Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: Jan. 28, 2025
Background
The
pathological
progression
from
liver
injury
to
fibrosis
is
a
hallmark
of
disease,
with
no
effective
strategies
halt
this
transition.
Ginsenoside
Rg1
has
demonstrated
range
hepatoprotective
properties;
however,
systematic
preclinical
evidence
supporting
its
therapeutic
potential
for
and
remains
limited.
Purpose.
This
study
evaluated
the
efficacy
underlying
mechanisms
ginsenoside
in
animal
models
fibrosis,
providing
basis
future
clinical
investigation.
Methods
A
review
was
conducted
on
studies
published
PubMed,
Web
Science,
Embase
databases
up
1
August
2024,
adhereing
rigorous
quality
standards.
methodological
assessed
using
SYRCLE’s
risk
bias
tool.
Meta-analysis
subgroup
analysis
were
performed
Revman
5.4
software,
while
publication
through
funnel
plots
Egger’s
test
STATA
15.0
software.
Additionally,
time-dose
interval
curve
utilized
assess
dose-response
relationship
identify
dose
treating
fibrosis.
Results
Twenty-four
trials
involving
423
animals
included.
findings
indicated
that
significantly
improved
function
markers
(ALT
AST),
reduced
indicators
associated
lowered
fibrosis-related
(α-SMA,
HYP,
PCIII).
Furthermore,
it
exhibited
beneficial
effects
mechanistic
inflammation,
oxidative
stress,
apoptosis,
compared
control
group
(
P
<
0.05).
Time-dose
revealed
between
4
800
mg/kg/d.
Conclusion
at
4–800
mg/kg/d
mitigates
via
anti-inflammatory,
antioxidative,
anti-apoptotic
pathways.
Systematic
Review
Registration
https://www.crd.york.ac.uk/PROSPERO/
,
identifier
CRD
42024557878.
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
174, P. 116453 - 116453
Published: March 20, 2024
Sepsis-associated
encephalopathy
(SAE),
a
common
neurological
complication
of
sepsis,
is
heterogenous
complex
clinical
syndrome
caused
by
the
dysfunctional
response
host
to
infection.
This
leads
excess
mortality
and
morbidity
worldwide.
Despite
relevance
with
high
incidence,
there
lack
understanding
for
its
both
acute/chronic
pathogenesis
therapeutic
management.
A
better
molecular
mechanisms
behind
SAE
may
provide
tools
enhance
efficacy.
Mounting
evidence
indicates
that
some
types
non-apoptotic
regulated
cell
death
(RCD),
such
as
ferroptosis,
pyroptosis,
autophagy,
contribute
SAE.
Targeting
these
RCD
meaningful
targets
future
treatments
against
review
summarizes
core
mechanism
which
We
focus
on
emerging
compounds
can
inhibit
delineate
their
beneficial
pharmacological
effects
Within
this
we
suggest
inhibition
serve
potential
strategy
Pharmaceutical Biology,
Journal Year:
2025,
Volume and Issue:
63(1), P. 68 - 81
Published: Jan. 25, 2025
Context
The
decline
in
ovarian
reserve
is
a
major
concern
female
reproductive
health,
often
associated
with
oxidative
stress
and
mitochondrial
dysfunction.
Although
ginsenoside
Rg1
known
to
modulate
mitophagy,
its
effectiveness
mitigating
remains
unclear.
Abstract
Background
Accumulation
of
amyloid
beta,
tau
hyperphosphorylation,
and
microglia
activation
are
the
three
highly
acknowledged
pathological
factors
Alzheimer's
disease
(AD).
However,
oligodendrocytes
(OLs)
were
also
widely
investigated
in
pathogenesis
treatment
for
AD.
Aims
We
aimed
to
update
regulatory
targets
differentiation
maturation
OLs,
emphasized
key
role
OLs
occurrence
Methods
This
review
first
concluded
OL
with
AD
pathogenesis,
then
advanced
based
on
both
clinic
basic
experiments.
Later,
we
extensively
discussed
possible
application
current
progress
diagnosis
this
complex
disease.
Results
Molecules
involving
OLs’
or
maturation,
including
various
transcriptional
factors,
cholesterol
homeostasis
regulators,
microRNAs
could
participate
Clinical
data
point
towards
impairment
patients.
Basic
research
further
supports
central
regulation
pathologies.
Additionally,
classic
drugs,
donepezil,
edaravone,
fluoxetine,
clemastine
demonstrate
their
potential
remedying
models,
new
therapeutics
from
perspective
is
constantly
being
developed.
Conclusions
believe
that
dysfunction
one
important
Factors
regulating
might
be
biomarkers
early
agents
stimulating
warrant
development
anti‐AD
drugs.
Pharmacological Research,
Journal Year:
2025,
Volume and Issue:
unknown, P. 107571 - 107571
Published: Jan. 1, 2025
Diverse
liver
diseases
are
characterised
by
late
diagnosis
and
rapid
progression
have
become
one
of
the
major
threats
to
human
health.
To
delay
transition
from
benign
tissue
lesions
a
substantial
organ
injury,
scientists
gradually
applied
natural
compounds
derived
plants
as
complementary
therapy
in
field
hepatology.
Ginseng
(Panax
ginseng
C.
A.
Meyer)
is
tonic
traditional
Chinese
herbal
medicine,
products,
including
ginsenoside
Rg1
(G-Rg1),
which
kind
20(S)-protopanaxatriol
saponin
with
relatively
high
biological
activity,
can
be
isolated
roots
or
stems
ginseng.
Given
these
information,
this
review
aimed
summarise
discuss
metabolic
mechanisms
G-Rg1
regulation
diverse
measures
improve
its
bioavailability.
As
monomer
medicine
multitarget
pharmacological
effects,
provide
significant
therapeutic
benefits
alleviation
alcoholic
disease,
nonalcoholic
fatty
fibrosis,
viral
hepatitis,
etc.,
mainly
rely
on
inhibition
apoptosis,
strengthening
endogenous
anti-inflammatory
antioxidant
mechanisms,
activation
immune
responses
efflux
transport
signals,
pathological
changes
caused
lipid
deposition,
inflammation,
oxidative
stress,
accumulation
hepatotoxic
product,
etc.
However,
poor
bioavailability
must
overcome
clinical
application
value.
In
summary,
focusing
hepatoprotective
will
new
insights
into
development
resources
their
pharmaceutical
products
target
treatment
diseases.
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: Jan. 27, 2025
Mood
disorders,
such
as
major
depressive
disorder
and
bipolar
disorder,
are
among
the
most
common
mental
illnesses
a
leading
cause
of
disability
worldwide.
Key
symptoms
these
conditions
include
depressed
mood
or
anhedonia,
sleep
psychomotor
disturbances,
changes
in
appetite
weight,
fatigue
loss
energy.
Prolonged
cognitive
disturbances
further
impair
ability
to
think
concentrate
often
accompanied
by
persistent
feelings
worthlessness
excessive
guilt.
Collectively,
underscore
depression
serious,
long-term
global
health
issue.
In
addition,
clinical
studies
indicate
growing
number
patients
experiencing
difficulties
responding
treatment,
even
long
term.
This
phenomenon
poses
significant
challenges
for
healthcare
professionals,
families,
alike.
As
result,
there
is
an
urgent
need
therapies
that
both
rapid-acting
safe.
review
aims
summarize
prevailing
trends
research
on
novel
antidepressants,
emphasizing
their
diversity
multi-directional
mechanisms
action.
The
development
drugs
increasingly
focused
achieving
high
efficacy,
particularly
treatment-resistant
depression.
Such
advances
offer
potential
rapid
therapeutic
effects
without
prolonged
tedious
administration
older
generation
antidepressants.
Findings
from
using
animal
models
continue
play
crucial
role
predicting
designing
new
strategies.
These
remain
indispensable
understanding
physiological
newly
developed
compounds,
thereby
guiding
creation
innovative
treatments.