Protective role of ginsenoside Rg1 in the dynamic progression of liver injury to fibrosis: a preclinical meta-analysis DOI Creative Commons

Lijuan Dan,

Xiuyan Li,

Shuanglan Chen

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 28, 2025

Background The pathological progression from liver injury to fibrosis is a hallmark of disease, with no effective strategies halt this transition. Ginsenoside Rg1 has demonstrated range hepatoprotective properties; however, systematic preclinical evidence supporting its therapeutic potential for and remains limited. Purpose. This study evaluated the efficacy underlying mechanisms ginsenoside in animal models fibrosis, providing basis future clinical investigation. Methods A review was conducted on studies published PubMed, Web Science, Embase databases up 1 August 2024, adhereing rigorous quality standards. methodological assessed using SYRCLE’s risk bias tool. Meta-analysis subgroup analysis were performed Revman 5.4 software, while publication through funnel plots Egger’s test STATA 15.0 software. Additionally, time-dose interval curve utilized assess dose-response relationship identify dose treating fibrosis. Results Twenty-four trials involving 423 animals included. findings indicated that significantly improved function markers (ALT AST), reduced indicators associated lowered fibrosis-related (α-SMA, HYP, PCIII). Furthermore, it exhibited beneficial effects mechanistic inflammation, oxidative stress, apoptosis, compared control group ( P < 0.05). Time-dose revealed between 4 800 mg/kg/d. Conclusion at 4–800 mg/kg/d mitigates via anti-inflammatory, antioxidative, anti-apoptotic pathways. Systematic Review Registration https://www.crd.york.ac.uk/PROSPERO/ , identifier CRD 42024557878.

Language: Английский

Ginsenoside Rg1: A natural triterpenoid glycoside with promising anti-depressive properties DOI
Yating Wang, Jun-Jie Jiang, Yi Zhang

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 105940 - 105940

Published: Jan. 1, 2025

Language: Английский

Citations

3
Targeting novel regulated cell death：Ferroptosis, pyroptosis, and autophagy in sepsis-associated encephalopathy DOI Open Access

Jingjing Sun,

Joshua S. Fleishman, Xueyan Liu

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 174, P. 116453 - 116453

Published: March 20, 2024

Sepsis-associated encephalopathy (SAE), a common neurological complication of sepsis, is heterogenous complex clinical syndrome caused by the dysfunctional response host to infection. This leads excess mortality and morbidity worldwide. Despite relevance with high incidence, there lack understanding for its both acute/chronic pathogenesis therapeutic management. A better molecular mechanisms behind SAE may provide tools enhance efficacy. Mounting evidence indicates that some types non-apoptotic regulated cell death (RCD), such as ferroptosis, pyroptosis, autophagy, contribute SAE. Targeting these RCD meaningful targets future treatments against review summarizes core mechanism which We focus on emerging compounds can inhibit delineate their beneficial pharmacological effects Within this we suggest inhibition serve potential strategy

Language: Английский

Citations

15
Exploring the effect of Anshen Dingzhi prescription on hippocampal mitochondrial signals in single prolonged stress mouse model DOI
Juan Wang, Panpan Zhao,

Ping Cheng

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 323, P. 117713 - 117713

Published: Jan. 4, 2024

Language: Английский

Citations

14
Ginsenoside Rk1 induces autophagy-dependent apoptosis in hepatocellular carcinoma by AMPK/mTOR signaling pathway DOI

Huanyan Wu,

Linlin Qu, Xue Bai

et al.

Food and Chemical Toxicology, Journal Year: 2024, Volume and Issue: 186, P. 114587 - 114587

Published: March 8, 2024

Language: Английский

Citations

12
A novel strategy for the protective effect of ginsenoside Rg1 against ovarian reserve decline by the PINK1 pathway DOI Creative Commons

Pengdi Yang,

Meiling Fan,

Ying Chen

et al.

Pharmaceutical Biology, Journal Year: 2025, Volume and Issue: 63(1), P. 68 - 81

Published: Jan. 25, 2025

Context The decline in ovarian reserve is a major concern female reproductive health, often associated with oxidative stress and mitochondrial dysfunction. Although ginsenoside Rg1 known to modulate mitophagy, its effectiveness mitigating remains unclear.

Language: Английский

Citations

1
Microbiome and metabolome integrally reveal the anti-depression effects of Cistanche deserticola polysaccharides from the perspective of gut homeostasis DOI Open Access

Xiaojie Liu,

Xiaoling Wu,

Senyan Wang

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 245, P. 125542 - 125542

Published: June 22, 2023

Language: Английский

Citations

18
Recognizing Alzheimer's disease from perspective of oligodendrocytes: Phenomena or pathogenesis? DOI Creative Commons
Jingji Wang, Yilan Zhen,

Jun Yang

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(3)

Published: March 1, 2024

Abstract Background Accumulation of amyloid beta, tau hyperphosphorylation, and microglia activation are the three highly acknowledged pathological factors Alzheimer's disease (AD). However, oligodendrocytes (OLs) were also widely investigated in pathogenesis treatment for AD. Aims We aimed to update regulatory targets differentiation maturation OLs, emphasized key role OLs occurrence Methods This review first concluded OL with AD pathogenesis, then advanced based on both clinic basic experiments. Later, we extensively discussed possible application current progress diagnosis this complex disease. Results Molecules involving OLs’ or maturation, including various transcriptional factors, cholesterol homeostasis regulators, microRNAs could participate Clinical data point towards impairment patients. Basic research further supports central regulation pathologies. Additionally, classic drugs, donepezil, edaravone, fluoxetine, clemastine demonstrate their potential remedying models, new therapeutics from perspective is constantly being developed. Conclusions believe that dysfunction one important Factors regulating might be biomarkers early agents stimulating warrant development anti‐AD drugs.

Language: Английский

Citations

9
Ginsenoside Rg5 inhibits glioblastoma by activating ferroptosis via NR3C1/HSPB1/NCOA4 DOI
Guoqing Zhang,

Jinpeng Hu,

Ao Li

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 129, P. 155631 - 155631

Published: April 12, 2024

Language: Английский

Citations

7
Ginsenoside Rg1: A bioactive therapeutic agent for diverse liver diseases DOI Creative Commons

Ming‐Kung Wu,

Ke Li,

Jiabin Wu

et al.

Pharmacological Research, Journal Year: 2025, Volume and Issue: unknown, P. 107571 - 107571

Published: Jan. 1, 2025

Diverse liver diseases are characterised by late diagnosis and rapid progression have become one of the major threats to human health. To delay transition from benign tissue lesions a substantial organ injury, scientists gradually applied natural compounds derived plants as complementary therapy in field hepatology. Ginseng (Panax ginseng C. A. Meyer) is tonic traditional Chinese herbal medicine, products, including ginsenoside Rg1 (G-Rg1), which kind 20(S)-protopanaxatriol saponin with relatively high biological activity, can be isolated roots or stems ginseng. Given these information, this review aimed summarise discuss metabolic mechanisms G-Rg1 regulation diverse measures improve its bioavailability. As monomer medicine multitarget pharmacological effects, provide significant therapeutic benefits alleviation alcoholic disease, nonalcoholic fatty fibrosis, viral hepatitis, etc., mainly rely on inhibition apoptosis, strengthening endogenous anti-inflammatory antioxidant mechanisms, activation immune responses efflux transport signals, pathological changes caused lipid deposition, inflammation, oxidative stress, accumulation hepatotoxic product, etc. However, poor bioavailability must overcome clinical application value. In summary, focusing hepatoprotective will new insights into development resources their pharmaceutical products target treatment diseases.

Language: Английский

Citations

1
Trends in research on novel antidepressant treatments DOI Creative Commons
Agnieszka Zelek-Molik, Ewa Litwa

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 27, 2025

Mood disorders, such as major depressive disorder and bipolar disorder, are among the most common mental illnesses a leading cause of disability worldwide. Key symptoms these conditions include depressed mood or anhedonia, sleep psychomotor disturbances, changes in appetite weight, fatigue loss energy. Prolonged cognitive disturbances further impair ability to think concentrate often accompanied by persistent feelings worthlessness excessive guilt. Collectively, underscore depression serious, long-term global health issue. In addition, clinical studies indicate growing number patients experiencing difficulties responding treatment, even long term. This phenomenon poses significant challenges for healthcare professionals, families, alike. As result, there is an urgent need therapies that both rapid-acting safe. review aims summarize prevailing trends research on novel antidepressants, emphasizing their diversity multi-directional mechanisms action. The development drugs increasingly focused achieving high efficacy, particularly treatment-resistant depression. Such advances offer potential rapid therapeutic effects without prolonged tedious administration older generation antidepressants. Findings from using animal models continue play crucial role predicting designing new strategies. These remain indispensable understanding physiological newly developed compounds, thereby guiding creation innovative treatments.

Language: Английский

Citations

1