The protective roles of citrus flavonoids, naringenin, and naringin on endothelial cell dysfunction in diseases

Heliyon, Journal Year: 2023, Volume and Issue: 9(6), P. e17166 - e17166

Published: June 1, 2023

The endothelial cells (ECs) make up the inner lining of blood vessels, acting as a barrier separating and tissues in several organs. ECs maintain endothelium integrity by controlling constriction relaxation vasculature, fluidity, adhesion, migration. These actions are efficiently coordinated via an intricate signaling network connecting receptors, wide range cellular macromolecules. naturally quiescent i.e.; they not stimulated do proliferate. Upon infection or disease, become activated, this alteration is pivotal pathogenesis spectrum human neurological, cardiovascular, diabetic, cancerous, viral diseases. Considering central position that play disease pathogenesis, therapeutic options have been targeted at improving integrity, assembly, functioning, health. dietary intake flavonoids present citrus fruits has associated with reduced risk dysfunction. Naringenin (NGN) Naringin (NAR), major grapefruit, tomatoes, oranges possess anti-inflammatory, antioxidant properties, cell survival potentials, which improve health vascular endothelium. In review, we provide comprehensive summary advances understanding mechanisms through NGN NAR modulate biomarkers dysfunction protect against unresolved inflammation, oxidative stress, atherosclerosis, angiogenesis. We also perspectives suggest further studies will help assess efficacy therapeutics

Language: Английский

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Interaction of Jania rubens Polyphenolic Extract as an Antidiabetic Agent with α-Amylase, Lipase, and Trypsin: In Vitro Evaluations and In Silico Studies

Catalysts, Journal Year: 2023, Volume and Issue: 13(2), P. 443 - 443

Published: Feb. 18, 2023

Jania rubens red seaweed has various bioactive compounds that can be used for several medicinal and pharmaceutical applications. In this study, we investigate the antidiabetic, anti-inflammatory, antioxidant competency of polyphenolic extract (JRPE) by assessing their interactions with α-amylase, lipase, trypsin enzymes. HPLC analysis revealed dominance twelve compounds. We performed computational using as target proteins polyphenols to explore activities based on predicted modes binding sites following molecular modeling analysis. The docking demonstrated a good affinity score noticeable compositions rubens. highest α-amylase (PDB: 4W93) were kaempferol, quercetin, chlorogenic acid, −8.4, −8.8 −8 kcal/mol, respectively. Similarly, lipase 1LPB) high scores −7.1, −7.4, −7.2 kcal/mol Furthermore, 4DOQ) results, acid −7.2, −7.1 findings verified in vitro evaluations, manifesting comparable results. Overall, these enlighten JRPE properties different diabetics’ enzymes could further studied vivo investigations diabetes treatment.

Language: Английский

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Consumption of dietary anthocyanins and their association with a reduction in obesity biomarkers and the prevention of obesity

Trends in Food Science & Technology, Journal Year: 2023, Volume and Issue: 140, P. 104140 - 104140

Published: Aug. 22, 2023

The emergency for treating obesity has increased, triggering severe economic issues worldwide. consumption of anthocyanins from different dietetic sources or by pharmaceutical prescription shown strong associations with ameliorating specific physiological biomarkers and genetic factors related to obesity. This review focuses on examining contrasting the findings past five years regarding precise effects anthocyanin compounds metabolic health. These were evaluated primarily in vivo models, assessed before after various fresh foods, food extracts, supplemental products. Descriptions a few elements connected to, among others, adipose tissue, vascular endothelium, systemic pro-inflammatory state, are reviewed. Clinical trials subjects overweight essays murine obesity-induced models have reported promising concerning consumption, specifically cyanidin-3-O-glucoside ingestion. main indicators significant reduction body weight fat mass (brown adipocytes), triglycerides, cholesterol (LDL VLDL), insulin resistance (HOMA) decrease inflammation such as IL-6, IL-10, TNF-α, promoting AMPK MAPK pathways regulating genes adipogenesis (PPAR-γ, GPx1, ACAT3, COX2, UCP1, IL1β). There is lack studies human corroborate beneficial (by diet prescribed). It necessary discuss policies nutritional advice regulations incentivizing ingestion therapeutic effect against

Language: Английский

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Signaling pathways and intervention for therapy of type 2 diabetes mellitus

MedComm, Journal Year: 2023, Volume and Issue: 4(3)

Published: June 1, 2023

Type 2 diabetes mellitus (T2DM) represents one of the fastest growing epidemic metabolic disorders worldwide and is a strong contributor for broad range comorbidities, including vascular, visual, neurological, kidney, liver diseases. Moreover, recent data suggest mutual interplay between T2DM Corona Virus Disease 2019 (COVID-19). characterized by insulin resistance (IR) pancreatic β cell dysfunction. Pioneering discoveries throughout past few decades have established notable links signaling pathways pathogenesis therapy. Importantly, number substantially control advancement core pathological changes in T2DM, IR dysfunction, as well additional pathogenic disturbances. Accordingly, an improved understanding these sheds light on tractable targets strategies developing repurposing critical therapies to treat its complications. In this review, we provide brief overview history pathways, offer systematic update role mechanism key underlying onset, development, progression T2DM. content, also summarize current therapeutic drugs/agents associated with treatment complications, discuss some implications directions future field.

Language: Английский

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The obesity-autophagy-cancer axis: Mechanistic insights and therapeutic perspectives

Seminars in Cancer Biology, Journal Year: 2024, Volume and Issue: 99, P. 24 - 44

Published: Feb. 1, 2024

Autophagy, a self-degradative process vital for cellular homeostasis, plays significant role in adipose tissue metabolism and tumorigenesis. This review aims to elucidate the complex interplay between autophagy, obesity, cancer development, with specific emphasis on how obesity-driven changes affect regulation of autophagy subsequent implications risk. The burgeoning epidemic obesity underscores relevance this research, particularly given established links various cancers. Our exploration delves into hormonal influence, notably INS (insulin) LEP (leptin), interactions. Further, we draw attention latest findings molecular factors linking cancer, including changes, altered metabolism, secretory autophagy. We posit that targeting modulation may offer potent therapeutic approach obesity-associated pointing promising advancements nanocarrier-based targeted therapies modulation. However, also recognize challenges inherent these approaches, concerning their precision, control, dual roles can play cancer. Future research directions include identifying novel biomarkers, refining therapies, harmonizing approaches precision medicine principles, thereby contributing more personalized, effective treatment paradigm obesity-mediated

Language: Английский

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Targeting JAK2/STAT3 for the treatment of cancer: A review on recent advancements in molecular development using structural analysis and SAR investigations

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 143, P. 107095 - 107095

Published: Jan. 4, 2024

Language: Английский

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Molecular mechanisms of semaglutide and liraglutide as a therapeutic option for obesity

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: April 29, 2024

Obesity, a chronic global health problem, is associated with an increase in various comorbidities, such as cardiovascular disease, type 2 diabetes mellitus, hypertension, and certain types of cancer. The increasing prevalence obesity requires research into new therapeutic strategies. Glucagon-like peptide-1 receptor agonists, specifically semaglutide liraglutide, designed for mellitus treatment, have been explored drugs the treatment obesity. This minireview describes molecular mechanisms liraglutide different metabolic pathways, its mechanism action processes appetite regulation, insulin secretion, glucose homeostasis, energy expenditure, lipid metabolism. Finally, several clinical trial outcomes are described to show safety efficacy these management.

Language: Английский

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Overview of growth differentiation factor 15 (GDF15) in metabolic diseases

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 176, P. 116809 - 116809

Published: May 29, 2024

GDF15 is a stress response cytokine and distant member of the transforming growth factor beta (TGFβ) superfamily, its levels increase in to cell certain diseases serum. To exert effects, binds glial-derived neurotrophic (GDNF) receptor alpha-like (GFRAL), which was firstly identified 2017 highly expressed brain stem. Many studies have demonstrated that elevated serum associated with anorexia weight loss. Herein, we focus on biology GDF15, specifically how this circulating protein regulates appetite metabolism influencing energy homeostasis through actions hindbrain neurons shed light impact such as obesity anorexia/cachexia syndromes. It works an endocrine transmits metabolic signals leading reduction effects by directly reducing indirectly affecting food intake complex mechanisms, could be promising target for treatment energy-intake disorders.

Language: Английский

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Far-Infrared Therapy Based on Graphene Ameliorates High-Fat Diet-Induced Anxiety-Like Behavior in Obese Mice via Alleviating Intestinal Barrier Damage and Neuroinflammation

Neurochemical Research, Journal Year: 2024, Volume and Issue: 49(7), P. 1735 - 1750

Published: March 26, 2024

Language: Английский

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An integrative framework to prioritize genes in more than 500 loci associated with body mass index

The American Journal of Human Genetics, Journal Year: 2024, Volume and Issue: 111(6), P. 1035 - 1046

Published: May 15, 2024

Obesity is a major risk factor for myriad of diseases, affecting >600 million people worldwide. Genome-wide association studies (GWASs) have identified hundreds genetic variants that influence body mass index (BMI), commonly used metric to assess obesity risk. Most are non-coding and likely act through regulating genes nearby. Here, we apply multiple computational methods prioritize the causal gene(s) within each 536 previously reported GWAS-identified BMI-associated loci. We performed summary-data-based Mendelian randomization (SMR), FINEMAP, DEPICT, MAGMA, transcriptome-wide (TWASs), mutation significance cutoff (MSC), polygenic priority score (PoPS), nearest gene strategy. Results method were weighted based on their success in identifying known be implicated obesity, ranking all prioritized according confidence (minimum: 0; max: 28). 292 high-scoring (≥11) 264 loci, including play role weight regulation (e.g., DGKI, ANKRD26, MC4R, LEPR, BDNF, GIPR, AKT3, KAT8, MTOR) related comorbidities FGFR1, ISL1, TFAP2B, PARK2, TCF7L2, GSK3B). For most genes, however, found limited or no evidence top-scoring BPTF. Many seem neuronal weight, whereas others affect peripheral pathways, circadian rhythm, insulin secretion, glucose carbohydrate homeostasis. The characterization these can increase our understanding underlying biology offer avenues develop therapeutics loss.

Language: Английский

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