The role of RNA modifications in hepatocellular carcinoma: functional mechanism and potential applications DOI Creative Commons

Jin‐Xiu Liu,

Xiaoping Zhang, Wenhua Xu

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 20, 2024

Hepatocellular carcinoma (HCC) is a highly aggressive cancer with poor prognosis. The molecular mechanisms underlying its development remain unclear. Recent studies have highlighted the crucial role of RNA modifications in HCC progression, which indicates their potential as therapeutic targets and biomarkers for managing HCC. In this review, we discuss functional through review summary relevant literature, to explore agents diagnostic prognostic This that specific modification pathways, such N6-methyladenosine, 5-methylcytosine, N7-methylguanosine, N1-methyladenosine, are erroneously regulated involved proliferation, autophagy, innate immunity, invasion, metastasis, immune cell infiltration, drug resistance These findings provide new perspective understanding HCC, well diagnosis treatment by targeting RNA-modifying enzymes or recognition proteins. More than ten regulators showed use diagnosis, prognosis decision utility Their application value necessitates extensive multi-center sample validation future. A growing number modifier inhibitors being developed, but lack preclinical experiments clinical poses significant obstacle, further research needed evaluate treatment. conclusion, provides an in-depth complex interplay between while emphasizing promising

Language: Английский

The emerging importance role of m6A modification in liver disease DOI Open Access

Sheng Wang,

Songsen Gao,

Wufei Ye

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 162, P. 114669 - 114669

Published: April 8, 2023

N6-methyladenosine (m6A) modification, as one of the most common types inner RNA modification in eukaryotes, plays a multifunctional role normal and abnormal biological processes. This type is modulated by m6A writer, eraser reader, which turn impact various processes metabolism, such processing, translation, nuclear export, localization decay. The current academic view holds that exerts crucial post-transcriptional modulation gene expression, involved multiple cellular functions, developmental disease However, potential molecular mechanism specific development liver have not been fully elucidated. In our review, we summarized latest research progress on disease, explored how these novel findings reshape knowledge metabolism. addition, also illustrated effect regeneration to prompt further exploration physiology pathology, providing new insights references for search therapeutic targets disease.

Language: Английский

Citations

30
Crosstalk between extracellular vesicles and tumor-associated macrophage in the tumor microenvironment DOI
Qiao Yi Chen, Beibei Gao,

Dongdong Tong

et al.

Cancer Letters, Journal Year: 2022, Volume and Issue: 552, P. 215979 - 215979

Published: Oct. 26, 2022

Language: Английский

Citations

35
Decoding Roles of Exosomal lncRNAs in Tumor-Immune Regulation and Therapeutic Potential DOI Open Access
Wen-Qin Zhang, Yuanliang Yan, Jinwu Peng

et al.

Cancers, Journal Year: 2022, Volume and Issue: 15(1), P. 286 - 286

Published: Dec. 31, 2022

Exosomes are nanovesicles secreted into biofluids by various cell types and have been implicated in different physiological pathological processes. Interestingly, a plethora of studies emphasized the mediating role exosomes bidirectional communication between donor recipient cells. Among cargoes exosomes, long non-coding RNAs (lncRNAs) identified as crucial regulators cancer cells immune tumor microenvironment (TME) that can interfere with innate adaptive responses to affect therapeutic efficiency. Recently, few major focused on exosomal lncRNA-mediated interaction infiltrated TME. Nevertheless, dearth pertains regulating lncRNAs is still early stages. Comprehensive mechanisms immunity not well understood. Herein, we provide an overview immunomodulatory function treatment resistance. In addition, also summarize potential strategies toward

Language: Английский

Citations

31
LncRNA A2M-AS1 Promotes Ferroptosis in Pancreatic Cancer via Interacting With PCBP3 DOI Open Access
Xin Qiu, Qiuyue Shi,

Xianglian Zhang

et al.

Molecular Cancer Research, Journal Year: 2022, Volume and Issue: 20(11), P. 1636 - 1645

Published: Aug. 3, 2022

Abstract Ferroptosis is a newly-discovered cell death mechanism involved in the progression of various tumors, role noncoding RNAs (ncRNAs) it was relatively less explored. This study identified low levels recently studied long RNA (lncRNA), A2M-AS1, pancreatic cancer and suggested its positive correlation with overall survival time patients cancer. A2M-AS1 mainly localized cytoplasm, inhibiting cellular proliferation, migration, invasion as well tumor growth cells. Moreover, Erastin-induced ferroptosis increased expression A2M-AS1. The overexpression promoted cancer, which inhibited by silencing Mechanically, could directly interact poly (rC) binding protein 3 (PCBP3), plays an important process iron metabolism, thereby promoting In addition, A2M-AS1/PCBP3 axis facilitate p38 activation inhibit phosphorylation AKT–mTOR signaling pathway; all these participate regulating ferroptosis. conclusion, regulation targeting might provide novel target for treatment future. Implications: be potential therapeutic

Language: Английский

Citations

28
Crosstalk between m6A modification and non-coding RNAs in HCC DOI

Zitong Qiu,

Xingxing Yuan, Xinyue Wang

et al.

Cellular Signalling, Journal Year: 2024, Volume and Issue: 117, P. 111076 - 111076

Published: Feb. 2, 2024

Language: Английский

Citations

6
N6-methyladenosine RNA methylation in liver diseases: from mechanism to treatment DOI

Lan Yang,

Siyuan Tian,

Xiaohong Zheng

et al.

Journal of Gastroenterology, Journal Year: 2023, Volume and Issue: 58(8), P. 718 - 733

Published: June 28, 2023

Language: Английский

Citations

15
Role of exosomes in the development of the immune microenvironment in hepatocellular carcinoma DOI Creative Commons

Tanghua Li,

Jiapeng Jiao,

Haoteng Ke

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: June 29, 2023

Despite numerous improved treatment methods used in recent years, hepatocellular carcinoma (HCC) is still a disease with high mortality rate. Many studies have shown that immunotherapy has great potential for cancer treatment. Exosomes play significant role negatively regulating the immune system HCC. Understanding how these exosomes innate and adaptive immunity HCC can significantly improve immunotherapeutic effects on Further, engineered deliver different drugs RNA molecules to regulate microenvironment of by aforementioned pathway, thereby improving rate This study aimed declare development list could be clinical transformation therapy. These findings might beneficial patients.

Language: Английский

Citations

14
Unveiling the Yin-Yang Balance of M1 and M2 Macrophages in Hepatocellular Carcinoma: Role of Exosomes in Tumor Microenvironment and Immune Modulation DOI Creative Commons
Stavros P. Papadakos, Nikolaos Machairas, Ioanna Ε. Stergiou

et al.

Cells, Journal Year: 2023, Volume and Issue: 12(16), P. 2036 - 2036

Published: Aug. 10, 2023

Hepatocellular carcinoma (HCC) is a primary liver cancer with high mortality rate and limited treatment options. Recent research has brought attention to the significant importance of intercellular communication in progression HCC, wherein exosomes have been identified as critical agents facilitating cell-to-cell signaling. In this article, we investigate impact macrophages both sources targets shedding light on intricate interplay between exosome-mediated macrophage involvement HCC pathogenesis. It investigates how derived from cells other cell types within tumor microenvironment (TME) can influence behavior, polarization, recruitment. Furthermore, section explores reciprocal interactions macrophage-derived cells, stromal immune elucidating their role growth, angiogenesis, metastasis, evasion. The findings presented here contribute better understanding offer new avenues for targeted interventions improved patient outcomes.

Language: Английский

Citations

13
Exosomes target HBV-host interactions to remodel the hepatic immune microenvironment DOI Creative Commons
Xiaojing Wu, Junqi Niu, Ying Shi

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: June 5, 2024

Chronic hepatitis B poses a significant global burden, modulating immune cells, leading to chronic inflammation and long-term damage. Due its hepatotropism, the virus (HBV) cannot infect other cells. The mechanisms underlying intercellular communication among different liver cells in HBV-infected individuals microenvironment imbalance remain elusive. Exosomes, as important cargo transportation tools between hepatocytes have been shown assist HBV regulate microenvironment. However, role of exosomes has only gradually received attention recent years. Minimal literature systematically elaborated on reshaping liver. This review unfolds sequentially based biological processes exosomes: exosomes' biogenesis, release, transport, uptake by recipient their impact We delineate how influences biogenesis exosomes, utilizing exosomal covert transmission, reshapes hepatic And characteristics functions potential applications are summarized predicted.

Language: Английский

Citations

5
The role of RNA modification in hepatocellular carcinoma DOI Creative Commons
Qiang Feng, Dongxu Wang,

Tianyi Xue

et al.

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: Sept. 2, 2022

Hepatocellular carcinoma (HCC) is a highly mortal type of primary liver cancer. Abnormal epigenetic modifications are present in HCC, and RNA modification dynamic reversible key post-transcriptional regulator. With the in-depth study modifications, aberrantly expressed human cancers. Moreover, regulators can be used as potential targets for cancer therapy. In N6-methyladenosine (m6A), N7-methylguanosine (m7G), 5-methylcytosine (m5C) their have important regulatory roles HCC progression represent novel biomarkers confirmation diagnosis treatment HCC. This review focuses on mechanisms m6A, m7G, m5C, N1-methyladenosine (m1A), N3-methylcytosine (m3C), pseudouridine (ψ) its development maintenance. The therapeutic strategies elaborated

Language: Английский

Citations

20