Molecular Cancer, Journal Year: 2023, Volume and Issue: 22(1)
Published: Jan. 21, 2023
Despite advances in early detection and therapies, cancer is still one of the most common causes death worldwide. Since each tumor unique, there a need to implement personalized care develop robust tools for monitoring treatment response assess drug efficacy prevent disease relapse.
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2021, Volume and Issue: 6(1)
Published: March 29, 2021
Abstract Currently, pyroptosis has received more and attention because of its association with innate immunity disease. The research scope expanded the discovery gasdermin family. A great deal evidence shows that can affect development tumors. relationship between tumors is diverse in different tissues genetic backgrounds. In this review, we provide basic knowledge pyroptosis, explain tumors, focus on significance tumor treatment. addition, further summarize possibility as a potential treatment strategy describe side effects radiotherapy chemotherapy caused by pyroptosis. brief, double-edged sword for rational use dual effect will help us explore formation ideas patients to develop new drugs based
Language: Английский
Citations
1577
Nature, Journal Year: 2020, Volume and Issue: 579(7799), P. 415 - 420
Published: March 11, 2020
Language: Английский
Citations
1292
Journal of Hematology & Oncology, Journal Year: 2020, Volume and Issue: 13(1)
Published: Aug. 10, 2020
Abstract In recent years, cancer immunotherapy based on immune checkpoint inhibitors (ICIs) has achieved considerable success in the clinic. However, ICIs are significantly limited by fact that only one third of patients with most types respond to these agents. The induction cell death mechanisms other than apoptosis gradually emerged as a new treatment strategy because tumors harbor innate resistance apoptosis. date, possibility combining two modalities not been discussed systematically. Recently, few studies revealed crosstalk between distinct and antitumor immunity. pyroptosis, ferroptosis, necroptosis combined showed synergistically enhanced activity, even ICI-resistant tumors. Immunotherapy-activated CD8+ T cells traditionally believed induce tumor via following main pathways: (i) perforin-granzyme (ii) Fas-FasL. identified mechanism which suppress growth inducing ferroptosis provoked review relationship system activation. Hence, this review, we summarize knowledge reciprocal interaction immunity mechanisms, particularly necroptosis, three potentially novel immunogenic death. Because evidence is derived from using animal models, also reviewed related bioinformatics data available for human tissues public databases, partially confirmed presence interactions activation
Language: Английский
Citations
980
Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)
Published: June 20, 2022
Abstract In recent years, immunotherapy represented by immune checkpoint inhibitors (ICIs) has led to unprecedented breakthroughs in cancer treatment. However, the fact that many tumors respond poorly or even not ICIs, partly caused absence of tumor-infiltrating lymphocytes (TILs), significantly limits application ICIs. Converting these “cold” into “hot” may ICIs is an unsolved question immunotherapy. Since it a general characteristic cancers resist apoptosis, induction non-apoptotic regulated cell death (RCD) emerging as new treatment strategy. Recently, several studies have revealed interaction between RCD and antitumor immunity. Specifically, autophagy, ferroptosis, pyroptosis, necroptosis exhibit synergistic responses while possibly exerting inhibitory effects on responses. Thus, targeted therapies (inducers inhibitors) against combination with exert potent activity, resistant This review summarizes multilevel relationship immunity RCD, including necroptosis, potential targeting improve efficacy malignancy.
Language: Английский
Citations
612
Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)
Published: June 8, 2023
Abstract Aging is characterized by systemic chronic inflammation, which accompanied cellular senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the multidimensional complexity of aging, there an urgent need for a systematic organization inflammaging through dimensionality reduction. Factors secreted senescent cells, known as senescence-associated secretory phenotype (SASP), promote inflammation can induce senescence in normal cells. At same time, accelerates immune resulting weakened function inability to clear cells inflammatory factors, creates vicious cycle senescence. Persistently elevated levels organs such bone marrow, liver, lungs cannot be eliminated leading damage aging-related Therefore, has been recognized endogenous factor elimination could potential strategy anti-aging. Here we discuss at molecular, cellular, organ, disease levels, review current aging models, implications cutting-edge single cell technologies, well anti-aging strategies. Since preventing alleviating diseases improving overall quality life are ultimate goals research, our highlights critical features mechanisms along with latest developments future directions providing theoretical foundation novel practical
Language: Английский
Citations
524
Journal of Hematology & Oncology, Journal Year: 2022, Volume and Issue: 15(1)
Published: Dec. 8, 2022
Abstract Many types of human cells self-destruct to maintain biological homeostasis and defend the body against pathogenic substances. This process, called regulated cell death (RCD), is important for various activities, including clearance aberrant cells. Thus, RCD pathways represented by apoptosis have increased in importance as a target development cancer medications recent years. However, because tumor show avoidance apoptosis, which causes treatment resistance recurrence, numerous studies been devoted alternative mortality processes, namely necroptosis, pyroptosis, ferroptosis, cuproptosis; these modalities extensively studied shown be crucial therapy effectiveness. Furthermore, evidence suggests that undergoing may alter immunogenicity microenvironment (TME) some extent, rendering it more suitable inhibiting progression metastasis. In addition, other components TME undergo abovementioned forms induce immune attacks on cells, resulting enhanced antitumor responses. Hence, this review discusses molecular processes features cuproptosis effects novel proliferation Importantly, introduces complex affect biology. It also summarizes potential agents nanoparticles or inhibit their therapeutic based from vivo vitro reports clinical trials inducers evaluated treatments patients. Lastly, we summarized impact modulating drug advantages adding modulators over conventional treatments.
Language: Английский
Citations
500
Cell Death Discovery, Journal Year: 2020, Volume and Issue: 6(1)
Published: Oct. 28, 2020
Abstract Apoptosis has long been recognized as a mechanism that kills the cancer cells by cytotoxic drugs. In recent years, studies have proved pyroptosis can also shrink tumors and inhibit proliferation. Both apoptosis are caspase-dependent programmed cell death pathways. Cysteinyl aspartate specific proteinase-3 (Caspase-3) is common key protein in pathways, when activated, expression level of tumor suppressor gene Gasdermin E (GSDME) determines death. When GSDME highly expressed, active caspase-3 cuts it releases N-terminal domain to punch holes membrane, resulting swelling, rupture, low, will lead classical death, which apoptosis. More interestingly, researchers found be located upstream caspase-3, connecting extrinsic, intrinsic apoptotic Then, promoting activation, forming self-amplifying feed-forward loop. GSDME-mediated correlated with side effects chemotherapy anti-tumor immunity. This article mainly reviews caspase-3/GSDME signal pathway switch between cancer, provide new strategies targets for treatment.
Language: Английский
Citations
474
Cellular and Molecular Immunology, Journal Year: 2022, Volume and Issue: 19(9), P. 971 - 992
Published: Aug. 15, 2022
Language: Английский
Citations
414
Cell Death Discovery, Journal Year: 2021, Volume and Issue: 7(1)
Published: April 7, 2021
Abstract Ovarian cancer (OC) is a highly malignant gynaecological tumour that has very poor prognosis. Pyroptosis been demonstrated in recent years to be an inflammatory form of programmed cell death. However, the expression pyroptosis-related genes OC and their correlations with prognosis remain unclear. In this study, we identified 31 pyroptosis regulators were differentially expressed between normal ovarian tissues. Based on these (DEGs), all cases could divided into two subtypes. The prognostic value each gene for survival was evaluated construct multigene signature using Cancer Genome Atlas (TCGA) cohort. By applying least absolute shrinkage selection operator (LASSO) Cox regression method, 7-gene built classified patients TCGA cohort low- or high-risk group. low-risk group showed significantly higher possibilities than those ( P < 0.001). Utilizing median risk score from cohort, Gene Expression Omnibus (GEO) subgroups, had increased overall (OS) time = 0.014). Combined clinical characteristics, found independent factor predicting OS patients. ontology (GO) Kyoto Encylopedia Genes Genomes (KEGG) analyses indicated immune-related enriched immune status decreased conclusion, play important roles immunity can used predict OCs.
Language: Английский
Citations
353
Cells, Journal Year: 2023, Volume and Issue: 12(4), P. 659 - 659
Published: Feb. 19, 2023
Doxorubicin (DOX) constitutes the major constituent of anti-cancer treatment regimens currently in clinical use. However, precise mechanisms DOX’s action are not fully understood. Emerging evidence points to pleiotropic anticancer activity DOX, including its contribution DNA damage, reactive oxygen species (ROS) production, apoptosis, senescence, autophagy, ferroptosis, and pyroptosis induction, as well immunomodulatory role. This review aims collect information on DOX influence anti-tumor immune response, providing a rationale behind importance modern cancer therapy.
Language: Английский
Citations
316