adjunctive Nassar, Ayad P100 Effect aerosolised weaning mechanical ventilation Trifi, Abdellatif, Daly, Nasri, Lakhal P101 independent factor colistin-induced kidney injury: Gul, P102 emphasis tobramycin Kuzovlev, Shabanov, Polovnikov, Moroz P103 In vitro evaluation amikacin inhale commercial nebulizers Kadrichu, Dang, Corkery, Challoner P104 nebulized amikacin/fosfomycin systemic meropenem amikacin-resistant meropenem-susceptible P.aeruginosa Li Aguilera, Chiurazzi, Travierso, Motos, Fernandez, Amaro, Senussi, Idone, Bobi, Rigol, Torres P105 Optimization gentamicin peak concentrations Hodiamont, Janssen, Bouman, Mathôt, Jong, Hest P106 Systematic review cefepime induced neurotoxicity Payne, Fraser P107 Unasyn® causes QT prolongation Tudor, Lahner, Roth, Krenn P108 Comparative teicoplanin vancomycin (mrsa) toxicological (ticu) Tehran, Iran P109 Phage resistance, design phagoburn Jault, Gabard, Leclerc, Jennes, Que, Rousseau, Ravat P110 Antibiotic dosing errors Eissa, Al-Harbi, Aldabbagh, P111 empiric antifungal survival patients? (immunocompromised excluded) P112 Neurocysticercosis-Qatar Paramba, Purayil, Naushad, Mohammad, Negi, Chandra P113 Early indicators haemorrhagic Kleinsasser P114 Filtering red cells reduces inflammatory pulmonary Witrz, Buchner-Doeven, Tuip-de Boer, Goslings, P115 Microparticles cell induce pro-coagulant pro-inflammatory endothelial Hezel, Boing, R Bruggen, N P116 contribution cytokines thrombosis development hospitalization Markopoulou, Venetsanou, Kaldis, Koutete, Chroni, Alamanos P117 Prophylactic enoxaparin adjustment anti-xa monitoring inpatient burn Koch, Jancik, Walter P118 Determination optimal cut-off values haemoglobin, count fibrinogen injury Maekawa, Hayakawa, Kushimoto, Shiraishi, Kato, Sasaki, Matauoka, Uejima, Morimura, Ishikura, Hagiwara, Takeda P119 Trauma-induced prothrombin complex concentrate vs fresh frozen plasma Tarabrin, Shcherbakow, Gavrychenko, Mazurenko, Ivanova, Chystikov P120 First prove superiority concentrates bleeding Plourde, Lessard, Chauny, Daoust P121 Prothrombin obstetric massive P122 FFP P123 Preoperative thrombin generation loss cardiac Kropman, het Panhuis, Konings, Huskens, Schurgers, Roest, Laat, Lance P124 Rotational versus standard tests Durila, Lukas, Astraverkhava, Jonas P125 Correction impaired stability activated thrombocytopenia Budnik, Shenkman P126 point-of-care time analyzer monitor cardiopulmonary bypass Hayami, Koide, Goto P127 Disseminated (dic) underdiagnosed do d-dimer measurements? Iqbal, Alhamdi, Venugopal, Abrams, Downey, Toh, Welters P128 Validity age-adjusted cutoff COPD Bombay, Daoust, Marquis, Paquet P129 scoping paediatric Siemens, Sangaran, Hunt, Durward, Nyman, Murdoch, Tibby P130 Nadir hemoglobulin bypass: morbidity Ampatzidou, Moisidou, Dalampini, Nastou, Vasilarou, Kalaizi, Chatzikostenoglou, Drossos P131 Red influence RDW Spadaro, Fogagnolo, Fiore, Schiavi, Fontana, Taccone, Volta P132 Reasons products transfusions Chochliourou, Volakli, Violaki, Samkinidou, Evlavis, Panagiotidou, Sdougka P133 implementation haemorrhage (mhp) major trauma: ten year, single-centre Mothukuri, Battle, Guy, P134 integrated pre-hospital retrieval teams Wijesuriya, Keogh P135 thresholds cardiovascular events (non-cardiac surgery): systematic meta-analysis Docherty, O’Donnell, Brunskill, Trivella, Doree, Holst, Parker, Gregersen, Almeida, Walsh, Stanworth P136 relationship poor pre-operative immune status specific peri-operative antigenic threat Moravcova, Mansell, Rogers, Smith, Hamilton-Davies P137 simple guidelines reducing post-operative atrial fibrillation surgery. Omar, Allam, Bilala, Kindawi, Ewila P138 Dexamethasone administration no beneficial elective Malamas, P139 Intra-aortic balloon counterpulsation undergoing (IABCS): results Ferreira, Caldas, Fukushima, Osawa, Arita, Camara, Zeferino, Jardim, Gaioto, Dallan, Jatene, Kalil Filho, .F Galas, Hajjar P140 Effects low-dose natriuretic peptide infusion surgery-associated Mitaka, Ohnuma, Murayama, Kunimoto, Nagashima, Takei, Tomita P141 Acute high troponin measurements Mahmoud, Hanoura, Sudarsanan, Sivadasan, Othamn, Shouman, Singh, Khulaifi P142 Complex markers prognosis Mandel, Mikheev, Suhodolo, Kiselev, Svirko, Podoksenov P143 New-onset care: incidence, Jenkins, Griffin P144 One single spot sublingual microcirculation hypertension pig Tovar Doncel, Lima, Aldecoa, Ince P145 levosimendan therapeutic option recruit cardiogenic initial Taha, Shafie, Mostafa, Syed, Hon P146 Terlipressin vs. Potential Multiorgan Donor(PMD) Righetti, Colombaroli, Castellano P147 Echocardiography potential donor exposed substitution hormonotherapy Colombaroli P148 Machine learning reduce alarms Hravnak, Chen, Dubrawski, Clermont, Pinsky P149 Peripherally inserted placed Gonzalez, Macias, Acosta, Jimenez, Loza, Lesmes, Lucena, Leon P150 Recordings abnormal pressure waveform morphology episode porcine Ince, Lima P151 Ultrasound guided access technique French intensivists Bastide, Richecoeur, Frenoy, Lemaire, Sauneuf, Tamion, Nseir, Du Cheyron, Dupont, Maizel P152 Predictive ability Pv-aCO2 gap Shaban, Kolko, Salahuddin, AbuRageila, AlHussain P153 echocardiography artery hemodynamic parameters Mercado, Maizel, Kontar, Titeca, Brazier, Riviere, Joris, Soupison, Cagny, Slama P154 volume clamp method noninvasive output cardiothoracic intermittent thermodilution Wagner, Körner, Kubik, Kluge, Reuter, Saugel P155 Hemodynamic (SS) CPCCO (continuous pulse contour output) TEE (transesophageal echocardiography) P156 Cardiac transthoracic pragmatic Tran, Bels, Cudia, Strachinaru, Ghottignies, Devriendt, Pierrakos P157 Left ventricular outflow velocity integral correlates stroke Ó. Martínez González, Blancas, Luján, Ballesteros, Díaz, Núñez, Martín Parra, Matamala, Alonso Fernández, Chana P158 Transpulmonary (TPTD) derived femoral jugular catheter: validation previously published correction formula proprietary global end-diastolic (GEDVI) Huber, Eckmann, Elkmann, Gruber, Klein, Schmid, Lahmer P160 Dynamic arterial elastance calculated lidcoplus challenge postsurgical Bastoni, Aya, Toscani, Pigozzi, Cecconi P159 Venous return driving resistance Moller, Sondergaard, Jakob, Takala, Berger P161 duration goal-directed Ostrowska, Abbas, Mellinghoff, Ryan, Dawson, P162 optimization back square one? Cronhjort, Wall, Nyberg, Zeng, Svensen, Mårtensson, Joelsson-Alm P163 thoracic content bioimpedance guiding P164 internal vein m

Language: Английский

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Advantages and Limitations of Bacteriophages for the Treatment of Bacterial Infections

Frontiers in Pharmacology, Journal Year: 2019, Volume and Issue: 10

Published: May 8, 2019

Bacteriophages (BPs) are viruses that can infect and kill bacteria without any negative effect on human or animal cells. For this reason, it is supposed they be used, alone in combination with antibiotics, to treat bacterial infections. In narrative review, the advantages limitations of BPs for use humans will discussed. PubMed was used search all studies published from January 2008 December 2018 using key words: “bacteriophages” “phages” “bacterial infection” “antibiotic” “infectious diseases”. More than 100 articles were found, but only those English providing evidence-based data included evaluation. Literature review showed rapid rise multi-drug-resistant worldwide coupled a decline development production novel antibacterial agents have led scientists consider treatment infection. Use overcome problem increasing resistance antibiotics attractive, some research seem indicate might rational measure. However, present knowledge seems insufficient allow purpose. To date, how prepare formulations clinical avoid limit risk emergence through transmission genetic material not completely solved problems. Further specifically devoted solve these problems needed before humans.

Language: Английский

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Rapid and efficient protein synthesis through expansion of the native chemical ligation concept

Nature Reviews Chemistry, Journal Year: 2018, Volume and Issue: 2(4)

Published: March 29, 2018

Language: Английский

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Dynamic biofilm architecture confers individual and collective mechanisms of viral protection

Nature Microbiology, Journal Year: 2017, Volume and Issue: 3(1), P. 26 - 31

Published: Oct. 27, 2017

Language: Английский

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Biotechnological applications of bacteriophages: State of the art

Microbiological Research, Journal Year: 2018, Volume and Issue: 212-213, P. 38 - 58

Published: April 30, 2018

Language: Английский

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