The obesity-breast cancer link: a multidisciplinary perspective

Cancer and Metastasis Reviews, Journal Year: 2022, Volume and Issue: 41(3), P. 607 - 625

Published: June 25, 2022

Abstract Obesity, exceptionally prevalent in the USA, promotes incidence and progression of numerous cancer types including breast cancer. Complex, interacting metabolic immune dysregulation marks development both obesity. Obesity chronic low-grade inflammation, particularly white adipose tissue, which drives dysfunction marked by increased pro-inflammatory cytokine production, alternative macrophage activation, reduced T cell function. Breast tissue is predominantly composed adipose, developing readily directly interacts with cells signals from remodeled This review discusses biological mechanisms through obesity cancer, role health disparities, dietary interventions to mitigate adverse effects on We detail intersection an emphasis shared unique patterns these disease processes. have highlighted key areas biology exacerbated obesity, incidence, progression, therapeutic response. posit that interception obesity-driven will require limit protumor signaling obese consider genetic, structural, social determinants obesity–breast link. Finally, we evidence for various offset clinical preclinical studies In light strong associations between rising rates many parts world, effective, safe, well-tolerated, equitable burden are urgently needed.

Language: Английский

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Circadian disruption and sleep disorders in neurodegeneration

Translational Neurodegeneration, Journal Year: 2023, Volume and Issue: 12(1)

Published: Feb. 13, 2023

Abstract Disruptions of circadian rhythms and sleep cycles are common among neurodegenerative diseases can occur at multiple levels. Accumulating evidence reveals a bidirectional relationship between disruptions diseases. Circadian disruption disorders aggravate neurodegeneration in turn disrupt sleep. Importantly, various increase the risk Thus, harnessing biology findings from preclinical translational research is importance for reducing improving symptoms quality life individuals with via approaches that normalize context precision medicine. In this review, we discuss implications by summarizing both human animal studies, focusing on links prevalent forms neurodegeneration. These provide valuable insights into pathogenesis suggest promising role circadian-based interventions.

Language: Английский

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Breast cancer: pathogenesis and treatments

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: Feb. 18, 2025

Abstract Breast cancer, characterized by unique epidemiological patterns and significant heterogeneity, remains one of the leading causes malignancy-related deaths in women. The increasingly nuanced molecular subtypes breast cancer have enhanced comprehension precision treatment this disease. mechanisms tumorigenesis progression been central to scientific research, with investigations spanning various perspectives such as tumor stemness, intra-tumoral microbiota, circadian rhythms. Technological advancements, particularly those integrated artificial intelligence, significantly improved accuracy detection diagnosis. emergence novel therapeutic concepts drugs represents a paradigm shift towards personalized medicine. Evidence suggests that optimal diagnosis models tailored individual patient risk expected are crucial, supporting era oncology for cancer. Despite rapid advancements increasing emphasis on clinical comprehensive update summary panoramic knowledge related disease needed. In review, we provide thorough overview global status including its epidemiology, factors, pathophysiology, subtyping. Additionally, elaborate latest research into contributing progression, emerging strategies, long-term management. This review offers valuable insights Cancer Research, thereby facilitating future progress both basic application.

Language: Английский

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Chronotherapy: Circadian Rhythms and Their Influence in Cancer Therapy

Cancers, Journal Year: 2022, Volume and Issue: 14(20), P. 5071 - 5071

Published: Oct. 17, 2022

Living organisms present rhythmic fluctuations every 24 h in their behavior and metabolism to anticipate changes the environment. These are controlled by a very complex molecular mechanism, circadian clock, that regulates expression of multiple genes ensure right functioning body. An individual’s system is altered during aging, this related numerous age-associated pathologies other alterations could contribute development cancer. Nowadays, there an increasing interest understanding how rhythms be used treatment Chronotherapy aims understand impact biological have on response therapy optimize its action, maximize health benefits minimize possible adverse effects. Clinical trials so far confirmed optimal timing with chemo or immunotherapies decrease drug toxicity increase efficacy. Instead, chronoradiotherapy seems treatment-related symptoms rather than tumor progression patient survival. In addition, potential therapeutic targets within clock also been identified. Therefore, results application chronotherapy cancer until now challenging, feasible, applied clinical practice improve without additional costs. However, different limitations variables such as age, sex, chronotypes, among others, should overcome before can really put into practice.

Language: Английский

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Clinical applications of plasma proteomics and peptidomics: Towards precision medicine

PROTEOMICS - CLINICAL APPLICATIONS, Journal Year: 2022, Volume and Issue: 16(6)

Published: May 1, 2022

In the context of precision medicine, disease treatment requires individualized strategies based on underlying molecular characteristics to overcome therapeutic challenges posed by heterogeneity. For this purpose, it is essential develop new biomarkers diagnose, stratify, or possibly prevent diseases. Plasma an available source that greatly reflects physiological and pathological conditions body. An increasing number studies are focusing proteins peptides, including many involving Human Proteome Project (HPP) Organization (HUPO), proteomics peptidomics techniques emerging as critical tools for developing novel medicine preventative measures. Excitingly, plasma toolbox exhibits a huge potential studying pathogenesis diseases (e.g., COVID-19 cancer), identifying valuable improving clinical management. However, enormous complexity wide dynamic range makes proteome profiling challenging. Herein, we summarize recent advances in with focus their roles cancer research, aiming emphasize significance applications medicine.

Language: Английский

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Effects of exercise on circadian rhythms in humans

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: Oct. 11, 2023

The biological clock system is an intrinsic timekeeping device that integrates internal physiology and external cues. Maintaining a healthy crucial for life. Disruptions to the body’s can lead disturbances in sleep-wake cycle abnormalities hormone regulation, blood pressure, heart rate, other vital processes. Long-term have been linked development of various common major diseases, including cardiovascular metabolic disorders, tumors, neuropsychiatric conditions, so on. External factors, such as diurnal rhythm light, significant impact on clock. Additionally, important non-photic zeitgeber, exercise regulate rhythms certain extent, making it possible become non-drug intervention preventing treating circadian disorders. This comprehensive review encompasses behavioral, physiological, molecular perspectives provide deeper understanding how influences its association with related diseases.

Language: Английский

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Circadian biology to advance therapeutics for mood disorders

Trends in Pharmacological Sciences, Journal Year: 2023, Volume and Issue: 44(10), P. 689 - 704

Published: Aug. 28, 2023

Mood disorders account for a significant global disease burden, and pharmacological innovation is needed as existing medications are suboptimal. A wide range of evidence implicates circadian sleep dysfunction in the pathogenesis mood disorders, there growing interest these chronobiological pathways focus treatment innovation. We review contemporary three promising areas circadian-clock-based therapeutics disorders: targeting system informed by mechanistic molecular advances; time-tailoring medications; personalizing using parameters. also consider limitations challenges accelerating development new circadian-informed pharmacotherapies disorders.

Language: Английский

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Melatonin Can Modulate Neurodegenerative Diseases by Regulating Endoplasmic Reticulum Stress

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 2381 - 2381

Published: Jan. 25, 2023

As people age, their risks of developing degenerative diseases such as cancer, diabetes, Parkinson’s Disease (PD), Alzheimer’s (AD), rheumatoid arthritis, and osteoporosis are generally increasing. Millions worldwide suffer from these they age. In most countries, neurodegenerative recognized the number one cause afflicting elderly. Endoplasmic reticulum (ER) stress has been suggested to be associated with some human neurological diseases, PD AD. Melatonin, a neuroendocrine hormone mainly synthesized in pineal gland, is involved pleiotropically biological functions, including control circadian rhythm, immune enhancement, antioxidant, anti-aging, anti-tumor effects. Although there many papers on prevention or suppression by melatonin, very few about effects melatonin ER neurons diseases. This paper aims summarize present reported so far, focusing its related stress. Studies have shown that primary target molecule for CHOP, PERK GRP78/BiP secondary molecules. Therefore, crucial protecting treating neurodegeneration against

Language: Английский

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Protein modification and degradation in ferroptosis

Redox Biology, Journal Year: 2024, Volume and Issue: 75, P. 103259 - 103259

Published: June 27, 2024

Ferroptosis is a form of iron-related oxidative cell death governed by an integrated redox system, encompassing pro-oxidative proteins and antioxidative proteins. These undergo precise control through diverse post-translational modifications, including ubiquitination, phosphorylation, acetylation, O-GlcNAcylation, SUMOylation, methylation, N-myristoylation, palmitoylation, modification. modifications play pivotal roles in regulating protein stability, activity, localization, interactions, ultimately influencing both the buildup iron lipid peroxidation. In mammalian cells, regulators ferroptosis typically degradation via two principal pathways: ubiquitin-proteasome which handles majority degradation, autophagy, primarily targeting long-lived or aggregated This comprehensive review aims to summarize recent advances modification linked ferroptosis. It also discusses strategies for modulating systems, providing new insights into potential therapeutic applications cancer non-neoplastic diseases.

Language: Английский

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The Relationship between Circadian Rhythm and Cancer Disease

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5846 - 5846

Published: May 28, 2024

The circadian clock regulates biological cycles across species and is crucial for physiological activities biochemical reactions, including cancer onset development. interplay between the rhythm involves regulating cell division, DNA repair, immune function, hormonal balance, potential chronotherapy. This highlights importance of maintaining a healthy prevention treatment. article investigates complex relationship cancer, exploring how disruptions to internal may contribute tumorigenesis influence progression. Numerous databases are utilized conduct searches articles, such as NCBI, MEDLINE, Scopus. keywords used throughout academic archives “circadian rhythm”, ”cancer”, ”circadian clock”. Maintaining cycle prioritizing sleep habits minimizing disruptions, consistent schedules, reduced artificial light exposure, meal timing adjustments. Dysregulation gene can cause tumor growth, leading need regulate better treatment outcomes. components significantly impact cellular responses damage, influencing Understanding rhythm’s role in diseases their therapeutic targets essential treating preventing cancer. Disruptions promote abnormal development metastasis, potentially due system imbalances fluctuations.

Language: Английский

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