Biology,
Journal Year:
2020,
Volume and Issue:
9(12), P. 474 - 474
Published: Dec. 16, 2020
Metabolic
reprogramming
is
crucial
to
respond
cancer
cell
requirements
during
tumor
development.
In
the
last
decade,
metabolic
alterations
have
been
shown
modulate
cells’
sensitivity
chemotherapeutic
agents
including
conventional
and
targeted
therapies.
Recently,
it
became
apparent
that
changes
in
lipid
metabolism
represent
important
mediators
of
resistance
anticancer
agents.
this
review,
we
highlight
associated
with
therapy
resistance,
their
significance
how
dysregulated
could
be
exploited
overcome
drug
resistance.
Theranostics,
Journal Year:
2021,
Volume and Issue:
11(10), P. 4839 - 4857
Published: Jan. 1, 2021
Reactive
oxygen
species
(ROS)
serve
as
cell
signaling
molecules
generated
in
oxidative
metabolism
and
are
associated
with
a
number
of
human
diseases.
The
reprogramming
redox
induces
abnormal
accumulation
ROS
cancer
cells.
It
has
been
widely
accepted
that
play
opposite
roles
tumor
growth,
metastasis
apoptosis
according
to
their
different
distributions,
concentrations
durations
specific
subcellular
structures.
These
double-edged
progression
include
the
ROS-dependent
malignant
transformation
stress-induced
death.
In
this
review,
we
summarize
notable
literatures
on
generation
scavenging,
discuss
related
signal
transduction
networks
corresponding
anticancer
therapies.
There
is
no
doubt
an
improved
understanding
sophisticated
mechanism
biology
imperative
conquer
cancer.
Cells,
Journal Year:
2021,
Volume and Issue:
10(5), P. 1056 - 1056
Published: April 29, 2021
Cancer
cells
alter
metabolic
processes
to
sustain
their
characteristic
uncontrolled
growth
and
proliferation.
These
alterations
include
(1)
a
shift
from
oxidative
phosphorylation
aerobic
glycolysis
support
the
increased
need
for
ATP,
(2)
glutaminolysis
NADPH
regeneration,
(3)
altered
flux
through
pentose
phosphate
pathway
tricarboxylic
acid
cycle
macromolecule
generation,
(4)
lipid
uptake,
lipogenesis,
cholesterol
synthesis,
(5)
upregulation
of
one-carbon
metabolism
production
NADH/NADPH,
nucleotides,
glutathione,
(6)
amino
metabolism,
(7)
metabolism-based
regulation
apoptosis,
(8)
utilization
alternative
substrates,
such
as
lactate
acetate.
Altered
in
cancer
is
controlled
by
tumor-host
cell
interactions,
key
oncogenes,
tumor
suppressors,
other
regulatory
molecules,
including
non-coding
RNAs.
Changes
pathways
are
dynamic,
exhibit
plasticity,
often
dependent
on
type
microenvironment,
leading
thought
Warburg
Effect
"reverse
Effect"
plasticity.
Understanding
complex
nature
these
multiple
can
development
new
therapies.
Signal Transduction and Targeted Therapy,
Journal Year:
2022,
Volume and Issue:
7(1)
Published: Feb. 28, 2022
Metabolic
enzymes
have
an
indispensable
role
in
metabolic
reprogramming,
and
their
aberrant
expression
or
activity
has
been
associated
with
chemosensitivity.
Hence,
targeting
remains
attractive
approach
for
treating
tumors.
However,
the
influence
regulation
of
cysteine
desulfurase
(NFS1),
a
rate-limiting
enzyme
iron-sulfur
(Fe-S)
cluster
biogenesis,
colorectal
cancer
(CRC)
remain
elusive.
Here,
using
vivo
gene-based
clustered
regularly
interspaced
short
palindromic
repeats
(CRISPR)-Cas9
library
screen,
we
revealed
that
loss
NFS1
significantly
enhanced
sensitivity
CRC
cells
to
oxaliplatin.
In
vitro
results
showed
deficiency
synergizing
oxaliplatin
triggered
PANoptosis
(apoptosis,
necroptosis,
pyroptosis,
ferroptosis)
by
increasing
intracellular
levels
reactive
oxygen
species
(ROS).
Furthermore,
oxaliplatin-based
oxidative
stress
phosphorylation
level
serine
residues
NFS1,
which
prevented
S293
phosphorylation-dependent
manner
during
treatment.
addition,
high
transcriptionally
regulated
MYC,
was
found
tumor
tissues
poor
survival
hyposensitivity
chemotherapy
patients
CRC.
Overall,
findings
this
study
provided
insights
into
underlying
mechanisms
identified
inhibition
as
promising
strategy
improving
outcome
platinum-based
treatment
Redox Biology,
Journal Year:
2021,
Volume and Issue:
46, P. 102065 - 102065
Published: July 11, 2021
Although
glucose,
through
pentose
phosphate
pathway
(PPP),
is
the
main
source
to
generate
NADPH,
solid
tumors
are
often
deprived
of
hence
alternative
metabolic
pathways
maintain
NADPH
homeostasis
in
cancer
cells
required.
Here,
we
report
that
lactate
and
glutamine
support
production
via
isocitrate
dehydrogenase
1
(IDH1)
malic
enzyme
(ME1),
respectively,
under
glucose-deprived
conditions.
Isotopic
tracing
demonstrates
participates
formation
isocitrate.
Malate
derived
from
mitochondria
shuttles
cytosol
produce
NADPH.
In
cultured
absence
knockout
IDH1
ME1
decreases
NADPH/NADP+
GSH/GSSG,
increases
ROS
level
facilitates
cell
necrosis.
4T1
murine
breast
tumors,
retards
tumor
growth
vivo,
with
combined
ME1/IDH1
more
strongly
suppressing
growth.
Our
findings
reveal
two
NADPH-producing
use
resist
glucose
starvation,
reflecting
plasticity
flexibility
adapting
nutrition
stress.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(23), P. 23223 - 23261
Published: Dec. 2, 2023
Stimuli-responsive
polymers
can
respond
to
internal
stimuli,
such
as
reactive
oxygen
species
(ROS),
glutathione
(GSH),
and
pH,
biological
enzymes,
external
lasers
ultrasound,
etc.,
by
changing
their
hydrophobicity/hydrophilicity,
degradability,
ionizability,
thus
have
been
widely
used
in
biomedical
applications.
Due
the
characteristics
of
tumor
microenvironment
(TME),
stimuli-responsive
that
cater
specifically
TME
extensively
prepare
smart
nanovehicles
for
targeted
delivery
therapeutic
diagnostic
agents
tissues.
Compared
conventional
drug
nanosystems,
TME-responsive
nanosystems
many
advantages,
high
sensitivity,
broad
applicability
among
different
tumors,
functional
versatility,
improved
biosafety.
In
recent
years,
a
great
deal
research
has
devoted
engineering
efficient
polymeric
significant
improvement
made
both
cancer
diagnosis
therapy.
this
review,
we
summarize
some
advances
involving
use
polymer
nanocarriers
delivery,
imaging,
therapy,
theranostics.
Various
chemical
stimuli
will
be
described
context
nanosystems.
Accordingly,
groups
responsible
responsiveness
strategies
incorporate
these
into
discussed
detail.
With
on
topic
expending
at
fast
pace,
innovative
concepts,
sequential
cascade
release,
NIR-II
multifunctional
formulations,
emerged
popular
enhanced
performance,
which
also
included
here
with
up-to-date
illustrations.
We
hope
review
offer
valuable
insights
selection
optimization
help
accelerate
future
applications
treatment.
Immunological Reviews,
Journal Year:
2023,
Volume and Issue:
321(1), P. 246 - 262
Published: Oct. 12, 2023
Summary
Cell
death
can
be
executed
through
distinct
subroutines.
PANoptosis
is
a
unique
inflammatory
cell
modality
involving
the
interactions
between
pyroptosis,
apoptosis,
and
necroptosis,
which
mediated
by
multifaceted
PANoptosome
complexes
assembled
via
integrating
components
from
other
modalities.
There
growing
interest
in
process
function
of
PANoptosis.
Accumulating
evidence
suggests
that
occurs
under
diverse
stimuli,
for
example,
viral
or
bacterial
infection,
cytokine
storm,
cancer.
Given
impact
across
disease
spectrum,
this
review
briefly
describes
relationships
highlights
key
molecules
formation
activation,
outlines
roles
diseases
together
with
potential
therapeutic
targeting.
We
also
discuss
important
concepts
pressing
issues
future
research.
Improved
understanding
its
mechanisms
crucial
identifying
novel
targets
strategies.
Journal of Translational Medicine,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: Aug. 2, 2023
Abstract
Cardiovascular
diseases
(CVDs)
continue
to
exert
a
significant
impact
on
global
mortality
rates,
encompassing
conditions
like
pulmonary
arterial
hypertension
(PAH),
atherosclerosis
(AS),
and
myocardial
infarction
(MI).
Oxidative
stress
(OS)
plays
crucial
role
in
the
pathogenesis
advancement
of
CVDs,
highlighting
its
significance
as
contributing
factor.
Maintaining
an
equilibrium
between
reactive
oxygen
species
(ROS)
antioxidant
systems
not
only
aids
mitigating
oxidative
but
also
confers
protective
benefits
cardiac
health.
Herbal
monomers
can
inhibit
OS
CVDs
by
activating
multiple
signaling
pathways,
such
increasing
activity
endogenous
decreasing
level
ROS
expression.
Given
actions
herbal
significantly
protect
normal
function
heart
reduce
damage
caused
organism.
Hence,
it
is
imperative
recognize
prospective
therapeutic
interventions
for
CVDs.
This
paper
aims
comprehensively
review
origins
mechanisms
underlying
OS,
elucidate
intricate
association
explore
potential
treatment
utilizing
monomers.
Furthermore,
particular
emphasis
will
be
placed
examining
cardioprotective
effects
evaluating
their
pathways
subsequent
treatment.
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