Ageing Research Reviews, Journal Year: 2025, Volume and Issue: 104, P. 102657 - 102657
Published: Jan. 7, 2025
Language: Английский
Aging, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 2, 2024
Objective: The objective of this study was to explore the potential correlation between composite dietary antioxidant index (CDAI) and biological aging, addressing insufficient epidemiological evidence in area. Methods: Participants meeting eligibility criteria were selected from National Health Nutrition Examination Surveys (NHANES) conducted 2001 2018. CDAI determined based on antioxidants obtained 24-hour recalls. Biological age using PhenoAge algorithms incorporating various clinical features. Weighted multiple models employed investigate assess association age. Results: Analysis quartile revealed disparities terms age, gender, ethnicity, educational level, marital status, poverty, calories intakes, smoking, drinking BMI, physical activity, PhenoAge. After adjusting for confounding factors, a significant inverse relationship found Phenotypic Age, with each standard deviation increase score correlating 0.18-year decrease Age. These negative correlations advancement observed regardless activity smoking body mass index. Conclusions: Our findings demonstrate positive higher scores delayed aging. results have implications public health initiatives aimed at promoting healthy aging through interventions.
Language: Английский
Citations
28
Advanced Materials, Journal Year: 2024, Volume and Issue: 36(18)
Published: Jan. 15, 2024
Abstract Mitochondria, widely known as the energy factories of eukaryotic cells, have a myriad vital functions across diverse cellular processes. Dysfunctions within mitochondria serve catalysts for various diseases, prompting widespread demise. Mounting research on remedying damaged indicates that constitute valuable target therapeutic intervention against diseases. But less clinical practice and lower recovery rate imply limitation traditional drugs, which need further breakthrough. Nanotechnology has approached favorable regiospecific biodistribution high efficacy by capitalizing excellent nanomaterials targeting drug delivery. Mitochondria‐remedying nanodrugs achieved ideal effects. This review elucidates significance in cells organs, while also compiling mortality data related Correspondingly, nanodrug‐mediate strategies applicable mitochondria‐remedying disease are detailed, with full understanding roles dysfunction advantages nanodrugs. In addition, future challenges directions discussed. conclusion, this provides comprehensive insights into design development nanodrugs, aiming to help scientists who desire extend their fields engage interdisciplinary subject.
Language: Английский
Citations
26
Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)
Published: Jan. 12, 2024
Abstract Exosomes are tiny extracellular vesicles secreted by most cell types, which filled with proteins, lipids, and nucleic acids (non-coding RNAs, mRNA, DNA), can be released donor cells to subsequently modulate the function of recipient cells. Skin photoaging is premature aging skin structures over time due repeated exposure ultraviolet (UV) evidenced dyspigmentation, telangiectasias, roughness, rhytides, elastosis, precancerous changes. associated aging-related processes including, oxidative stress, inflammation, senescence. Anti-aging features exosomes have been implicated in various vitro pre-clinical studies. Stem cell-derived restore physiological regenerate or rejuvenate damaged tissue through mechanisms such as decreased expression matrix metalloproteinase (MMP), increased collagen elastin production, modulation intracellular signaling pathways well as, intercellular communication. All these evidences promising for therapeutic potential photoaging. This review aims investigate molecular effects
Language: Английский
Citations
25
npj Vaccines, Journal Year: 2024, Volume and Issue: 9(1)
Published: April 10, 2024
Immunosenescence increases the risk and severity of diseases in elderly individuals leads to impaired vaccine-induced immunity. With aging global population emerging epidemics, developing adjuvants vaccines for improve their immune protection is pivotal healthy worldwide. Deepening our understanding role immunosenescence vaccine efficacy could accelerate research focused on optimizing delivery individuals. In this review, we analyzed characteristics at cellular molecular levels. Strategies vaccination potency are summarized, including increasing antigen dose, preparing multivalent vaccines, adding appropriate adjuvants, inhibiting chronic inflammation, immunosenescence. We hope that review can provide a new findings with regards impacts vaccine-mediated inspire development individualized
Language: Английский
Citations
25
Nutrients, Journal Year: 2024, Volume and Issue: 16(2), P. 240 - 240
Published: Jan. 12, 2024
The escalating prevalence of metabolic diseases and an aging demographic has been correlated with a concerning rise in Alzheimer's disease (AD) incidence. This study aimed to access the protective effects curcumin, bioactive flavonoid from turmeric, on spatial memory, functions, regulation gut microbiome AD-induced (3xTg-AD) mice fed either normal chow diet (NCD) or high-fat high-sugar (HFHSD). Our findings revealed augmented susceptibility HFHSD-fed 3xTg-AD for weight gain memory impairment, while curcumin supplementation demonstrated effect against these changes. was evidenced by significantly reduced body improved behavioral cognitive function curcumin-treated group. These improvements were substantiated diminished fatty acid synthesis, altered cholesterol metabolism, suppressed adipogenesis-related pathways liver, along modified synaptic plasticity-related brain. Moreover, enriched beneficial microbiota, including
Language: Английский
Citations
23
Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 95, P. 102204 - 102204
Published: Jan. 23, 2024
The pursuit for the fountain of youth has long been a fascination amongst scientists and humanity. Ageing is broadly characterized by cellular decline with increased susceptibility to age-related diseases, being intimately associated epigenetic modifications. Recently, reprogramming-induced rejuvenation strategies have begun greatly alter longevity research not only tackle defects but also possibly reverse ageing process. Hence, in this review, we highlight major changes during state-of-art current emerging reprogramming leveraging on transcription factors. Notably, partial enables resetting clock without erasing identity. Promising chemical-based harnessing small molecules, including DNA methyltransferase histone deacetylase inhibitors are discussed. Moreover, parallel interventions, foundations clocks accurate assessment evaluation approaches briefly presented. Going further, such scientific breakthroughs, witnessing rise biotech industry aiming extend health span ideally achieve human one day. In context, overview main scenarios proposed future socio-economic ethical challenges an field. Ultimately, review aims inspire interventions that promote healthy all.
Language: Английский
Citations
20
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5805 - 5805
Published: May 26, 2024
The testes serve as the primary source of androgens and site spermatogenesis, with their development function governed by hormonal actions via endocrine paracrine pathways. Male fertility hinges on availability testosterone, a cornerstone while follicle-stimulating hormone (FSH) signaling is indispensable for proliferation, differentiation, proper functioning Sertoli germ cells. This review covers research how androgens, FSH, other hormones support processes crucial male in testis reproductive tract. These are regulated hypothalamic–pituitary–gonad (HPG) axis, which either quiescent or activated at different stages life course, regulation axis normal system. Hormonal imbalances, whether due to genetic predispositions environmental influences, leading hypogonadism hypergonadism, can precipitate disorders. Investigating regulatory network molecular mechanisms involved testicular spermatogenesis instrumental developing new therapeutic methods, drugs, contraceptives.
Language: Английский
Citations
20
Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 100, P. 102428 - 102428
Published: July 20, 2024
Language: Английский
Citations
19
Cells, Journal Year: 2024, Volume and Issue: 13(22), P. 1838 - 1838
Published: Nov. 6, 2024
Cell survival and death are intricately governed by apoptosis, a meticulously controlled programmed cell death. Apoptosis is vital in facilitating embryonic development maintaining tissue homeostasis immunological functioning. It complex interplay of intrinsic extrinsic signaling pathways that ultimately converges on executing the apoptotic program. The pathway initiated binding ligands such as TNF-α Fas to their respective receptors surface. In contrast, leads increased permeability outer mitochondrial membrane release apoptogenic factors like cytochrome c, which regulated Bcl-2 family proteins. Once activated, these lead cascade biochemical events, including caspase activation, DNA fragmentation, dismantling cellular components. Dysregulation apoptosis implicated various disorders, cancer, autoimmune diseases, neurodegenerative cardiovascular diseases. This article focuses elucidating molecular mechanisms underlying regulation, develop targeted therapeutic strategies. Modulating holds immense potential cancer treatment, where promoting malignant cells could tumor regression. demonstrates targeting providing options for treating neurological illnesses. safety effectiveness apoptosis-targeting drugs being assessed ongoing preclinical clinical trials (phase I-III), opening door more effective approaches better patient outcomes.
Language: Английский
Citations
19
Redox Biology, Journal Year: 2024, Volume and Issue: 70, P. 103032 - 103032
Published: Jan. 21, 2024
Thioredoxin (Trx) is a compact redox-regulatory protein that modulates cellular redox state by reducing oxidized proteins. Trx exhibits dual functionality as an antioxidant and cofactor for diverse enzymes transcription factors, thereby exerting influence over their activity function. has emerged pivotal biomarker various diseases, particularly those associated with oxidative stress, inflammation, aging. Recent clinical investigations have underscored the significance of in disease diagnosis, treatment, mechanistic elucidation. Despite its paramount importance, intricate interplay between senescence-a condition characterized irreversible growth arrest induced multiple aging stimuli-remains inadequately understood. In this review, our objective to present comprehensive up-to-date overview structure function Trx, involvement signaling pathways senescence, association age-related well potential therapeutic target. Our review aims elucidate novel extensive role senescence while highlighting implications diseases.
Language: Английский
Citations
18