The interdependence of excitation and inhibition for the control of dynamic breathing rhythms DOI Creative Commons
Nathan A. Baertsch, Hans Baertsch, Jan‐Marino Ramirez

et al.

Nature Communications, Journal Year: 2018, Volume and Issue: 9(1)

Published: Feb. 20, 2018

The preBötzinger Complex (preBötC), a medullary network critical for breathing, relies on excitatory interneurons to generate the inspiratory rhythm. Yet, half of preBötC neurons are inhibitory, and role inhibition in rhythmogenesis remains controversial. Using optogenetics electrophysiology vitro vivo, we demonstrate that intrinsic excitability is reduced following large depolarizing bursts. This refractory period limits very slow breathing frequencies. Inhibition integrated within required prevent overexcitation neurons, thereby regulating allowing rapid breathing. In sensory feedback also regulates period, slowly mice with removed, activity but not excitatory, restores physiological We conclude excitation interdependent rhythm, because permits bursting by controlling properties neurons.

Language: Английский

Controlled delivery of a neurotransmitter–agonist conjugate for functional recovery after severe spinal cord injury DOI

Yanming Zuo,

Jingjia Ye, Wanxiong Cai

et al.

Nature Nanotechnology, Journal Year: 2023, Volume and Issue: 18(10), P. 1230 - 1240

Published: June 12, 2023

Language: Английский

Citations

50
Basal ganglia–spinal cord pathway that commands locomotor gait asymmetries in mice DOI Creative Commons
Jared M. Cregg, Simrandeep Kaur Sidhu, Roberto Leiras

et al.

Nature Neuroscience, Journal Year: 2024, Volume and Issue: 27(4), P. 716 - 727

Published: Feb. 12, 2024

Abstract The basal ganglia are essential for executing motor actions. How the engage spinal networks has remained elusive. Medullary Chx10 gigantocellular (Gi) neurons required turning gait programs, suggesting that gaits organized by executed via this descending pathway. Performing deep brainstem recordings of Gi Ca 2+ activity in adult mice, we show striatal projection initiate a dominant crossed pathway to on contralateral side. Using intersectional viral tracing and cell-type-specific modulation, uncover principal ganglia–spinal cord locomotor asymmetries mice: → pontine reticular nucleus, oral part (PnO) cord. Modulating restricted PnO restores competence upon damage, dysfunction may contribute debilitating deficits observed Parkinson’s disease. Our results reveal stratified circuit architecture underlying critical program.

Language: Английский

Citations

20
Integrating hydrogels manipulate ECM deposition after spinal cord injury for specific neural reconnections via neuronal relays DOI Creative Commons
Zan Tan, Longyou Xiao, Junwu Ma

et al.

Science Advances, Journal Year: 2024, Volume and Issue: 10(27)

Published: July 3, 2024

A bioinspired hydrogel composed of hyaluronic acid-

Language: Английский

Citations

20
Integrating physiology into movement ecology of large terrestrial mammals DOI Creative Commons
Robyn S. Hetem, Kiara A. Haylock, Melinda Boyers

et al.

Journal of Experimental Biology, Journal Year: 2025, Volume and Issue: 228(Suppl_1)

Published: Feb. 15, 2025

ABSTRACT Movement paths are influenced by external factors and depend on an individual's navigation capacity (Where to move?), motion (How move?) ultimately driven internal physiological state (Why move?). Despite physiology underlying most aspects of this movement ecology framework, the physiology–movement nexus remains understudied in large terrestrial mammals. Within Commentary, we highlight processes that underpin framework how integrating measurements can provide mechanistic insights may enhance our understanding drivers animal movement. We focus mammals, which well represented within literature but under-represented studies integrate state. Recent advances biologging technology allow for variables, such as heart rate body movements, be recorded remotely continuously free-living animals. Biologging temperature additional into states driving Body not only provides a measure thermal stress, also index wellbeing through quantification nutrition, hydration, reproductive disease drive movements. Integrating measures with fine-scale GPS locations causality improve movement, is crucial population performance monitoring reintroduction success. recommend baseline undertaken, linking mechanisms, development realistic predictive models conservation efforts Anthropocene.

Language: Английский

Citations

2
The interdependence of excitation and inhibition for the control of dynamic breathing rhythms DOI Creative Commons
Nathan A. Baertsch, Hans Baertsch, Jan‐Marino Ramirez

et al.

Nature Communications, Journal Year: 2018, Volume and Issue: 9(1)

Published: Feb. 20, 2018

The preBötzinger Complex (preBötC), a medullary network critical for breathing, relies on excitatory interneurons to generate the inspiratory rhythm. Yet, half of preBötC neurons are inhibitory, and role inhibition in rhythmogenesis remains controversial. Using optogenetics electrophysiology vitro vivo, we demonstrate that intrinsic excitability is reduced following large depolarizing bursts. This refractory period limits very slow breathing frequencies. Inhibition integrated within required prevent overexcitation neurons, thereby regulating allowing rapid breathing. In sensory feedback also regulates period, slowly mice with removed, activity but not excitatory, restores physiological We conclude excitation interdependent rhythm, because permits bursting by controlling properties neurons.

Language: Английский

Citations

161