International Journal of Nanomedicine,
Journal Year:
2025,
Volume and Issue:
Volume 20, P. 1263 - 1284
Published: Jan. 1, 2025
Clinically,
a
multitude
of
factors
can
contribute
to
the
development
bone
defects.
In
process
healing,
nervous
system
plays
vital
role
in
regeneration.
Small
molecules
from
system,
such
as
neurotrophic
and
neuropeptides,
have
been
found
stimulate
osteoblast
proliferation
differentiation
by
activating
signaling
pathways
associated
with
calcification
angiogenesis.
These
small
play
crucial
regulatory
at
various
stages
healing.
The
systematic
release
mechanism
within
through
diverse
tissue
engineering
materials
holds
significant
clinical
implications
for
controlled
regulation
healing
process.
This
review
provides
an
overview
involvement
different
discusses
their
mechanisms,
aiming
establish
theoretical
foundation
programmed
regeneration
design
replacement
engineering.
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 1189 - 1204
Published: Feb. 1, 2024
Abstract:
Tissue
engineering
holds
great
potential
for
tissue
repair
and
rejuvenation.
Plant-derived
exosome-like
nanoparticles
(ELNs)
have
recently
emerged
as
a
promising
avenue
in
engineering.
However,
there
is
an
urgent
need
to
understand
how
plant
ELNs
can
be
therapeutically
applied
clinical
disease
management,
especially
regeneration.
In
this
review,
we
comprehensively
examine
the
properties,
characteristics,
isolation
techniques
of
ELNs.
We
also
discuss
their
impact
on
immune
system,
compatibility
with
human
body,
role
To
ensure
suitability
engineering,
explore
various
modification
strategies.
Additionally,
provide
insights
into
progress
commercialization
industrial
perspectives
This
review
aims
highlight
regenerative
medicine
by
exploring
current
research
landscape
key
findings.
Keywords:
plant,
nanoparticles,
nanomedicine,
cartilage,
wound,
bone
Bone Research,
Journal Year:
2023,
Volume and Issue:
11(1)
Published: Dec. 20, 2023
The
skeleton
is
a
highly
innervated
organ
in
which
nerve
fibers
interact
with
various
skeletal
cells.
Peripheral
endings
release
neurogenic
factors
and
sense
signals,
mediate
bone
metabolism
pain.
In
recent
years,
tissue
engineering
has
increasingly
focused
on
the
effects
of
nervous
system
regeneration.
Simultaneous
regeneration
nerves
through
use
materials
or
by
enhancement
endogenous
repair
signals
been
proven
to
promote
functional
Additionally,
emerging
information
mechanisms
interoception
central
regulation
homeostasis
provide
an
opportunity
for
advancing
biomaterials.
However,
comprehensive
reviews
this
topic
are
lacking.
Therefore,
review
provides
overview
relationship
between
regeneration,
focusing
applications.
We
discuss
novel
regulatory
explore
innovative
approaches
based
nerve-bone
interactions
Finally,
challenges
future
prospects
field
briefly
discussed.
PubMed,
Journal Year:
2023,
Volume and Issue:
4(4), P. 248 - 269
Published: Jan. 1, 2023
While
bone
tissue
is
known
for
its
inherent
regenerative
abilities,
various
pathological
conditions
and
trauma
can
disrupt
meticulously
regulated
processes
of
formation
resorption.
Bone
engineering
aims
to
replicate
the
extracellular
matrix
as
well
sophisticated
biochemical
mechanisms
crucial
effective
regeneration.
Traditionally,
field
has
relied
on
external
agents
like
growth
factors
pharmaceuticals
modulate
these
processes.
Although
efficacious
in
certain
scenarios,
this
strategy
compromised
by
limitations
such
safety
issues
transient
nature
compound
release
half-life.
Conversely,
bioactive
elements
zinc
(Zn),
magnesium
(Mg)
silicon
(Si),
have
garnered
increasing
interest
their
therapeutic
benefits,
superior
stability,
reduced
biotic
risks.
Moreover,
are
often
incorporated
into
biomaterials
that
function
multifaceted
components,
facilitating
regeneration
via
on-demand.
By
elucidating
mechanistic
roles
efficacy
elements,
review
establish
a
robust
clinically
viable
advanced
Medicinal Research Reviews,
Journal Year:
2024,
Volume and Issue:
44(4), P. 1867 - 1903
Published: Feb. 29, 2024
Over
the
past
decades,
emerging
evidence
in
literature
has
demonstrated
that
innervation
of
bone
is
a
crucial
modulator
for
skeletal
physiology
and
pathophysiology.
The
nerve-bone
axis
sparked
extensive
preclinical
clinical
investigations
aimed
at
elucidating
contribution
crosstalks
to
skeleton
metabolism,
homeostasis,
injury
repair
through
perspective
neurobiology.
To
date,
peripheral
nerves
have
been
widely
reported
mediate
growth
development
fracture
healing
via
secretion
neurotransmitters,
neuropeptides,
axon
guidance
factors,
neurotrophins.
Relevant
studies
further
identified
several
critical
neural
pathways
stimulate
profound
alterations
cell
biology,
revealing
complex
interplay
between
nerve
systems.
In
addition,
inspired
by
crosstalk,
novel
drug
delivery
systems
bioactive
materials
developed
emulate
facilitate
process
natural
neuromodulation,
eventually
boosting
osteogenesis
ideal
tissue
regeneration.
Overall,
this
work
aims
review
research
findings
contribute
deepening
current
understanding
axis,
bringing
forth
some
schemas
can
be
translated
into
scenario
highlight
roles
neuromodulation
system.
National Science Review,
Journal Year:
2024,
Volume and Issue:
11(5)
Published: Feb. 27, 2024
China's
aging
demographic
poses
a
challenge
for
treating
prevalent
bone
diseases
impacting
life
quality.
As
regeneration
capacity
diminishes
with
age
due
to
cellular
dysfunction
and
inflammation,
advanced
biomaterials-based
approaches
offer
hope
aged
regeneration.
This
review
synthesizes
materiobiology
principles,
focusing
on
biomaterials
that
target
specific
biological
functions
restore
tissue
integrity.
It
covers
strategies
stem
cell
manipulation,
regulation
of
the
inflammatory
microenvironment,
blood
vessel
regeneration,
intervention
in
anabolism
catabolism,
nerve
regulation.
The
also
explores
molecular
mechanisms
underlying
proposes
database-driven
design
process
future
biomaterial
development.
These
insights
may
guide
therapies
other
age-related
conditions,
contributing
pursuit
'healthy
aging'.
Military Medical Research,
Journal Year:
2024,
Volume and Issue:
11(1)
Published: Oct. 21, 2024
Abstract
Severe
tissue
defects
present
formidable
challenges
to
human
health,
persisting
as
major
contributors
mortality
rates.
The
complex
pathological
microenvironment,
particularly
the
disrupted
immune
landscape
within
these
defects,
poses
substantial
hurdles
existing
regeneration
strategies.
However,
emergence
of
nanobiotechnology
has
opened
a
new
direction
in
immunomodulatory
nanomedicine,
providing
encouraging
prospects
for
and
restoration.
This
review
aims
gather
recent
advances
nanomedicine
foster
regeneration.
We
begin
by
elucidating
distinctive
features
local
microenvironment
defective
tissues
its
crucial
role
Subsequently,
we
explore
design
functional
properties
nanosystems.
Finally,
address
clinical
translation
development,
aiming
propose
potent
approach
enhance
through
synergistic
modulation
integration.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 5, 2024
Abstract
Infected
fracture
healing
is
a
complicated
process
that
includes
intricate
interactions
at
the
cellular
and
molecular
levels.
In
addition
to
angiogenesis
osteogenesis,
significance
of
neurogenesis
in
has
also
been
recognized
recent
years.
Here,
nanocomposite
hydrogel
containing
pH‐responsive
zinc‐gallium‐humic
acids
(HAs)
nanoparticles
developed.
Through
timed
release
Zn
2+
,
Ga
3+
HAs,
exhibits
potent
antibacterial
effects
promotes
angiogenesis,
neurogenesis.
The
enhanced
further
forming
mutually
supportive
angiogenesis–osteogenesis–neurogenesis
cycle
site.
achieves
rapid
infected
improves
tissue
regeneration
mice.
This
study
proposes
comprehensive
treatment
approach
combines
with
regulation
improve
healing.
