Next-generation GRAB sensors for monitoring dopaminergic activity in vivo

Nature Methods, Journal Year: 2020, Volume and Issue: 17(11), P. 1156 - 1166

Published: Oct. 21, 2020

Language: Английский

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Neurotransmitters—Key Factors in Neurological and Neurodegenerative Disorders of the Central Nervous System

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(11), P. 5954 - 5954

Published: May 25, 2022

Neurotransmitters are molecules that amplify, transmit, and convert signals in cells, having an essential role information transmission throughout the nervous system. Hundreds of such chemicals have been discovered last century, continuing to be identified studied concerning their action on brain health. These substances observed influence numerous functions, including emotions, thoughts, memories, learning, movements. Thus, disturbances neurotransmitters' homeostasis started being correlated with a plethora neurological neurodegenerative disorders. In this respect, present paper aims describe most important neurotransmitters, broadly classified into canonical (e.g., amino acids, monoamines, acetylcholine, purines, soluble gases, neuropeptides) noncanonical neurotransmitters exosomes, steroids, D-aspartic acid), explain link some relevant conditions. Moreover, brief overview recently developed detection methods is offered, followed by several considerations modulation these towards restoring homeostasis.

Language: Английский

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Dopamine in Parkinson's disease

Clinica Chimica Acta, Journal Year: 2021, Volume and Issue: 522, P. 114 - 126

Published: Aug. 11, 2021

Language: Английский

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An Optical/Photoacoustic Dual-Modality Probe: Ratiometric in/ex Vivo Imaging for Stimulated H₂S Upregulation in Mice

Journal of the American Chemical Society, Journal Year: 2019, Volume and Issue: 141(45), P. 17973 - 17977

Published: Oct. 28, 2019

Tracking signaling H2S in live mice demands responsive imaging with fine tissue depth and low interferences from scattering/autofluorescence probe concentration. With complementary advantages of fluorescence photoacoustic (PA) imaging, optical/PA dual-modality was suggested for in/ex vivo imaging. Therefore, a meso-benzoyloxyltricarboheptamethine cyanine, HS-CyBz, prepared as the first ratiometric H2S, profiting keto–enol transition sensing mechanism. Tail intravenous injection this leads to accumulation liver mice, endogenous upregulation triggered by S-adenosyl-l-methionine has been verified suggesting promising potential

Language: Английский

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Electrochemical Biosensing of Dopamine Neurotransmitter: A Review

Biosensors, Journal Year: 2021, Volume and Issue: 11(6), P. 179 - 179

Published: June 3, 2021

Neurotransmitters are biochemical molecules that transmit a signal from neuron across the synapse to target cell, thus being essential function of central and peripheral nervous system. Dopamine is one most important catecholamine neurotransmitters since it involved in many functions human system, including motor control, reward, or reinforcement. It utmost importance quantify amount dopamine abnormal levels can cause variety medical behavioral problems. For instance, Parkinson’s disease partially caused by death dopamine-secreting neurons. To date, various methods have been developed measure levels, electrochemical biosensing seems be viable due its robustness, selectivity, sensitivity, possibility achieve real-time measurements. Even if detection not facile presence electroactive interfering species with similar redox potentials real biological samples, numerous strategies employed resolve this issue. The objective paper review materials (metals metal oxides, carbon materials, polymers) frequently used for point out their respective advantages drawbacks. Different types biosensors, (micro)electrodes, platforms, field-effect transistors, also described.

Language: Английский

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Emerging porous organic polymers for biomedical applications

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(4), P. 1377 - 1414

Published: Jan. 1, 2022

This review summarizes and discusses the recent progress in porous organic polymers for diverse biomedical applications such as drug delivery, biomacromolecule immobilization, phototherapy, biosensing, bioimaging, antibacterial applications.

Language: Английский

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Brain Neurotransmitter Modulation by Gut Microbiota in Anxiety and Depression

Frontiers in Cell and Developmental Biology, Journal Year: 2021, Volume and Issue: 9

Published: March 11, 2021

Anxiety and depression are highly prevalent mental illnesses worldwide have long been thought to be closely associated neurotransmitter modulation. There is growing evidence indicating that changes in the composition of gut microbiota related health including anxiety depression. In this review, we focus on combining intestinal with serotonergic, dopaminergic, noradrenergic neurotransmission brain, special emphasis anxiety- depression-like behaviors stress-related rodent models. Therefore, reviewed studies conducted germ-free rodents, or animals subjected absence using antibiotics, as well via usage probiotics. All results strongly support brain modulation by indispensable physiopathology However, a lot work needed determine how mediated human has any physiological significance and, if any, it can used therapy. Overall, provides novel way alter treat gut–brain axis diseases, such

Language: Английский

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Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia

Molecular Neurodegeneration, Journal Year: 2022, Volume and Issue: 17(1)

Published: June 17, 2022

A consequence of our progressively ageing global population is the increasing prevalence worldwide age-related cognitive decline and dementia. In absence effective therapeutic interventions, identifying risk factors associated with becomes increasingly vital. Novel perspectives suggest that a dynamic bidirectional communication system between gut, its microbiome, central nervous system, commonly referred to as microbiota-gut-brain axis, may be contributing factor for health disease. However, exact mechanisms remain undefined. Microbial-derived metabolites produced in gut can cross intestinal epithelial barrier, enter systemic circulation trigger physiological responses both directly indirectly affecting functions. Dysregulation this (i.e., dysbiosis) modulate cytotoxic metabolite production, promote neuroinflammation negatively impact cognition. review, we explore critical connections microbial-derived (secondary bile acids, trimethylamine-N-oxide (TMAO), tryptophan derivatives others) their influence upon function neurodegenerative disorders, particular interest less-explored role decline.

Language: Английский

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Comorbidity between major depressive disorder and physical diseases: a comprehensive review of epidemiology, mechanisms and management

World Psychiatry, Journal Year: 2023, Volume and Issue: 22(3), P. 366 - 387

Published: Sept. 15, 2023

Populations with common physical diseases – such as cardiovascular diseases, cancer and neurodegenerative disorders experience substantially higher rates of major depressive disorder (MDD) than the general population. On other hand, people living MDD have a greater risk for many diseases. This high level comorbidity is associated worse outcomes, reduced adherence to treatment, increased mortality, health care utilization costs. Comorbidity can also result in range clinical challenges, more complicated therapeutic alliance, issues pertaining adaptive behaviors, drug‐drug interactions adverse events induced by medications used mental disorders. Potential explanations prevalence above involve shared genetic biological pathways. These latter include inflammation, gut microbiome, mitochondrial function energy metabolism, hypothalamic‐pituitary‐adrenal axis dysregulation, brain structure function. Furthermore, several antecedents related social factors (e.g., socioeconomic status), lifestyle variables activity, diet, sleep), stressful live childhood trauma). Pharmacotherapies psychotherapies are effective treatments comorbid MDD, introduction interventions well collaborative models digital technologies provide promising strategies improving management. paper aims detailed overview epidemiology specific including bidirectional risk; pathways potentially implicated pathogenesis diseases; socio‐environmental that serve both protective factors; management prevention treatment. We conclude future directions emerging research optimal

Language: Английский

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A critical review on the bio-mediated green synthesis and multiple applications of magnesium oxide nanoparticles

Chemosphere, Journal Year: 2022, Volume and Issue: 312, P. 137301 - 137301

Published: Nov. 18, 2022

Language: Английский

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