Cell Metabolism, Journal Year: 2023, Volume and Issue: 35(4), P. 555 - 570
Published: March 22, 2023
Language: Английский
Nature Neuroscience, Journal Year: 2021, Volume and Issue: 24(3), P. 312 - 325
Published: Feb. 15, 2021
Language: Английский
Citations
1673
Nature reviews. Neuroscience, Journal Year: 2020, Volume and Issue: 21(3), P. 139 - 152
Published: Feb. 10, 2020
Language: Английский
Citations
307
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: Feb. 9, 2024
Abstract Worldwide, the incidence of major depressive disorder (MDD) is increasing annually, resulting in greater economic and social burdens. Moreover, pathological mechanisms MDD underlying effects pharmacological treatments for are complex unclear, additional diagnostic therapeutic strategies still needed. The currently widely accepted theories pathogenesis include neurotransmitter receptor hypothesis, hypothalamic-pituitary-adrenal (HPA) axis cytokine neuroplasticity hypothesis systemic influence but these cannot completely explain mechanism MDD. Even it hard to adopt only one reveal MDD, thus recent years, great progress has been made elucidating roles multiple organ interactions identifying novel approaches multitarget modulatory strategies, further revealing disease features Furthermore, some newly discovered potential targets studied antidepressants have attracted widespread attention, reagents even approved clinical treatment methods such as phototherapy acupuncture effective improvement symptoms. In this work, we comprehensively summarize latest research on diagnosis preventive medicines, well related trials.
Language: Английский
Citations
259
Nature reviews. Neuroscience, Journal Year: 2020, Volume and Issue: 21(3), P. 121 - 138
Published: Feb. 10, 2020
Language: Английский
Citations
254
Nature Neuroscience, Journal Year: 2020, Volume and Issue: 23(10), P. 1229 - 1239
Published: Aug. 3, 2020
Language: Английский
Citations
230
Nature reviews. Neuroscience, Journal Year: 2020, Volume and Issue: 21(12), P. 682 - 694
Published: Oct. 12, 2020
Language: Английский
Citations
225
Brain Behavior and Immunity, Journal Year: 2020, Volume and Issue: 91, P. 740 - 755
Published: Oct. 8, 2020
Central nervous system (CNS) innate immunity plays essential roles in infections, neurodegenerative diseases, and brain or spinal cord injuries. Astrocytes microglia are the principal cells that mediate CNS. Pattern recognition receptors (PRRs), expressed by astrocytes microglia, sense pathogen-derived endogenous ligands released damaged initiate immune response. Toll-like (TLRs) a well-characterized family of PRRs. The contribution microglial TLR signaling to CNS pathology has been extensively investigated. Even though assume wide variety key functions, information about role astroglial TLRs disease injuries is limited. Because display heterogeneity exhibit phenotypic plasticity depending on effectors present local milieu, they can exert both detrimental beneficial effects. modulators these paradoxical properties. goal current review highlight played diseases. We discuss host defense as well dissemination viral bacterial infections examine link between pathogenesis diseases evidence showing pivotal influence sterile inflammation injury. Finally, we define research questions areas warrant further investigations context astrocytes, TLRs, dysfunction.
Language: Английский
Citations
219
Cell Reports, Journal Year: 2020, Volume and Issue: 32(11), P. 108132 - 108132
Published: Sept. 1, 2020
Gene and protein expression data provide useful resources for understanding brain function, but little is known about the lipid composition of brain. Here, we perform quantitative shotgun lipidomics, which enables a cell-type-resolved assessment mouse composition. We quantify around 700 species evaluate features including fatty acyl chain length, hydroxylation, number double bonds, thereby identifying cell-type- brain-region-specific profiles in adult mice, as well aged apolipoprotein-E-deficient model Alzheimer's disease, mice fed different diets. also integrate with to predict pathways enriched specific cell types, such acid β-oxidation astrocytes sphingolipid metabolism microglia. This resource complements existing atlases gene may be role lipids function.
Language: Английский
Citations
204
Frontiers in Immunology, Journal Year: 2019, Volume and Issue: 10
Published: July 24, 2019
Cellular and non-cellular components of the tumor microenvironment (TME) are emerging as key regulators primary progression, organ-specific metastasis, therapeutic response. In era TME-targeted- immunotherapies, cancer-associated inflammation has gained increasing attention. this regard, brain represents a unique highly specialized organ. It long been regarded an immunological sanctuary site where presence blood barrier (BBB) cerebrospinal fluid (BCB) restricts entry immune cells from periphery. Consequently, that metastasize to were thought be shielded systemic surveillance destruction. However, detailed characterization landscape within border-associated areas central nervous system (CNS), such meninges choroid plexus, well discovery lymphatics channels connect CNS with periphery, have recently challenged dogma privileged status brain. Moreover, metastases (BrM) disrupts integrity BBB BCB. Indeed, BrM induce recruitment different myeloid lymphoid lineage CNS. Blood-borne together brain-resident cell-types, astrocytes, microglia, neurons, form complex dynamic TME affects cell survival modulates mode responses elicited by metastatic cells. review, we will summarize recent findings on heterotypic interactions highlight specific functions recruited at rate-limiting steps cascade. Based insight studies, discuss new opportunities challenges for TME-targeted immunotherapies BrM.
Language: Английский
Citations
191
Neuroscience, Journal Year: 2020, Volume and Issue: 456, P. 71 - 84
Published: March 26, 2020
Language: Английский
Citations
186