Chemical Society Reviews,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
This
review
provides
a
comprehensive
summary
of
the
dysregulation
redox
metabolism
in
cancer
cells
and
advantages
latest
advances
nanomaterial-assisted
metabolic
regulation
therapy.
Frontiers in Oncology,
Journal Year:
2025,
Volume and Issue:
14
Published: Jan. 8, 2025
Colorectal
cancer
(CRC)
is
one
of
thes
most
prevalent
malignant
tumors
worldwide.
Current
therapeutic
strategies
for
CRC
have
limitations,
while
nanomaterials
show
significant
potential
diagnosing
and
treating
CRC.
This
study
utilizes
bibliometric
analysis
to
evaluate
the
current
status
trends
in
this
field.
Research
on
from
2003
2024
was
retrieved
Web
Science
Core
Collection
(WOSCC).
Tools
such
as
CiteSpace,
VOSviewer,
RStudio,
GraphPad
Prism,
Excel
were
used
analyze
hotspots,
covering
publication
trends,
countries,
institutions,
authors,
journals,
co-citation
analysis,
keywords.
Visual
maps
created
forecast
future
developments.
The
includes
3,683
publications
by
17,261
authors
3,721
institutions
across
100
countries/regions,
published
840
journals.
Global
steadily
increased,
particularly
since
2018.
China
leads
volume
citations,
with
six
top
ten
research
seven
cited
United
States
excels
citation
impact
academic
centrality.
Both
countries
currently
dominate
field,
underscoring
urgent
need
enhanced
international
collaboration.
Ramezani
M
Abnous
K
lead
H-index,
Siegel
RL
highly
cited.
International
Journal
Nanomedicine
has
highest
volume,
Controlled
Release
In
addition
"colorectal
cancer"
"nanoparticles,"
common
keyword
"drug
delivery."
Emerging
areas
"metal-organic
frameworks
(MOFs)"
"green
synthesis"
are
gaining
attention
leading
hotspots.
offers
an
in-depth
application
CRC,
promoting
interdisciplinary
collaboration
advancing
scientific
progress
The
development
of
lanthanide-doped
upconversion
nanoparticle
(UCNP)-based
imaging
with
minimal
autofluorescence
and
improved
penetration
depth
is
important
in
medical
applications.
Exogenous
nanocarriers
readily
adsorb
plasma
proteins
following
intravenous
administration
(<0.5
min),
resulting
the
formation
a
protein
corona
on
fixed
surface.
facilitates
UCNP
interception
by
immune
system,
preventing
targeted
delivery
to
disease
sites.
In
this
study,
we
report
novel
surface-camouflaging
strategy
using
lanthanide
hydroxyl
carbonate
that
slowly
dissolved
physiological
phosphate
serum.
"self-consuming"
inorganic-shell-modified
UCNPs
(denoted
as
UCSP-PEG)
effectively
reduce
adhesion
more
than
90%
through
dissociation
effect
associated
amphiphilic
poly(ethylene
glycol)
(PEG)-modified
determined
an
ex
vivo
assay.
UCSP-PEG
exhibits
prolonged
blood
circulation
time
(t1/2
=
73.9
±
9.5
185
times
camouflage
materials
without
"stealth"
feature,
can
employ
upconverted
luminescence
(UCL)
monitor
tumor-related
vessels
for
at
least
120
min.
Based
superior
optical
properties
UCSP-PEG,
application
UCL
dual-channel
stereoscope
magnification
system
has
enabled
observation
capillaries
high
resolution,
offering
powerful
tool
monitoring
biological
activities
fine
tissue
level.
This
work
provides
nanovehicle,
resisting
based
significantly
advance
target-specific
cancer
diagnosis.
Applied Biosciences,
Journal Year:
2025,
Volume and Issue:
4(1), P. 16 - 16
Published: March 5, 2025
Hematologic
malignancies,
including
leukemia,
lymphoma,
and
multiple
myeloma,
pose
significant
therapeutic
challenges
due
to
their
heterogeneity
high
relapse
rates.
Nanotechnology
has
emerged
as
a
promising
avenue
for
precision
drug
delivery
in
these
allowing
enhanced
concentration
at
tumor
sites
reducing
systemic
toxicity.
Recent
developments
nanocarriers—such
liposomes,
polymeric
nanoparticles,
inorganic
nanoparticles—have
enabled
targeted
approaches,
utilizing
molecular
markers
specific
malignant
cells
increase
efficacy
while
minimizing
adverse
effects.
Evidence
from
preclinical
clinical
studies
underscores
the
potential
of
nanotechnology
improve
patient
outcomes
by
facilitating
controlled
release,
improved
bioavailability,
reduced
However,
translating
advancements
into
practice
requires
further
research
validate
safety
efficacy.
This
review
provides
comprehensive
analysis
latest
innovations
hematologic
addressing
current
achievements
future
directions
integrating
approaches
Clinical
Hemato-Oncology.
Materials Today Bio,
Journal Year:
2025,
Volume and Issue:
32, P. 101652 - 101652
Published: March 12, 2025
Intracerebral
hemorrhage
(ICH)
remains
a
life-threatening
condition
due
to
its
high
mortality
and
limited
treatment
options.
This
study
explores
novel
therapeutic
strategy
using
engineered
exosomes
derived
from
endothelial
progenitor
cells
(EPC-EXOs)
improve
ICH
outcomes.
EPC-EXOs
were
modified
with
CD47-enriched
red
blood
cell
membrane
via
co-extrusion
enhance
their
anti-phagocytic
properties,
thereby
reducing
degradation
by
activated
microglia
after
ICH.
A
minimally
invasive
endoscopic-guided
delivery
system
was
developed
facilitate
the
targeted
intranasal
administration
of
these
(m-Oe-EXOs),
allowing
direct
entry
into
brain
tissue.
We
confirmed
m-Oe-EXOs'
retention
effective
distribution
in
brain.
Functional
analysis
demonstrated
that
significantly
promoted
proliferation,
migration,
angiogenesis
microvascular
(BMECs),
proteomic
identifying
HSP90
as
key
protein
activating
Akt
pathway
BMECs.
In
vivo,
m-Oe-EXOs
efficacy
improving
blood-brain
barrier
integrity,
hematoma
volume,
enhancing
neurological
recovery
rats.
Collectively,
our
findings
highlight
potential
invasive,
an
innovative
approach
for
treatment,
providing
new
insights
targeted,
exosomes-based
regenerative
therapies.
