Frontiers in Physiology, Journal Year: 2024, Volume and Issue: 15
Published: April 25, 2024
Oxygen (O
Language: Английский
Cancers, Journal Year: 2022, Volume and Issue: 14(4), P. 976 - 976
Published: Feb. 15, 2022
Emerging evidence suggests that a small subpopulation of cancer stem cells (CSCs) is responsible for initiation, progression, and metastasis cascade in tumors. CSCs share characteristics with normal cells, i.e., self-renewal differentiation potential, suggesting they can drive progression. Consequently, targeting to prevent tumor growth or regrowth might offer chance lead the fight against cancer. create their niche, specific area within tissue unique microenvironment sustains vital functions. Interactions between niches play critical role regulating CSCs' tumorigenesis. Differences observed frequency CSCs, due phenotypic plasticity many remain challenge therapeutics, since modulate transcriptional activities into more stem-like state protect themselves from destruction. This represents an essential step future therapeutic approaches. Regarding self-renewal, are modulated by same molecular pathways found such as Wnt/β-catenin signaling, Notch Hedgehog signaling. Another key characteristic resistance standard chemotherapy radiotherapy treatments, capacity rest quiescent state. review will analyze primary mechanisms involved CSC tumorigenesis, particular attention roles progression benign malignant diseases; examine perspectives on identification new markers better control well dissecting process.
Language: Английский
Citations
92
Seminars in Cancer Biology, Journal Year: 2022, Volume and Issue: 86, P. 117 - 125
Published: Sept. 29, 2022
Language: Английский
Citations
89
Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14
Published: Feb. 15, 2023
Adenosine monophosphate-activated protein kinase (AMPK) is a key metabolic sensor that pivotal for the maintenance of cellular energy homeostasis. AMPK contributes to diverse and physiological effects besides its fundamental role in glucose lipid metabolism. Aberrancy signaling one determining factors which lead development chronic diseases such as obesity, inflammation, diabetes, cancer. The activation downstream cascades orchestrate dynamic changes tumor bioenergetics. It well documented possesses suppressor context progression by modulating inflammatory pathways. In addition, plays central potentiating phenotypic functional reprogramming various classes immune cells reside microenvironment (TME). Furthermore, AMPK-mediated responses facilitate recruitment certain types TME, impedes development, progression, metastasis Thus, appears play an important regulation anti-tumor response regulating plasticity cells. effectuates modulation immunity via nutrient TME virtue molecular crosstalk with major checkpoints. Several studies including from our lab emphasize on anticancer several phytochemicals, are potential drug candidates. scope this review encompasses significance cancer metabolism influence drivers within special emphasis use phytochemicals target combat
Language: Английский
Citations
88
Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)
Published: Sept. 18, 2024
Language: Английский
Citations
62
Pharmacological Reports, Journal Year: 2023, Volume and Issue: 75(4), P. 876 - 890
Published: June 19, 2023
Abstract Although Warburg's discovery of intensive glucose uptake by tumors, followed lactate fermentation in oxygen presence was made a century ago, it is still an area intense research and development new hypotheses that, layer layer, unravel the complexities neoplastic transformation. This seemingly simple metabolic reprogramming cancer cells reveals intriguing, multi-faceted nature that may link various phenomena including cell signaling, proliferation, ROS generation, energy supply, macromolecules synthesis/biosynthetic precursor immunosuppression, or cooperation cancerous with cancer-associated fibroblasts (CAFs), known as reversed Warburg effect. According to current perception causes consequences effect, PI3K/Akt/mTOR are main signaling pathways concert transcription factors HIF-1, p53, c-Myc, modulate activity/expression key regulatory enzymes, PKM2, PDK1 tune most optimal setting for cell. turn secures adequate levels biosynthetic precursors, NADPH, NAD + , rapid ATP production meet increased demands intensively proliferating tumor cells. The end-product “aerobic glycolysis”, lactate, oncometabolite, provide fuel neighboring cells, facilitate metastasis immunosuppression together enabling progression. importance possible applicability presented issue best illustrated numerous trials agents targeting constituting promising strategy future anti-cancer regimens. In this review, we present aspects multifactorial phenomenon, depicting mechanisms benefits behind also pointing selected field anticancer therapy.
Language: Английский
Citations
58
Experimental Hematology and Oncology, Journal Year: 2024, Volume and Issue: 13(1)
Published: Jan. 29, 2024
Abstract Metabolic reprogramming is an emerging hallmark of cancer cells, enabling them to meet increased nutrient and energy demands while withstanding the challenging microenvironment. Cancer cells can switch their metabolic pathways, allowing adapt different microenvironments therapeutic interventions. This refers heterogeneity, in which cell populations use pathways sustain survival proliferation impact response conventional therapies. Thus, targeting heterogeneity represents innovative avenue with potential overcome treatment resistance improve outcomes. review discusses patterns developmental stages, summarizes molecular mechanisms involved intricate interactions within metabolism, highlights clinical vulnerabilities as a promising regimen. We aim unravel complex characteristics develop personalized approaches address distinct traits, ultimately enhancing patient
Language: Английский
Citations
35
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(4), P. 2251 - 2251
Published: Feb. 13, 2024
This review focuses on the question of metabolic syndrome (MS) being a complex, but essentially monophyletic, galaxy associated diseases/disorders, or just related rather independent pathologies. The human nature MS (its exceptionality in Nature and its close interdependence with action evolution) is presented discussed. text also describes components, special emphasis description their interrelations (including syndromic development recruitment), as well consequences upon energy handling partition. main theories MS’s origin are relation to hepatic steatosis, type 2 diabetes, obesity, encompass most components described so far. differential effects sex biological considered under light social needs evolution, which directly epidemiology, severity, relations senescence. triggering maintenance factors discussed, especial inflammation, complex process affecting different levels organization critical element for development. Inflammation operation connective tissue adipose organ) widely studied acknowledged influence diet. role diet composition, including transcendence anaplerotic Krebs cycle from dietary amino acid supply (and timing), developed context testosterone β-estradiol control insulin-glycaemia core system carbohydrate-triacylglycerol handling. high probability acting unique (essentially monophyletic) presented, together additional perspectives/considerations treatment this ‘very’ disease.
Language: Английский
Citations
29
Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 14
Published: Jan. 17, 2024
Cancer is the most common cause of human death worldwide, posing a serious threat to health and having negative impact on economy. In past few decades, significant progress has been made in anticancer therapies, but traditional including radiation therapy, surgery, chemotherapy, molecular targeted immunotherapy antibody-drug conjugates (ADCs), have side effects, low specificity, emergence drug resistance. Therefore, there an urgent need develop new treatment methods improve efficacy reduce effects. Antimicrobial peptides (AMPs) exist innate immune system various organisms. As promising alternatives drugs for treating cancers, some AMPs also proven possess activities, which are defined as (ACPs). These advantages being able specifically target cancer cells less toxicity normal tissues. More more studies found that marine terrestrial animals contain large amount ACPs. this article, we introduced animal derived with anti-cancer activity, summarized types tumor inhibited by ACPs, mechanisms they exert anti-tumor effects clinical applications
Language: Английский
Citations
21
FEBS Letters, Journal Year: 2024, Volume and Issue: 598(10), P. 1301 - 1327
Published: Feb. 7, 2024
A hallmark of cancer cells is their remarkable ability to efficiently adapt favorable and hostile environments. Due a unique metabolic flexibility, tumor can grow even in the absence extracellular nutrients or stressful scenarios. To achieve this, need large amounts lipids build membranes, synthesize lipid‐derived molecules, generate energy other nutrients. Tumor potentiate strategies obtain from cells, pathways new lipids, mechanisms for efficient storage, mobilization, utilization these lipids. Lipid droplets (LDs) are organelles that collect supply eukaryotes it increasingly recognized accumulation LDs cells. Furthermore, an active role LD proteins processes underlying tumorigenesis has been proposed. Here, by focusing on three major classes LD‐resident (perilipins, lipases, acyl‐CoA synthetases), we provide overview contribution progression discuss during proliferation, invasion, metastasis, apoptosis, stemness
Language: Английский
Citations
17
Nature Nanotechnology, Journal Year: 2024, Volume and Issue: unknown
Published: June 11, 2024
Language: Английский
Citations
16