Rashba exciton in a 2D perovskite quantum dot DOI
Michael W. Swift, John L. Lyons, Alexander L. Efros

et al.

Nanoscale, Journal Year: 2021, Volume and Issue: 13(39), P. 16769 - 16780

Published: Jan. 1, 2021

The Rashba effect has been proposed to give rise a bright exciton ground state in halide perovskite nanocrystals (NCs), resulting very fast radiative recombination at room temperature and extremely low temperature. In this paper we find the dispersion of "Rashba exciton", i.e., whose bulk reflects large spin-orbit terms conduction valence bands thus minima non-zero quasi-momenta. Placing excitonsin quasi-2D cylindrical quantum dots, calculate size-dependent levels confined excitons their oscillator transition strengths. We consider implications model for two-dimensional hybrid organic-inorganic perovskites, discuss generalizations 3D NCs, establish criteria under which could be realized.

Language: Английский

Peripheral arterial rather than venous blood is a better source of circulating tumor cells in early lung cancer DOI Creative Commons
Zhendan Wang, Yifei Feng,

Y Wang

et al.

Thoracic Cancer, Journal Year: 2024, Volume and Issue: 15(8), P. 654 - 660

Published: Jan. 31, 2024

Abstract Background Circulating tumor cells (CTCs) play a crucial role in the early diagnosis and prognosis of lung cancer. Identification more suitable sample source could be breakthrough towards enhancing CTC detectability early‐stage We investigated differences detectable CTCs between peripheral arterial venous blood early‐ mid‐stage cancer patients undergoing surgery analyzed association clinicopathological factors blood. Methods Peripheral was collected 5‐mL samples from 56 with surgically resected pathologically clear at or Blood specimens were enriched for based on isolation by size epithelial cells. The identified using Swiss Giemsa staining immunohistochemistry CD45/CD31. Results In stage I cancer, CTC‐positive rate significantly higher than (45.45% vs. 17.39%). There no significant difference number A low degree differentiation associated high positive circulating microemboli >3 cm compared ≤3 cm. Conclusion levels differed little patients.Compared to blood, had positivity cancer.This study favorable detection monitoring

Language: Английский

Citations

3

Near-infrared diffuse in vivo flow cytometry DOI Creative Commons
Joshua Pace, Fernando Ivich,

Eric Marple

et al.

Journal of Biomedical Optics, Journal Year: 2022, Volume and Issue: 27(09)

Published: Sept. 16, 2022

SignificanceDiffuse in vivo flow cytometry (DiFC) is an emerging technique for enumerating rare fluorescently labeled circulating cells noninvasively the bloodstream. Thus far, we have reported red and blue-green versions of DiFC. Use near-infrared (NIR) fluorescent light would principle allow use DiFC deeper tissues be compatible with NIR fluorescence molecular contrast agents.AimWe describe design a NIR-DiFC instrument demonstrate its optical phantoms vitro mice vivo.ApproachWe developed improved fiber probe efficient collection from individual rejection autofluorescence. We built instrument. tested this microspheres cell lines OTL38 agent phantom model. also nude injected intravenously OTL38-labeled L1210A cells.ResultsNIR-DiFC allowed detection tumor (CTCs) mean signal-to-noise ratios (SNRs) 19 to 32 dB. In mice, CTCs were detectable SNR 26 exhibited orders significantly lower autofluorescence false-alarm rates than DiFC.ConclusionsNIR-DiFC allows agents. Our work could pave way future humans.

Language: Английский

Citations

15

Advanced flow cytometry for biomedical applications DOI
Kai Pang, Sihan Dong, Yuxi Zhu

et al.

Journal of Biophotonics, Journal Year: 2023, Volume and Issue: 16(9)

Published: June 2, 2023

Abstract Flow cytometry (FC) is a versatile tool with excellent capabilities to detect and measure multiple characteristics of population cells or particles. Notable advancements in vivo photoacoustic FC, coherent Raman microfluidic so on, have been achieved the last two decades, which endows FC new functions expands its applications basic research clinical practice. Advanced broadens tools available researchers conduct involving cancer detection, microbiology (COVID‐19, HIV, bacteria, etc.), nucleic acid analysis. This review presents an overall picture advanced flow cytometers provides not only clear understanding their mechanisms but also insights into practical applications. We identify latest trends this area aim raise awareness techniques FC. hope accelerates translation.

Language: Английский

Citations

9

Prospects for Fluorescence Molecular In Vivo Liquid Biopsy of Circulating Tumor Cells in Humans DOI Creative Commons
Mark Niedre

Frontiers in Photonics, Journal Year: 2022, Volume and Issue: 3

Published: May 9, 2022

Our team recently developed “Diffuse in vivo Flow Cytometry” (DiFC) for detection and enumeration rare circulating tumor cells (CTCs) mice with highly-scattered fluorescent light. We have used DiFC to study dissemination of CTCs a number mouse models metastasis protein expressing cells. Because uses diffuse light interrogates large blood vessels relatively deep tissue, principle it could be translated larger limbs, species, even humans clinically. In this perspective, we discuss the technical challenges human translation context current state technology, as well potential strategies labeling targeted molecular probes. also advantages disadvantages clinical tool. principle, represent powerful complementary technique (to liquid biopsy draws) accurate sensitive measurement changes CTC numbers over time.

Language: Английский

Citations

13

Rashba exciton in a 2D perovskite quantum dot DOI
Michael W. Swift, John L. Lyons, Alexander L. Efros

et al.

Nanoscale, Journal Year: 2021, Volume and Issue: 13(39), P. 16769 - 16780

Published: Jan. 1, 2021

The Rashba effect has been proposed to give rise a bright exciton ground state in halide perovskite nanocrystals (NCs), resulting very fast radiative recombination at room temperature and extremely low temperature. In this paper we find the dispersion of "Rashba exciton", i.e., whose bulk reflects large spin-orbit terms conduction valence bands thus minima non-zero quasi-momenta. Placing excitonsin quasi-2D cylindrical quantum dots, calculate size-dependent levels confined excitons their oscillator transition strengths. We consider implications model for two-dimensional hybrid organic-inorganic perovskites, discuss generalizations 3D NCs, establish criteria under which could be realized.

Language: Английский

Citations

16