European Journal of Pharmaceutics and Biopharmaceutics,
Journal Year:
2024,
Volume and Issue:
203, P. 114460 - 114460
Published: Aug. 31, 2024
Glioblastoma
(GBM)
stands
for
the
most
common
and
aggressive
type
of
brain
tumour
in
adults.
It
is
highly
invasive,
which
explains
its
short
rate
survival.
Little
known
about
risk
factors,
current
therapy
still
ineffective.
Hence,
efforts
are
underway
to
develop
novel
effective
treatment
approaches
against
this
cancer.
Exosomes
being
explored
as
a
promising
strategy
conveying
delivering
therapeutic
cargo
GBM
cells.
They
can
fuse
with
cell
membrane
and,
consequently,
serve
delivery
systems
context.
Due
their
nanoscale
size,
exosomes
cross
blood-brain
barrier
(BBB),
constitutes
significant
hurdle
chemotherapeutic
drugs
used
GBM.
subsequently
inhibit
oncogenes,
activate
suppressor
genes,
induce
immune
responses,
control
growth.
However,
despite
representing
tool
GBM,
further
research
clinical
studies
regarding
exosome
biology,
engineering,
applications
need
be
completed.
Here,
we
sought
review
application
through
an
in-depth
analysis
scientific
on
entire
process,
from
isolation
purification
design
transformation
into
anti-oncogenic
drug
systems.
Surface
modification
enhance
BBB
penetration
GBM-cell
targeting
also
topic
discussion.
Journal of Nanotheranostics,
Journal Year:
2023,
Volume and Issue:
4(3), P. 299 - 322
Published: July 24, 2023
The
introduction
of
cancer
therapeutics
and
nanotechnology
has
resulted
in
a
paradigm
shift
from
conventional
therapy
to
precision
medicine.
Nanotechnology,
an
interdisciplinary
field
with
focus
on
biomedical
applications,
holds
immense
promise
bringing
about
novel
approaches
for
detection,
diagnosis,
therapy.
past
decade
witnessed
significant
research
material
applications
related
nanoparticles
(NPs).
NPs
differ
small-molecule
drugs
as
they
possess
unique
physicochemical
characteristics,
such
large
surface-to-volume
ratio,
enabling
them
penetrate
live
cells
efficiently.
Traditional
therapies,
chemotherapy,
radiation
therapy,
targeted
immunotherapy,
have
limitations,
cytotoxicity,
lack
specificity,
multiple
drug
resistance,
which
pose
challenges
effective
treatment.
However,
nanomaterials
properties
that
enable
new
therapeutic
modalities
beyond
delivery
the
fight
against
cancer.
Moreover,
(1–100
nm)
numerous
benefits,
biocompatibility,
reduced
toxicity,
excellent
stability,
enhanced
permeability
retention
effect,
precise
targeting,
making
ideal
purpose
this
article
is
provide
consolidated
information
various
bio-inspired
aid
theranostics.
Burns & Trauma,
Journal Year:
2024,
Volume and Issue:
12
Published: Jan. 1, 2024
Abstract
Diabetic
foot
ulcer
(DFU),
characterized
by
high
recurrence
rate,
amputations
and
mortality,
poses
a
significant
challenge
in
diabetes
management.
The
complex
pathology
involves
dysregulated
glucose
homeostasis
leading
to
systemic
local
microenvironmental
complications,
including
peripheral
neuropathy,
micro-
macro-angiopathy,
recurrent
infection,
persistent
inflammation
re-epithelialization.
Novel
approaches
accelerate
DFU
healing
are
actively
pursued,
with
focus
on
utilizing
exosomes.
Exosomes
natural
nanovesicles
mediating
cellular
communication
containing
diverse
functional
molecular
cargos,
DNA,
mRNA,
microRNA
(miRNA),
lncRNA,
proteins,
lipids
metabolites.
While
some
exosomes
show
promise
modulating
function
promoting
healing,
their
efficacy
is
limited
low
yield,
impurities,
loading
content
inadequate
targeting.
Engineering
enhance
curative
activity
represents
potentially
more
efficient
approach
for
DFUs.
This
could
facilitate
focused
repair
regeneration
of
nerves,
blood
vessels
soft
tissue
after
development.
review
provides
an
overview
pathogenesis,
strategies
exosome
engineering
the
targeted
therapeutic
application
engineered
addressing
critical
pathological
changes
associated
Exploration,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 17, 2024
Abstract
Cancer
vaccines
are
promising
to
treat
malignancy
by
delivering
antigens
and
adjuvants
elicit
host
immunity.
Beyond
aluminum
adjuvants,
liposomes
show
efficient
adjuvant
effects
through
regulating
the
accumulation,
internalization
release
of
payloads.
However,
it
remains
unknown
that
whether
liposome
will
perform
intrinsic
in
absence
adjuvants.
Herein,
a
library
antigen/adjuvant‐free
with
variable
surface
charges
has
been
developed
found
highly
anionic
for
boosting
immune
responses.
The
mobilizes
MyD88
pathways
dendritic
cells
(DCs)
activate
T
helper
CD8
+
cells.
enhance
immunity
population
Th1,
Th2
regulatory
(Tregs),
boost
adaptive
lymphoid
organs
good
biosafety.
It
shows
most
protection
against
MC38
colorectal
cancer
mice
after
parallel
injection
liposomes.
Overall,
this
study
reveals
charge
affects
its
efficiency
provides
an
nanosized
formulation
enhancing
immunization.
European Journal of Pharmaceutics and Biopharmaceutics,
Journal Year:
2024,
Volume and Issue:
203, P. 114460 - 114460
Published: Aug. 31, 2024
Glioblastoma
(GBM)
stands
for
the
most
common
and
aggressive
type
of
brain
tumour
in
adults.
It
is
highly
invasive,
which
explains
its
short
rate
survival.
Little
known
about
risk
factors,
current
therapy
still
ineffective.
Hence,
efforts
are
underway
to
develop
novel
effective
treatment
approaches
against
this
cancer.
Exosomes
being
explored
as
a
promising
strategy
conveying
delivering
therapeutic
cargo
GBM
cells.
They
can
fuse
with
cell
membrane
and,
consequently,
serve
delivery
systems
context.
Due
their
nanoscale
size,
exosomes
cross
blood-brain
barrier
(BBB),
constitutes
significant
hurdle
chemotherapeutic
drugs
used
GBM.
subsequently
inhibit
oncogenes,
activate
suppressor
genes,
induce
immune
responses,
control
growth.
However,
despite
representing
tool
GBM,
further
research
clinical
studies
regarding
exosome
biology,
engineering,
applications
need
be
completed.
Here,
we
sought
review
application
through
an
in-depth
analysis
scientific
on
entire
process,
from
isolation
purification
design
transformation
into
anti-oncogenic
drug
systems.
Surface
modification
enhance
BBB
penetration
GBM-cell
targeting
also
topic
discussion.
