Prevotella diversity, niches and interactions with the human host

Nature Reviews Microbiology, Journal Year: 2021, Volume and Issue: 19(9), P. 585 - 599

Published: May 28, 2021

Language: Английский

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Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain

Microbiome, Journal Year: 2022, Volume and Issue: 10(1)

Published: April 29, 2022

Altered intestinal microbiota composition in later life is associated with inflammaging, declining tissue function, and increased susceptibility to age-associated chronic diseases, including neurodegenerative dementias. Here, we tested the hypothesis that manipulating influences development of major comorbidities aging and, particular, inflammation affecting brain retina.

Language: Английский

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Therapeutic Benefits and Dietary Restrictions of Fiber Intake: A State of the Art Review

Nutrients, Journal Year: 2022, Volume and Issue: 14(13), P. 2641 - 2641

Published: June 26, 2022

Throughout history, malnutrition and deficiency diseases have been a problem for our planet's population. A balanced diet significantly influences everyone's health, fiber intake appears to play more important role than previously thought. The natural dietary fibers are category of carbohydrates in the constitution plants that not completely digested human intestine. High-fiber foods, such as fruits, vegetables whole grains, consistently highly beneficial health effectively reduced risk disease. Although mode action consumer body is fully understood, nutritionists professionals unanimously recognize therapeutic benefits. This paper presents consumption different countries, metabolism range benefits associated with intake. In addition, influence on intestinal microbiome, metabolic (obesity diabetes), neurological aspects, cardiovascular diseases, autoimmune cancer prevention discussed. Finally, restrictions excess addressed, which can cause episodes diarrhea dehydration increase likelihood bloating flatulence or even bowel obstruction. However, extensive studies needed regarding composition required amount relation saprotrophic microorganisms from enteral level various pathologies they be correlated.

Language: Английский

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Gut microbiota and rheumatoid arthritis: From pathogenesis to novel therapeutic opportunities

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Sept. 8, 2022

Rheumatoid arthritis (RA) is a chronic autoimmune disease that primarily affects the joints. Microbial infection considered crucial inducer of RA. Alterations in composition intestinal bacteria individuals with preclinical and established RA suggest vital role gut microbiota immune dysfunction characteristic However, mechanisms by which dysbiosis contributes to are not fully understood. Furthermore, multiple therapies commonly used treat may alter diversity, suggesting modulating help prevent or Hence, better understanding changes accompany should aid development novel therapeutic approaches. This mini-review discusses impact pathogenesis RA, selection microbiota-related biomarkers for diagnosing provides examples cross-modulation between some drugs Some suggestions outlooks also raised, guide future research efforts.

Language: Английский

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Role of Gut Microbiome in Autism Spectrum Disorder and Its Therapeutic Regulation

Frontiers in Cellular and Infection Microbiology, Journal Year: 2022, Volume and Issue: 12

Published: July 22, 2022

Autism spectrum disorder (ASD) is a neurological that affects normal brain development. The recent finding of the microbiota-gut-brain axis indicates bidirectional connection between our gut and brain, demonstrating microbiota can influence many disorders such as autism. Most autistic patients suffer from gastrointestinal (GI) symptoms. Many studies have shown early colonization, mode delivery, antibiotic usage significantly affect microbiome onset Microbial fermentation plant-based fiber produce different types short-chain fatty acid (SCFA) may beneficial or detrimental effect on development patients. Several comprehensive help to understand mechanism leads find possible treatments for This review integrates findings years ASD association, mainly focusing characterization specific addressing potential therapeutic interventions restore healthy balance composition treat autism-associated

Language: Английский

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Microbial dysbiosis in the gut drives systemic autoimmune diseases

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Oct. 20, 2022

Trillions of microbes survive and thrive inside the human body. These tiny creatures are crucial to development maturation our immune system maintain gut homeostasis. Microbial dysbiosis is main driver local inflammatory autoimmune diseases such as colitis bowel diseases. Dysbiosis in can also drive systemic type 1 diabetes, rheumatic arthritis, multiple sclerosis. Gut directly interact with by mechanisms including modulation host microRNAs affecting gene expression at post-transcriptional level or production microbial metabolites that cellular receptors TLRs GPCRs. This interaction modulates functions differentiation lymphocytes, interleukins, controlling leakage molecules from circulation. In this review, we compile analyze data gain insights into underpinning mediating Understanding how trigger protect (1) tackle these through diet lifestyle modification, (2) develop new microbiome-based therapeutics prebiotics probiotics, (3) identify diagnostic biomarkers predict disease risk, (4) observe intervene population change flare-up responses. Considering microbiome signature a player might hold promise turn untreatable manageable preventable ones.

Language: Английский

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The gut ileal mucosal virome is disturbed in patients with Crohn’s disease and exacerbates intestinal inflammation in mice

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Feb. 22, 2024

Abstract Gut bacteriome dysbiosis is known to be implicated in the pathogenesis of inflammatory bowel disease (IBD). Crohn’s (CD) an IBD subtype with extensive mucosal inflammation, yet virome, empirical modulator and immunity, remains largely unclear regarding its composition role. Here, we exploited trans-cohort CD patients healthy individuals compositionally functionally investigate small (terminal ileum) virome bacteriome. The ileal was characterised by under-representation both lytic temperate bacteriophages (especially those targeting bacterial pathogens), particularly flare-up. Meanwhile, virome-bacteriome ecology mucosa featured a lack Bifidobacterium - Lachnospiraceae-led mutualistic interactions between bacteria bacteriophages; surprisingly it more pronounced remission than flare-up, underlining refractory recurrent nature inflammation CD. Lastly, substantiated that virions from causally exacerbated intestinal mouse models, reshaping gut preceding (microbial trigger) augmenting microbial sensing/defence pathways intestine cells (host response). Altogether, our results highlight significance importance restoration therapeutics.

Language: Английский

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Integration of 168,000 samples reveals global patterns of the human gut microbiome

Cell, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

The factors shaping human microbiome variation are a major focus of biomedical research. While other fields have used large sequencing compendia to extract insights requiring otherwise impractical sample sizes, the field has lacked comparably sized resource for 16S rRNA gene amplicon commonly quantify composition. To address this gap, we processed 168,464 publicly available gut samples with uniform pipeline. We use compendium evaluate geographic and technical effects on variation. find that regions such as Central Southern Asia differ significantly from more thoroughly characterized microbiomes Europe Northern America composition alone can be predict sample's region origin. also strong associations between primers DNA extraction. anticipate growing work, Human Microbiome Compendium, will enable advanced applied methodological

Language: Английский

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Sesamin Alleviates Allergen-Induced Diarrhea by Restoring Gut Microbiota Composition and Intestinal Barrier Function

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

Food allergens are the key triggers of allergic diarrhea, causing damage to immune-rich ileum. This weakens mucosal barrier and tight junctions, increases intestinal permeability, exacerbates allergen exposure, thereby worsening condition. Sesamin, a natural lignan isolated from sesame seed, has shown potential in regulating immune responses, but its effects on health remain unclear. In this study, we constructed an ovalbumin (OVA)-induced diarrhea mouse model, which demonstrated increased mast cell degranulation, reduced junction integrity, impaired function. Pro-inflammatory cytokines were significantly ileum, along with unbalanced cluster differentiation 4 (CD4

Language: Английский

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Protective Effects of Bifidobacterium Breve MCC1274 as a Novel Therapy for Alzheimer’s Disease

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 558 - 558

Published: Jan. 31, 2025

Alzheimer’s disease (AD) is the most common form of dementia and characterized by memory impairment that significantly interferes with daily life. Therapeutic options for AD substantively modify progression remain a critical unmet need. In this regard, gut microbiota crucial in maintaining human health regulating metabolism immune responses, increasing evidence suggests probiotics, particularly beneficial bacteria, can enhance cognitive functions. Recent studies have highlighted positive effects Bifidobacterium breve MCC1274 (B. MCC1274) on individuals mild (MCI) schizophrenia. Additionally, oral supplementation B. has been shown to effectively prevent decline AppNL–G–F mice. relation pathology, found reduce amyloid-β (Aβ) accumulation tau phosphorylation both wild-type (WT) It also decreases microglial activation increases levels synaptic proteins. review, we examine AD, exploring potential mechanisms action how probiotic strain may aid preventing or treating disease. Furthermore, discuss broader implications improving overall host provide insights into future research directions promising therapy.

Language: Английский

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