Oxidative stress in oocyte aging and female reproduction

Journal of Cellular Physiology, Journal Year: 2021, Volume and Issue: 236(12), P. 7966 - 7983

Published: June 14, 2021

In a healthy body, reactive oxygen species (ROS) and antioxidants remain balanced. When the balance is broken toward an overabundance of ROS, oxidative stress appears may lead to oocyte aging. Oocyte aging mainly reflected as gradual decrease quantity quality. Here, we aim review relationship between First, introduced that defective mitochondria, age-related ovarian aging, repeated ovulation, high-oxygen environment were sources ROS in vivo vitro. And also other accumulation ovaries, such overweight unhealthy lifestyles. Then, figured act "initiator" for reproductive pathology, which specifically causes follicular abnormally atresia, abnormal meiosis, lower fertilization rate, delayed embryonic development, disease, including polycystic ovary syndrome endometriosis cyst. Finally, discussed current strategies delaying We three autophagy antioxidant pathways like Beclin-VPS34-Atg14, adenosine 5'-monophosphate (AMP)-activated protein kinase/mammalian target rapamycin (AMPK/mTOR), p62-Keap1-Nrf2. describe different used combat addition, hypoxic (5% O2 ) culture oocytes avoiding So, this not only contribute our general understanding but lay foundations therapies treat premature failure women.

Language: Английский

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Health Benefits of Quercetin in Age-Related Diseases

Molecules, Journal Year: 2022, Volume and Issue: 27(8), P. 2498 - 2498

Published: April 13, 2022

Polyphenols are the known group of phytochemicals that essentially consists phenolic rings. These plant product present in varied fruits and vegetables. secondary metabolites perform a protective function plants from environmental biological stress. When consumed as human diet these also to prevent various age-associated diseases. possess antioxidant properties protect against oxidative The literature survey was carried out using databases such PubMed, Science direct Springer. research articles last 10-12 years were selected for this review based on its relevancy with topic. mainly focused quercetin health benefits. highlights main functions flavonoid, quercetin. Quercetin is among widely occurring polyphenol, found abundantly nature. It commonly different products. Onion have highest quantity This compound possessed considered aging. be both free conjugated forms. has anti-oxidative, anti-inflammatory, anti-proliferative, anti-carcinogenic, anti-diabetic, anti-viral properties. molecule lipophilic can easily cross BBB (Blood-Brain Barrier) hence protects neurodegenerative Various vivo vitro studies demonstrated role here detailed curative agent neurodegeneration, diabetes, cancer, inflammation been out. Studies proved plays crucial prevention age-related disorders. potent which currently being used pharmaceuticals. Properties further explored other Nanoformulations liposomal formulations made treat age associated

Language: Английский

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Recent Advances in Potential Health Benefits of Quercetin

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(7), P. 1020 - 1020

Published: July 18, 2023

Quercetin, a flavonoid found in fruits and vegetables, has been part of human diets for centuries. Its numerous health benefits, including antioxidant, antimicrobial, anti-inflammatory, antiviral, anticancer properties, have extensively studied. strong antioxidant properties enable it to scavenge free radicals, reduce oxidative stress, protect against cellular damage. Quercetin’s anti-inflammatory involve inhibiting the production inflammatory cytokines enzymes, making potential therapeutic agent various conditions. It also exhibits effects by cancer cell proliferation inducing apoptosis. Finally, quercetin cardiovascular benefits such as lowering blood pressure, reducing cholesterol levels, improving endothelial function, promising candidate preventing treating diseases. This review provides an overview chemical structure, biological activities, bioavailability quercetin, well different delivery systems available quercetin. Incorporating quercetin-rich foods into diet or taking supplements may be beneficial maintaining good chronic As research progresses, future perspectives appear promising, with applications nutraceuticals, pharmaceuticals, functional promote overall well-being disease prevention. However, further studies are needed elucidate its mechanisms action, optimize bioavailability, assess long-term safety widespread utilization.

Language: Английский

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The Role of Mitochondria in Oocyte Maturation

Cells, Journal Year: 2021, Volume and Issue: 10(9), P. 2484 - 2484

Published: Sept. 19, 2021

With the nucleus as an exception, mitochondria are only animal cell organelles containing their own genetic information, called mitochondrial DNA (mtDNA). During oocyte maturation, mtDNA copy number dramatically increases and distribution of changes significantly. As maturation requires a large amount ATP for continuous transcription translation, availability right functional is crucial. There correlation between quality oocytes both ATP. Suboptimal conditions in vitro (IVM) might lead to morphology well alternations expression genes encoding proteins associated with function. Dysfunctional have lower ability counteract reactive oxygen species (ROS) production which leads oxidative stress. The function be improved application antioxidants significant expectations laid on development new IVM systems supplemented mitochondria-targeted reagents. Different types been tested already models human rescue oocytes, showing promising results. This review focuses recent observations oocytes' intracellular genomes during vivo vitro. Recent supplementation studies, aiming improve developmental potential, summarized.

Language: Английский

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Role of Reactive Oxygen Species in Aging and Age-Related Diseases: A Review

ACS Applied Bio Materials, Journal Year: 2022, Volume and Issue: 5(9), P. 4028 - 4054

Published: Aug. 31, 2022

Research on the role of reactive oxygen species (ROS) in aging process has advanced significantly over last two decades. In light recent findings, ROS takes part cells along with contributing to various physiological signaling pathways. Antioxidants being cells' natural defense mechanism against ROS-mediated alteration, play an imperative maintain intracellular homeostasis. Although complete understanding regulated is yet be fully comprehended, current insights into sources cellular and their correlation age-related diseases are portrayed this review. addition, results effect antioxidants homeostasis as well advances clinical trials also discussed detail. The future perspective ROS-antioxidant dynamics antiaging research marshaled provide directions for fields.

Language: Английский

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The Role of Quercetin, a Flavonoid in the Management of Pathogenesis Through Regulation of Oxidative Stress, Inflammation, and Biological Activities

Biomolecules, Journal Year: 2025, Volume and Issue: 15(1), P. 151 - 151

Published: Jan. 20, 2025

Quercetin, a flavonoid found in vegetables and fruits, has been extensively studied for its health benefits disease management. Its role the prevention of various pathogenesis well-documented, primarily through ability to inhibit oxidative stress, inflammation, enhance endogenous antioxidant defense mechanisms. Electronic databases such as Google Scholar, Scopus, PubMed, Medline, Web Science were searched information regarding quercetin pathogeneses. The included literature comprised experimental studies, randomized controlled trials, epidemiological studies related quercetin, while editorials, case analyses, theses, letters excluded. It reported have wide range including hepatoprotective, antidiabetic, anti-obesity, neuroprotective, cardioprotective, wound healing, antimicrobial, immunomodulatory effects, achieved modulation biological activities. Additionally, numerous vitro vivo shown that quercetin’s efficacies cancer management involve inhibiting cell signaling pathways, cycle, angiogenesis, activating pathways tumor suppressor genes, inducing apoptosis. This review aims provide comprehensive understanding this outlines sources nanoformulations, applications management, along with key findings from important clinical trial studies. Limited data safety mechanism action are available. is conduct more trials gain deeper disease-preventive potential, mechanisms action, safety, optimal therapeutic dosages. Furthermore, research based on nanoformulations should be performed minimize/overcome hindrance associated bioavailability, rapid degradation, toxicity.

Language: Английский

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The process of ovarian aging: it is not just about oocytes and granulosa cells

Journal of Assisted Reproduction and Genetics, Journal Year: 2022, Volume and Issue: 39(4), P. 783 - 792

Published: March 29, 2022

Language: Английский

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Quercetin inhibits DNA damage responses to induce apoptosis via SIRT5/PI3K/AKT pathway in non-small cell lung cancer

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 165, P. 115071 - 115071

Published: June 28, 2023

SIRT5 is a mitochondrial NAD+ -dependent lysine deacylase. Downregulation of has been linked to several primary cancers and DNA damage. In clinical therapy for non-small cell lung cancer (NSCLC), the Feiyiliu Mixture (FYLM) an experience effective Chinese herb prescription. And we found that quercetin important ingredient in FYLM. However, whether regulates damage repair (DDR) induces apoptosis through NSCLC remains unknown. The present study revealed directly binds inhibits phosphorylation PI3K/AKT interaction between PI3K, thus inhibiting process homologous recombination (HR) non-homologous end-joining (NHEJ) NSCLC, which raise mitotic catastrophe apoptosis. Our provided novel mechanism action treatment NSCLC.

Language: Английский

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The Importance of Natural Antioxidants in Female Reproduction

Antioxidants, Journal Year: 2023, Volume and Issue: 12(4), P. 907 - 907

Published: April 11, 2023

Oxidative stress (OS) has an important role in female reproduction, whether it is ovulation, endometrium decidualization, menstruation, oocyte fertilization, or development andimplantation of embryo the uterus. The menstrual cycle regulated by physiological concentration reactive forms oxygen and nitrogen as redox signal molecules, which trigger regulate length individual phases cycle. It been suggested that decline fertility modulated pathological OS. excess OS compared to antioxidants triggers many disorders reproduction could lead gynecological diseases infertility. Therefore, are crucial for proper reproductive function. They play a part metabolism oocytes; maturation via activation antioxidant signaling pathways Nrf2 NF-κB; hormonal regulation vascular action. Antioxidants can directly scavenge radicals act cofactor highly valuable enzymes cell differentiation development, enhance activity enzymes. Compensation low levels through their supplementation improve fertility. This review considers selected vitamins, flavonoids, peptides, trace elements with effects mechanisms.

Language: Английский

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Antiaging effects of dietary supplements and natural products

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: June 27, 2023

Aging is an inevitable process influenced by genetics, lifestyles, and environments. With the rapid social economic development in recent decades, proportion of elderly has increased rapidly worldwide, many aging-related diseases have shown upward trend, including nervous system diseases, cardiovascular metabolic cancer. The rising burden become urgent global health challenge requires immediate attention solutions. Natural products been used for a long time to treat various human diseases. primary cellular pathways that mediate longevity-extending effects natural involve nutrient-sensing pathways. Among them, sirtuin, AMP-activated protein kinase, mammalian target rapamycin, p53, insulin/insulin-like growth factor-1 signaling are most widely studied. Several studies reviewed individual compounds on aging along with underlying mechanisms. from food sources, such as polyphenols, saponins, alkaloids, polysaccharides, classified antiaging promote prolong life via In this article, we several recently identified potential properties highlighted their molecular discovery use dietary supplements can prevent multiple humans will be beneficial. Thus, review provides theoretical background existing agents.

Language: Английский

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