Functional
diversity
of
midbrain
dopamine
(DA)
neurons
ranges
across
multiple
scales,
from
differences
in
intrinsic
properties
and
connectivity
to
selective
task
engagement
behaving
animals.
Distinct
vitro
biophysical
features
DA
have
been
associated
with
different
axonal
projection
targets.
However,
it
is
unknown
how
this
translates
firing
patterns
projection-defined
subpopulations
the
intact
brain.
We
combined
retrograde
tracing
single-unit
recording
labelling
mouse
brain
create
an
vivo
functional
topography
system.
identified
burst
among
projecting
dorsolateral
striatum.
Bursting
also
differentiated
medial
substantia
nigra
(SN)
either
dorsal
or
ventral
found
mean
rates
pause
durations
tegmental
area
(VTA)
lateral
shell
nucleus
accumbens.
Our
data
establishes
a
high-resolution
landscape
neurons.
Journal of Neuroscience,
Journal Year:
2016,
Volume and Issue:
36(45), P. 11469 - 11481
Published: Nov. 9, 2016
Signals
of
energy
homeostasis
interact
closely
with
neural
circuits
motivation
to
control
food
intake.
An
emerging
hypothesis
is
that
the
transition
maladaptive
feeding
behavior
seen
in
eating
disorders
or
obesity
may
arise
from
dysregulation
these
interactions.
Focusing
on
key
brain
regions
involved
intake
(ventral
tegmental
area,
striatum,
hypothalamus,
and
thalamus),
we
describe
how
activity
specific
cell
types
embedded
within
can
influence
distinct
components
motivated
behavior.
We
review
signals
behavioral
output
present
evidence
experience-dependent
adaptations
represent
cellular
correlates
impaired
control.
Future
research
into
mechanisms
restore
balance
between
inspire
new
treatment
options
for
obesity.
