The Importance of Metabolism for Immune Homeostasis in Allergic Diseases DOI Creative Commons
Juan Rodríguez‐Coira, Alma Villaseñor, Elena Izquierdo

et al.

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12

Published: July 28, 2021

There is increasing evidence that the metabolic status of T cells and macrophages associated with severe phenotypes chronic inflammation, including allergic inflammation. Metabolic changes in immune have a crucial role their inflammatory or regulatory responses. This notion reinforced by diseases influencing global energy metabolism, such as diabetes obesity, which are known risk factors severity conditions, due to metabolic-associated inflammation present these patients. Since several pathways closely tied cell macrophage differentiation, better understanding alterations disorders could help restore modulate functions. link between metabolism can be studied employing animal, human cellular models. Analytical approaches rank from classic immunological studies integrated analysis metabolomics, transcriptomics, proteomics. review summarizes main involved reaction focus on describes different models platforms used study system its relationship metabolism.

Language: Английский

Macrophages in immunoregulation and therapeutics DOI Creative Commons
Shanze Chen, Abdullah F. U. H. Saeed, Quan Liu

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: May 22, 2023

Abstract Macrophages exist in various tissues, several body cavities, and around mucosal surfaces are a vital part of the innate immune system for host defense against many pathogens cancers. possess binary M1/M2 macrophage polarization settings, which perform central role an array tasks via intrinsic signal cascades and, therefore, must be precisely regulated. Many crucial questions about signaling modulation yet to uncovered. In addition, clinical importance tumor-associated macrophages is becoming more widely recognized as significant progress has been made understanding their biology. Moreover, they integral tumor microenvironment, playing regulation wide variety processes including angiogenesis, extracellular matrix transformation, cancer cell proliferation, metastasis, immunosuppression, resistance chemotherapeutic checkpoint blockade immunotherapies. Herein, we discuss signaling, mechanical stresses modulation, metabolic pathways, mitochondrial transcriptional, epigenetic regulation. Furthermore, have broadly extended traps essential roles autophagy aging regulating functions. discussed recent advances macrophages-mediated autoimmune diseases tumorigenesis. Lastly, targeted therapy portray prospective targets therapeutic strategies health diseases.

Language: Английский

Citations

792
Metabolism of tissue macrophages in homeostasis and pathology DOI Creative Commons
Stefanie K. Wculek, Gillian Dunphy, Ignacio Heras‐Murillo

et al.

Cellular and Molecular Immunology, Journal Year: 2021, Volume and Issue: 19(3), P. 384 - 408

Published: Dec. 7, 2021

Abstract Cellular metabolism orchestrates the intricate use of tissue fuels for catabolism and anabolism to generate cellular energy structural components. The emerging field immunometabolism highlights importance maintenance activities immune cells. Macrophages are embryo- or adult bone marrow-derived leukocytes that key healthy homeostasis but can also contribute pathologies such as metabolic syndrome, atherosclerosis, fibrosis cancer. Macrophage has largely been studied in vitro. However, different organs contain diverse macrophage populations specialize distinct often tissue-specific functions. This context specificity creates diverging challenges fulfill their homeostatic roles particular microenvironment conditions response pathological conditions. Here, we outline current knowledge on requirements adaptations macrophages located tissues during selected diseases.

Language: Английский

Citations

259
The Role of Macrophages in the Development of Acute and Chronic Inflammatory Lung Diseases DOI Creative Commons
Jae‐Won Lee, Wanjoo Chun, Hee Jae Lee

et al.

Cells, Journal Year: 2021, Volume and Issue: 10(4), P. 897 - 897

Published: April 14, 2021

Macrophages play an important role in the innate and adaptive immune responses of organ systems, including lungs, to particles pathogens. Cumulative results show that macrophages contribute development progression acute or chronic inflammatory through secretion cytokines/chemokines activation transcription factors pathogenesis lung diseases, such as injury (ALI), respiratory distress syndrome (ARDS), ARDS related COVID-19 (coronavirus disease 2019, caused by severe coronavirus 2 (SARS-CoV-2)), allergic asthma, obstructive pulmonary (COPD), idiopathic fibrosis (IPF). This review summarizes functions their associated underlying mechanisms ALI, ARDS, COVID-19-related COPD, IPF briefly introduces experimental animal models. Thus, this suggests effective therapeutic approach focuses on regulation macrophage function context diseases.

Language: Английский

Citations

190
The impact of the lung environment on macrophage development, activation and function: diversity in the face of adversity DOI Creative Commons
Calum C. Bain, Andrew S. MacDonald

Mucosal Immunology, Journal Year: 2022, Volume and Issue: 15(2), P. 223 - 234

Published: Jan. 11, 2022

The last decade has been somewhat of a renaissance period for the field macrophage biology. This renewed interest, combined with advent new technologies and development novel model systems to assess different facets biology, led major advances in our understanding diverse roles macrophages play health, inflammation, infection repair, dominance tissue environments influencing all these areas. Here, we discuss recent developments lung heterogeneity, ontogeny, metabolism function context health disease, highlight core conceptual key unanswered questions that believe should be focus work coming years.

Language: Английский

Citations

149
Macrophage immunometabolism in inflammatory bowel diseases: From pathogenesis to therapy DOI

Xiaohua Pan,

Qing Zhu, Li‐Long Pan

et al.

Pharmacology & Therapeutics, Journal Year: 2022, Volume and Issue: 238, P. 108176 - 108176

Published: March 26, 2022

Language: Английский

Citations

118
Immunometabolic crosstalk during bacterial infection DOI
Gili Rosenberg, Sebastián A. Riquelme, Alice Prince

et al.

Nature Microbiology, Journal Year: 2022, Volume and Issue: 7(4), P. 497 - 507

Published: April 1, 2022

Language: Английский

Citations

102
Targeted delivery of TGF-β mRNA to murine lung parenchyma using one-component ionizable amphiphilic Janus Dendrimers DOI Creative Commons
J. Meshanni, Emily Stevenson, Dapeng Zhang

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 21, 2025

Language: Английский

Citations

2
Nanoparticle targeting of de novo profibrotic macrophages mitigates lung fibrosis DOI Creative Commons
Abhalaxmi Singh, Sreeparna Chakraborty, Sing Wan Wong

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2022, Volume and Issue: 119(15)

Published: April 4, 2022

The pathogenesis of lung fibrosis involves hyperactivation innate and adaptive immune pathways that release inflammatory cytokines growth factors such as tumor factor (TGF)β1 induce aberrant extracellular matrix protein production. During the genesis pulmonary fibrosis, resident alveolar macrophages are replaced by a population newly arrived monocyte-derived interstitial subsequently transition into (Mo-AMs). These transitioning cells initiate releasing profibrotic remodeling matrix. Here, we describe strategy for leveraging up-regulation mannose receptor CD206 in Mo-AM to treat fibrosis. We engineered mannosylated albumin nanoparticles, which were found be internalized fibrogenic CD206+ monocyte derived (Mo-Macs). Mannosylated nanoparticles incorporating TGFβ1 small-interfering RNA (siRNA) targeted subpopulation prevented findings point potential utility delivering TGFβ-siRNA an antilung strategy.

Language: Английский

Citations

63
Regulatory Immune Cells in Idiopathic Pulmonary Fibrosis: Friends or Foes? DOI
Chiel van Geffen,

Astrid Deißler,

Markus Quante

et al.

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12

Published: April 22, 2021

The immune system is receiving increasing attention for interstitial lung diseases, as knowledge on its role in fibrosis development and response to therapies expanding. Uncontrolled responses unbalanced injury-inflammation-repair processes drive the initiation progression of idiopathic pulmonary fibrosis. regulatory plays important roles controlling pathogenic responses, regulating inflammation modulating transition This review aims summarize critically discuss current potential cells, including mesenchymal stromal/stem T B macrophages, dendritic cells myeloid-derived suppressor Furthermore, we emerging anti-fibrotic therapy transplantation. A comprehensive understanding regulation could pave way towards new therapeutic or preventive approaches

Language: Английский

Citations

62
Lung Fibrosis and Fibrosis in the Lungs: Is It All about Myofibroblasts? DOI Creative Commons
Elena Ortiz‐Zapater, Jaime Signes‐Costa, Paula Montero

et al.

Biomedicines, Journal Year: 2022, Volume and Issue: 10(6), P. 1423 - 1423

Published: June 15, 2022

In the lungs, fibrosis is a growing clinical problem that results in shortness of breath and can end up respiratory failure. Even though main fibrotic disease affecting lung idiopathic pulmonary (IPF), which affects interstitial space, there are many events have high dangerous consequences for lungs. Asthma, chronic obstructive (COPD), excessive allergies, clearance infection or COVID-19, all frequent diseases show fibrosis. this review, we describe different kinds analyse types cells involved-myofibroblasts other cells, like macrophages-and review mechanisms. Finally, present treatments lungs highlight potential targets anti-fibrotic therapies.

Language: Английский

Citations

55