Neuroimmune regulation of the prefrontal cortex tetrapartite synapse

Neuropharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 110335 - 110335

Published: Feb. 1, 2025

The prefrontal cortex (PFC) is an essential driver of cognitive, affective, and motivational behavior. There clear evidence that the neuroimmune system directly influences PFC synapses, in addition to its role as first line defense against toxins pathogens. In this review, we describe core structures form tetrapartite synapse, focusing on signaling microdomain created by astrocytic cradling synapse well emerging extracellular matrix synaptic organization plasticity. Neuroimmune signals (e.g. pro-inflammatory interleukin 1β) can impact function each structure within promote intra-synaptic crosstalk, will provide overview recent advances field. Finally, from post mortem human brain tissue preclinical studies indicate inflammation may be a key contributor dysfunction. Therefore, conclude with mechanistic discussion neuroimmune-mediated maladaptive plasticity neuropsychiatric disorders, focus alcohol use disorder (AUD). Growing recognition system's critical regulator provides strong support for targeting develop new pharmacotherapeutics.

Language: Английский

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Preface to the Special Issue “Matrix Metalloproteinases in Health and Disease”

Journal of Neurochemistry, Journal Year: 2025, Volume and Issue: 169(3)

Published: March 1, 2025

ABSTRACT This preface introduces a collection of new work focused on matrix metalloproteinases (MMPs) and select MMP substrates in the nervous system. Discovered over 60 years ago during study collagen degradation tadpole tail metamorphosis by Gross Lapiere, MMPs are now known to play critical roles adaptive non‐adaptive physiological processes varied species. Though early studies predominantly their role inflammation, wound healing, angiogenesis, last 20 has expanded include an abundance related brain disease plasticity. Particularly novel intriguing numerous those mood memory, as well period closure. The manuscripts herein review MMP‐9, that is released from resident cells brain, including neurons microglia, comprehensive perineuronal nets (PNNs), which composed brevican. Additional focus fragile X messenger ribonucleoprotein 1 product (FMRP) translational regulation aggrecan, important PNN component, showing chondroitin sulfate‐glycosaminoglycan compositional changes mouse model tauopathy, localization PNN‐like structures enteric system, mechanism MMP‐2 could contribute disruption blood‐brain barrier, differential effects sirtuin agonist glial neuronal release.

Language: Английский

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Choice impulsivity after repeated social stress is associated with increased perineuronal nets in the medial prefrontal cortex

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: March 26, 2024

Abstract Repeated stress can predispose to substance abuse. However, behavioral and neurobiological adaptations that link abuse remain unclear. This study investigates whether intermittent social defeat (ISD), a protocol promotes drug-seeking behavior, alters intertemporal decision-making cortical inhibitory function in the medial prefrontal cortex (mPFC). Male long evans rats were trained delay discounting task (DDT) where make choice between fast (1 s) small reward sugar pellet) large (3 pellets) comes with time (10 s or 20 s). A decreased preference for delayed rewards was used as an index of impulsivity. Rats exposed ISD tested DDT 24 h after each episode, one- two-weeks last episode. Immunohistochemistry performed rat’s brains evaluate perineuronal nets (PNNs) parvalbumin GABA interneurons (PV) labeling markers mPFC. significantly low impulsive, but not high animals. also increased density PNNs These results suggest impulsivity inhibition animals seek out stress.

Language: Английский

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Perineuronal net density in schizophrenia: A systematic review of postmortem brain studies

Schizophrenia Research, Journal Year: 2024, Volume and Issue: 271, P. 100 - 109

Published: July 16, 2024

Language: Английский

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Perineuronal Nets in the CNS: Architects of Memory and Potential Therapeutic Target in Neuropsychiatric Disorders

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(6), P. 3412 - 3412

Published: March 18, 2024

The extracellular matrix (ECM) within the brain possesses a distinctive composition and functionality, influencing spectrum of physiological pathological states. Among its constituents, perineuronal nets (PNNs) are unique ECM structures that wrap around cell body many neurons extend along their dendrites central nervous system (CNS). PNNs pivotal regulators plasticity in CNS, both during development adulthood stages. Characterized by condensed glycosaminoglycan-rich heterogeneous molecular composition, not only offer neuroprotection but also participate signal transduction, orchestrating neuronal activity plasticity. Interfering with adult animals induces reactivation critical period plasticity, permitting modifications connections promoting recovery neuroplasticity following spinal cord damage. Interestingly, brain, PNN expression is dynamic, potentially modulating plasticity-associated Given multifaceted roles, have emerged as domains learning, memory, addiction behaviors, other neuropsychiatric disorders. In this review, we aimed to address how contribute memory processes conditions.

Language: Английский

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Perineuronal Net Microscopy: From Brain Pathology to Artificial Intelligence

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(8), P. 4227 - 4227

Published: April 11, 2024

Perineuronal nets (PNN) are a special highly structured type of extracellular matrix encapsulating synapses on large populations CNS neurons. PNN undergo structural changes in schizophrenia, epilepsy, Alzheimer's disease, stroke, post-traumatic conditions, and some other brain disorders. The functional role the microstructure pathologies has remained largely unstudied until recently. Here, we review recent research implicating microstructural schizophrenia We further concentrate high-resolution studies mesh units surrounding synaptic boutons to elucidate fine details behind mutual regulation between ECM terminal. also updates regarding as potential pharmacological target. Artificial intelligence (AI)-based methods now arriving new tool that may have grasp brain's complexity through wide range organization levels-from molecular events scale tissue rearrangements whole-brain connectome function. This scope matches exactly complex physiology pathology processes, first AI-assisted microscopy been reported. To end, report here machine learning-assisted for contour tracing.

Language: Английский

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Modulation of stress-, pain-, and alcohol-related behaviors by perineuronal nets

Neurobiology of Stress, Journal Year: 2024, Volume and Issue: 33, P. 100692 - 100692

Published: Nov. 1, 2024

Perineuronal nets (PNNs) are a special form of central nervous system extracellular matrix enriched in hyaluronan, chondroitin sulfate proteoglycans, tenascins, and link proteins that regulate synaptic plasticity. Most PNNs the brain surround parvalbumin-expressing inhibitory interneurons, which tightly excitatory/inhibitory balance activity associated with optimal cognitive functioning. Alterations have been observed neurological diseases psychiatric disorders, suggesting they may be key contributors to neuropathological progression behavioral changes these diseases. Alcohol use disorder (AUD), major depressive (MDD), chronic pain highly comorbid conditions, animal models as well postmortem tissue from individuals diagnosed AUD MDD. This review focuses on literature describing stress-, alcohol-, pain-induced adaptations PNNs, potential cellular altered role behaviors related disorders. Medicines can restore non-pathological state novel therapeutic approach treating pain, AUD,

Language: Английский

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