A cortico-subcortical loop for motor control via the pontine reticular formation DOI Open Access
Emília Bősz, Viktor Plattner, László Bíró

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 12, 2023

Summary Movement and locomotion are controlled by large neuronal circuits like the cortex-basal ganglia (BG)-thalamus loop. Inhibitory output of BG loop can directly control movement via specialized connections with brainstem. Whether other parallel loops similar logic exist is presently unclear. Here we demonstrate that glycine transporter 2-positive (GlyT2+) cells pontine reticular formation (PRF) receive cortical inputs in turn innervate thalamus. Thalamus-projecting GlyT2+ subcortical regions distinct from targets. Cortical co-innervate PRF/GlyT2+ thalamus as loops. Cortex exerts strong excitatory on these neurons powerfully inhibit their thalamic Activation projecting leads to contralateral turning. These results PRF part a cortico-subcortical regulates motor activity circuits. The cortico-PRF-thalamus synergistically turning descending pathways. Graphical abstract

Language: Английский

Neural circuit mechanisms for steering control in walkingDrosophila DOI Creative Commons

Aleksandr Rayshubskiy,

Stephen L. Holtz,

Alexander Shakeel Bates

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2020, Volume and Issue: unknown

Published: April 5, 2020

Abstract Orienting behaviors provide a continuous stream of information about an organism’s sensory experiences and plans. Thus, to study the links between sensation action, it is useful identify neurons in brain that control orienting behaviors. Here we describe descending Drosophila predict influence orientation (heading) during walking. We show these cells have specialized functions: whereas one cell type predicts sustained low-gain steering, other transient high-gain steering. These latter integrate internally-directed steering signals from head direction system with stimulus-directed multimodal pathways. The inputs are organized produce “see-saw” commands, so increasing output hemisphere accompanied by decreasing hemisphere. Together, our results internal external drives integrated motor commands different timescales, for flexible precise space.

Language: Английский

Citations

72
Neural circuit mechanisms for steering control in walking Drosophila DOI Open Access

Aleksandr Rayshubskiy,

Stephen L. Holtz,

Alexander Shakeel Bates

et al.

Published: Nov. 27, 2024

Orienting behaviors provide a continuous stream of information about an organism’s sensory experiences and plans. Thus, to study the links between sensation action, it is useful identify neurons in brain that control orienting behaviors. Here we describe descending Drosophila predict influence orientation (heading) during walking. We show these cells have specialized functions: whereas one cell type predicts sustained low-gain steering, other transient high-gain steering. These latter integrate internally-directed steering signals from head direction system with stimulus-directed multimodal pathways. The inputs are organized produce “see-saw” commands, so increasing output hemisphere accompanied by decreasing hemisphere. Together, our results internal external drives integrated motor commands different timescales, for flexible precise space.

Language: Английский

Citations

14
Fine-grained descending control of steering in walking Drosophila DOI Creative Commons
Helen H. Yang,

Bella E. Brezovec,

Laia Serratosa Capdevila

et al.

Cell, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

Citations

13
A cortico-subcortical loop for motor control via the pontine reticular formation DOI
Emília Bősz, Viktor Plattner, László Bíró

et al.

Cell Reports, Journal Year: 2025, Volume and Issue: 44(2), P. 115230 - 115230

Published: Jan. 22, 2025

Language: Английский

Citations

1
Re-examining the pathobiological basis of gait dysfunction in Parkinson’s disease DOI
Newton Cho, Lorraine V. Kalia, Suneil K. Kalia

et al.

Trends in Neurosciences, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

1
A central steering circuit inDrosophila DOI Creative Commons
Kai Feng, Mariam Khan, Ryo Minegishi

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 2, 2024

Abstract Locomotion steering control enables animals to pursue targets, evade threats, avoid obstacles, and explore their environment. Steering commands are generated in the brain communicated via descending neurons leg or wing motor circuits. The diversity of ways which turns triggered executed has led view that might rely on distributed neural processing across multiple Here, however, we present evidence for a central circuit Drosophila is used both goal-directed exploratory capable eliciting ranging from subtle course corrections rapid saccades. organized hierarchy, top layer comprises reciprocally connected DNa03 LAL013 neurons. Our data suggest initiated by reinforced stabilized through winner-take-all mechanism involving LAL013. DNa11 form an intermediate layer. They receive input target circuits directly as well indirectly subordinate activation coordinately changes stepping directions all six legs generate saccadic turns. Together, these define flexibly fly exploits explores its

Language: Английский

Citations

8
Dopamine-sensitive neurons in the mesencephalic locomotor region control locomotion initiation, stop, and turns DOI Creative Commons

Andrea Juárez Tello,

Cornelis Immanuel van der Zouwen, Léonie Dejas

et al.

Cell Reports, Journal Year: 2024, Volume and Issue: 43(5), P. 114187 - 114187

Published: May 1, 2024

The locomotor role of dopaminergic neurons is traditionally attributed to their ascending projections the basal ganglia, which project mesencephalic region (MLR). In addition, descending MLR are present from vertebrates mammals. However, targeted in and behavioral unknown Here, we identify genetically defined cells that express D

Language: Английский

Citations

4
Bradykinesia and postural instability in a model of prodromal synucleinopathy with α-synuclein aggregation initiated in the gigantocellular nuclei DOI Creative Commons
Vasileios Theologidis, Sara A. Ferreira, Nanna Møller Jensen

et al.

Acta Neuropathologica Communications, Journal Year: 2025, Volume and Issue: 13(1)

Published: Feb. 17, 2025

α-Synuclein (aSyn) accumulation within the extra-nigral neuronal populations in brainstem, including gigantocellular nuclei (GRN/Gi) of reticular formation, is a recognized feature during prodromal phase Parkinson disease (PD). Accordingly, there burgeoning interest animal model development for understanding pathological significance synucleinopathy, relation to motor and/or non-motor symptomatology PD. Here, we report an experimental paradigm induction aSyn aggregation with stereotaxic delivery pre-formed fibrillar (PFF) pontine GRN transgenic mice expressing mutant human Ala53Thr (M83 line). Our data show that PFF aSyn-induced aggregate pathology and distinct subcortical system leads progressive decline home cage activity, which was accompanied by postural instability impaired coordination. The brainstem neurons lumbar spinal cord heralded onset moribund stage, culminated survival. Collectively, our observations suggest framework studying features movement disability With further refinements, anticipate this holds promise as test-bed translational research PD related disorders.

Language: Английский

Citations

0
Temporally and Functionally Distinct Contributions to Value Based Choice Along the Anterior-Posterior Dorsomedial Striatal Axis DOI Creative Commons
Luigim Vargas Cifuentes, Edgar Díaz-Hernández, Michael Granato

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: March 15, 2025

While the dorsoventral and mediolateral organization of striatum has resolved clear functional distinctions, far less is known about how anterior-posterior striatal axis contributes to behavioral control. We explore this within dorsomedial (DMS), a key region for value-based choice, by comparing population neuronal activity function anterior (A-DMS) posterior (P-DMS) subregions while mice operantly seek reward. Neural recordings show that P-DMS encoded action values strategy information prior choice selection A-DMS represented recently selected choices their anticipated via dynamic reorganization immediately following selection. Optogenetic perturbations were consistent with these temporally distinct coding properties as unilateral manipulation biased contralaterally in value-dependent manner inhibition impaired future Using anterograde tracing, we found projected common ventromedial substantia nigra pars reticulata (vmSNr), which contained value-related signals combining aspects upstream DMS processing. Together, our results support model distributed influence on across DMS.

Language: Английский

Citations

0
Activation of hypothalamic-pontine-spinal pathway promotes locomotor initiation and functional recovery after spinal cord injury in mice DOI Creative Commons
Yi Li,

Chengyue Ji,

Y. Zhang

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Abstract The hypothalamus is critical for regulating behaviors essential survival and locomotion, but how it integrates internal needs transmits locomotion commands to the spinal cord (SC) remains unclear. We found that glutamatergic neurons in lateral hypothalamic area (LHA) are motivated locomotor activity. Using single-neuron projectome analysis, trans-synaptic tracing, optogenetic manipulation, we showed LHA facilitates during food seeking via pontine oral part (PnO) projection neurons, rather than direct SC projections or indirect stress signaling medial septum diagonal band. Activating PnO-SC also initiated locomotion. Importantly, LHA-PnO were crucial recovery following mouse injury (SCI). Motor cortex signals gated deep brain stimulation treatment markedly promoted long-term restoration of hindlimb motor functions after severe SCI. Thus, have identified a hypothalamic-pontine-spinal pathway paradigm potential therapeutic intervention

Language: Английский

Citations

0