Cited by The potential of curcumin in mitigating acetaminophen-induced liver damage

Oxidase mimicking nanozyme: Classification, catalytic mechanisms and sensing applications DOI

Ziting Lin,

Jinlong Yuan,

Lingxi Niu

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 520, P. 216166 - 216166

Published: Aug. 22, 2024

Language: Английский

Citations

Cell death pathways: molecular mechanisms and therapeutic targets for cancer DOI

Shaohui Wang, Sa Guo, Jing Guo

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(9)

Published: Sept. 1, 2024

Abstract Cell death regulation is essential for tissue homeostasis and its dysregulation often underlies cancer development. Understanding the different pathways of cell can provide novel therapeutic strategies battling cancer. This review explores several key mechanisms apoptosis, necroptosis, autophagic death, ferroptosis, pyroptosis. The research gap addressed involves a thorough analysis how these be precisely targeted therapy, considering tumor heterogeneity adaptation. It delves into genetic epigenetic factors signaling cascades like phosphatidylinositol 3‐kinase/protein kinase B/mammalian target rapamycin (PI3K/AKT/mTOR) mitogen‐activated protein kinase/extracellular signal‐regulated (MAPK/ERK) pathways, which are critical death. Additionally, interaction microenvironment with cells, particularly influence hypoxia, nutrient deprivation, immune cellular interactions, explored. Emphasizing strategies, this highlights emerging modulators inducers such as B lymphoma 2 (BCL2) homology domain 3 (BH3) mimetics, tumour necrosis factor‐related apoptosis‐inducing ligand (TRAIL), chloroquine, innovative approaches to induce ferroptosis provides insights therapy's future direction, focusing on multifaceted circumvent drug resistance. examination evolving underlines considerable clinical potential continuous necessity in‐depth exploration within scientific domain.

Language: Английский

Citations

Role of mitochondria in inflammatory lung diseases DOI

Venkata Ramireddy Narala,

Sahithi Reddy Narala,

Parasuraman Aiya Subramani

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 20, 2024

Mitochondria play a significant and varied role in inflammatory lung disorders. Mitochondria, known as the powerhouse of cell because their producing energy, are now recognized crucial regulators inflammation immunological responses. Asthma, chronic obstructive pulmonary disease, acute respiratory distress syndrome characterized by complex interactions between immune cells, substances, tissue damage. Dysfunctional mitochondria can increase generation reactive oxygen species (ROS), triggering pathways. Moreover, mitochondrial failure impacts cellular signaling, which turn affects expression molecules that promote inflammation. In addition, have controlling behavior such activation differentiation, is essential development diseases. Their dynamic behavior, encompassing fusion, fission, mitophagy, also responses to oxidative stress. Gaining comprehensive understanding intricate correlation order develop accurate treatment strategies. Targeting ROS generation, dynamics, function may offer novel approaches treating diseases while minimizing Additional investigation into precise contributions will provide knowledge regarding disease mechanisms potential therapeutic approaches. This review focus on how regulate these processes involvement

Language: Английский

Citations

Macroautophagy/autophagy promotes resistance to KRASG12D-targeted therapy through glutathione synthesis DOI

Leng Han,

Lingjun Meng,

Jiao Liu

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 604, P. 217258 - 217258

Published: Sept. 13, 2024

Language: Английский

Citations

Targeting cell death mechanisms: the potential of autophagy and ferroptosis in hepatocellular carcinoma therapy DOI

Beibei Liu,

Ling Liu,

Yang Liu

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 9, 2024

Ferroptosis is a type of cell death that plays remarkable role in the growth and advancement malignancies including hepatocellular carcinoma (HCC). Non-coding RNAs (ncRNAs) have considerable impact on HCC by functioning as either oncogenes or suppressors. Recent research has demonstrated non-coding ability to control ferroptosis cells, hence impacting tumors resistance these cells drugs. Autophagy mechanism conserved throughout evolution maintaining balance body under normal settings. Nevertheless, occurrence dysregulation autophagy evident progression various human disorders, specifically cancer. dual roles cancer, potentially influencing both survival death. prevalent kind liver genetic mutations changes molecular pathways might worsen its advancement. The subject debate, it capacity repress promote tumor growth. activation can apoptosis, proliferation glucose metabolism, facilitate spread through EMT. Inhibiting hinder enhance respond treatment. regulated several signaling pathways, such STAT3, Wnt, miRNAs, lncRNAs, circRNAs. Utilizing anticancer drugs target may advantageous implications for efficacy cancer

Language: Английский

Citations

Probing the interaction of hesperidin showing antiproliferative activity in colorectal cancer cells and human hemoglobin DOI

Ruiming Deng,

Yanfang Liu, Xiangyu Wu

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 281, P. 136078 - 136078

Published: Sept. 26, 2024

Language: Английский

Citations

Temperature-responsive two-dimensional polydopamine hydrogel: Preparation, mechanisms, and applications in cancer treatment DOI

Tiantian Gong,

Jiahui Jiang, Cheng Chen

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 136891 - 136891

Published: Oct. 28, 2024

Language: Английский

Citations

Oxidase mimicking nanozyme based sensors: From classification and catalytic mechanisms to food safety applications DOI

Mohammed Asiri, Ayad Abdulrazzaq Mutar, Enwa Felix Oghenemaro

et al.

Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 112640 - 112640

Published: Jan. 1, 2025

Language: Английский

Citations

Curcumin mitigates dichlorvos-initiated multi-organ dysfunction in rats by attenuating systemic oxidative stress and brain inflammatory mRNA transcripts DOI

Adio Jamiu Akamo,

Boluwatife A. Olagunju,

Adio Jamiu Akamo

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown, P. 100029 - 100029

Published: Jan. 1, 2025

Language: Английский

Citations

Parthenolide improves sepsis-induced coagulopathy by inhibiting mitochondrial-mediated apoptosis in vascular endothelial cells through BRD4/BCL-xL pathway DOI

Jun Zhang, Xing Zhu, Yong Li

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 17, 2025

Sepsis is a systemic inflammatory syndrome that can cause coagulation abnormalities, leading to damage in multiple organs. Vascular endothelial cells (VECs) are crucial the development of sepsis-induced coagulopathy (SIC). The role Parthenolide (PTL) regulating SIC by protecting VECs remains unclear. study utilized septic rats and lipopolysaccharide (LPS)-stimulated simulate model observe therapeutic effects PTL. Additionally, nanotechnology was employed produce Nano-PTL (N-PTL), whether it has advantages over PTL treating SIC. been shown mitigate lung injury rats, significantly reduce tumor necrosis factor-α (TNF-α) levels, increase survival rates. treatment also enhances function, augments vascular cell (VEC) reduces mitochondrial fragmentation, increases both oxygen consumption rate (OCR) membrane potential (MMP), while inhibiting reactive species (ROS) production. By increasing BRD4/BCL-xL prevent mitochondrial-mediated apoptosis VECs, improve VEC consequently ameliorate nanotechnology-synthesized N-PTL further protective on function. This clarifies mechanisms SIC, offering new strategies directions for sepsis.

Language: Английский

Citations