Neuroscience, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Diagnostics, Journal Year: 2025, Volume and Issue: 15(3), P. 327 - 327
Published: Jan. 30, 2025
Wearable devices have gained increasing attention for use in multifunctional applications related to health monitoring, particularly research of the circadian rhythms cognitive functions and metabolic processes. In this comprehensive review, we encompass how wearables can be used study disease. We highlight importance these as markers well-being potential predictors outcomes. focus on wearable technologies sleep research, medicine, chronomedicine beyond domain emphasize actigraphy a validated tool monitoring sleep, activity, light exposure. discuss various mathematical methods currently analyze actigraphic data, such parametric non-parametric approaches, linear, non-linear, neural network-based applied quantify non-circadian variability. also introduce novel actigraphy-derived markers, which personalized proxies status, assisting discriminating between disease, offering insights into neurobehavioral status. lifestyle factors physical activity exposure modulate brain health. establishing reference standards measures further refine data interpretation improve clinical The review calls existing tools methods, deepen our understanding health, develop healthcare strategies.
Language: Английский
Citations
4
Frontiers in Neurology, Journal Year: 2023, Volume and Issue: 14
Published: Dec. 6, 2023
In the realm of Alzheimer's disease, most prevalent form dementia, impact environmental factors has ignited intense curiosity due to its substantial burden on global health. Recent investigations have unveiled these as key contributors, shedding new light their profound influence. Notably, emerging evidence highlights detrimental role various contaminants in incidence and progression disease. These encompass a broad spectrum, including air pollutants laden with ozone, neurotoxic metals like lead, aluminum, manganese, cadmium, pesticides insidious effects, ubiquitous presence plastics microplastics. By meticulously delving into intricate web connecting this devastating neurological disorder, comprehensive chapter takes deep dive involvement significant risk for Furthermore, it explores underlying molecular mechanisms through which exert influence, aiming unravel complex interactions that drive pathogenesis Additionally, proposes potential strategies mitigate effects brain health, ultimate goal restoring preserving typical cognitive function. Through exploration, we aim enhance our understanding multifaceted relationship between neurotoxins providing solid foundation developing innovative in-vivo models advancing knowledge pathological processes debilitating condition.
Language: Английский
Citations
31
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7530 - 7530
Published: July 9, 2024
Aging is a multifaceted process influenced by hereditary factors, lifestyle, and environmental elements. As time progresses, the human body experiences degenerative changes in major functions. The external internal signs of aging manifest various ways, including skin dryness, wrinkles, musculoskeletal disorders, cardiovascular diseases, diabetes, neurodegenerative cancer. Additionally, cancer, like aging, complex disease that arises from accumulation genetic epigenetic alterations. Circadian clock dysregulation has recently been identified as an important risk factor for cancer development. Natural compounds herbal medicines have gained significant attention their potential preventing age-related diseases inhibiting progression. These demonstrate antioxidant, anti-inflammatory, anti-proliferative, pro-apoptotic, anti-metastatic, anti-angiogenic effects well circadian regulation. This review explores cancers, specific natural targeting key features these conditions.
Language: Английский
Citations
11
Translational Psychiatry, Journal Year: 2025, Volume and Issue: 15(1)
Published: March 21, 2025
The circadian rhythm system consists of a master clock located in the suprachiasmatic nucleus (SCN) hypothalamus and peripheral clocks dispersed throughout other brain areas (including striatum, Str) as well various tissues organs. Circadian disturbance is major risk factor common comorbidity for mood disorders, especially anxiety depression. Bmal1 one fundamental protein genes that required to maintain rhythm. Recent research has revealed link between dysfunction depression, but underlying mechanisms remain be fully elucidated. This study aimed investigate how may lead anxiety- depression-like behaviors. Through behavioral tests, virus tracing, molecular biology techniques, we found neural connection from striatum. SCN lesions Bmal1flox/flox + pAAV-hSyn-Cre-GFP (conditional knockout, cKO) mice exhibited disruptions core body temperature rhythm, Importantly, these displayed altered expression patterns an upregulation Brain-Derived Neurotrophic Factor (BDNF) - Tyrosine Kinase receptor B (TrkB) signaling pathway within Microinjection TrkB inhibitor ANA-12 can effectively reverse These findings indicate contribute pathogenesis depression through BDNF-TrkB potentially mediated by projections SCN. gene represent novel therapeutic target disorders.
Language: Английский
Citations
2
Brain Sciences, Journal Year: 2023, Volume and Issue: 13(8), P. 1202 - 1202
Published: Aug. 14, 2023
Parkinson’s disease (PD) is a common multidimensional neurological disorder characterized by motor and non-motor features more prevalent in the elderly. Sleep disorders cognitive disturbances are also significant characteristics of PD. an important physiological process for normal human cognition physical functioning. deprivation negatively impacts physical, mental, behavioral functions. include problems falling asleep, occurring during sleep, abnormal movements insufficient excessive sleep. The most recognizable known sleep disorders, such as rapid-eye-movement behavior (RBD), insomnia, daytime sleepiness (EDS), restless legs syndrome (RLS), sleep-related breathing (SRBDs), circadian-rhythm-related sleep–wake (CRSWDs), have been associated with RBD emotional symptoms In individuals, impairment prognostic factors predicting progressing neurodegeneration developing dementia conditions Studies focused on its changes functional deficits PD patients. Other risks, decline, anxiety, depression, related to RBD. Sleep-disorder diagnosis challenging, especially identifying essential that disturb cycle co-existence other concomitant issues, symptoms, disorders. Focusing patterns their disturbances, including genetic neurochemical changes, helps us better understand central causes alterations functions Relations between α-synuclein aggregation brain gender differences reported. existing correlation levels cerebrospinal fluid indicates risk progression synucleinopathies. Multidirectional approaches required correlate neuropsychiatric diagnose sensitive biomarkers neurodegeneration. evaluation pattern may aid development novel effective treatments
Language: Английский
Citations
24
Neuroscience Bulletin, Journal Year: 2023, Volume and Issue: 40(4), P. 500 - 516
Published: Sept. 27, 2023
Parkinson's disease (PD) is a complicated neurodegenerative disease, characterized by the accumulation of α-synuclein (α-syn) in Lewy bodies and neurites, massive loss midbrain dopamine neurons. Increasing evidence suggests that gut microbiota microbial metabolites are involved development PD. Among these, short-chain fatty acids (SCFAs), most abundant metabolites, have been proven to play key role brain-gut communication. In this review, we analyze SCFAs pathology PD from multiple dimensions summarize alterations patients as well their correlation with motor non-motor symptoms. Future research should focus on further elucidating neuroinflammation, developing novel strategies employing derivatives treat
Language: Английский
Citations
24
Neuropharmacology, Journal Year: 2024, Volume and Issue: 246, P. 109834 - 109834
Published: Jan. 3, 2024
Language: Английский
Citations
7
Maturitas, Journal Year: 2025, Volume and Issue: unknown, P. 108254 - 108254
Published: March 1, 2025
Language: Английский
Citations
1
Science Signaling, Journal Year: 2025, Volume and Issue: 18(881)
Published: April 8, 2025
Sleep loss dysregulates cellular metabolism and energy homeostasis. Highly metabolically active cells, such as neurons, enter a catabolic state during periods of sleep loss, which consequently disrupts physiological functioning. Specific to the central nervous system, results in impaired synaptogenesis long-term memory, effects that are also characteristic neurodegenerative diseases. In this review, we describe how deprivation increases resting expenditure, leading development negative balance—a with insufficient metabolic resources support expenditure—in highly cells like neurons. This disruption energetic homeostasis alters balance metabolites, including adenosine, lactate, lipid peroxides, energetically costly processes, synapse formation, attenuated. During shunt away from those processes not acutely essential, memory cell survival. Ultimately, these findings characterize disorder.
Language: Английский
Citations
1
Sleep Medicine, Journal Year: 2025, Volume and Issue: 131, P. 106528 - 106528
Published: April 21, 2025
Language: Английский
Citations
1