Gut Microbiota-Induced Changes in β-Hydroxybutyrate Metabolism Are Linked to Altered Sociability and Depression in Alcohol Use Disorder DOI Creative Commons
Sophie Leclercq, Tiphaine Le Roy,

Sonia Furgiuele

et al.

Cell Reports, Journal Year: 2020, Volume and Issue: 33(2), P. 108238 - 108238

Published: Oct. 1, 2020

Patients with alcohol use disorder (AUD) present important emotional, cognitive, and social impairments. The gut microbiota has been recently shown to regulate brain functions behavior but convincing evidence of its role in AUD is lacking. Here, we show that dysbiosis associated metabolic alterations affect behavioral (depression, sociability) neurobiological (myelination, neurotransmission, inflammation) processes involved addiction. By transplanting the from patients mice, point out production ethanol by specific bacterial genera reduction lipolysis are a lower hepatic synthesis β-hydroxybutyrate (BHB), which thereby prevents neuroprotective effect BHB. We confirm these results detoxified patients, observe persisting feces as well correlations among low plasma BHB levels impairments, depression, or white matter alterations.

Language: Английский

The hormesis principle of neuroplasticity and neuroprotection DOI Creative Commons
Mark P. Mattson, Rehana K. Leak

Cell Metabolism, Journal Year: 2024, Volume and Issue: 36(2), P. 315 - 337

Published: Jan. 10, 2024

Language: Английский

Citations

19
Brain-wide cell-type-specific transcriptomic signatures of healthy ageing in mice DOI Creative Commons
Kelly Jin, Zizhen Yao, Cindy T. J. van Velthoven

et al.

Nature, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Biological ageing can be defined as a gradual loss of homeostasis across various aspects molecular and cellular function1,2. Mammalian brains consist thousands cell types3, which may differentially susceptible or resilient to ageing. Here we present comprehensive single-cell RNA sequencing dataset containing roughly 1.2 million high-quality transcriptomes brain cells from young adult aged mice both sexes, regions spanning the forebrain, midbrain hindbrain. High-resolution clustering all results in 847 clusters reveals at least 14 age-biased that are mostly glial types. At broader subclass supertype levels, find age-associated gene expression signatures provide list 2,449 unique expressed genes (age-DE genes) for many neuronal non-neuronal Whereas most age-DE specific types, observe common with including decrease related structure function neuron major astrocyte types mature oligodendrocytes, an increase immune function, antigen presentation, inflammation, motility some vascular Finally, demonstrate greatest sensitivity concentrated around third ventricle hypothalamus, tanycytes, ependymal cells, certain arcuate nucleus, dorsomedial nucleus paraventricular express canonically energy homeostasis. Many these response. These findings suggest hypothalamus hub mouse brain. Overall, this study systematically delineates dynamic landscape cell-type-specific transcriptomic changes associated normal will serve foundation investigation functional interaction disease. A inform into

Language: Английский

Citations

7
Serotonin regulates mitochondrial biogenesis and function in rodent cortical neurons via the 5-HT2Areceptor and SIRT1–PGC-1α axis DOI Creative Commons
Sashaina E. Fanibunda, Sukrita Deb, Babukrishna Maniyadath

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2019, Volume and Issue: 116(22), P. 11028 - 11037

Published: May 9, 2019

Significance Neuronal mitochondria are crucial organelles that regulate bioenergetics and also modulate survival function under environmental challenges. Here, we show the neurotransmitter serotonin (5-HT) plays an important role in making of new (mitochondrial biogenesis) cortical neurons, through 5-HT 2A receptor via master regulators mitochondrial biogenesis, SIRT1 PGC-1α. Mitochondrial is enhanced by 5-HT, increasing cellular respiration ATP, energy currency cell. We found reduces reactive oxygen species exerts potent neuroprotective action neurons challenged with stress, effect requires SIRT1. These findings highlight a for effects facilitation stress adaptation identify drug targets to ameliorate dysfunction neurons.

Language: Английский

Citations

139
Exercise training improves motor skill learning via selective activation of mTOR DOI Creative Commons
Kai Chen,

Yuhan Zheng,

Ji‐an Wei

et al.

Science Advances, Journal Year: 2019, Volume and Issue: 5(7)

Published: July 3, 2019

Our ex vivo and in studies demonstrate a molecular pathway for exercise-induced learning enhancement.

Language: Английский

Citations

135
Gut Microbiota-Induced Changes in β-Hydroxybutyrate Metabolism Are Linked to Altered Sociability and Depression in Alcohol Use Disorder DOI Creative Commons
Sophie Leclercq, Tiphaine Le Roy,

Sonia Furgiuele

et al.

Cell Reports, Journal Year: 2020, Volume and Issue: 33(2), P. 108238 - 108238

Published: Oct. 1, 2020

Patients with alcohol use disorder (AUD) present important emotional, cognitive, and social impairments. The gut microbiota has been recently shown to regulate brain functions behavior but convincing evidence of its role in AUD is lacking. Here, we show that dysbiosis associated metabolic alterations affect behavioral (depression, sociability) neurobiological (myelination, neurotransmission, inflammation) processes involved addiction. By transplanting the from patients mice, point out production ethanol by specific bacterial genera reduction lipolysis are a lower hepatic synthesis β-hydroxybutyrate (BHB), which thereby prevents neuroprotective effect BHB. We confirm these results detoxified patients, observe persisting feces as well correlations among low plasma BHB levels impairments, depression, or white matter alterations.

Language: Английский

Citations

134