Photodynamic and Photothermal Therapies: Synergy Opportunities for Nanomedicine

ACS Nano, Journal Year: 2023, Volume and Issue: 17(9), P. 7979 - 8003

Published: April 27, 2023

Tumoricidal photodynamic (PDT) and photothermal (PTT) therapies harness light to eliminate cancer cells with spatiotemporal precision by either generating reactive oxygen species or increasing temperature. Great strides have been made in understanding biological effects of PDT PTT at the cellular, vascular tumor microenvironmental levels, as well translating both modalities clinic. Emerging evidence suggests that may synergize due their different mechanisms action, nonoverlapping toxicity profiles make such combination potentially efficacious. Moreover, PDT/PTT combinations gained momentum recent years development multimodal nanoplatforms simultaneously incorporate photodynamically- photothermally active agents. In this review, we discuss how combining can address limitations each modality alone enhance treatment safety efficacy. We provide an overview literature featuring dual nanoparticles analyze strengths various nanoparticle design strategies. also detail sequence dose affect cellular states, pathophysiology drug delivery, ultimately shaping response. Lastly, common experimental pitfalls complicate preclinical assessment propose rational guidelines elucidate underlying interactions.

Language: Английский

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Pt Decorated Ti₃C₂T_x MXene with NIR-II Light Amplified Nanozyme Catalytic Activity for Efficient Phototheranostics

ACS Nano, Journal Year: 2022, Volume and Issue: 16(2), P. 3105 - 3118

Published: Jan. 18, 2022

The clinical application of photothermal therapy (PTT) is severely limited by the tissue penetration depth excitation light, and enzyme hampered its low therapeutic efficiency. As a two-dimensional ultrathin nanosheet with high absorbance in near-infrared-II (NIR-II) region, titanium carbide (Ti3C2) can be used as substrate to anchor functional components, like nanozymes nanodrugs. Here, we decorate Pt artificial on Ti3C2 nanosheets synthesize Ti-based MXene nanocomposites (Ti3C2Tx-Pt-PEG). In tumor microenvironment, nanoparticles exhibit peroxidase-like (POD-like) activity, which situ catalyze hydrogen peroxide generate hydroxyl radicals (•OH) induce cell apoptosis necrosis. Meanwhile, composite shows desirable effect upon NIR-II light irradiation power density (0.75 W cm-2). Especially, POD-like activity significantly enhanced elevated temperature arising from Ti3C2Tx. Therefore, satisfactory synergistic PTT/enzyme has been accomplished, accompanied an applicable photoacoustic imaging capability monitor guide process. This work may provide approach for hyperthermia-amplified nanozyme catalytic therapy, especially based metal catalysts nanocomposites.

Language: Английский

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Nanotechnology for Boosting Cancer Immunotherapy and Remodeling Tumor Microenvironment: The Horizons in Cancer Treatment

ACS Nano, Journal Year: 2021, Volume and Issue: 15(8), P. 12567 - 12603

Published: Aug. 2, 2021

Immunotherapy that harnesses the human immune system to fight cancer has received widespread attention and become a mainstream strategy for treatment. Cancer immunotherapy not only eliminates primary tumors but also treats metastasis recurrence, representing major advantage over traditional treatments. Recently with development of nanotechnology, there exists much work applying nanomaterials on basis their excellent physiochemical properties, such as efficient tissue-specific delivery function, huge specific surface area, controllable chemistry. Consequently, nanotechnology holds significant potential in improving efficacy immunotherapy. Nanotechnology-based mainly manifests its inhibitory effect via two different approaches: one is produce an effective anti-tumor response during tumorigenesis, other enhance tumor defense ability by modulating suppression mechanism microenvironment. With success immunotherapy, understanding interaction between smart nanomedicine provided vigorous vitality This review highlights application, progress, prospect process immunoediting discusses several engineering methods improve efficiency

Language: Английский

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Chemistry, Functionalization, and Applications of Recent Monoelemental Two-Dimensional Materials and Their Heterostructures

Chemical Reviews, Journal Year: 2021, Volume and Issue: 122(1), P. 1127 - 1207

Published: Nov. 15, 2021

The past decades have witnessed a rapid expansion in investigations of two-dimensional (2D) monoelemental materials (Xenes), which are promising various fields, including applications optoelectronic devices, biomedicine, catalysis, and energy storage. Apart from graphene phosphorene, recently emerging 2D Xenes, specifically graphdiyne, borophene, arsenene, antimonene, bismuthene, tellurene, attracted considerable interest due to their unique optical, electrical, catalytic properties, endowing them broader range intriguing applications. In this review, the structures properties these Xenes summarized based on theoretical experimental results. synthetic approaches for fabrication, mainly bottom-up top-down, presented. Surface modification strategies also shown. wide nonlinear optical optoelectronics, application further discussed. Finally, review concludes with an assessment current status, description existing scientific challenges, discussion possible directions advance fertile field.

Language: Английский

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Defect engineering in nanozymes

Materials Today, Journal Year: 2021, Volume and Issue: 52, P. 327 - 347

Published: Nov. 29, 2021

Language: Английский

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Copper Doped Carbon Dots for Addressing Bacterial Biofilm Formation, Wound Infection, and Tooth Staining

ACS Nano, Journal Year: 2022, Volume and Issue: 16(6), P. 9479 - 9497

Published: June 17, 2022

Oral infectious diseases and tooth staining, the main challenges of dental healthcare, are inextricably linked to microbial colonization formation pathogenic biofilms. However, dentistry has so far still lacked simple, safe, universal prophylactic options therapy. Here, we report copper-doped carbon dots (Cu-CDs) that display enhanced catalytic (catalase-like, peroxidase-like) activity in oral environment for inhibiting initial bacteria (Streptococcus mutans) adhesion subsequent biofilm eradication without impacting surrounding tissues via oxygen (O2) reactive species (ROS) generation. Especially, Cu-CDs exhibit strong affinity lipopolysaccharides (LPS) peptidoglycans (PGN), thus conferring them with excellent antibacterial ability against Gram-positive (Staphylococcus aureus) Gram-negative (Escherichia coli), such they can prevent wound purulent infection promoting rapid healing. Additionally, Cu-CDs/H2O2 system shows a better performance whitening, compared results obtained other alternatives, e.g., CDs clinically used H2O2, particularly its negligible enamel dentin destruction. It is anticipated biocompatible presented this work promising nano-mouthwash eliminating biofilms, prompting healing as well highlighting their significance health management.

Language: Английский

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MXenes and MXene-based materials for tissue engineering and regenerative medicine: recent advances

Materials Advances, Journal Year: 2021, Volume and Issue: 2(9), P. 2906 - 2917

Published: Jan. 1, 2021

Tissue engineering and regenerative medicine applications of MXenes are described along with present challenges future perspectives.

Language: Английский

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Multi-enzyme activity nanozymes for biosensing and disease treatment

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 473, P. 214784 - 214784

Published: Sept. 13, 2022

Language: Английский

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Recent and emerging applications of Graphene-based metamaterials in electromagnetics

Materials & Design, Journal Year: 2022, Volume and Issue: 221, P. 110920 - 110920

Published: July 7, 2022

Surface Plasmon Polaritons (SPPs) operating in mid-infrared up to terahertz (THz) frequencies have been traditionally manufactured on expensive metals such as gold, silver, etc. However, poor surface confinement that limits the optical applications of SPPs. The invention graphene is a breakthrough plasmon-based devices terms design, fabrication and applications, thanks its plasmonic wave distribution, low-cost prototyping inherent reconfigurability. In addition, recent advancements metamaterials metasurfaces led elimination past constraints regular devices, opening new door THz applications. This paper provides an operational perspective advanced graphene-based electromagnetic with focus enabled antennas, absorbers sensors, analyzing strengths limitations various design methodologies.

Language: Английский

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Boosting Checkpoint Immunotherapy with Biomaterials

ACS Nano, Journal Year: 2023, Volume and Issue: 17(4), P. 3225 - 3258

Published: Feb. 6, 2023

The immune checkpoint blockade (ICB) therapy has revolutionized the field of cancer treatment, while low response rates and systemic toxicity limit its clinical outcomes. With rapid advances in nanotechnology materials science, various types biomaterials have been developed to maximize therapeutic efficacy minimizing side effects by increasing tumor antigenicity, reversing immunosuppressive microenvironment, amplifying antitumor response, reducing extratumoral distribution inhibitors as well enhancing their retention within target sites. In this review, we reviewed current design strategies for different augment ICB effectively then discussed present representative biomaterial-assisted modulation targeted delivery boost therapy. Current challenges future development prospects expanding with were also summarized. We anticipate review will be helpful developing emerging promoting application

Language: Английский

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