Journal of Inflammation Research,
Journal Year:
2023,
Volume and Issue:
Volume 16, P. 5545 - 5564
Published: Nov. 1, 2023
Abstract:
Metformin
is
a
classical
drug
used
to
treat
type
2
diabetes.
With
the
development
of
research
on
metformin,
it
has
been
found
that
metformin
also
several
advantages
aside
from
its
hypoglycemic
effect,
such
as
anti-inflammatory,
anti-aging,
anti-cancer,
improving
intestinal
flora,
and
other
effects.
The
prevention
inflammation
critical
because
chronic
associated
with
numerous
diseases
considerable
public
health.
Therefore,
there
growing
interest
in
role
treating
various
inflammatory
conditions.
However,
precise
anti-inflammatory
mechanisms
were
inconsistent
reported
studies.
Thus,
this
review
aims
summarize
currently
known
possible
involved
provide
references
for
clinical
application
metformin.
Keywords:
AMPK,
inflammation,
Molecular Metabolism,
Journal Year:
2023,
Volume and Issue:
74, P. 101755 - 101755
Published: June 16, 2023
Recently,
the
hallmarks
of
aging
were
updated
to
include
dysbiosis,
disabled
macroautophagy,
and
chronic
inflammation.
In
particular,
low-grade
inflammation
during
aging,
without
overt
infection,
is
defined
as
"inflammaging,"
which
associated
with
increased
morbidity
mortality
in
population.
Emerging
evidence
suggests
a
bidirectional
cyclical
relationship
between
development
age-related
conditions,
such
cardiovascular
diseases,
neurodegeneration,
cancer,
frailty.
How
crosstalk
other
underlies
biological
mechanisms
disease
thus
particular
interest
current
geroscience
research.
Biomedicine & Pharmacotherapy,
Journal Year:
2022,
Volume and Issue:
146, P. 112610 - 112610
Published: Jan. 4, 2022
Neurodegenerative
disorders
(NDs)
including
Alzheimer's
disease,
Parkinson's
amyotrophic
lateral
sclerosis,
Huntington's
and
multiple
sclerosis
have
various
disease-specific
causal
factors
pathological
features.
A
very
common
characteristic
of
NDs
is
oxidative
stress
(OS),
which
takes
place
due
to
the
elevated
generation
reactive
oxygen
species
during
progression
NDs.
Furthermore,
condition
an
increased
level
protein
aggregates
can
further
lead
chronic
inflammation
because
microglial
activation.
Carotenoids
(CTs)
are
naturally
occurring
pigments
that
play
a
significant
role
in
averting
brain
disorders.
More
than
750
CTs
present
nature,
they
widely
available
plants,
microorganisms,
animals.
accountable
for
red,
yellow,
orange
several
animals
these
colors
usually
indicate
types
CTs.
exert
bioactive
properties
its
structure,
anti-inflammatory
antioxidant
properties.
Due
protective
CTs,
levels
human
body
been
markedly
linked
with
prevention
treatment
diseases
In
this
review,
we
summarized
relationship
between
OS,
neuroinflammation,
addition,
also
particularly
focused
on
antioxidants
management
Signal Transduction and Targeted Therapy,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: March 14, 2023
Abstract
The
ageing
process
is
a
systemic
decline
from
cellular
dysfunction
to
organ
degeneration,
with
more
predisposition
deteriorated
disorders.
Rejuvenation
refers
giving
aged
cells
or
organisms
youthful
characteristics
through
various
techniques,
such
as
reprogramming
and
epigenetic
regulation.
great
leaps
in
rejuvenation
prove
that
not
one-way
street,
many
rejuvenative
interventions
have
emerged
delay
even
reverse
the
process.
Defining
mechanism
by
which
roadblocks
signaling
inputs
influence
complex
programs
essential
for
understanding
developing
strategies.
Here,
we
discuss
intrinsic
extrinsic
factors
counteract
cell
rejuvenation,
targeted
core
mechanisms
involved
this
Then,
critically
summarize
latest
advances
state-of-art
strategies
of
rejuvenation.
Various
methods
also
provide
insights
treating
specific
ageing-related
diseases,
including
reprogramming,
removal
senescence
(SCs)
suppression
senescence-associated
secretory
phenotype
(SASP),
metabolic
manipulation,
stem
cells-associated
therapy,
dietary
restriction,
immune
heterochronic
transplantation,
etc.
potential
applications
therapy
extend
cancer
treatment.
Finally,
analyze
detail
therapeutic
opportunities
challenges
technology.
Deciphering
will
further
into
anti-ageing
disease
treatment
clinical
settings.
Cells,
Journal Year:
2022,
Volume and Issue:
11(4), P. 672 - 672
Published: Feb. 15, 2022
Senescence
is
a
complex
cellular
stress
response
that
abolishes
proliferative
capacity
and
generates
unique
secretory
pattern
implicated
in
organismal
aging
age-related
disease.
How
cell
transitions
to
senescent
state
multifactorial
often
requires
transcriptional
regulation
of
multiple
genes.
Epigenetic
alterations
DNA
chromatin
are
powerful
regulators
genome
architecture
gene
expression,
they
play
crucial
role
mediating
the
induction
maintenance
senescence.
This
review
will
highlight
changes
chromatin,
methylation,
histone
establish
maintain
senescence,
alongside
specific
epigenetic
senescence-associated
phenotype
(SASP).
Immunity & Ageing,
Journal Year:
2023,
Volume and Issue:
20(1)
Published: June 8, 2023
Aging
is
a
gradual,
continuous
series
of
natural
changes
in
biological,
physiological,
immunological,
environmental,
psychological,
behavioral,
and
social
processes.
entails
the
immune
system
characterized
by
decrease
thymic
output
naïve
lymphocytes,
an
accumulated
chronic
antigenic
stress
notably
caused
infections
such
as
cytomegalovirus
(CMV),
cell
senescence
with
acquisition
inflammatory
senescence-associated
secretory
phenotype
(SASP).
For
this
reason,
due
to
SASP
originating
from
other
tissues,
aging
commonly
accompanied
low-grade
inflammation,
termed
"inflammaging".
After
decades
accumulating
evidence
regarding
age-related
processes
domain
now
appears
mature
enough
allow
integrative
reinterpretation
old
data.
Here,
we
provide
overview
topics
discussed
recent
workshop
"Aging
Chronic
Inflammation"
which
many
major
players
field
contributed.
We
highlight
advances
systematic
measurement
interpretation
biological
markers
aging,
well
their
implications
for
human
health
longevity
interventions
that
can
be
envisaged
maintain
or
improve
function
older
people.
Frontiers in Endocrinology,
Journal Year:
2022,
Volume and Issue:
13
Published: Sept. 15, 2022
Osteoporosis
is
defined
as
a
systemic
skeletal
disease
characterized
by
decreased
bone
mass
and
micro-architectural
deterioration
leading
to
increased
fracture
risk.
incidence
increases
with
age
in
both
post-menopausal
women
aging
men.
Among
other
important
contributing
factors
fragility
observed
osteoporosis,
that
also
affect
the
elderly
population,
are
metabolic
disturbances
obesity
Type
2
Diabetes
(T2D).
These
complications
associated
impaired
homeostasis
higher
Expansion
of
Bone
Marrow
Adipose
Tissue
(BMAT),
at
expense
formation,
thought
be
one
key
pathogenic
mechanisms
underlying
osteoporosis
T2D.
Our
review
provides
summary
behind
Adiposity
(BMA)
during
highlights
pre-clinical
clinical
studies
connecting
T2D,
BMA
osteoporotic
Aging and Disease,
Journal Year:
2023,
Volume and Issue:
14(5), P. 1633 - 1633
Published: Jan. 1, 2023
Fibrosis
is
the
abnormal
accumulation
of
extracellular
matrix
proteins
such
as
collagen
and
fibronectin.
Aging,
injury,
infections,
inflammation
can
cause
different
types
tissue
fibrosis.
Numerous
clinical
investigations
have
shown
a
correlation
between
degree
liver
pulmonary
fibrosis
in
patients
telomere
length
mitochondrial
DNA
content,
both
which
are
signs
aging.
Aging
involves
gradual
loss
function
over
time,
results
homeostasis
and,
ultimately,
an
organism's
fitness.
A
major
feature
aging
senescent
cells.
Senescent
cells
abnormally
continuously
accumulate
late
stages
life,
contributing
to
age-related
deterioration,
among
other
characteristics.
Furthermore,
generates
chronic
inflammation,
decreases
organ
function.
This
finding
suggests
that
closely
related.
The
transforming
growth
factor-beta
(TGF-β)
superfamily
plays
crucial
role
physiological
pathological
processes
aging,
immune
regulation,
atherosclerosis,
In
this
review,
functions
TGF-β
normal
organs,
fibrotic
tissues
discussed:
signalling
altered
with
age
indicator
pathology
associated
addition,
review
discusses
potential
targeting
noncoding.
