Neurophysiological response to social feedback in stressful situations DOI
Michela Balconi, Laura Angioletti, Katia Rovelli

et al.

European Journal of Neuroscience, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 18, 2024

Abstract The relationship between external feedback and cognitive neurophysiological performance has been extensively investigated in social neuroscience. However, few studies have considered the role of positive negative on electroencephalographic (EEG) moderate stress response. Twenty‐six healthy adults underwent a moderately stressful job interview consisting modified version Trier Social Stress Test. After each preparation, was provided by an committee, ranging from to with increasing impact subjects. response measured analysing times (RTs) during speech phase, while assessed using Stroop‐like task before after test. Results indicate that RTs used deliver final speeches were significantly lower compared those for initial feedback. Moreover, generalized improvement observed post‐SST pre‐SST. Consistent behavioural results, EEG data indicated greater delta, theta, alpha band responses right prefrontal left central areas, delta theta bands, also parietal areas aversive‐neutral feedback, highlighting effort required former. Conversely, increase these bands temporal occipital following aversive indicative adaptive emotion‐regulatory processes. These findings suggest noncritical conditions could contribute improving individual performance.

Language: Английский

Post-traumatic stress disorder: clinical and translational neuroscience from cells to circuits DOI
Kerry J. Ressler, Sabina Berretta, Vadim Y. Bolshakov

et al.

Nature Reviews Neurology, Journal Year: 2022, Volume and Issue: 18(5), P. 273 - 288

Published: March 29, 2022

Language: Английский

Citations

257
Temporally and anatomically specific contributions of the human amygdala to threat and safety learning DOI Creative Commons

Zhenfu Wen,

Candace M. Raio, Edward F. Pace‐Schott

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2022, Volume and Issue: 119(26)

Published: June 21, 2022

Neural plasticity in subareas of the rodent amygdala is widely known to be essential for Pavlovian threat conditioning and safety learning. However, less consistent results have been observed human neuroimaging studies. Here, we identify test three important factors that may contribute these discrepancies: temporal profile response conditioning, anatomical specificity responses during learning, insufficient power responses. We combined data across multiple studies using a well-validated paradigm examine involvement In 601 humans, show two subregions tracked conditioned stimulus with aversive shock early while only one demonstrated delayed responding not paired shock. Our findings cross-species similarities temporal- anatomical-specific contributions affirm associative learning highlight future research humans.

Language: Английский

Citations

48
Diverse therapeutic developments for post-traumatic stress disorder (PTSD) indicate common mechanisms of memory modulation DOI
Sanket B. Raut,

Padmaja A Marathe,

Liza van Eijk

et al.

Pharmacology & Therapeutics, Journal Year: 2022, Volume and Issue: 239, P. 108195 - 108195

Published: April 27, 2022

Language: Английский

Citations

44
Therapeutic mechanisms of psychedelics and entactogens DOI
Boris D. Heifets, David E. Olson

Neuropsychopharmacology, Journal Year: 2023, Volume and Issue: 49(1), P. 104 - 118

Published: July 24, 2023

Language: Английский

Citations

30
Adverse Life Experiences and Brain Function DOI Creative Commons
Niki Hosseini-Kamkar,

Mahdieh Varvani Farahani,

Maja Nikolic

et al.

JAMA Network Open, Journal Year: 2023, Volume and Issue: 6(11), P. e2340018 - e2340018

Published: Nov. 1, 2023

Importance Adverse life experiences have been proposed to contribute diverse mental health problems through an association with corticolimbic functioning. Despite compelling evidence from animal models, findings studies in humans mixed; activation likelihood estimation (ALE) meta-analyses failed identify a consistent of adverse events brain function. Objective To investigate the adversity exposure altered reactivity using multilevel kernel density analyses (MKDA), meta-analytic approach considered more robust than ALE small sample sizes and methodological differences between studies. Data Sources Searches were conducted PsycInfo, Medline, EMBASE, Web Science inception May 4, 2022. The following search term combinations used for each database: trauma , posttraumatic stress disorder ( PTSD ), abuse maltreatment poverty or ; functional magnetic resonance imaging fMRI ) neuroimaging; emotion regulation memory processing inhibitory control executive functioning reward . Study Selection Task-based within 4 domains (emotion processing, control, processing) that included measure whole-brain coordinate results reported Talairach Montreal Neurological Institute space included. Conference abstracts, books, reviews, meta-analyses, opinions, studies, articles not English, fewer 5 participants excluded. Extraction Synthesis Using Preferred Reporting Items Systematic Reviews Meta-Analyses reporting guideline, 2 independent reviewers assessed abstracts full-text entry criteria. A third reviewer resolved conflicts errors data extraction. pooled random-effects model analysis occurred August November Main Outcomes Measures Peak x-axis (left-right), y-axis (posterior-anterior), z-axis (inferior-superior) coordinates extracted all submitted MKDA meta-analyses. Results total 83 meta-analysis, yielding combined 5242 801 coordinates. Adversity was associated higher amygdala (familywise error rate corrected at P < .001; = 22; −4; −17) lower prefrontal cortical 10; 60; 10) across range task domains. These responses only observed adult clearest among those who had exposed severe threat trauma. Conclusions Relevance In this meta-analysis function, prior challenges. might better how diminishes ability cope later stressors produces enduring susceptibility problems.

Language: Английский

Citations

30
Neural Mechanisms of Resting-State Networks and the Amygdala Underlying the Cognitive and Emotional Effects of Psilocybin DOI Creative Commons
Devon Stoliker, Leonardo Novelli, Franz X. Vollenweider

et al.

Biological Psychiatry, Journal Year: 2024, Volume and Issue: 96(1), P. 57 - 66

Published: Jan. 6, 2024

Background Serotonergic psychedelics, such as psilocybin, alter perceptual and cognitive systems that are functionally integrated with the amygdala. These changes can cognition emotions hypothesised to contribute their therapeutic utility. However, neural mechanisms of subcortical altered by psychedelics not well understood. Methods We used functional MRI resting state images collected during a randomised, double-blinded, placebo-controlled clinical trial 24 healthy adults under 0.2mg/kg psilocybin estimate directed (i.e., effective) between amygdala three large-scale resting-state networks involved in cognition. default mode network (DMN), salience (SN), central executive (CEN). Results found pattern decreased top-down effective connectivity from these Effective within DMN SN however increased CEN. were statistically associated behavioural measures emotion influence psilocybin. Conclusions Our findings suggest temporary signal attenuation is mechanistic RSN connectivity. significant for perception suggests targets research investigating efficacy psychedelic therapy internalising psychiatric disorders. More broadly, our study value quantifying brain's hierarchical organisation using identify important basic function how they give rise subjective experiences.

Language: Английский

Citations

13
Prefrontal cortical dynorphin peptidergic transmission constrains threat-driven behavioral and network states DOI
Huikun Wang, Rodolfo J. Flores, Héctor E. Yarur

et al.

Neuron, Journal Year: 2024, Volume and Issue: 112(12), P. 2062 - 2078.e7

Published: April 12, 2024

Language: Английский

Citations

12
Distributed neural representations of conditioned threat in the human brain DOI Creative Commons

Zhenfu Wen,

Edward F. Pace‐Schott, Sara W. Lazar

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: March 12, 2024

Abstract Detecting and responding to threat engages several neural nodes including the amygdala, hippocampus, insular cortex, medial prefrontal cortices. Recent propositions call for integration of more distributed that process sensory cognitive facets related threat. Integrative, sensitive, reproducible decoders detection response safety have yet be established. We combine functional MRI data across varying conditioning negative affect paradigms from 1465 participants with multivariate pattern analysis investigate representations safety. The trained sensitively specifically distinguish between cues multiple datasets. further show many dynamically shift Our results establish integrate circuits, merging well-characterized ‘threat circuit’ nodes, discriminating regardless experimental designs or acquisition parameters.

Language: Английский

Citations

9
A systematic review of neural, cognitive, and clinical studies of anger and aggression DOI Creative Commons

Yuliya Richard,

Nadia Tazi, Dorota Frydecka

et al.

Current Psychology, Journal Year: 2022, Volume and Issue: 42(20), P. 17174 - 17186

Published: June 8, 2022

Abstract Anger and aggression have large impact on people’s safety the society at large. In order to provide an intervention minimise aggressive behaviours, it is important understand neural cognitive aspects of anger aggression. this systematic review, we investigate anger-related processes, including behaviours reduction. Using information, then review prior existing methods treatment disorders as well management, mindfulness behavioural therapy. At level, our that associated with excessive attention stimuli impulsivity. abnormal functioning amygdala ventromedial prefrontal cortex. conclusions, based studies, here argue therapy may be better reducing than other treatments, such or alone. We key information future research work best ways manage reduce Importantly, should how related acquired stress impacts development anger.

Language: Английский

Citations

32
360-Degree Perspectives on Obesity DOI Creative Commons
Magdalena Cuciureanu,

Cătălin-Cezar Caratașu,

Levon Gabrielian

et al.

Medicina, Journal Year: 2023, Volume and Issue: 59(6), P. 1119 - 1119

Published: June 9, 2023

Alarming statistics show that the number of people affected by excessive weight has surpassed 2 billion, representing approximately 30% world's population. The aim this review is to provide a comprehensive overview one most serious public health problems, considering obesity requires an integrative approach takes into account its complex etiology, including genetic, environmental, and lifestyle factors. Only understanding connections between many contributors synergy treatment interventions can ensure satisfactory outcomes in reducing obesity. Mechanisms such as oxidative stress, chronic inflammation, dysbiosis play crucial role pathogenesis associated complications. Compounding factors deleterious effects novel challenge posed obesogenic digital (food) environment, stigma with should not be overlooked. Preclinical research animal models been instrumental elucidating these mechanisms, translation clinical practice provided promising therapeutic options, epigenetic approaches, pharmacotherapy, bariatric surgery. However, more studies are necessary discover new compounds target key metabolic pathways, innovative ways deliver drugs, optimal combinations allopathic treatments, and, last but least, emerging biological markers for effective monitoring. With each passing day, crisis tightens grip, threatening only individual lives also burdening healthcare systems societies at large. It high time we took action confront urgent imperative address escalating global head-on.

Language: Английский

Citations

21