Nkd1 functions downstream of Axin2 to attenuate Wnt signaling DOI

Ian Bell,

Haider Ali Khan,

Nathan Stutt

et al.

Molecular Biology of the Cell, Journal Year: 2024, Volume and Issue: 35(7)

Published: April 24, 2024

Wnt signaling is a crucial developmental pathway involved in early development as well stem-cell maintenance adults and its misregulation leads to numerous diseases. Thus, understanding the regulation of this becomes vitally important. Axin2 Nkd1 are widely utilized negative feedback regulators where functions destabilize cytoplasmic β-catenin, inhibit nuclear localization β-catenin. Here, we set out further understand how regulate by creating

Language: Английский

Signaling pathways of oxidative stress response: the potential therapeutic targets in gastric cancer DOI Creative Commons
Yingying Liu, Yu Shi, Ruiqin Han

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: April 18, 2023

Gastric cancer is one of the top causes cancer-related death globally. Although novel treatment strategies have been developed, attempts to eradicate gastric proven insufficient. Oxidative stress continually produced and present in human body. Increasing evidences show that oxidative contributes significantly development cancer, either through initiation, promotion, progression cells or causing cell death. As a result, purpose this article review role response subsequent signaling pathways as well potential stress-related therapeutic targets cancer. Understanding pathophysiology developing new therapies for depends on more researches focusing contributors carcinogenesis.

Language: Английский

Citations

33
Glioblastoma biomarkers in urinary extracellular vesicles reveal the potential for a ‘liquid gold’ biopsy DOI Creative Commons
Susannah Hallal, Ágota Tűzesi,

Liam A. Sida

et al.

British Journal of Cancer, Journal Year: 2024, Volume and Issue: 130(5), P. 836 - 851

Published: Jan. 11, 2024

Abstract Background Biomarkers that reflect glioblastoma tumour activity and treatment response are urgently needed to help guide clinical management, particularly for recurrent disease. As the urinary system is a major clearance route of circulating extracellular vesicles (EVs; 30–1000 nm nanoparticles) we explored whether sampling urinary-EVs could serve as simple non-invasive liquid biopsy approach measuring glioblastoma-associated biomarkers. Methods Fifty urine specimens (15–60 ml) were collected from 24 catheterised patients immediately prior primary ( n = 17) recurrence 7) surgeries, following gross total resection 9), age/gender-matched healthy participants 14). EVs isolated by differential ultracentrifugation characterised extracted proteomes analysed high-resolution data-independent acquisition chromatography tandem mass spectrometry (DIA-LC-MS/MS). Results Overall, 6857 proteins confidently identified in q -value ≤ 0.01), including 94 EV marker proteins. Glioblastoma-specific proteomic signatures determined, putative urinary-EV biomarkers corresponding burden (FC ≥ | 2 , adjust p -val≤0.05, AUC > 0.9). Conclusion In-depth DIA-LC-MS/MS characterisation substantiates viable source The promising ‘liquid gold’ biomarker panels described here warrant further investigation.

Language: Английский

Citations

14
Single-Cell RNA Sequencing in Ovarian Cancer: Current Progress and Future Prospects DOI
Zhi Xiong Chong

Progress in Biophysics and Molecular Biology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

1
Epithelial-mesenchymal transition in cancer stemness and heterogeneity: updated DOI
Keywan Mortezaee, Jamal Majidpoor, Ebrahim Kharazinejad

et al.

Medical Oncology, Journal Year: 2022, Volume and Issue: 39(12)

Published: Sept. 7, 2022

Language: Английский

Citations

28
A potential tumor marker: Chaperonin containing TCP‑1 controls the development of malignant tumors (Review) DOI Creative Commons

Liming Zheng,

Xingyue Chen,

Li Zhang

et al.

International Journal of Oncology, Journal Year: 2023, Volume and Issue: 63(3)

Published: Aug. 1, 2023

Due to concealment, high invasiveness and a lack of indicators, malignant tumors have emerged as one the deadliest diseases worldwide their incidence is rising yearly. Research has revealed that chaperonin family member, containing TCP‑1 (CCT), serves crucial role in tumors. CCT involved growth numerous such lung cancer, breast hepatocellular carcinoma colorectal cancer assists folding number proteins linked KRAS, p53 STAT3. According clinical data, highly expressed range tumor cells associated with poor patient prognosis. In addition, through controlling cell cycle or interacting other (including YAP1, HoXB2 SMAD2), an effect on proliferation, invasion migration cells. As result, it possible will become new marker therapeutic target, which provide some guidance for early screening late present review, molecular properties are introduced, alongside summary its interactions cancer‑related discussion function common It expected review offer fresh approaches treatment cancer.

Language: Английский

Citations

14
Revisiting the chaperonin T‐complex protein‐1 ring complex in human health and disease: A proteostasis modulator and beyond DOI

Chenglong Zeng,

Shenqi Han, Yonglong Pan

et al.

Clinical and Translational Medicine, Journal Year: 2024, Volume and Issue: 14(2)

Published: Feb. 1, 2024

Language: Английский

Citations

5
Phenotypic Transitions the Processes Involved in Regulation of Growth and Proangiogenic Properties of Stem Cells, Cancer Stem Cells and Circulating Tumor Cells DOI Creative Commons
Magdalena Kulus,

Maryam Farzaneh,

Artur Bryja

et al.

Stem Cell Reviews and Reports, Journal Year: 2024, Volume and Issue: 20(4), P. 967 - 979

Published: Feb. 19, 2024

Epithelial-mesenchymal transition (EMT) is a crucial process with significance in the metastasis of malignant tumors. It through acquisition plasticity that cancer cells become more mobile and gain ability to metastasize other tissues. The mesenchymal-epithelial (MET) return an epithelial state, which allows for formation secondary Both processes, EMT MET, are regulated by different pathways mediators, affects sophistication overall tumorigenesis process. Not insignificant also stem their participation angiogenesis, occur very intensively within Difficulties effectively treating primarily dependent on potential rapidly expand occupy secondarily vital organs. Due these spread, concept circulating tumor cell (CTC) has emerged. Interestingly, CTCs exhibit molecular diversity stem-like mesenchymal features, even when derived from primary tissue single patient. While necessary metastasis, MET required establish site. A thorough understanding processes govern balance between malignancy crucial.

Language: Английский

Citations

5
Wnt signaling in gastric cancer: current progress and future prospects DOI Creative Commons
Ruyue Han, Jing Yang, Yingying Zhu

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: June 7, 2024

Levels of the Wnt pathway components are abnormally altered in gastric cancer cells, leading to malignant cell proliferation, invasion and metastasis, poor prognosis chemoresistance. Therefore, it is important understand mechanism signaling cancer. We systematically reviewed molecular mechanisms development; summarize progression challenges research on agents pathway.

Language: Английский

Citations

5
New insight in urological cancer therapy: From epithelial-mesenchymal transition (EMT) to application of nano-biomaterials DOI
Peng He, Qiang Dai, Xiaojun Wu

et al.

Environmental Research, Journal Year: 2023, Volume and Issue: 229, P. 115672 - 115672

Published: March 10, 2023

Language: Английский

Citations

12
Cytosolic Cadherin 4 promotes angiogenesis and metastasis in papillary thyroid cancer by suppressing the ubiquitination/degradation of β-catenin DOI Creative Commons

Luyao Wu,

Jian Xiao, Dandan Yi

et al.

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Feb. 24, 2024

Abstract Background Although the long-term prognosis of papillary thyroid cancer (PTC) is favorable, distant metastasis significantly compromises and quality life for patients with PTC. The Cadherin family plays a pivotal role in tumor metastasis; however, involvement 4 (CDH4) metastatic cascade remains elusive. Methods expression subcellular localization CDH4 were determined through immunohistochemistry, immunofluorescence, western blot analyses. impact on cell migration, invasion, angiogenesis, was assessed using transwell assays, tube formation animal experiments. Immunoprecipitation assay mass spectrometry employed to examine protein associations. influence β-catenin active investigated via blotting immunofluorescence. Protein stability ubiquitination verify degradation. Rescue experiments performed ensure significance regulating nuclear signaling. Results found be overexpressed PTC tissues predominantly localized cytoplasm. Furthermore, overexpression associated lymph node patients. Cytosolic promoted lung cells stimulated angiogenesis tumorigenesis PTC; this effect could reversed by Tegavivint, an antagonist β-catenin. Mechanistically, cytosolic disrupted interaction between β-TrCP1, consequently impeding process activating Conclusions induces inhibition β-TrCP1-dependent β-Catenin.

Language: Английский

Citations

4