Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Авг. 20, 2024
Hepatocellular
carcinoma
(HCC)
is
a
highly
aggressive
cancer
with
poor
prognosis.
The
molecular
mechanisms
underlying
its
development
remain
unclear.
Recent
studies
have
highlighted
the
crucial
role
of
RNA
modifications
in
HCC
progression,
which
indicates
their
potential
as
therapeutic
targets
and
biomarkers
for
managing
HCC.
In
this
review,
we
discuss
functional
through
review
summary
relevant
literature,
to
explore
agents
diagnostic
prognostic
This
that
specific
modification
pathways,
such
N6-methyladenosine,
5-methylcytosine,
N7-methylguanosine,
N1-methyladenosine,
are
erroneously
regulated
involved
proliferation,
autophagy,
innate
immunity,
invasion,
metastasis,
immune
cell
infiltration,
drug
resistance
These
findings
provide
new
perspective
understanding
HCC,
well
diagnosis
treatment
by
targeting
RNA-modifying
enzymes
or
recognition
proteins.
More
than
ten
regulators
showed
use
diagnosis,
prognosis
decision
utility
Their
application
value
necessitates
extensive
multi-center
sample
validation
future.
A
growing
number
modifier
inhibitors
being
developed,
but
lack
preclinical
experiments
clinical
poses
significant
obstacle,
further
research
needed
evaluate
treatment.
conclusion,
provides
an
in-depth
complex
interplay
between
while
emphasizing
promising
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
162, С. 114669 - 114669
Опубликована: Апрель 8, 2023
N6-methyladenosine
(m6A)
modification,
as
one
of
the
most
common
types
inner
RNA
modification
in
eukaryotes,
plays
a
multifunctional
role
normal
and
abnormal
biological
processes.
This
type
is
modulated
by
m6A
writer,
eraser
reader,
which
turn
impact
various
processes
metabolism,
such
processing,
translation,
nuclear
export,
localization
decay.
The
current
academic
view
holds
that
exerts
crucial
post-transcriptional
modulation
gene
expression,
involved
multiple
cellular
functions,
developmental
disease
However,
potential
molecular
mechanism
specific
development
liver
have
not
been
fully
elucidated.
In
our
review,
we
summarized
latest
research
progress
on
disease,
explored
how
these
novel
findings
reshape
knowledge
metabolism.
addition,
also
illustrated
effect
regeneration
to
prompt
further
exploration
physiology
pathology,
providing
new
insights
references
for
search
therapeutic
targets
disease.
Cancers,
Год журнала:
2022,
Номер
15(1), С. 286 - 286
Опубликована: Дек. 31, 2022
Exosomes
are
nanovesicles
secreted
into
biofluids
by
various
cell
types
and
have
been
implicated
in
different
physiological
pathological
processes.
Interestingly,
a
plethora
of
studies
emphasized
the
mediating
role
exosomes
bidirectional
communication
between
donor
recipient
cells.
Among
cargoes
exosomes,
long
non-coding
RNAs
(lncRNAs)
identified
as
crucial
regulators
cancer
cells
immune
tumor
microenvironment
(TME)
that
can
interfere
with
innate
adaptive
responses
to
affect
therapeutic
efficiency.
Recently,
few
major
focused
on
exosomal
lncRNA-mediated
interaction
infiltrated
TME.
Nevertheless,
dearth
pertains
regulating
lncRNAs
is
still
early
stages.
Comprehensive
mechanisms
immunity
not
well
understood.
Herein,
we
provide
an
overview
immunomodulatory
function
treatment
resistance.
In
addition,
also
summarize
potential
strategies
toward
Molecular Cancer Research,
Год журнала:
2022,
Номер
20(11), С. 1636 - 1645
Опубликована: Авг. 3, 2022
Abstract
Ferroptosis
is
a
newly-discovered
cell
death
mechanism
involved
in
the
progression
of
various
tumors,
role
noncoding
RNAs
(ncRNAs)
it
was
relatively
less
explored.
This
study
identified
low
levels
recently
studied
long
RNA
(lncRNA),
A2M-AS1,
pancreatic
cancer
and
suggested
its
positive
correlation
with
overall
survival
time
patients
cancer.
A2M-AS1
mainly
localized
cytoplasm,
inhibiting
cellular
proliferation,
migration,
invasion
as
well
tumor
growth
cells.
Moreover,
Erastin-induced
ferroptosis
increased
expression
A2M-AS1.
The
overexpression
promoted
cancer,
which
inhibited
by
silencing
Mechanically,
could
directly
interact
poly
(rC)
binding
protein
3
(PCBP3),
plays
an
important
process
iron
metabolism,
thereby
promoting
In
addition,
A2M-AS1/PCBP3
axis
facilitate
p38
activation
inhibit
phosphorylation
AKT–mTOR
signaling
pathway;
all
these
participate
regulating
ferroptosis.
conclusion,
regulation
targeting
might
provide
novel
target
for
treatment
future.
Implications:
be
potential
therapeutic
Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Июнь 29, 2023
Despite
numerous
improved
treatment
methods
used
in
recent
years,
hepatocellular
carcinoma
(HCC)
is
still
a
disease
with
high
mortality
rate.
Many
studies
have
shown
that
immunotherapy
has
great
potential
for
cancer
treatment.
Exosomes
play
significant
role
negatively
regulating
the
immune
system
HCC.
Understanding
how
these
exosomes
innate
and
adaptive
immunity
HCC
can
significantly
improve
immunotherapeutic
effects
on
Further,
engineered
deliver
different
drugs
RNA
molecules
to
regulate
microenvironment
of
by
aforementioned
pathway,
thereby
improving
rate
This
study
aimed
declare
development
list
could
be
clinical
transformation
therapy.
These
findings
might
beneficial
patients.
Cells,
Год журнала:
2023,
Номер
12(16), С. 2036 - 2036
Опубликована: Авг. 10, 2023
Hepatocellular
carcinoma
(HCC)
is
a
primary
liver
cancer
with
high
mortality
rate
and
limited
treatment
options.
Recent
research
has
brought
attention
to
the
significant
importance
of
intercellular
communication
in
progression
HCC,
wherein
exosomes
have
been
identified
as
critical
agents
facilitating
cell-to-cell
signaling.
In
this
article,
we
investigate
impact
macrophages
both
sources
targets
shedding
light
on
intricate
interplay
between
exosome-mediated
macrophage
involvement
HCC
pathogenesis.
It
investigates
how
derived
from
cells
other
cell
types
within
tumor
microenvironment
(TME)
can
influence
behavior,
polarization,
recruitment.
Furthermore,
section
explores
reciprocal
interactions
macrophage-derived
cells,
stromal
immune
elucidating
their
role
growth,
angiogenesis,
metastasis,
evasion.
The
findings
presented
here
contribute
better
understanding
offer
new
avenues
for
targeted
interventions
improved
patient
outcomes.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Июнь 5, 2024
Chronic
hepatitis
B
poses
a
significant
global
burden,
modulating
immune
cells,
leading
to
chronic
inflammation
and
long-term
damage.
Due
its
hepatotropism,
the
virus
(HBV)
cannot
infect
other
cells.
The
mechanisms
underlying
intercellular
communication
among
different
liver
cells
in
HBV-infected
individuals
microenvironment
imbalance
remain
elusive.
Exosomes,
as
important
cargo
transportation
tools
between
hepatocytes
have
been
shown
assist
HBV
regulate
microenvironment.
However,
role
of
exosomes
has
only
gradually
received
attention
recent
years.
Minimal
literature
systematically
elaborated
on
reshaping
liver.
This
review
unfolds
sequentially
based
biological
processes
exosomes:
exosomes'
biogenesis,
release,
transport,
uptake
by
recipient
their
impact
We
delineate
how
influences
biogenesis
exosomes,
utilizing
exosomal
covert
transmission,
reshapes
hepatic
And
characteristics
functions
potential
applications
are
summarized
predicted.
Frontiers in Pharmacology,
Год журнала:
2022,
Номер
13
Опубликована: Сен. 2, 2022
Hepatocellular
carcinoma
(HCC)
is
a
highly
mortal
type
of
primary
liver
cancer.
Abnormal
epigenetic
modifications
are
present
in
HCC,
and
RNA
modification
dynamic
reversible
key
post-transcriptional
regulator.
With
the
in-depth
study
modifications,
aberrantly
expressed
human
cancers.
Moreover,
regulators
can
be
used
as
potential
targets
for
cancer
therapy.
In
N6-methyladenosine
(m6A),
N7-methylguanosine
(m7G),
5-methylcytosine
(m5C)
their
have
important
regulatory
roles
HCC
progression
represent
novel
biomarkers
confirmation
diagnosis
treatment
HCC.
This
review
focuses
on
mechanisms
m6A,
m7G,
m5C,
N1-methyladenosine
(m1A),
N3-methylcytosine
(m3C),
pseudouridine
(ψ)
its
development
maintenance.
The
therapeutic
strategies
elaborated
