Microsystems & Nanoengineering,
Journal Year:
2025,
Volume and Issue:
11(1)
Published: March 10, 2025
Hypertrophic
scar
(HS)
is
a
plaque
fibrous
and
indurated
dermal
lesion
that
may
cause
physical,
psychological,
cosmetic
challenges
for
patients.
Intralesional
injection
of
triamcinolone
acetonide
(TA)
commonly
used
in
clinical
practice,
which
unbearable
pain
uneven
drug
delivery
within
HS
tissue.
Herein,
we
developed
paper
battery
powered
iontophoresis-driven
microneedles
patch
(PBIMNP)
self-management
HS.
The
high
integration
PBIMNP
was
achieved
by
incorporating
as
the
power
source
iontophoresis.
transdermal
strategy
combined
iontophoresis
techniques,
involving
"pressing
poking,
phase
transformation,
diffusion
iontophoresis",
can
actively
deliver
90.19%
into
tissue
with
excellent
vitro
permeation
performance.
administration
effectively
reduced
mRNA
protein
levels,
leading
to
decrease
expression
TGF-β1
Col
I
associated
formation,
demonstrating
its
efficacy
treatment.
wearable
design
endow
highly
promising
platform
self-administration
on
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
36(11)
Published: Dec. 20, 2023
Abstract
Effective
treatment
of
deep‐seated
tumors
relies
on
enhanced
drug
penetration
in
transdermal
delivery
systems.
While
microneedles
(MNs)
and
iontophoresis
techniques
have
shown
improved
efficiency,
challenges
such
as
skin
elasticity,
high
electrical
resistance
the
stratum
corneum,
external
power
supply
requirements
hinder
their
efficacy
treating
tumors.
In
this
study,
a
wearable,
self‐powered
MN
patch
that
integrates
flexible
triboelectric
nanogenerator
(F‐TENG)
is
presented,
aimed
at
advancing
tumor
therapy.
MNs
are
composed
water‐soluble
materials
mixed
with
negatively
charged
pH‐responsive
nanoparticles
(NPs)
loaded
therapeutic
drugs.
The
F‐TENG
harnesses
personal
mechanical
movements
generate
energy.
Leveraging
advantages
both
F‐TENG,
NPs
can
penetrate
deep
locations
upon
insertion,
releasing
drugs
rapidly
acidic
tissues.
Owing
to
these
features,
single
administration
integrated
MN‐patch
mouse
model
melanoma
exhibits
superior
inhibiting
deep‐located
compared
using
alone,
indicating
promising
potential
for
sites.
Molecular Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 15, 2025
Microneedles
(MNs)
are
emerging
as
versatile
tools
for
both
therapeutic
drug
delivery
and
diagnostic
monitoring.
Unlike
hypodermic
needles,
MNs
achieve
these
applications
with
minimal
or
no
pain
customizable
designs,
making
them
suitable
personalized
medicine.
Understanding
the
key
design
parameters
challenges
during
contact
biofluids
is
crucial
to
optimizing
their
use
across
applications.
This
review
summarizes
current
fabrication
techniques
considerations
tailored
meet
distinct
requirements
biosensing
We
further
underscore
state
of
theranostic
that
integrate
propose
future
directions
advancing
toward
clinical
use.
International Journal of Pharmaceutics X,
Journal Year:
2025,
Volume and Issue:
9, P. 100317 - 100317
Published: Feb. 10, 2025
The
conventional
oral
administration
of
pioglitazone
for
Type
II
diabetes
management
is
frequently
compromised
by
hepatic
first-pass
metabolism
and
associated
systemic
adverse
effects,
necessitating
the
development
enhanced
transdermal
delivery
approaches.
This
study
developed
a
drug
system
combining
conductive
hydrogel
microneedles
iontophoresis
to
improve
hydrochloride
(PIO)
its
therapeutic
efficacy
in
treatment
type
diabetes.
microneedles,
fabricated
using
poly(methyl
vinyl
ether-alt-maleic
anhydride)
as
main
matrix
material,
exhibited
excellent
conductivity,
mechanical
strength,
high
loading
capacity.
In
vitro
permeation
experiments
demonstrated
that,
when
combined
with
at
current
intensity
0.5
mA,
cumulative
PIO
reached
238.1
±
27.14
μg/cm2
within
48
h,
significantly
higher
than
that
microneedle
group
alone.
diabetic
rat
model,
microneedle-iontophoresis
displayed
better
hypoglycemic
effect
group,
blood
glucose
reduction
6.3
mmol/L
on
day
8,
5.1
positive
control
group.
Pharmacokinetic
analysis
indicated
Tmax,
T1/2,
mean
residence
time
were
longer
those
administration,
indicating
sustained-release
characteristics.
Skin
irritation
tests
revealed
caused
only
mild,
transient
skin
irritation,
complete
recovery
24
h.
conclusion,
can
effectively
enhance
delivery,
bioavailability,
while
also
exhibiting
good
safety
potential
clinical
application
value.
Advanced Drug Delivery Reviews,
Journal Year:
2024,
Volume and Issue:
208, P. 115292 - 115292
Published: March 24, 2024
Vaccination
is
one
of
the
most
successful
measures
in
modern
medicine
to
combat
diseases,
especially
infectious
and
saves
millions
lives
every
year.
Vaccine
design
development
remains
critical
involves
many
aspects,
including
choice
platform,
antigen,
adjuvant,
route
administration.
Topical
vaccination,
defined
herein
as
introduction
a
vaccine
any
three
layers
human
skin,
has
attracted
interest
recent
years
an
alternative
vaccination
approach
conventional
intramuscular
administration
because
its
potential
be
needle-free
induce
superior
immune
response
against
pathogens.
In
this
review,
we
describe
progress
developing
topical
vaccines,
highlight
delivery
technologies
for
discuss
factors
that
might
impact
efficacy,
provide
overview
current
clinical
landscape
vaccines.
Small Science,
Journal Year:
2024,
Volume and Issue:
4(7)
Published: May 18, 2024
Rapid
technological
advancements
have
transformed
the
healthcare
sector
from
traditional
diagnosis
and
treatment
to
personalized
health
management.
Biofluids
such
as
teardrops,
sweat,
interstitial
fluids,
exhaled
breath
condensate
offer
a
rich
source
of
metabolites
that
can
be
linked
physiological
status
an
individual.
More
importantly,
these
biofluids
contain
biomarkers
similar
those
in
blood.
Therefore,
developing
sensors
for
noninvasive
determination
biofluid‐based
overcome
traditionally
invasive
laborious
blood‐test‐based
diagnostics.
In
this
context,
wearable
devices
real‐time
continuous
conditions
activity
monitoring.
The
first‐generation
wearables
included
wristwatches
capable
tracking
heart
rate
variations,
breathing
rate,
body
temperature,
stress
responses,
sleeping
patterns.
However,
accurately
measure
are
needed
achieve
analysis
biomarkers.
review,
recent
progresses
utilized
monitor
condensate,
fluids
thoroughly
analyzed.
how
selectively
detected,
quantified,
monitored
is
discussed.
Furthermore,
review
includes
discussion
on
utility
of,
multifunctional
combine
metabolite
sensing,
human
monitoring,
on‐demand
drug
delivery
system
theranostic
applications.
