Nucleus accumbens and dorsal medial striatal dopamine and neural activity are essential for action sequence performance DOI
Kurt M. Fraser, Bridget J. Chen, Patricia H. Janak

et al.

European Journal of Neuroscience, Journal Year: 2023, Volume and Issue: 59(2), P. 220 - 237

Published: Dec. 13, 2023

Separable striatal circuits have unique functions in Pavlovian and instrumental behaviors but how these roles relate to performance of sequences actions with without associated cues are less clear. Here, we tested whether dopamine transmission neural activity more generally three subdomains necessary for an action chain leading reward delivery. Male female Long-Evans rats were trained press a series spatially distinct levers receive reward. We assessed the contribution or within each subdomain when progression through sequence was explicitly cued absence cues. Behavior both task variations substantially impacted following microinfusion antagonist, flupenthixol, into nucleus accumbens core (NAc) dorsomedial striatum (DMS), impairments timing numbers rewards earned after NAc flupenthixol. In contrast, pharmacological inactivation suppress overall activity, there minimal impact on total earned. Instead, DMS impaired led errors uncued, not task. There no antagonism reversible dorsolateral either uncued completion. These results highlight essential systems motivational aspects chains actions, internally generated, as well intact function correct performance.

Language: Английский

A novel hypothalamic-midbrain circuit for model-based learning DOI Open Access

Ivy B. Hoang,

Joseph J. Munier,

Anna Verghese

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: March 2, 2023

Abstract Behavior is often dichotomized into model-free and model-based systems 1, 2 . Model-free behavior prioritizes associations that have high value, regardless of the specific consequence or circumstance. In contrast, involves considering all possible outcomes to produce best fits current We typically exhibit a mixture these behaviors so we can trade-off efficiency flexibility. However, substance use disorder shifts more strongly towards systems, which produces difficulty abstaining from drug-seeking due an inability withhold making high-value response 3–10 The lateral hypothalamus (LH) implicated in 11–17 demonstrated this region critical Pavlovian cue-reward learning 18, 19 it unknown whether occurring LH model-based, where necessary teaching signal comes facilitate LH, relevant for deficits drive disorder. Here, reveal model-based. Further, confirm existence understudied projection extending dopamine neurons ventral tegmental area (VTA) demonstrate input underlies LH. Finally, examine impact methamphetamine self-administration on LH-dependent processes. These experiments history administration enhances control cues over decision-making, was accompanied by bidirectional strengthening VTA circuit. Together, work reveals novel circuit behavioral cognitive changes arise with disorders. This represents new addition models addiction, focus instrumental components drug addiction increases habits after exposure

Language: Английский

Citations

8
Biased choice and incentive salience: Implications for addiction DOI Open Access
Mike E. Le Pelley, Poppy Watson, Reínout W. Wiers

et al.

Published: Feb. 13, 2024

Before we can make any choice, must gather information from the environment about what our options are. This information-gathering process is critically mediated by attention, and attention is, in turn, shaped previous experiences with—and learning about—stimuli their consequences. In this review highlight studies demonstrating a rapid automatic influence of reward on attentional capture, argue that these findings provide human analogue sign-tracking behaviour observed non-human animals – wherein signals gain incentive salience become attractive targets for (and overt behaviour) own right. We then consider implications idea understanding drivers cue-controlled behaviour, with focus addiction as case which choices regard to reward-related stimuli injurious health. motivated general—and particular—can be understood within ‘biased competition’ framework: different outcomes compete priority function top-down goals, bottom-up salience, prior experience, winner competition becomes target subsequent outcome-directed flexible behaviour. Finally, outline biased-competition framework cognitive, behavioural, socioeconomic interventions addiction.

Language: Английский

Citations

2
Habit learning shapes activity dynamics in the central nucleus of the amygdala DOI Creative Commons
Kenneth A. Amaya, James E. Carmichael, Erica S. Townsend

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 21, 2024

Abstract As animals perform instrumental tasks, they may develop a habit response with extended experience. Habits are automatic, inflexible, outcome value insensitive behaviors that regulated by network of brain regions including the central nucleus amygdala (CeA). Prior work has demonstrated CeA governs motivational pursuit and is necessary for formation. However, behavioral features neurons encode in formation remain relatively unknown. To address this, we first used male female Long-Evans rats to quantify cFos expression after performance maze task. There, found training show elevated expression. Then, implanted drivable silicon probes record in-vivo single unit electrophysiological activity from as developed responding on maze. We observed significant during consumption late while also observing when consumed outcomes larger magnitudes. Outcome related did not persist probe tests following devaluation, despite continuing Together, these data add growing evidence suggests involved processes contribute development

Language: Английский

Citations

2
Pavlovian-to-instrumental transfer and outcome-devaluation effects in individuals with gaming experience DOI
Linxuan Xu, Jialin Zhang, Xiaomin Geng

et al.

Computers in Human Behavior, Journal Year: 2024, Volume and Issue: 155, P. 108188 - 108188

Published: March 7, 2024

Language: Английский

Citations

2
Encoding and context-dependent control of reward consumption within the central nucleus of the amygdala DOI Creative Commons
Kurt M. Fraser,

Tabitha H. Kim,

Matilde Castro

et al.

iScience, Journal Year: 2024, Volume and Issue: 27(5), P. 109652 - 109652

Published: April 1, 2024

Dysregulation of the central amygdala is thought to underlie aberrant choice in alcohol use disorder, but role neural activity during reward and consumption unclear. We recorded neurons male rats as they consumed or sucrose. observed changes at time approach, well lick-entrained ongoing both rewards. In scenarios where could drink sucrose, alcohol, quinine-adulterated with without optogenetic stimulation, drank more stimulation-paired options when two bottles contained identical options. Given a among different options, stimulation usually enhanced However, less-preferred option, was unable enhance intake while sucrose available. These findings indicate that contributes refining motivated pursuit toward preferred available option.

Language: Английский

Citations

2
Compulsivity-related behavioral features of problematic usage of the internet: A scoping review of paradigms, progress, and perspectives DOI Creative Commons
Lu Liu, Yuan‐Wei Yao, Xiaoyi Fang

et al.

Journal of Behavioral Addictions, Journal Year: 2024, Volume and Issue: 13(2), P. 429 - 449

Published: April 24, 2024

Compulsivity contributes to the development and maintenance of multiple addictive disorders. However, relationship between compulsivity-related cognitive features problematic usage internet (PUI), an umbrella term for various use disorders/interfering behaviors, remains largely unclear, partly due multidimensional nature compulsivity. This scoping review utilized a four-domain framework compulsivity consider this topic aimed summarize available evidence on neuropsychological characteristics in PUI based framework.

Language: Английский

Citations

2
Lack of action monitoring as a prerequisite for habitual and chunked behavior: Behavioral and neural correlates DOI Creative Commons
Youna Vandaele, Patricia H. Janak

iScience, Journal Year: 2022, Volume and Issue: 26(1), P. 105818 - 105818

Published: Dec. 16, 2022

We previously reported the rapid development of habitual behavior in a discrete-trials instrumental task which lever insertion and retraction act as reward-predictive cues delineating sequence execution. Here we asked whether or performance variables reflective skill automaticity might account for male rats. Behavior habit-promoting was compared with two variants lacking sequence-delineating extension retraction. find that is under goal-directed control absence but not their presence, skilled does predict vs. behavior. Neural activity recordings revealed an engagement dorsolateral striatum disengagement dorsomedial during execution task, specifically. Together, these results indicate delineation promote habit differential striatal subregions responding, pattern may reflect cue-elicited behavioral chunking.

Language: Английский

Citations

11
Caloric state modulates locomotion, heart rate and motor neuron responses to acute administration of d-amphetamine in zebrafish larvae DOI Creative Commons
Pushkar Bansal, Mitchell F. Roitman, Erica E. Jung

et al.

Physiology & Behavior, Journal Year: 2023, Volume and Issue: 264, P. 114144 - 114144

Published: March 6, 2023

Language: Английский

Citations

6
The contextual regulation of goal-directed actions DOI
Arvie Abiero, Laura A Bradfield

Current Opinion in Behavioral Sciences, Journal Year: 2021, Volume and Issue: 41, P. 57 - 62

Published: April 23, 2021

Language: Английский

Citations

14
A neuroeconomic signature of opioid craving: How fluctuations in craving bias drug-related and nondrug-related value DOI Creative Commons
Kathryn Biernacki, Silvia López-Guzmán, John C. Messinger

et al.

Neuropsychopharmacology, Journal Year: 2021, Volume and Issue: 47(8), P. 1440 - 1448

Published: Dec. 16, 2021

Abstract How does craving bias decisions to pursue drugs over other valuable, and healthier, alternatives in addiction? To address this question, we measured the in-the-moment economic of people with opioid use disorder as they experienced craving, shortly after receiving their scheduled maintenance medication ~24 h later. We found that higher cravers had drug-related valuation, moments within-person also led valuation. When experiencing increased participants were willing pay more for personalized consumer items foods closely related drug use, but not alternative “nondrug-related” equally desirable options. This selective increase value was greater when options offered quantities separable from effects fluctuating psychological states like negative mood. These findings suggest narrows focuses motivation toward object by selectively multiplicatively amplifying perceived along a “drug relatedness” dimension.

Language: Английский

Citations

14