The combination of flaxseed lignans and PD-1/ PD-L1 inhibitor inhibits breast cancer growth via modulating gut microbiome and host immunity DOI Creative Commons

Hao Wu,

J.F. Liu, Xinghua Zhang

et al.

Drug Resistance Updates, Journal Year: 2025, Volume and Issue: 80, P. 101222 - 101222

Published: Feb. 28, 2025

Patients with breast cancer (BC) who benefit from the PD-1/PD-L1 inhibitor (PDi) is limited, necessitating novel strategies to improve immunotherapy efficacy of BC. Here we aimed investigate inhibitory effects flaxseed lignans (FL) on biological behaviors BC and evaluate roles FL in enhancing anticancer PDi. HPLC was used detect content enterolactone (ENL), bacterial transformation product FL. Transcript sequencing performed identified CD38 as a downstream target gene ENL. CD38-overexpressing cells were constructed cell proliferation, colony formation, wound healing transwell assays assess function ENL/CD38 axis vitro. Multiplexed immunohistochemistry (mIHC) CyTOF changes tumor immune microenvironment (TIM). 16S rDNA explore gut microbiota mice. A series vivo experiments conducted mechanisms converted ENL by administration inhibited progression malignant downregulating CD38, key associated immunosuppression blockade resistance. The mIHC assay revealed that enhanced CD3+, CD4+ CD8+ reduced F4/80+ TIM. confirmed regulatory combination PDi (FLcPDi) In addition, analysis demonstrated FLcPDi treatment significantly elevated abundance Akkermansia and, importantly, response mice treated antibiotics. FL/ENL/CD38 progression. modulating host immunity.

Language: Английский

Regulatory T cells in immune checkpoint blockade antitumor therapy DOI Creative Commons

An Zhang,

Tao Fan,

Yixiao Liu

et al.

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: Nov. 8, 2024

Regulatory T cells (Tregs), an essential component of the human immune system, are a heterogeneous group lymphocytes with ability to suppress responses and maintain homeostasis. Recent evidence indicates that Tregs may impair antitumor immunity facilitate cancer progression by weakening functions effector (Teffs). Consequently, targeting eliminate them from tumor microenvironments improve Teffs' activity could emerge as effective strategy for immunotherapy. This review outlines biology Tregs, detailing their origins, classification, crucial markers. Our focus lies on complex role in cancer's development, treatment, particularly suppressive upon via multiple mechanisms. We delve into Tregs' involvement checkpoint blockade (ICB) therapy, dual effect immunotherapy potential biomarkers ICB therapy effectiveness. also summarize advances therapies adjust optimize which be devising innovative treatment strategies.

Language: Английский

Citations

14
Multiomics profiling reveals the benefits of gamma-delta (γδ) T lymphocytes for improving the tumor microenvironment, immunotherapy efficacy and prognosis in cervical cancer DOI Creative Commons
Junyi Li,

Yuanjie Cao,

Yan‐Cheng Liu

et al.

Journal for ImmunoTherapy of Cancer, Journal Year: 2024, Volume and Issue: 12(1), P. e008355 - e008355

Published: Jan. 1, 2024

As an unconventional subpopulation of T lymphocytes, γδ cells can recognize antigens independently major histocompatibility complex restrictions. Recent studies have indicated that play contrasting roles in tumor microenvironments-promoting progression some cancers (eg, gallbladder and leukemia) while suppressing it others lung gastric). are mainly enriched peripheral mucosal tissues. the cervix is a mucosa-rich tissue, role cervical cancer warrants further investigation.

Language: Английский

Citations

13
How do sphingosine-1-phosphate affect immune cells to resolve inflammation? DOI Creative Commons

Gehui Sun,

Bin Wang, Xiaoyu Wu

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 28, 2024

Inflammation is an important immune response of the body. It a physiological process self-repair and defense against pathogens taken up by biological tissues when stimulated damage factors such as trauma infection. main cause high morbidity mortality in most diseases basis disease. Targeted therapeutic strategies can achieve efficient toxicity clearance at inflammatory site, reduce complications, mortality. Sphingosine-1-phosphate (S1P), lipid signaling molecule, involved cell transport binding to S1P receptors (S1PRs). plays key role innate adaptive responses closely related inflammation. In homeostasis, lymphocytes follow concentration gradient from into circulation. One widely accepted mechanism that during response, altered, are blocked entering circulation are, therefore, unable reach site. However, full its involvement inflammation not fully understood. This review focuses on bacterial viral infections, autoimmune diseases, immunological aspects Sphks/S1P/S1PRs pathway, highlighting their promoting intradial-adaptive interactions. How regulated how shapes through cells explained detail. We teased apart composition critical pathway modulators host system. By understanding pathogenesis we linked genomic studies S1P-targeted drugs provide for targeted drug development.

Language: Английский

Citations

13
Metabolic dysregulation of lymphocytes in autoimmune diseases DOI
Shuyi Wang, Niansheng Yang, Hui Zhang

et al.

Trends in Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: 35(7), P. 624 - 637

Published: Feb. 13, 2024

Language: Английский

Citations

12
Zinc Oxide‐Enhanced Copper Sulfide Nanozymes Promote the Healing of Infected Wounds by Activating Immune and Inflammatory Responses DOI Open Access
Wei Zhang, Yang Lv,

Qiang Niu

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 9, 2024

Bacterial infection and an excessive inflammatory response are two major factors that affect the healing of infected wounds. The zinc oxide/copper sulfide (ZnO-CuS) microspheres (MSs) developed in this work can kill bacteria resist inflammation. ZnO-CuS exhibits different enzyme-like activities depending on pH. In acidic environments, peroxidase-like (POD-like) activity convert hydrogen peroxide (H

Language: Английский

Citations

12
The Role of the Immune System in the Course of Hashimoto’s Thyroiditis: The Current State of Knowledge DOI Open Access

Karolina Wrońska,

Maciej Hałasa, Małgorzata Szczuko

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 6883 - 6883

Published: June 23, 2024

The process of thyroid autoimmunization develops against the background genetic predispositions associated with class II human leukocyte antigens (HLA-DR), as well cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), tyrosine phosphatase non-receptor type 22 (PTPN22), and forkhead transcription box P3 (FOXP3). Environmental factors, such vitamin D deficiency, Zn, Se, Mg, infections, chronic stress, pregnancy, smoking, alcohol, medications, intestinal dysbiosis, malnutrition, also play an important role. first stage involves accumulation macrophages dendritic cells, plasma cells. In second stage, mutual interactions individual cells in immune system lead to a decrease level CD8+ favor CD4+, which intensifies synthesis T lymphocyte derivatives, especially Th1, Th17, Tfh, Tc, reducing Treg. Consequently, number anti-inflammatory cytokines IL10 IL2 decreases, pro-inflammatory IL-2, Il-12, Il-17, IL-21, IL-22, IFN-γ, TNF-α increases. latter two trigger pyroptosis involving inflammasome. Activation inflammasome by IL-β IL-18 produced is one mechanisms course Hashimoto's thyroiditis, Gram-negative bacteria NLRC4. next step, apoptosis initiated intensification perforin, granzyme, proteoglycan Tc NK current findings raise many possibilities regarding interventions related inhibition stimulation both B lymphocytes. Furthermore, since there currently no effective method for treating autoimmunity, summary review may provide answers treatment not only but other autoimmune diseases autoimmunity.

Language: Английский

Citations

11
Stability and plasticity of regulatory T cells in health and disease DOI Creative Commons
Eugenio Contreras-Castillo,

Verónica Yutsil García-Rasilla,

María Guadalupe García-Patiño

et al.

Journal of Leukocyte Biology, Journal Year: 2024, Volume and Issue: 116(1), P. 33 - 53

Published: March 1, 2024

The mechanisms that negatively regulate inflammation upon a pathogenic stimulus are crucial for the maintenance of tissue integrity and organ function. T regulatory cells one main drivers in controlling inflammation. ability to adapt different inflammatory cues suppress is relevant features cells. During this process, express transcription factors associated with their counterparts, Th helper cells, including Tbx21, GATA-3, Bcl6, Rorc. acquisition factor helps migrate inflamed tissues. Additionally, have preserve stability while acquiring particular cell subtype. This review focuses on describing subtypes maintain identity health diseases.

Language: Английский

Citations

10
Therapeutic delivery systems for rheumatoid arthritis based on hydrogel carriers DOI Creative Commons
Fabiola A. Chapa-Villarreal,

Madeleine Stephens,

Rachel Pavlicin

et al.

Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 208, P. 115300 - 115300

Published: March 26, 2024

Language: Английский

Citations

10
M7G-related tumor immunity: novel insights of RNA modification and potential therapeutic targets DOI Creative Commons
Mengzhen Han,

Qibo Huang,

Xinxin Li

et al.

International Journal of Biological Sciences, Journal Year: 2024, Volume and Issue: 20(4), P. 1238 - 1255

Published: Jan. 1, 2024

RNA modifications play a pivotal role in regulating cellular biology by exerting influence over distribution features and molecular functions at the post-transcriptional level.Among these modifications, N7-methylguanosine (m7G) stands out as one of most prevalent.Over recent years, significant attention has been directed towards understanding implications m7G modification.This modification is present diverse molecules, including transfer RNAs, messenger ribosomal other noncoding RNAs.Its regulation occurs through series specific methyltransferases m7G-binding proteins.Notably, implicated various diseases, prominently across multiple cancer types.Earlier studies have elucidated significance context immune within tumor microenvironment.This comprehensive review culminates synthesis findings related to modulation cells infiltration, encompassing T cells, B innate all orchestrated modification.Furthermore, interplay between its regulatory proteins can profoundly affect efficacy adjuvant therapeutics, thereby potentially serving biomarker therapeutic target for combinatory interventions types.

Language: Английский

Citations

9
Hybrid Cellular Nanovesicles Block PD‐L1 Signal and Repolarize M2 Macrophages for Cancer Immunotherapy DOI
Chenchen Zhao,

Yuanwei Pan,

Lujie Liu

et al.

Small, Journal Year: 2024, Volume and Issue: 20(31)

Published: March 8, 2024

Abstract The PD1/PD‐L1 immune checkpoint blocking is a promising therapy, while immunosuppressive tumor microenvironment (TME) and poor penetration of therapeutic antibodies limit its efficacy. Repolarization tumor‐associated macrophages (TAMs) offers potential method to ameliorate immunosuppression TME further boost T cell antitumor immunity. Herein, hybrid membrane biomimetic nanovesicles (hNVs) are developed by fusing M1 macrophage‐derived (M1‐NVs) PD1‐overexpressed cell‐derived (PD1‐NVs) improve cancer immunotherapy. M1‐NVs promote the transformation M2‐like TAMs M1‐like phenotype increase release pro‐inflammatory cytokines, resulting in improved TME. Concurrently, PD1‐NVs block pathway, which boosts immunotherapy when combined with M1‐NVs. In breast mouse model, hNVs efficiently accumulate at site after intravenous injection significantly inhibit growth. Mechanically, CD8 + lymphocytes twofold treatment, indicating effective activation. These results suggest as strategy integrate improvement blockade for

Language: Английский

Citations

9