Serotonin regulation of mitochondria in kidney diseases DOI Creative Commons
Kevin Hurtado, Natalie E. Scholpa,

Jennifer G Schnellmann

et al.

Pharmacological Research, Journal Year: 2024, Volume and Issue: 203, P. 107154 - 107154

Published: March 22, 2024

Serotonin, while conventionally recognized as a neurotransmitter in the CNS, has recently gained attention for its role kidney. Specifically, serotonin is not only synthesized kidney, but it also regulates glomerular function, vascular resistance, and mitochondrial homeostasis. Because of serotonin's importance to health, this review focused on receptors function context acute kidney injury, chronic disease, diabetic all which are characterized by dysfunction none approved pharmacological treatments. Evidence indicates that activation certain can stimulate biogenesis (MB) restore homeostasis, resulting improved renal function. Serotonin receptor agonists induce MB therefore interest potential therapeutic strategies injury disease. Mitochondrial associated with many human diseases such increased morbidity mortality. Unfortunately, these pathologies an FDA-approved intervention, underscoring urgency identifying new therapeutics disorders. Studies show induction via (5-hydroxytryptamine, 5-HT) reduces markers, restores after decreases mortality, suggesting targeting 5-HT may be promising avenue diseases. While numerous reviews describe mitochondria quality control mechanisms relevance receptor-mediated metabolic modulation yet thoroughly explored.

Language: Английский

Neurotoxicity of methamphetamine: Main effects and mechanisms DOI
Subramaniam Jayanthi, Atul P. Daiwile, Jean Lud Cadet

et al.

Experimental Neurology, Journal Year: 2021, Volume and Issue: 344, P. 113795 - 113795

Published: June 26, 2021

Language: Английский

Citations

148
Heat shock protein 22 modulates NRF1/TFAM-dependent mitochondrial biogenesis and DRP1-sparked mitochondrial apoptosis through AMPK-PGC1α signaling pathway to alleviate the early brain injury of subarachnoid hemorrhage in rats DOI Creative Commons
Haiyan Fan, Rui Ding, Wenchao Liu

et al.

Redox Biology, Journal Year: 2021, Volume and Issue: 40, P. 101856 - 101856

Published: Jan. 10, 2021

Mitochondrial dysfunction has been widely accepted as a detrimental factor in subarachnoid hemorrhage (SAH)-induced early brain injury (EBI), which is eminently related to poor neurologic function outcome. Previous studies have revealed that enhancement of heat shock protein 22 (hsp22) under conditions stress friendly mediator mitochondrial homeostasis, oxidative and apoptosis, thus accelerating neurological recovery. However, no study confirmed whether hsp22 attenuates apoptosis the setting SAH-induced EBI. Our results indicated endogenous hsp22, p-AMPK/AMPK, PGC1α, TFAM, Nrf1 Drp1 were significantly upregulated cortical neurons response SAH, accompanied by impairment, edema, neuronal degeneration, lower level mtDNA ATP, mitochondria-cytosol translocation cytochrome c, caspase 3-involved apoptosis. exogenous maintained function, reduced improved these effects highly dependent on PGC1α-related biogenesis/fission, evidenced co-application PGC1α siRNA. Furthermore, we demonstrated blockade AMPK with dorsomorphin also compromised neuroprotective actions along alterations its associated pathway molecules. These data exerted salvaging an AMPK-PGC1α manner, modulates TFAM/Nrf1-induced biogenesis positive feedback DRP1-triggered negative feedback, further reducing injury. Boosting repressing excessive fission mitochondria may be efficient treatment relieve SAH-elicited

Language: Английский

Citations

116
Revitalizing Ancient Mitochondria with Nano‐Strategies: Mitochondria‐Remedying Nanodrugs Concentrate on Disease Control DOI

Xingyu Long,

Min Liu,

Yayun Nan

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(18)

Published: Jan. 15, 2024

Abstract Mitochondria, widely known as the energy factories of eukaryotic cells, have a myriad vital functions across diverse cellular processes. Dysfunctions within mitochondria serve catalysts for various diseases, prompting widespread demise. Mounting research on remedying damaged indicates that constitute valuable target therapeutic intervention against diseases. But less clinical practice and lower recovery rate imply limitation traditional drugs, which need further breakthrough. Nanotechnology has approached favorable regiospecific biodistribution high efficacy by capitalizing excellent nanomaterials targeting drug delivery. Mitochondria‐remedying nanodrugs achieved ideal effects. This review elucidates significance in cells organs, while also compiling mortality data related Correspondingly, nanodrug‐mediate strategies applicable mitochondria‐remedying disease are detailed, with full understanding roles dysfunction advantages nanodrugs. In addition, future challenges directions discussed. conclusion, this provides comprehensive insights into design development nanodrugs, aiming to help scientists who desire extend their fields engage interdisciplinary subject.

Language: Английский

Citations

29
T-2 toxin neurotoxicity: role of oxidative stress and mitochondrial dysfunction DOI
Chongshan Dai, Xilong Xiao, Feifei Sun

et al.

Archives of Toxicology, Journal Year: 2019, Volume and Issue: 93(11), P. 3041 - 3056

Published: Sept. 30, 2019

Language: Английский

Citations

131
Pivotal mental states DOI Creative Commons
Ari Brouwer, Robin Carhart‐Harris

Journal of Psychopharmacology, Journal Year: 2020, Volume and Issue: 35(4), P. 319 - 352

Published: Nov. 11, 2020

This paper introduces a new construct, the 'pivotal mental state', which is defined as hyper-plastic state aiding rapid and deep learning that can mediate psychological transformation. We believe this construct bears relevance to broad range of psychiatric phenomena. argue pivotal states serve an important evolutionary function, is, aid transformation when actual or perceived environmental pressures demand this. cite evidence chronic stress neurotic traits are primers for state, whereas acute be trigger. Inspired by research with serotonin 2A receptor agonist psychedelics, we highlight how activity at particular robustly reliably induce states, but capacity inherent property human brain itself. Moreover, hypothesize serotonergic psychedelics hijack system has evolved its need sensed. breadth evidences linking via variety inducers, upregulated (e.g. availability and/or binding receptor) 5-HT release, activate primed state. The model multi-level, specific molecular gateway (increased signaling) inception mind enhanced rate associative potential mediation

Language: Английский

Citations

114
Systemic effects of mitochondrial stress DOI Open Access
Raz Bar‐Ziv, Theodore Bolas, Andrew Dillin

et al.

EMBO Reports, Journal Year: 2020, Volume and Issue: 21(6)

Published: May 24, 2020

Language: Английский

Citations

71
Sensing, signaling and surviving mitochondrial stress DOI Creative Commons

Eva-Maria Eckl,

Olga Ziegemann,

Luisa Krumwiede

et al.

Cellular and Molecular Life Sciences, Journal Year: 2021, Volume and Issue: 78(16), P. 5925 - 5951

Published: July 6, 2021

Mitochondrial fidelity is a key determinant of longevity and was found to be perturbed in multitude disease contexts ranging from neurodegeneration heart failure. Tight homeostatic control the mitochondrial proteome crucial aspect function, which severely complicated by evolutionary origin resulting peculiarities organelle. This is, on one hand, reflected range basal quality factors such as mitochondria-resident chaperones proteases, that assist import folding precursors well removal aggregated proteins. On other stress causes activation several additional mechanisms counteract any damage may threaten function. Countermeasures depend location intensity are equipped sense signal nature encountered perturbation. Defective activates combat accumulation cytosol pore. To resolve proteotoxic organelle interior, mitochondria nuclear transcriptional programs, unfolded protein response integrated response. If too severe, for their own destruction process termed mitophagy, thereby preventing further harm network allowing cell salvage biological building blocks. Here, we provide an overview how different types intensities activate distinct pathways aimed at preserving fidelity.

Language: Английский

Citations

65
PGC-1s in the Spotlight with Parkinson’s Disease DOI Open Access
Elena Piccinin, Anna Maria Sardanelli,

Peter Seibel

et al.

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(7), P. 3487 - 3487

Published: March 28, 2021

Parkinson's disease is one of the most common neurodegenerative disorders worldwide, characterized by a progressive loss dopaminergic neurons mainly localized in substantia nigra pars compacta. In recent years, detailed analyses both genetic and idiopathic forms have led to better understanding molecular cellular pathways involved PD, pointing centrality mitochondrial dysfunctions pathogenic process. Failure quality control now considered hallmark disease. The peroxisome proliferator-activated receptor gamma coactivator 1 (PGC-1) family acts as master regulator biogenesis. Therefore, keeping PGC-1 level proper range fundamental guarantee functional neurons. Here we review major findings that tightly bond PD PGC-1s, raising important points might lead future investigations.

Language: Английский

Citations

64
The Effect of Combined Treatment of Psilocybin and Eugenol on Lipopolysaccharide-Induced Brain Inflammation in Mice DOI Creative Commons
Timur Zanikov, Marta Gerasymchuk,

Esmaeel Ghasemi Gojani

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(6), P. 2624 - 2624

Published: March 14, 2023

Inflammation is an organism's biological defense mechanism. Acute and chronic inflammation of the body triggers production pro- anti-inflammatory pathways that can affect content cytokines in brain thus cause inflammation. Disorders such as depression posttraumatic stress disorder (PTSD) are often associated with elevated Recently, positive promising clinical results psilocybin for treatment PTSD were reported. Thus, we decided to test whether alone or combination eugenol, antioxidant agent, would prevent increase decrease C57BL/6J mice injected lipopolysaccharides (LPS). Two experiments performed, one pre-treatment through gavage (0.88 mg/kg), eugenol (17.6 combinations (1:10, 1:20, 1:50), followed by intraperitoneal injection LPS, second, post-treatment, initial psilocybin, their combination. Brain tissues collected, analyzed qRT-PCR, Western blot, ELISA. Data a one-way ANOVA Tukey's post hoc multiple unpaired t-tests. LPS upregulated mRNA expression COX-2, TNF-α, IL-1β, IL-6. All pre-treatments decreased COX-2 1:50 combination, being most effective. In all effective reducing inflammation, ratio displaying prominent tested cytokines. blot analysis confirmed effect on IL-1β proteins. Finally, ELISA showed post-treatment + (1:50) demonstrated best results, decreasing markers including IL-6 IL-8. This demonstrates effects animals systemically induced

Language: Английский

Citations

28
Psychedelics for acquired brain injury: a review of molecular mechanisms and therapeutic potential DOI
Josh Allen, Shannon Dames, Claire J. Foldi

et al.

Molecular Psychiatry, Journal Year: 2024, Volume and Issue: 29(3), P. 671 - 685

Published: Jan. 4, 2024

Language: Английский

Citations

14