Diet and depression: exploring the biological mechanisms of action

Molecular Psychiatry, Journal Year: 2020, Volume and Issue: 26(1), P. 134 - 150

Published: Nov. 3, 2020

Language: Английский

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Epigenetics and depression

Dialogues in Clinical Neuroscience, Journal Year: 2019, Volume and Issue: 21(4), P. 397 - 405

Published: Dec. 31, 2019

The risk for major depression is both genetically and environmentally determined. It has been proposed that epigenetic mechanisms could mediate the lasting increases in following exposure to adverse life events provide a mechanistic framework within which genetic environmental factors can be integrated. Epigenetics refers processes affecting gene expression translation do not involve changes DNA sequence include methylation (DNAm) microRNAs (miRNAs) as well histone modifications. Here we review evidence role of epigenetics pathogenesis from studies investigating DNAm, miRNAs, modifications using different tissues various experimental designs. From these studies, model emerges where underlying factors, interactions between two, drive aberrant targeting stress response pathways, neuronal plasticity, other behaviorally relevant pathways have implicated depression.

Language: Английский

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Pathophysiology and Current Drug Treatments for Post-Stroke Depression: A Review

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(23), P. 15114 - 15114

Published: Dec. 1, 2022

Post-stroke depression (PSD) is a biopsychosocial disorder that affects individuals who have suffered stroke at any point. PSD has 20 to 60 percent reported prevalence among survivors. Its effects are usually adverse, can lead disability, and may increase mortality if not managed or treated early. linked several other medical conditions, including anxiety, hyper-locomotor activity, poor functional recovery. Despite significant awareness of its adverse impacts, understanding the pathogenesis proved challenging. The exact pathophysiology unknown, yet complexity been definitively shown, involving mechanisms such as dysfunction monoamine, glutamatergic systems, gut-brain axis, neuroinflammation. current effectiveness treatment about 30–40 all cases. In this review, we examined different pathophysiological pharmacological non-pharmacological approaches for PSD.

Language: Английский

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Major depression and the biological hallmarks of aging

Ageing Research Reviews, Journal Year: 2022, Volume and Issue: 83, P. 101805 - 101805

Published: Nov. 21, 2022

Major depressive disorder (MDD) is characterized by psychological and physiological manifestations contributing to the disease severity outcome. In recent years, several lines of evidence have suggested that individuals with MDD an elevated risk age-related adverse outcomes across lifespan. This review provided a significant overlap between biological abnormalities in changes commonly observed during aging process (i.e., hallmarks aging). Based on such evidence, we formulate mechanistic model showing how can be common denominator mediate health MDD. Finally, proposed roadmap for novel studies investigate intersection biology MDD, including use geroscience-guided interventions, as senolytics, delay or improve major depression targeting aging.

Language: Английский

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The role of DNA methylation in progression of neurological disorders and neurodegenerative diseases as well as the prospect of using DNA methylation inhibitors as therapeutic agents for such disorders

IBRO Neuroscience Reports, Journal Year: 2022, Volume and Issue: 14, P. 28 - 37

Published: Dec. 12, 2022

Genome-wide studies related to neurological disorders and neurodegenerative diseases have pointed the role of epigenetic changes such as DNA methylation, histone modification, noncoding RNAs. methylation machinery controls dynamic regulation patterns in discrete brain regions.This review aims describe inhibiting progressing therapeutic approaches.A Systematic search PubMed, Web Science, Cochrane Library was conducted for all qualified from 2000 2022.For current need time, we focused on expression genes involved neurodegeneration Alzheimer's, Depression, Rett Syndrome. Finally, it appears that various do not occur separately modification side by affect each other. We several associated with depression (NR3C1, NR3C2, CRHR1, SLC6A4, BDNF, FKBP5), syndrome (MECP2), (APP, BACE1, BIN1 or ANK1) Parkinson's disease (SNCA), well co-occurring modifications histones non-coding Understanding these their interactions will lead better treatment strategies.This captures state understanding epigenetics diseases. With new mechanisms targets undoubtedly horizon, pharmacological modulation processes holds great promise therapy.

Language: Английский

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Maternal Hypertensive Pregnancy Disorders and Mental Disorders in Children

Hypertension, Journal Year: 2020, Volume and Issue: 75(6), P. 1429 - 1438

Published: April 20, 2020

The associations of maternal hypertensive pregnancy disorders with offspring mental remain unclear. We examined whether and maximum blood pressure during predict childhood disorders, the are independent paternal or additive early overweight/obesity diabetes mellitus mediated moderated by preterm birth, small-for-gestational-age birth neonatal intensive care unit admission. Our prospective study comprised 4743 mother-child dyads Prediction Prevention Preeclampsia Intrauterine Growth Restriction study. Women were recruited to in at Finnish maternity hospitals. Children born 2006 2010 followed-up until December 31, 2016, ages 6.4 10.8 years. Hypertensive identified from medical records, Medical Birth Register, Care Register for Health Care. Systolic diastolic measured antenatal clinics hospital visits. Mental disorder diagnoses Maternal gestational chronic hypertension, preeclampsia its severity increased hazard any disorder. (hazard ratio=1.66 [95% CI, 1.14–2.42]) severe ratio=2.01 1.08–3.73]) all covariates. also additively disorders. Preterm births admission partially effects on To conclude, carry adverse consequences health.

Language: Английский

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The Relationship between DNA Methylation and Antidepressant Medications: A Systematic Review

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(3), P. 826 - 826

Published: Jan. 28, 2020

Major depressive disorder (MDD) is the leading cause of disability worldwide and associated with high rates suicide medical comorbidities. Current antidepressant medications are suboptimal, as most MDD patients fail to achieve complete remission from symptoms. At present, clinicians unable predict which effective for a particular patient, exposing multiple medication trials side effects. Since MDD’s etiology includes interactions between genes environment, epigenome interest predictive utility treatment monitoring. Epigenetic mechanisms incompletely understood. Differences in epigenetic profiles may impact response. A systematic literature search yielded 24 studies reporting interaction antidepressants eight (BDNF, MAOA, SLC6A2, SLC6A4, HTR1A, HTR1B, IL6, IL11) whole genome methylation. Methylation certain sites within BDNF, IL11, was Comparing DNA methylation during episodes, treatment, remission, after cessation would help clarify influence on Individuals’ unique be used clinically personalization choice future.

Language: Английский

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Epigenetics and Depression: An Update

Psychiatry Investigation, Journal Year: 2019, Volume and Issue: 16(9), P. 654 - 661

Published: Aug. 28, 2019

Depression is associated with various environmental risk factors such as stress, childhood maltreatment experiences, and stressful life events. Current approaches to assess the pathophysiology of depression, epigenetics gene-environment (GxE) interactions, have been widely leveraged determine plausible markers, genes, variants for developing depression.We focus on most recent developments genomic research in GxE interactions.In this review, we first survey a variety association studies regarding depression consideration interactions. We then illustrate evidence epigenetic mechanisms DNA methylation, microRNAs, histone modifications influence terms animal models human studies. Finally, highlight their limitations future directions.In light emerging technologies artificial intelligence machine learning, interactions promises achieve novel innovations that may lead disease prevention potential therapeutic treatments depression.

Language: Английский

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Genome-wide DNA methylation and gene expression analyses in monozygotic twins identify potential biomarkers of depression

Translational Psychiatry, Journal Year: 2021, Volume and Issue: 11(1)

Published: Aug. 2, 2021

Abstract Depression is currently the leading cause of disability around world. We conducted an epigenome-wide association study (EWAS) in a sample 58 depression score-discordant monozygotic twin pairs, aiming to detect specific epigenetic variants potentially related and further integrate with gene expression profile data. Association between methylation level each CpG site score was tested by applying linear mixed effect model. Weighted co-expression network analysis (WGCNA) performed for The DNA levels 66 sites reached P < 1 × 10 −4 . These top were located at 34 genes, especially PTPRN2 , HES5 GATA2 PRDM7 KCNIP1 Many ontology enrichments highlighted, including Notch signaling pathway, Huntington disease, p53 pathway glucose deprivation, hedgehog binding, nucleic acid metabolic process. detected 19 differentially methylated regions (DMRs), some which GRIK2 DGKA NIPA2 While integrating data, HELZ2 ZNF624 expressed. In WGCNA, one module positively correlated ( r = 0.62, 0.002). Some common genes (including BMP2 ) enrichment terms complement coagulation cascades neuron fate specification, glial cell differentiation, thyroid gland development) both identified WGCNA. Our identifies variations are significantly involved regions, functional biological function, pathways that mediate disorder.

Language: Английский

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Gender-affirming hormone therapy induces specific DNA methylation changes in blood

Clinical Epigenetics, Journal Year: 2022, Volume and Issue: 14(1)

Published: Feb. 17, 2022

Abstract Background DNA methylation is an epigenetic mark that influenced by underlying genetic profile, environment, and ageing. In addition to X-linked methylation, sex-specific patterns are widespread across autosomal chromosomes can be present from birth or arise over time. individuals where gender identity sex assigned at markedly incongruent, as in the case of transgender people, feminization masculinization may sought through gender-affirming hormone therapy (GAHT). GAHT a cornerstone care, yet no studies date have investigated its effect on genome-wide methylation. We profiled blood women ( n = 13) men before during (6 months 12 into feminizing masculinizing therapy). Results identified several thousand differentially methylated CpG sites (DMPs) (Δ β ≥ 0.02, unadjusted p value < 0.05) regions (DMRs) both people undergoing GAHT, vast majority which were progressive changes X chromosome established early development largely refractory change association with only 3% affected 0.05). The small number DMPs those become lifetime, known sex-and-age DMPs, including DMRs PRR4 VMP1 genes. GAHT-induced these sex-associated probes consistently demonstrated shift towards signature GAHT-naïve opposite sex, we observed enrichment previously reported adolescence-associated changes. Conclusion provide evidence for inducing unique people. This study advances our understanding complex interplay between hormones, chromosomes, context immunity. highlight need broaden field ‘sex-specific’ immunity beyond cisgender males females, exhibit molecular profile.

Language: Английский

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