Nucleus accumbens and dorsal medial striatal dopamine and neural activity are essential for action sequence performance DOI
Kurt M. Fraser, Bridget J. Chen, Patricia H. Janak

et al.

European Journal of Neuroscience, Journal Year: 2023, Volume and Issue: 59(2), P. 220 - 237

Published: Dec. 13, 2023

Separable striatal circuits have unique functions in Pavlovian and instrumental behaviors but how these roles relate to performance of sequences actions with without associated cues are less clear. Here, we tested whether dopamine transmission neural activity more generally three subdomains necessary for an action chain leading reward delivery. Male female Long-Evans rats were trained press a series spatially distinct levers receive reward. We assessed the contribution or within each subdomain when progression through sequence was explicitly cued absence cues. Behavior both task variations substantially impacted following microinfusion antagonist, flupenthixol, into nucleus accumbens core (NAc) dorsomedial striatum (DMS), impairments timing numbers rewards earned after NAc flupenthixol. In contrast, pharmacological inactivation suppress overall activity, there minimal impact on total earned. Instead, DMS impaired led errors uncued, not task. There no antagonism reversible dorsolateral either uncued completion. These results highlight essential systems motivational aspects chains actions, internally generated, as well intact function correct performance.

Language: Английский

Context, attention, and the switch between habit and goal-direction in behavior DOI Creative Commons
Mark E. Bouton

Learning & Behavior, Journal Year: 2021, Volume and Issue: 49(4), P. 349 - 362

Published: Oct. 28, 2021

Abstract This article reviews recent findings from the author’s laboratory that may provide new insights into how habits are made and broken. Habits extensively practiced behaviors automatically evoked by antecedent cues performed without their goal (or reinforcer) “in mind.” Goal-directed actions, in contrast, instrumental because is remembered valued. New results suggest actions transition to habit after extended practice when conditions encourage reduced attention behavior. Consistent with theories of learning, a behavior command less (and become habitual) as its reinforcer becomes well-predicted environment; learning prevented if presentation uncertain. Other not permanent, goal-direction can be restored several environmental manipulations, including exposure unexpected reinforcers or context change. more context-dependent than goal-directed are. Habit causes retroactive interference way reminiscent extinction: It inhibits, but does erase, way. The have implications for understanding habitual control well disordered like addictions.

Language: Английский

Citations

73
Dopamine Circuit Mechanisms of Addiction-Like Behaviors DOI Creative Commons
Carli L. Poisson,

Liv Engel,

Benjamin T. Saunders

et al.

Frontiers in Neural Circuits, Journal Year: 2021, Volume and Issue: 15

Published: Nov. 9, 2021

Addiction is a complex disease that impacts millions of people around the world. Clinically, addiction formalized as substance use disorder (SUD), with three primary symptom categories: exaggerated use, social or lifestyle impairment, and risky use. Considerable efforts have been made to model features these criteria in non-human animal research subjects, for insight into underlying neurobiological mechanisms. Here we review evidence from rodent models SUD-inspired criteria, focusing on role striatal dopamine system. We identify distinct mesostriatal nigrostriatal circuit functions behavioral outcomes are relevant addictions SUDs. This work suggests essential not only positive SUDs, such elevated intake craving, but also impairments decision making underlie compulsive behavior, reduced sociality, risk taking. Understanding functional heterogeneity system related networks can offer this symptomatology may lead more targeted treatments.

Language: Английский

Citations

57
Making habits measurable beyond what they are not: A focus on associative dual-process models DOI
Poppy Watson, Claire O’Callaghan, Iain Perkes

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2022, Volume and Issue: 142, P. 104869 - 104869

Published: Sept. 13, 2022

Language: Английский

Citations

38
A dual-pathway architecture for stress to disrupt agency and promote habit DOI
Jacqueline Giovanniello,

Natalie Paredes,

Anna Wiener

et al.

Nature, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Language: Английский

Citations

1
Control of complex behavior by astrocytes and microglia DOI Creative Commons

PI Ortinski,

KJ Reissner,

Jill Turner

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2022, Volume and Issue: 137, P. 104651 - 104651

Published: April 1, 2022

Language: Английский

Citations

22
Animal Models of Addiction DOI
Christopher J. Evans, David Jentsch,

Brigitte Kieffer

et al.

Oxford University Press eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 651 - 660

Published: Jan. 1, 2025

Abstract Substance use disorders (SUDs) are characterized by chronic relapsing episodes of drug seeking and/or taking, often despite negative outcomes. Although animal models cannot recapitulate all aspects SUDs because the complexities societal interactions and human-specific processing rewards affect, there many components that can be effectively modeled. This chapter reviews key concepts, advantages, caveats using to study initiation, maintenance, escalation taking adverse consequences, abstinence relapse. The discusses have direct translational impact where interpretation limitations. It also used interrogate both genetic environmental factors influencing vulnerability at different stages SUD. Animal made important contributions current knowledge drug-mediated responses adaptations brain circuitry could never been acquired via human research.

Language: Английский

Citations

0
A Critical Review and Meta-Analysis of Interventions to Reduce Compulsivity in Behavioral Addictions and Related Conditions DOI
José Antonio López‐Guerrero, Miguel A. Vadillo, Francisco Rivero

et al.

Current Addiction Reports, Journal Year: 2025, Volume and Issue: 12(1)

Published: Feb. 4, 2025

Language: Английский

Citations

0
Habit loop in addictive behaviors formation among adolescents: The mediating role of impulsivity DOI
Alireza Karimpour Vazifehkhorani, Issa Hekmati

Current Psychology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

Language: Английский

Citations

0
Differential effects of acute and prolonged morphine withdrawal on motivational and goal‐directed control over reward‐seeking behaviour DOI Creative Commons
Briac Halbout,

Collin Hutson,

Stuti Agrawal

et al.

Addiction Biology, Journal Year: 2024, Volume and Issue: 29(5)

Published: May 1, 2024

Abstract Opioid addiction is a relapsing disorder marked by uncontrolled drug use and reduced interest in normally rewarding activities. The current study investigated the impact of spontaneous withdrawal from chronic morphine exposure on emotional, motivational cognitive processes involved regulating pursuit consumption food rewards male rats. In Experiment 1, rats experiencing acute lost weight displayed somatic signs dependence. However, hedonically driven sucrose was significantly elevated, suggesting intact potentially heightened reward processing. 2, undergoing motivation when performing an effortful response for palatable reward. Subsequent devaluation testing revealed that disrupted their ability to exert flexible goal‐directed control over seeking. Specifically, morphine‐withdrawn were impaired using value select actions both relying prior action‐outcome learning given direct feedback about consequences actions. 3, tested after prolonged rather than diminished retained engage action selection. brief re‐exposure sufficient impair disrupt selection, though this case, only presence morphine‐paired context cues absence response‐contingent feedback. We suggest these opioid‐withdrawal induced deficits may contribute interfering with adaptive alternatives use.

Language: Английский

Citations

3
Reward, relief, and habit drinking profiles in treatment seeking individuals with an AUD DOI Creative Commons
Erica N. Grodin, Wave‐Ananda Baskerville, Lindsay R. Meredith

et al.

Alcohol and Alcoholism, Journal Year: 2024, Volume and Issue: 59(3)

Published: March 16, 2024

Abstract Aims This study aimed to compare reward, relief, and habit treatment-seeking individuals on recent drinking, alcohol use disorder (AUD) phenomenology, mood. The second aim of the was evaluate predictive validity profiles. Method Treatment-seeking with an AUD (n = 169) were recruited participate in a medication trial for (NCT03594435). Reward, drinking groups assessed using UCLA Reward Relief Habit Drinking Scale. Group differences at baseline evaluated univariate analyses variance. A subset participants enrolled 12-week, double-blind, placebo-controlled 102), provided longitudinal phenomenology data. group membership linear regression analyses. Results At baseline, who drink primarily relief had higher craving negative mood than those reward habit. Prospectively, predicted greater use, heavy fewer days abstinent compared group. Membership also craving, more alcohol-related consequences, anxiety symptoms over 12 weeks Conclusions provides support motive profiles AUD. poorer outcomes symptomology weeks, indicating that may be particularly vulnerable sub-population

Language: Английский

Citations

3