Integrated analysis of M2 macrophage-related gene prognostic model and single-cell sequence to predict immunotherapy response in lung adenocarcinoma DOI Creative Commons
Meifang Li, Zhiping Wang, Bin Huang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 24, 2024

Abstract Introduction Lung adenocarcinoma (LUAD) patients have high heterogeneity. The significance and clinical value of M2 macrophage related genes in LUAD require further exploration. We aimed to construct a prognostic signature predict the immunotherapy efficacy prognosis LUAD. Methods GSE26939 GSE19188 chips were downloaded from Gene Expression Omnibus (GEO). Weighted gene co-expression network analysis (WGCNA) least absolute shrinkage selection operator (LASSO) used screen macrophage-related genes. A based on was established Results Twenty-two associated with confirmed using WGNNA, then two molecular subtypes identified significant different survival, expressions clinic characteristics classified. LASSO nine establish risk signature, classifying into low- high-risk groups. Data indicated that low-risk had better survival. Moreover, an independent factor for potential biomarker receiving immunotherapy. Single-cell transcriptome may provide important information Conclusions Risk is valuable tool predicting response

Language: Английский

Metal‐Coordinated Polydopamine Structures for Tumor Imaging and Therapy DOI
Lihua Wang,

Kai‐Yue Song,

Cong Jiang

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(28)

Published: July 17, 2024

Meticulously engineered nanomaterials achieve significant advances in the diagnosis and therapy of solid tumors by improving tumor delivery efficiency; thereby, enhancing imaging therapeutic efficacy. Currently, polydopamine (PDA) attracts widespread attention because its biocompatibility, simplicity preparation, abundant surface groups, high photothermal conversion efficiency, which can be applied drug delivery, therapy, theranostics, other nanomedicine fields. Inspired PDA structures that are rich catechol amino functional groups coordinate with various metal ions, have charming qualities characteristics, metal-coordinated exploited for but not thoroughly summarized. Herein, this review summarizes recent progress fabrication their availabilities further in-depth discussion challenges future perspectives structures, aim systematic promote interdisciplinary intersections provide inspiration growth clinical translation materials.

Language: Английский

Citations

11
Extracellular Vesicle‐Inspired Therapeutic Strategies for the COVID‐19 DOI
Ziwei Hu, Wei Wang,

Ying Lin

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(29)

Published: June 25, 2024

Emerging infectious diseases like coronavirus pneumonia (COVID-19) present significant challenges to global health, extensively affecting both human society and the economy. Extracellular vesicles (EVs) have demonstrated remarkable potential as crucial biomedical tools for COVID-19 diagnosis treatment. However, due limitations in performance titer of natural vesicles, their clinical use remains limited. Nonetheless, EV-inspired strategies are gaining increasing attention. Notably, biomimetic inspired by EVs, possess specific receptors that can act "Trojan horses," preventing virus from infecting host cells. Genetic engineering enhance these enabling them carry more receptors, significantly specificity absorbing novel coronavirus. Additionally, inherit numerous cytokine parent cells, allowing effectively mitigate "cytokine storm" adsorbing pro-inflammatory cytokines. Overall, this strategy offers new avenues treatment emerging diseases. Herein, review systematically summarizes current applications COVID-19. The status associated with implementation also discussed. goal is provide insights into design expand application combating

Language: Английский

Citations

7
Potential mechanisms of rheumatoid arthritis therapy: Focus on macrophage polarization DOI

Xinyu Yang,

Jinling Li, Chengchao Xu

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 142, P. 113058 - 113058

Published: Sept. 4, 2024

Language: Английский

Citations

5
Engineering Cellular Vesicles for Immunotherapy DOI Creative Commons
Xinyu Lin, Ludan Yue, Ke Cheng

et al.

Accounts of Materials Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Language: Английский

Citations

0
Integrated analysis of M2 macrophage-related gene prognostic model and single-cell sequence to predict immunotherapy response in lung adenocarcinoma DOI Creative Commons
Meifang Li, Zhiping Wang, Bin Huang

et al.

Frontiers in Genetics, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 3, 2025

Background Lung adenocarcinoma (LUAD) patients have high heterogeneity. The significance and clinical value of M2 macrophage-related genes in LUAD require further exploration. We aimed to construct a prognostic signature predict the immunotherapy efficacy prognosis LUAD. Methods GSE26939 GSE19188 chips were downloaded from Gene Expression Omnibus (GEO). Weighted gene co-expression network analysis (WGCNA) least absolute shrinkage selection operator (LASSO) used screen genes. A based on was established Results Twenty-two associated with confirmed using WGCNA, then two molecular subtypes identified significantly different survival, expressions, clinic characteristics classified. LASSO nine establish risk signature, classifying into low- high-risk groups. Data indicated that low-risk had better survival. Moreover, an independent factor for potential biomarker receiving immunotherapy. Single-cell transcriptome may provide important information Conclusion Risk is valuable tool predicting response

Language: Английский

Citations

0
Engineered hybrid cell membrane nanovesicles for potentiated cancer immunotherapy through dual immune checkpoint inhibition DOI

Fuxu Yang,

Xue Han, Yuxin Fan

et al.

Biomaterials Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

In this study, we developed a PD-1/LAG-3 receptors-decorated cell membrane nanovesicle for combination immunotherapy in colorectal cancer. The hybrid substantially inhibited tumor growth and elicited robust antitumor immune response MC38 xenograft-bearing mice.

Language: Английский

Citations

0
Metabolic reprogramming of macrophages in cancer therapy DOI
Xudong Wang, Shaolong Zhang,

Dixuan Xue

et al.

Trends in Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

Citations

2
Concurrent immune checkpoint blockade for enhanced cancer immunotherapy utilizing engineered hybrid nanovesicles DOI Creative Commons
Yuxuan Liu,

Fuxu Yang,

Zhimin Li

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 11, 2024

Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, demonstrating unprecedented efficacy against advanced cancers. However, their clinical applications are significantly hampered by low overall response rates. Dual blockade of two immune checkpoints represents a promising strategy to enhance immunotherapeutic efficacy. In this study, we developed hybrid cell membrane nanovesicles adorned with PD-1 and SIRPα receptors for combination immunotherapy in melanoma. Our (PD-1/SIRPα NVs) demonstrated high specificity PD-L1 CD47 ligands, facilitating the phagocytosis melanoma cells macrophages. mouse model, PD-1/SIRPα NVs suppressed 77% tumor growth elicited robust antitumor immunotherapy. conclusion, our findings highlight potential as novel effective ICIs

Language: Английский

Citations

2
Integrated analysis of M2 macrophage-related gene prognostic model and single-cell sequence to predict immunotherapy response in lung adenocarcinoma DOI Creative Commons
Meifang Li, Zhiping Wang, Bin Huang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 24, 2024

Abstract Introduction Lung adenocarcinoma (LUAD) patients have high heterogeneity. The significance and clinical value of M2 macrophage related genes in LUAD require further exploration. We aimed to construct a prognostic signature predict the immunotherapy efficacy prognosis LUAD. Methods GSE26939 GSE19188 chips were downloaded from Gene Expression Omnibus (GEO). Weighted gene co-expression network analysis (WGCNA) least absolute shrinkage selection operator (LASSO) used screen macrophage-related genes. A based on was established Results Twenty-two associated with confirmed using WGNNA, then two molecular subtypes identified significant different survival, expressions clinic characteristics classified. LASSO nine establish risk signature, classifying into low- high-risk groups. Data indicated that low-risk had better survival. Moreover, an independent factor for potential biomarker receiving immunotherapy. Single-cell transcriptome may provide important information Conclusions Risk is valuable tool predicting response

Language: Английский

Citations

0