Host-microbe-cancer interactions on-a-chip DOI Creative Commons

Mauricio G. C. Sousa,

Danielle S.K. Brasino, Madeline Krieger

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13

Published: March 31, 2025

The tumor microbiota has emerged as a pivotal contributor to variety of cancers, impacting disease development, progression, and therapeutic resistance. Due the complexity microenvironment, reproducing interactions between microbes, cells, immune system remains great challenge for both in vitro vivo studies. To this end, significant progress been made toward leveraging tumor-on-a-chip model systems replicate critical hallmarks native vitro. These microfluidic platforms offer ability mimic essential components including controllable fluid flow conditions, manipulable extracellular matrix dynamics, intricate 3D multi-cellular communication. primary objective review is discuss recent challenges advances engineering host-microbiota on-a-chip. Ultimately, overcoming these obstacles will help us gain deeper insights into tumor-microbe enhance avenues developing more effective cancer therapies.

Language: Английский

Recent advances in the epithelial barrier theory DOI Creative Commons
Yağız Pat, Duygu Yazıcı, Paolo D’Avino

et al.

International Immunology, Journal Year: 2024, Volume and Issue: 36(5), P. 211 - 222

Published: Jan. 16, 2024

Abstract The epithelial barrier theory links the recent rise in chronic non-communicable diseases, notably autoimmune and allergic disorders, to environmental agents disrupting barrier. Global pollution toxic agent exposure have worsened over six decades because of uncontrolled growth, modernization, industrialization, affecting human health. Introducing new chemicals without any reasonable control their health effects through these years has led documented adverse effects, especially on skin mucosal barriers. These substances, such as particulate matter, detergents, surfactants, food emulsifiers, micro- nano-plastics, diesel exhaust, cigarette smoke, ozone, been shown compromise integrity. This disruption is linked opening tight-junction barriers, inflammation, cell death, oxidative stress, metabolic regulation. Consideration must be given interplay underlying inflammatory medications, affected tissues. review article discusses detrimental effect barrier-damaging compounds involves cellular molecular mechanisms.

Language: Английский

Citations

21
Mitochondrial function and gastrointestinal diseases DOI

Parsa Haque,

Neeraj Kapur,

Terrence A. Barrett

et al.

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2024, Volume and Issue: 21(8), P. 537 - 555

Published: May 13, 2024

Language: Английский

Citations

20
Type 2 immunity in allergic diseases DOI Creative Commons
İsmail Öğülür, Yasutaka Mitamura,

Duygu Yazıcı

et al.

Cellular and Molecular Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Language: Английский

Citations

7
Metagenome-informed metaproteomics of the human gut microbiome, host, and dietary exposome uncovers signatures of health and inflammatory bowel disease DOI
Rafael Valdés‐Mas, Avner Leshem,

Danping Zheng

et al.

Cell, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

4
Gut dysbiosis: Ecological causes and causative effects on human disease DOI Creative Commons
Sebastian Winter, Andreas J. Bäumler

Proceedings of the National Academy of Sciences, Journal Year: 2023, Volume and Issue: 120(50)

Published: Dec. 4, 2023

The gut microbiota plays a role in many human diseases, but high-throughput sequence analysis does not provide straightforward path for defining healthy microbial communities. Therefore, understanding mechanisms that drive compositional changes during disease (gut dysbiosis) continues to be central goal microbiome research. Insights from the pathogenesis field show an ecological cause dysbiosis is increased availability of host-derived respiratory electron acceptors, which are dominant drivers community composition. Similar host environment also several chronic illnesses, and better underlying informs approaches causatively link exacerbation symptoms. emerging picture suggests homeostasis maintained by functions control resources governing growth. Defining as weakening these directs attention identifies potential targets therapeutic intervention.

Language: Английский

Citations

40
Butyrate’s (a short-chain fatty acid) microbial synthesis, absorption, and preventive roles against colorectal and lung cancer DOI
Md Rezaul Karim, Safia Iqbal, Shahnawaz Mohammad

et al.

Archives of Microbiology, Journal Year: 2024, Volume and Issue: 206(4)

Published: March 4, 2024

Language: Английский

Citations

16
Co-exposure of polystyrene nanoplastics and copper induces development toxicity and intestinal mitochondrial dysfunction in vivo and in vitro DOI

Jinyu Rong,

Chenwei Yuan,

Yin Xiang

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 930, P. 172681 - 172681

Published: April 24, 2024

Language: Английский

Citations

9
Age-related alterations in gut homeostasis are microbiota dependent DOI Creative Commons

Yingli Jing,

Qiuying Wang, Fan Bai

et al.

npj Biofilms and Microbiomes, Journal Year: 2025, Volume and Issue: 11(1)

Published: March 25, 2025

Accumulating data suggest that remodeling aged gut microbiota improves aging-related imbalance in intestinal homeostasis. However, evidence favor of the beneficial effect on stress and immune responses during aging is scarce. The current study revealed old mice presented impaired barrier integrity. Transcriptome sequencing coupled with bioinformatics analysis altered gene expression profiles colon mesenteric lymph nodes, which are involved mainly responses, respectively. Notably, was closely related to differentially expressed genes. Microbiota depletion ameliorated integrity partially reversed inflammatory factors upregulated mice. Furthermore, fecal transplantation from young resulted a significant improvement These findings highlight potential microbiota-targeted interventions physiological processes call for further investigation.

Language: Английский

Citations

1
Gastro-Intestinal Microbiota in Equines and Its Role in Health and Disease: The Black Box Opens DOI Creative Commons
Frédérique Chaucheyras‐Durand,

A. Sacy,

K. Karges

et al.

Microorganisms, Journal Year: 2022, Volume and Issue: 10(12), P. 2517 - 2517

Published: Dec. 19, 2022

Horses are large non-ruminant herbivores and rely on microbial fermentation for energy, with more than half of their maintenance energy requirement coming from occurring in enlarged caecum colon. To achieve that, the gastro-intestinal tract (GIT) horses harbors a broad range various microorganisms, differing each GIT segment, which essential efficient utilization feed, especially to use nutrients that not or little degraded by endogenous enzymes. In addition, like other animal species, microbiota is permanent interplay host's cells involved lot functions among inflammation, immune homeostasis, metabolism. As animals humans, horse gut microbiome sensitive diet, consumption starch, fiber, fat. Age, breeds, stress during competitions, transportation, exercise may also impact microbiome. Because its size complexity, equine prone perturbations caused external internal stressors result digestive diseases gastric ulcer, diarrhea, colic, colitis, thought be linked systemic laminitis, metabolic syndrome obesity. Thus, this review we aim at understanding common core -in terms structure function- segment GIT, as well identifying potential biomarkers health disease crucial anticipate putative perturbations, optimize global practices develop adapted nutritional strategies personalized nutrition.

Language: Английский

Citations

33
Gut–Brain Interactions and Their Impact on Astrocytes in the Context of Multiple Sclerosis and Beyond DOI Creative Commons

Julia Zißler,

Veit Rothhammer, Mathias Linnerbauer

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(6), P. 497 - 497

Published: March 13, 2024

Multiple Sclerosis (MS) is a chronic autoimmune inflammatory disease of the central nervous system (CNS) that leads to physical and cognitive impairment in young adults. The increasing prevalence MS underscores critical need for innovative therapeutic approaches. Recent advances neuroimmunology have highlighted significant role gut microbiome pathology, unveiling distinct alterations patients’ microbiota. Dysbiosis not only impacts gut-intrinsic processes but also influences production bacterial metabolites hormones, which can regulate remote tissues, such as CNS. Central this paradigm gut–brain axis, bidirectional communication network linking gastrointestinal tract brain spinal cord. Via specific routes, hormones influence CNS-resident cells both directly indirectly. Exploiting novel interventions, including pro- prebiotic treatments, emerged promising avenues with aim mitigating severity MS. This review delves into complex interplay between context MS, summarizing current knowledge on key signals cross-organ crosstalk, routes communication, potential relevance microbiome. Moreover, places particular emphasis elucidating these interactions astrocyte functions within CNS, offering insights their pathophysiology interventions.

Language: Английский

Citations

8