Computational psychiatry as a bridge from neuroscience to clinical applications

Nature Neuroscience, Journal Year: 2016, Volume and Issue: 19(3), P. 404 - 413

Published: Feb. 23, 2016

Language: Английский

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Dopamine: Functions, Signaling, and Association with Neurological Diseases

Cellular and Molecular Neurobiology, Journal Year: 2018, Volume and Issue: 39(1), P. 31 - 59

Published: Nov. 16, 2018

Language: Английский

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The Nucleus Accumbens: Mechanisms of Addiction across Drug Classes Reflect the Importance of Glutamate Homeostasis

Pharmacological Reviews, Journal Year: 2016, Volume and Issue: 68(3), P. 816 - 871

Published: June 30, 2016

The nucleus accumbens is a major input structure of the basal ganglia and integrates information from cortical limbic structures to mediate goal-directed behaviors. Chronic exposure several classes drugs abuse disrupts plasticity in this region, allowing drug-associated cues engender pathologic motivation for drug seeking. A number alterations glutamatergic transmission occur within after withdrawal chronic exposure. These drug-induced neuroadaptations serve as molecular basis relapse vulnerability. In review, we focus on role that glutamate signal transduction plays addiction-related First, explore accumbens, including cell types neuronal populations present well afferent efferent connections. Next discuss rodent models addiction assess viability these testing candidate pharmacotherapies prevention relapse. Then provide review literature describing how synaptic altered also pharmacological manipulation systems can inhibit seeking laboratory setting. Finally, examine results clinical trials which designed manipulate have been effective treating human patients. Further elucidation alter will be necessary development new therapeutics treatment across all addictive substances.

Language: Английский

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The transition to compulsion in addiction

Nature reviews. Neuroscience, Journal Year: 2020, Volume and Issue: 21(5), P. 247 - 263

Published: March 30, 2020

Language: Английский

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Keep off the grass? Cannabis, cognition and addiction

Nature reviews. Neuroscience, Journal Year: 2016, Volume and Issue: 17(5), P. 293 - 306

Published: April 7, 2016

Language: Английский

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Gambling disorder

Nature Reviews Disease Primers, Journal Year: 2019, Volume and Issue: 5(1)

Published: July 25, 2019

Language: Английский

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Association of Stimulant Use With Dopaminergic Alterations in Users of Cocaine, Amphetamine, or Methamphetamine

JAMA Psychiatry, Journal Year: 2017, Volume and Issue: 74(5), P. 511 - 511

Published: March 15, 2017

Stimulant use disorder is common, affecting between 0.3% and 1.1% of the population, costs more than $85 billion per year globally. There are no licensed treatments to date. Several lines evidence implicate dopamine system in pathogenesis substance disorder. Therefore, understanding nature dysfunction seen stimulant users has potential aid development new therapeutics.To comprehensively review vivo imaging for dopaminergic alterations (cocaine, amphetamine, or methamphetamine) abuse dependence.The entire PubMed, EMBASE, PsycINFO databases were searched studies from inception date May 14, 2016.Case-control identified that compared measures healthy controls using positron emission tomography single-photon computed measure striatal synthesis release assess transporter availability receptor availability.Demographic, clinical, extracted each study, meta-analyses sensitivity analyses conducted stimulants combined, as well cocaine amphetamine methamphetamine separately if there sufficient studies.Differences measured (assessed change D2/D3 after administration methylphenidate), availability, users, controls.A total 31 519 512 included final analysis. In most studies, duration abstinence varied 5 days 3 weeks. was a significant decrease with controls: effect size -0.84 (95% CI, -1.08 -0.60; P < .001) combined -0.87 -1.15 cocaine. addition, availability: -0.91 -1.50 -0.32; .01) -1.47 -1.83 -1.10; methamphetamine. also -0.76 -0.92 -0.73 -0.94 -0.53; cocaine, -0.81 -1.12 -0.49; Consistent not found vesicular monoamine transporter, synthesis, D1 studies.Data suggest both presynaptic postsynaptic aspects striatum down-regulated users. The commonality differences these findings discrepancies preclinical literature models drug addiction discussed, their implications future development.

Language: Английский

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Time to connect: bringing social context into addiction neuroscience

Nature reviews. Neuroscience, Journal Year: 2016, Volume and Issue: 17(9), P. 592 - 599

Published: June 9, 2016

Language: Английский

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Cognitive deficits in individuals with methamphetamine use disorder: A meta-analysis

Addictive Behaviors, Journal Year: 2018, Volume and Issue: 80, P. 154 - 160

Published: Jan. 30, 2018

Language: Английский

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The Emergence of a Circuit Model for Addiction

Annual Review of Neuroscience, Journal Year: 2016, Volume and Issue: 39(1), P. 257 - 276

Published: May 5, 2016

Addiction is a disease of altered behavior. Addicts use drugs compulsively and will continue to do so despite negative consequences. Even after prolonged periods abstinence, addicts are at risk relapse, particularly when cues evoke memories that associated with drug use. Rodent models mimic many the core components addiction, from initial reinforcement cue-associated relapse continued intake have also enabled unprecedented mechanistic insight into revealing plasticity glutamatergic synaptic transmission evoked by strong activation mesolimbic dopamine—a defining feature all addictive drugs—as neural substrate for these drug-adaptive behaviors. Cell type–specific optogenetic manipulations allowed both identification relevant circuits design protocols reverse drug-evoked establish links causality The emergence circuit model addiction open door novel therapies, such as deep brain stimulation.

Language: Английский

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