The role of microRNAs in depression DOI Creative Commons
Ruidong Ding,

Dingyuan Su,

Qian Zhao

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: March 29, 2023

Major depressive disorder (MDD) is a psychiatric with increasing prevalence worldwide. It leading cause of disability and suicide, severely affecting physical mental health. However, the study depression remains at an exploratory stage in terms diagnostics treatment due to complexity its pathogenesis. MicroRNAs are endogenous short-stranded non-coding RNAs capable binding 3’untranslated region mRNAs. Because their ability repress translation process genes found high levels brain tissues, investigation role has gradually increased recently. This article summarizes recent research progress on relationship between microRNAs depression. The play regulatory pathophysiology depression, involving dysregulation monoamines, abnormalities neuroplasticity neurogenesis, hyperactivity HPA axis, inflammatory responses. These might provide new clue for diagnosis MDD, development antidepressant drugs.

Language: Английский

HPA Axis in the Pathomechanism of Depression and Schizophrenia: New Therapeutic Strategies Based on Its Participation DOI Creative Commons
Joanna Mikulska,

Gabriela Juszczyk,

Monika Gawrońska‐Grzywacz

et al.

Brain Sciences, Journal Year: 2021, Volume and Issue: 11(10), P. 1298 - 1298

Published: Sept. 30, 2021

The hypothalamic-pituitary-adrenal (HPA) axis is involved in the pathophysiology of many neuropsychiatric disorders. Increased HPA activity can be observed during chronic stress, which plays a key role depression. Overactivity occurs major depressive disorder (MDD), leading to cognitive dysfunction and reduced mood. There also correlation between activation gut microbiota, has significant impact on development MDD. It believed that microbiota influence function through cytokines, prostaglandins, or bacterial antigens various microbial species. schizophrenia varies depends mainly severity disease. This review summarizes involvement pathogenesis disorders, focusing depression schizophrenia, highlights possible these conditions. Although effective antidepressants are available, large proportion patients do not respond initial treatment. discusses new therapeutic strategies affect axis, such as glucocorticoid receptor (GR) antagonists, vasopressin V1B antagonists non-psychoactive CB1 agonists and/or schizophrenia.

Language: Английский

Citations

248
The cortisol switch between vulnerability and resilience DOI
E. R. de Kloet, Marian Joëls

Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 29(1), P. 20 - 34

Published: Jan. 4, 2023

Language: Английский

Citations

91
Depression and Its Phytopharmacotherapy—A Narrative Review DOI Open Access
Łukasz Dobrek, Krystyna Głowacka

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(5), P. 4772 - 4772

Published: March 1, 2023

Depression is a mental health disorder that develops as result of complex psycho-neuro-immuno-endocrinological disturbances. This disease presents with mood disturbances, persistent sadness, loss interest and impaired cognition, which causes distress to the patient significantly affects ability function have satisfying family, social professional life. requires comprehensive management, including pharmacological treatment. Because pharmacotherapy depression long-term process associated risk numerous adverse drug effects, much attention paid alternative therapy methods, phytopharmacotherapy, especially in treating mild or moderate depression. Preclinical studies previous clinical confirm antidepressant activity active compounds plants, such St. John’s wort, saffron crocus, lemon balm lavender, less known European ethnopharmacology, roseroot, ginkgo, Korean ginseng, borage, brahmi, mimosa tree magnolia bark. The these plants exert antidepressive effects similar mechanisms those found synthetic antidepressants. description phytopharmacodynamics includes inhibiting monoamine reuptake oxidase complex, agonistic antagonistic on multiple central nervous system (CNS) receptors. Moreover, it noteworthy anti-inflammatory effect also important mentioned above light hypothesis immunological disorders CNS are significant pathogenetic factor narrative review results from traditional, non-systematic literature review. It briefly discusses pathophysiology, symptomatology treatment depression, particular focus role phytopharmacology its provides action revealed experimental ingredients isolated herbal antidepressants selected confirming their effectiveness.

Language: Английский

Citations

62
What do DNA methylation studies tell us about depression? A systematic review DOI Creative Commons

Muzi Li,

Carl D’Arcy, Xintong Li

et al.

Translational Psychiatry, Journal Year: 2019, Volume and Issue: 9(1)

Published: Feb. 4, 2019

Abstract There has been a limited number of systematic reviews conducted to summarize the overview relationship between DNA methylation and depression, critically appraise roles major study characteristics in accuracy findings. This review aims impact on association this association. Electronic databases gray literatures until December 2017 were searched for English-language studies with standard diagnostic criteria depression. A total 67 included along summary their characteristics. We grouped findings into etiological treatment studies. Majority these selected recently published from developed countries. Whole blood samples most studied common tissues. Bisulfite conversion, pyrosequencing, was widely used test level across all High heterogeneity existed among terms experimental statistical methodologies designs. As recommended by Cochrane guideline, without meta-analysis should be undertaken. has, general, found that modifications associated Subgroup analyses showed BDNF SLC6A4 hypermethylations MDD or depression general. In contrast, NR3C1 , OXTR other genes, which tested only few studies, reported mixed More longitudinal using standardized laboratory are needed future enable more systematical comparisons quantitative synthesis.

Language: Английский

Citations

106
Potential Mechanisms and Clinical Effectiveness of Acupuncture in Depression DOI
Nana Yang,

Lu‐Lu Lin,

Yue-Jie Li

et al.

Current Neuropharmacology, Journal Year: 2021, Volume and Issue: 20(4), P. 738 - 750

Published: July 19, 2021

Major depressive disorder is the most common mental with significant economic burden and limited treatments. Acupuncture has emerged as a promising non-pharmacological treatment for reducing symptoms. However, potential mechanisms clinical effectiveness of acupuncture are not fully understood. This review aimed to: (1) summarize available evidence on depression, then (2) compare pharmacological interventions, guiding future studies. Studies animal models depression patients have shown that could increase hippocampal network neuroplasticity decrease brain inflammation, potentially to alleviating disorders. Overall studies indicated relieve primary particularly milder cases, was helpful in management post-stroke pain-related postpartum both an isolated adjunct treatment. It emphasized combined antidepressant only enhanced improvement secondary symptoms but also reduced side effects medical treatment, which main cause high dropout rates drug In summary, substantial from human researches supported beneficial effect depression. trials were small, it unclear whether their findings can be generalized, so more needed.

Language: Английский

Citations

88
Chronic Stress-Induced Depression and Anxiety Priming Modulated by Gut-Brain-Axis Immunity DOI Creative Commons
Susan Westfall,

Francesca Caracci,

Molly Estill

et al.

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12

Published: June 24, 2021

Chronic stress manifests as depressive- and anxiety-like behavior while recurrent elicits disproportionate behavioral impairments linked to stress-induced immunological priming. The gut-brain-microbiota-axis is a promising therapeutic target for it simultaneously modulates peripheral brain landscapes. In this study, combination of probiotics prebiotics, known synbiotic, promoted resilience chronic by normalizing gut microbiota populations promoting regulatory T cell (Treg) expansion through modulation ileal innate lymphoid (ILC)3 activity, an impact reflecting responses better than limbic region neuroinflammation. Supporting conclusion, multivariate machine learning model correlatively predicted cross-tissue signature impairment where the Treg/T helper17 ratio associated hippocampal chemotactic chemokine prefrontal cortex IL-1β production in context deficits. depend on immune regulation, synbiotics attenuate behavior.

Language: Английский

Citations

87
The role of epigenetics in psychological resilience DOI
Demelza Smeeth, Stephan Beck, Elie G. Karam

et al.

The Lancet Psychiatry, Journal Year: 2021, Volume and Issue: 8(7), P. 620 - 629

Published: April 27, 2021

Language: Английский

Citations

66
Association between organophosphorus pesticide exposure and depression risk in adults: A cross-sectional study with NHANES data DOI Open Access
Yudong Wu, Jian Song, Qin Zhang

et al.

Environmental Pollution, Journal Year: 2022, Volume and Issue: 316, P. 120445 - 120445

Published: Oct. 18, 2022

Language: Английский

Citations

45
A sex-specific genome-wide association study of depression phenotypes in UK Biobank DOI Creative Commons
Patrícia Pelufo Silveira,

Irina Pokhvisneva,

David M. Howard

et al.

Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 28(6), P. 2469 - 2479

Published: Feb. 7, 2023

Abstract There are marked sex differences in the prevalence, phenotypic presentation and treatment response for major depression. While genome-wide association studies (GWAS) adjust differences, to date, no seek identify sex-specific markers pathways. In this study, we performed a sex-stratified analysis broad depression with UK Biobank total participants ( N = 274,141), including only non-related participants, as well males 127,867) females 146,274) separately. Bioinformatics analyses were characterize common associated processes/pathways. We identified 11 loci passing genome-level significance P < 5 × 10 −8 ) one males. both females, genetic correlations significant between GWA other psychopathologies; however, educational attainment metabolic features body fat, waist circumference, waist-to-hip ratio triglycerides females. Gene-based showed 147 genes significantly sample, 64 53 revealed “Regulation of Gene Expression” biological process, but suggested molecular mechanisms. Finally, polygenic risk scores (PRSs) outperformed opposite PRSs prediction depressive disorder. These findings provide evidence sex-dependent pathways clinical health conditions comorbid

Language: Английский

Citations

39
A Microbial-Based Approach to Mental Health: The Potential of Probiotics in the Treatment of Depression DOI Open Access
Dinyadarshini Johnson, Vengadesh Letchumanan, C. Thum

et al.

Nutrients, Journal Year: 2023, Volume and Issue: 15(6), P. 1382 - 1382

Published: March 13, 2023

Probiotics are currently the subject of intensive research pursuits and also represent a multi-billion-dollar global industry given their vast potential to improve human health. In addition, mental health represents key domain healthcare, which has limited, adverse-effect prone treatment options, probiotics may hold be novel, customizable for depression. Clinical depression is common, potentially debilitating condition that amenable precision psychiatry-based approach utilizing probiotics. Although our understanding not yet reached sufficient level, this could therapeutic can tailored specific individuals with own unique set characteristics issues. Scientifically, use as valid basis rooted in microbiota-gut-brain axis (MGBA) mechanisms, play role pathophysiology theory, appear ideal adjunct therapeutics major depressive disorder (MDD) stand-alone mild MDD revolutionize disorders. there wide range an almost limitless combinations, review aims narrow focus most widely commercialized studied strains, namely Lactobacillus Bifidobacterium, bring together arguments usage patients (MDD). Clinicians, scientists, industrialists critical stakeholders exploring groundbreaking concept.

Language: Английский

Citations

36