Nature Reviews Neurology, Journal Year: 2024, Volume and Issue: 20(11), P. 647 - 659
Published: Oct. 7, 2024
Language: Английский
Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(17), P. 9795 - 9806
Published: April 12, 2024
Gut microbiota can influence cognitive ability via the gut–brain axis. Lactiplantibacillus plantarum MWFLp-182 (L. MWFLp-182) was obtained from feces of long-living individuals and could exert marked antioxidant ability. Interestingly, this strain reduced D-galactose-induced impaired in BALB/c mice. To comprehensively elucidate underlying mechanism, we evaluated colonization, antioxidant, anti-inflammatory activities L. MWFLp-182, along with expression potential genes associated influenced gut microbiota. enhanced cytokines, proinflammatory increased tight junction protein colon. Moreover, modify Notably, treatment upregulated postsynaptic density protein-95, nuclear factor erythroid 2-related factor, nerve growth superoxide dismutase, brain-derived neurotrophic factor/neuronal nuclei, while downregulating bcl-2-associated X malondialdehyde hippocampus upregulating short-chain fatty acids against mouse brain deficits. Accordingly, improve a D-galactose-inducing model.
Language: Английский
Citations
8
Stem Cell Research & Therapy, Journal Year: 2024, Volume and Issue: 15(1)
Published: May 31, 2024
In the past decade, intestinal organoid technology has paved way for reproducing tissue or organ morphogenesis during physiological processes in vitro and studying pathogenesis of various diseases. Intestinal organoids are favored drug screening due to their ability high-throughput cultivation closer resemblance patient genetic characteristics. Furthermore, as disease models, find wide applications diagnostic markers, identifying therapeutic targets, exploring epigenetic mechanisms Additionally, a transplantable cellular system, have played significant role reconstruction damaged epithelium conditions such ulcerative colitis short bowel syndrome, well material exchange metabolic function restoration. The rise interdisciplinary approaches, including organoid-on-chip technology, genome editing techniques, microfluidics, greatly accelerated development organoids. this review, VOSviewer software is used visualize hot co-cited journal keywords trends firstly. Subsequently, we summarized current modeling, screening, regenerative medicine. This will deepen our understanding further explore intestine
Language: Английский
Citations
8
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7621 - 7621
Published: July 11, 2024
Multiple organs and tissues coordinate to respond dietary environmental challenges. It is interorgan crosstalk that contributes systemic metabolic homeostasis. The liver brain, as key organs, have their unique dialogue transmit messages. interconnected pathogenesis of brain implicated in numerous neurodegenerative disorders. Recent insights positioned the not only a central hub but also an endocrine organ, capable secreting hepatokines signals throughout body via bloodstream. Metabolites from or gut microbiota facilitate complex between brain. In parallel humoral factors, neural pathways, particularly hypothalamic nuclei autonomic nervous system, are pivotal modulating bilateral interplay cerebral hepatic compartments. term “liver–brain axis” vividly portrays this interaction. At end review, we summarize cutting-edge technical advancements enabled observation manipulation these signals, including genetic engineering, molecular tracing, delivery technologies. These innovations paving way for deeper understanding liver–brain axis its role
Language: Английский
Citations
8
Nature Immunology, Journal Year: 2025, Volume and Issue: 26(1), P. 29 - 41
Published: Jan. 1, 2025
Language: Английский
Citations
1
Biomedicines, Journal Year: 2025, Volume and Issue: 13(1), P. 100 - 100
Published: Jan. 3, 2025
The gut microbiota, a dynamic ecosystem of trillions microorganisms, produces secondary metabolites that profoundly influence host health. Recent research has highlighted the significant role these metabolites, particularly short-chain fatty acids, indoles, and bile in modulating immune responses, impacting epigenetic mechanisms, contributing to disease processes. In gastrointestinal (GI) cancers such as colorectal, liver, gastric cancer, microbial can drive tumorigenesis by promoting inflammation, DNA damage, evasion. Conversely, same hold therapeutic promise, potentially enhancing responses chemotherapy immunotherapy even directly suppressing tumor growth. addition, play crucial roles infectious susceptibility resilience, mediating pathways impact pathogen resistance. By consolidating recent insights into microbiota's shaping health, this review underscores potential targeting microbiome-derived for treating GI diseases calls further microbiome-based interventions.
Language: Английский
Citations
1
Theranostics, Journal Year: 2025, Volume and Issue: 15(5), P. 1715 - 1740
Published: Jan. 2, 2025
Chronic liver diseases, primarily metabolic dysfunction-associated steatotic disease (MASLD), and alcoholic (MetALD), viral hepatitis, can lead to fibrosis, cirrhosis, cancer. Hepatic stellate cell (HSC) activation plays a central role in the development of myofibroblasts fibrogenesis chronic diseases. However, HSC is influenced by complex microenvironments within liver, which are largely shaped interactions between HSCs various other types. Changes phenotypes mechanisms involve glucose, lipid, cholesterol metabolism, oxidative stress, unfolded protein response (UPR), autophagy, ferroptosis, senescence, nuclear receptors. Clinical interventions targeting these pathways have shown promising results addressing inflammation as well modulating glucose lipid metabolism stress responses. Therefore, comprehensive understanding presents opportunities for novel therapeutic approaches aimed at halting or even reversing
Language: Английский
Citations
1
Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)
Published: Feb. 4, 2025
Abstract As a highly complex organ with digestive, endocrine, and immune-regulatory functions, the liver is pivotal in maintaining physiological homeostasis through its roles metabolism, detoxification, immune response. Various factors including viruses, alcohol, metabolites, toxins, other pathogenic agents can compromise function, leading to acute or chronic injury that may progress end-stage diseases. While sharing common features, diseases exhibit distinct pathophysiological, clinical, therapeutic profiles. Currently, contribute approximately 2 million deaths globally each year, imposing significant economic social burdens worldwide. However, there no cure for many kinds of diseases, partly due lack thorough understanding development these Therefore, this review provides comprehensive examination epidemiology characteristics covering spectrum from conditions manifestations. We also highlight multifaceted mechanisms underlying initiation progression spanning molecular cellular levels networks. Additionally, offers updates on innovative diagnostic techniques, current treatments, potential targets presently under clinical evaluation. Recent advances pathogenesis hold critical implications translational value novel strategies.
Language: Английский
Citations
1
Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)
Published: Feb. 8, 2025
The liver‒brain axis is critical in neurodegenerative diseases (NDs), with lipid metabolism influencing neuroinflammation and microglial function. A systematic investigation of the genetic relationship between abnormalities ND, namely, Alzheimer's disease (AD), Parkinson's (PD), multiple sclerosis (MS), amyotrophic lateral (ALS), lacking. To assess potential causal links ND six parameters, two-sample Mendelian randomization (MR) was used. Large-scale European ancestry GWAS data for parameters (AD, ALS, PD, MS) were Genetic variants demonstrating significant correlations (P < 5 × 10-8) identified employed as instrumental variables (IVs) after proper validation. research incorporated UK Biobank genomic to examine associations parameters. analysis included primary MR, sensitivity analyses, multivariable which considered mediators. MR via inverse-variance weighted method revealed effects cholesterol (CHOL, OR = 1.10, 95% CI: 1.03-1.18, P 4.23 10⁻3) low-density lipoprotein (LDLC, 1.03-1.17, 3.28 on risk validated across methods. Potential observed ApoB ALS inversely correlated AD, whereas no found PD or MS. CHOL LDLC demonstrated heterogeneity pleiotropy, supporting their reliability. Higher levels associated increased risk, suggesting a link, hypothesis ND. Current evidence does not support role MS etiology, other NDs may be more complex warrants further investigation.
Language: Английский
Citations
1
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 27, 2025
Abstract This article provides an overview of the advancements in application fecal microbiota transplantation (FMT) treating diseases related to intestinal dysbiosis. FMT involves transfer healthy donor into patient's body, aiming restore balance and thereby treat a variety such as recurrent Clostridioides difficile infection (rCDI), inflammatory bowel disease (IBD), constipation, short syndrome (SBS), irritable (IBS). While has shown high efficacy treatment rCDI, further research is needed for its other chronic conditions. elaborates on mechanisms dysbiosis, well discusses key factors influencing effectiveness FMT, including selection, recipient characteristics, protocols, methods assessing microbiota. Additionally, it emphasizes successful FMT. Future should focus optimizing process ensure long‐term safety explore potential broader range medical
Language: Английский
Citations
1
Sclerosis, Journal Year: 2025, Volume and Issue: 3(1), P. 8 - 8
Published: March 5, 2025
Background/Objectives: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the progressive degeneration of motor neurons. The gut microbiota, community microorganisms in digestive tract, has recently been implicated ALS pathogenesis through its influence on neuroinflammation and metabolic pathways. This review explores potential role microbiota metabolites progression investigates therapeutic approaches targeting microbiota. Methods: A comprehensive current literature was conducted to assess relationship between composition, microbial metabolites, patients. We searched for published reports ALS, emphasizing complex interplay dysbiosis, neuroinflammation, systemic metabolism. Special emphasis placed studies exploring short-chain fatty acids (SCFAs), bacterial amyloids (curli-like factors), neurotoxins such as β-methylamino-L-alanine (BMAA). liver–gut axis evaluated well. changes would sustain rationale strategies probiotics, prebiotics, fecal transplantation (FMT), dietary interventions. Results: patients exhibit reduced SCFA-producing bacteria an increase potentially pathogenic genera. Of note, different do not agree common patterns being linked supporting need further, more extensive studies. Dysbiosis sometimes correlates with inflammation disrupted liver function, amplifying neuroinflammatory responses. Key including SCFAs, amyloids, BMAA, may exacerbate neuron promoting protein misfolding, oxidative stress, neuroinflammation. Emerging strategies, probiotics FMT, show restoring balance, although clinical data remain limited. Conclusions: could modulate metabolism ALS. Microbiota-targeted therapies, interventions, represent promising avenues mitigating disease progression. Further research required validate these interventions large-scale, longitudinal develop personalized microbiota-based treatments tailored individual phenotypes.
Language: Английский
Citations
1