Deciphering the mechanisms of long non-coding RNAs in ferroptosis: insights into its clinical significance in cancer progression and immunology DOI Creative Commons

S.-H.I. Ou,

Xiaoya Nie,

Xiangyu Qiu

et al.

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 18, 2025

A new type of nonapoptotic, iron-dependent cell death induced by lipid peroxidation is known as ferroptosis. Numerous pathological processes, including inflammation and cancer, have been demonstrated to be influenced changes in the ferroptosis-regulating network. Long non-coding RNAs (LncRNAs) are a group functional RNA molecules that not translated into proteins, which can regulate gene expression various manners. An increasing number studies shown lncRNAs interfere with progression ferroptosis modulating ferroptosis-related genes directly or indirectly. Despite evidence implicating cancer inflammation, on their mechanisms therapeutic potential remain scarce. We investigate lncRNA-mediated regulation immunity, assessing feasibility challenges targets these conditions.

Language: Английский

Competing endogenous RNA networks and ferroptosis in cancer: novel therapeutic targets DOI Creative Commons

Fatemeh Nejadi Orang,

Mahdi Abdoli Shadbad

Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(5)

Published: May 22, 2024

Abstract As a newly identified regulated cell death, ferroptosis is metabolically driven process that relies on iron and associated with polyunsaturated fatty acyl peroxidation, elevated levels of reactive oxygen species (ROS), mitochondrial damage. This distinct death dysregulated in various cancers; activating malignant cells increases cancer immunotherapy chemoradiotherapy responses across different malignancies. Over the last decade, accumulating research has provided evidence cross-talk between non-coding RNAs (ncRNAs) competing endogenous RNA (ceRNA) networks highlighted their significance developing progressing Aside from pharmaceutical agents to regulate ferroptosis, recent studies have shed light potential restoring ferroptosis-related ceRNA treatment. The present study provides comprehensive up-to-date review significance, pathways, role chemoradiotherapy, biogenesis, ferroptosis-regulating cancers. insights can offer authorship state-of-the-art findings future perspectives regarding implication treatment determining prognosis affected patients.

Language: Английский

Citations

10
AHR activation relieves deoxynivalenol-induced disruption of porcine intestinal epithelial barrier functions DOI

Zi-Yan Hu,

Shang-Jia Yang,

Yuan‐Hang Chang

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 480, P. 136095 - 136095

Published: Oct. 8, 2024

Language: Английский

Citations

10
Targeting LINC00152 activates cAMP/Ca2+/ferroptosis axis and overcomes tamoxifen resistance in ER+ breast cancer DOI Creative Commons
Özge Saatci, Rashedul Alam,

Kim‐Tuyen Huynh‐Dam

et al.

Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(6)

Published: June 15, 2024

Abstract Tamoxifen has been the mainstay therapy to treat early, locally advanced, and metastatic estrogen receptor-positive (ER + ) breast cancer, constituting around 75% of all cases. However, emergence resistance is common, necessitating identification novel therapeutic targets. Here, we demonstrated that long-noncoding RNA LINC00152 confers tamoxifen by blocking tamoxifen-induced ferroptosis, an iron-mediated cell death. Mechanistically, inhibiting reduces mRNA stability phosphodiesterase 4D ( PDE4D ), leading activation cAMP/PKA/CREB axis increased expression TRPC1 Ca 2+ channel. This causes cytosolic overload generation reactive oxygen species (ROS) is, on one hand, accompanied downregulation FTH1, a member iron sequestration unit, thus increasing intracellular Fe levels; other inhibition peroxidase activity upon reduced GPX4 xCT levels, in part cAMP/CREB. These ultimately restore tamoxifen-dependent lipid peroxidation ferroptotic death which are reversed chelating or overexpressing xCT. Overexpressing reverses inhibition-mediated sensitization de-activating cAMP/Ca /ferroptosis axis. Importantly, high significantly correlated with PDE4D/low ferroptosis worse survival multiple cohorts tamoxifen- tamoxifen-containing endocrine therapy-treated ER+ cancer patients. Overall, identified as mechanism via restoring destabilizing PDE4D, cAMP ROS peroxidation. Our findings reveal its effectors actionable targets improve clinical outcome refractory cancer.

Language: Английский

Citations

9
Targeting ferroptosis: the role of non-coding RNAs in hepatocellular carcinoma progression and therapy DOI
Weijia Wang,

Behishta Hashimi,

Ping Wang

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

Language: Английский

Citations

1
Deciphering the mechanisms of long non-coding RNAs in ferroptosis: insights into its clinical significance in cancer progression and immunology DOI Creative Commons

S.-H.I. Ou,

Xiaoya Nie,

Xiangyu Qiu

et al.

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 18, 2025

A new type of nonapoptotic, iron-dependent cell death induced by lipid peroxidation is known as ferroptosis. Numerous pathological processes, including inflammation and cancer, have been demonstrated to be influenced changes in the ferroptosis-regulating network. Long non-coding RNAs (LncRNAs) are a group functional RNA molecules that not translated into proteins, which can regulate gene expression various manners. An increasing number studies shown lncRNAs interfere with progression ferroptosis modulating ferroptosis-related genes directly or indirectly. Despite evidence implicating cancer inflammation, on their mechanisms therapeutic potential remain scarce. We investigate lncRNA-mediated regulation immunity, assessing feasibility challenges targets these conditions.

Language: Английский

Citations

1