Anatomical location, sex, and age modulate adipocyte progenitor populations in perivascular adipose tissues DOI Creative Commons
C. Javier Rendon, Lorenzo F. Sempere, Adam Lauver

et al.

Frontiers in Physiology, Journal Year: 2024, Volume and Issue: 15

Published: July 12, 2024

Perivascular adipose tissue (PVAT) regulates vascular function due to its capacity synthesize vasoactive products and mechanical properties. PVATs most abundant cells are adipocytes, their populations maintained by the maturation of adipocyte progenitor (APC), which may play a pivotal role in pathogenesis cardiovascular diseases. However, distribution APC within PVAT depots, potential variation spatial location, influence sex age on abundance remain unknown. We hypothesize that is affected age, subtypes have specific distributions. from thoracic abdominal aorta, mesenteric arteries, AT interscapular, gonadal, subcutaneous depots 13-week 30-week-old females males Pdgfrα-CreERT2 x LSL-tdTomato mice (n = 28) were analyzed. Abdominal aorta had fewer progenitors than gonadal AT. Aging reduced but increased numbers PVAT. Females more depots. exhibited unique where they localized neighboring vasa vasorum arteries. (APC1, APC2, APC3, diff APC) identified all Thoracic APC3 located adventitia while parenchyma. This study variability based depot, sex. The distinctive presence diverse suggest contribute differently diseases-induced remodeling.

Language: Английский

Overnutrition causes insulin resistance and metabolic disorder through increased sympathetic nervous system activity DOI
Kenichi Sakamoto,

Mary A. Butera,

Chun‐Xue Zhou

et al.

Cell Metabolism, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

Citations

16
Adipose tissue in older individuals: a contributing factor to sarcopenia DOI
Tiantian Wang, Dongmei Zhou, Zhen Hong

et al.

Metabolism, Journal Year: 2024, Volume and Issue: 160, P. 155998 - 155998

Published: Aug. 10, 2024

Language: Английский

Citations

10
Sarcopenia and cachexia: molecular mechanisms and therapeutic interventions DOI Creative Commons
Tiantian Wang, Dong Zhou, Zhen Hong

et al.

MedComm, Journal Year: 2025, Volume and Issue: 6(1)

Published: Jan. 1, 2025

Abstract Sarcopenia is defined as a muscle‐wasting syndrome that occurs with accelerated aging, while cachexia severe wasting associated conditions such cancer and immunodeficiency disorders, which cannot be fully addressed through conventional nutritional supplementation. can considered component of cachexia, the bidirectional interplay between adipose tissue skeletal muscle potentially serving molecular mechanism for both conditions. However, underlying mechanisms differ. Recognizing distinctions these disorders essential advancing basic translational research in this area, enhancing diagnostic accuracy ultimately achieving effective therapeutic solutions affected patients. This review discusses microenvironment's changes contributing to conditions, recent approaches like lifestyle modifications, small molecules, interventions, emerging strategies gene editing, stem cell therapy, gut microbiome modulation. We also address challenges opportunities multimodal aiming provide insights into pathogenesis sarcopenia aiding innovative strategy development improved treatments.

Language: Английский

Citations

1
Does Lifelong Exercise Counteract Low-Grade Inflammation Associated with Aging? A Systematic Review and Meta-Analysis DOI Creative Commons
Íñigo M. Pérez-Castillo, Ricardo Rueda,

Hakim Bouzamondo

et al.

Sports Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract Background Aging is associated with sustained low-grade inflammation, which has been linked to age-related diseases and mortality. Long-term exercise programs have shown be effective for attenuating this process; however, subsequent detraining might negate some of these benefits. Master athletes, as a model lifelong consistent practice, suggested present similar inflammatory profiles untrained young adults. Nonetheless, it unclear whether maintaining training habits throughout life can completely counteract inflammation aging. Objectives We aimed systematically evaluate comparisons baseline in middle-aged older adults, individuals elucidate Methods A systematic review was conducted following the Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) statement, protocol prospectively registered PROSPERO (CRD42024521339). Studies reporting systemic levels proinflammatory anti-inflammatory markers athletes controls were eligible inclusion. total six databases (PubMed [MEDLINE], Embase, Cochrane Central Register Controlled Trials [CENTRAL], Scopus, SPORTDiscus, Web Science [WoS]) searched September 2024, studies independently screened by two reviewers. Risk bias assessed using an adapted version Joanna Briggs Institute Critical Appraisal tool cross-sectional trials, random-effect meta-analyses standardized mean differences (SMDs) between age-matched adults well subjects. Subgroup analyses performed based on intensity type, participants’ sex. Results 17 ( n = 649 participants) included both qualitative quantitative synthesis. Lifelong appears attenuate increases C-reactive protein, elevate interleukin (IL)-10 compared (C-reactive protein: SMD − 0.71, 95% confidence interval 0.97, 0.45, I 2 0%, p 0.78; IL-10: 1.44, 0.55, 2.32, 87%, < 0.00001). Statistical significance maintained protein IL-10 sub-analyses. No difference tumor necrosis factor-α observed (SMD 0.40, 0.15, 0.96, 72%, 0.0008). trend towards decreased IL-6 pooled comparing rendered statistically significant However, indicated that still elevated IL-6, along IL-10. Conclusions exhibit more profile denoted circulating and, potentially, increased healthy peers. insufficient changes factor-α, IL-10,

Language: Английский

Citations

1
Age-specific and sex-specific associations of visceral adipose tissue with metabolic health status and cardiovascular disease risk DOI
Wenhao Zhang, Xiangqian Su,

SiHua Liu

et al.

Acta Diabetologica, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Language: Английский

Citations

1
BMI trajectories are associated with NAFLD and advanced fibrosis via aging-inflammation mediation DOI Creative Commons

Haiyang Peng,

Zhibo Zhao, Jian-Ping Gong

et al.

BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: Jan. 14, 2025

As the global epidemic of obesity fuels metabolic conditions, burden nonalcoholic fatty liver disease (NAFLD) will become enormous. Abundant studies revealed association between high body mass index (BMI) and NAFLD but overlooked BMI patterns across life stages. We aimed to explore how trajectories over age relate NAFLD. Selecting 3212 participants in NHANES 2017–2020, we tracked records at different ages. Using a latent class trajectory model (LCTM), identified age. Multinomial logistic regression assessed their with advanced fibrosis. Structural equation modeling (SEM) mediation effects. 3 trajectories: Steady Progression, Increase Decrease, Rapid Ascending. There was no significant difference NAFLD/advanced fibrosis risk increase-to-decrease group steady progression group. The Ascending significantly correlated (OR = 2.21, 95% CI 1.29–3.77) 3.04, 1.13–8.22). This influenced by chain-mediated process phenotypic C-reactive protein (mediated effect 0.010, p < 0.01; mediated 0.003, 0.05). on independent insulin resistance (IR). rapid ascending more pronounced among male subgroup (p for interaction 0.008). correlates an increased susceptibility BMI, aging inflammation. Our results suggest that long-term maintenance is pivotal prevention. Aging-inflammation may represent distinct mechanism sustained NAFLD, IR.

Language: Английский

Citations

1
Combined effects of natural products and exercise on apoptosis pathways in obesity-related skeletal muscle dysfunction DOI
Chun Pan, Yiying Yang, Zhifeng Zhao

et al.

APOPTOSIS, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 20, 2025

Language: Английский

Citations

1
The association of visceral and subcutaneous fat areas with phenotypic age in non-elderly adults, mediated by HOMA-IR and HDL-C DOI Creative Commons
Yuanhong Liu, Min Xu, Liqing Wang

et al.

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 24, 2025

Ageing results in diminished adaptability, as well declines physiological and psychological functions resilience. The epigenetic clock 'Phenotypic Age' (PhenoAge) represents 'preclinical ageing'. Phenotypic Age Acceleration (PhenoAgeAccel) is defined the residual from a linear regression model predicting PhenoAge on basis of chronological age. Abdominal subcutaneous adipose tissue, visceral Homeostasis Model Assessment Insulin Resistance (HOMA-IR), high-density lipoprotein cholesterol (HDL-C) have all been shown to correlate with ageing; however, connections between these factors are still insufficiently investigated. Data for this study were sourced National Health Nutrition Examination Survey (2015–2018), comprising 2580 participants. Complex survey designs considered. To examine association body fat area PhenoAgeAccel, logistic was applied. Additionally, subgroup analysis used identify variations population characteristics. dose‒response relationship PhenoAgeAccel determined via restricted cubic spline analysis. Mediation interaction analyses further employed investigate roles HOMA-IR HDL-C association. In nonelderly adults, relationships differed For abdominal (SFA), nonlinear individuals aged 18–44 years 45–59 years, thresholds 2.969 m² 3.394 m², respectively. contrast, (VFA) observed while 0.769 1.220 effect revealed that had more pronounced mediation accounting 13.4% VFA 6.9% SFA PhenoAgeAccel. Conversely, greater mediating 21.7% 11.6% ≥ 2.73 or > 0.925 3.137 accelerated PhenoAge, whereas 1.60 < ≤ 3.90 mmol/L combined decelerated PhenoAge. study, among SFA, VFA, elucidated, characteristic across different age groups identified. emphasize complex influence distribution ageing process refine various cohorts. These findings provide biological future screening appropriate intervention high-risk populations offer valuable insights guiding personalized clinical interventions health management strategies.

Language: Английский

Citations

1
Sex-specific and cell-type-specific changes in chaperone-mediated autophagy across tissues during aging DOI Creative Commons
Rabia R. Khawaja, Adrián Martín‐Segura, Olaya Santiago‐Fernández

et al.

Nature Aging, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Aging leads to progressive decline in organ and tissue integrity function, partly due loss of proteostasis autophagy malfunctioning. A decrease with age chaperone-mediated (CMA), a selective type lysosomal degradation, has been reported various organs cells from rodents humans. Disruption CMA recapitulates features aging, whereas activating mice protects against age-related diseases such as Alzheimer's, retinal degeneration and/or atherosclerosis. However, sex-specific cell-type-specific differences aging remain unexplored. Here, using reporter single-cell transcriptomic data, we report that most cell types show age, males exhibiting greater aging. Reduced is often associated fewer lysosomes competent for CMA. Transcriptional downregulation genes may further contribute decline, especially males. These findings suggest influence vulnerability degeneration. Using imaging fluorescent (CMA) RNA sequencing the authors present resource on basal activity across organs, sexes young old mice, offering comprehensive overview changes this proteostatic mechanism context

Language: Английский

Citations

1
Metabolaging: a new geroscience perspective linking aging pathologies and metabolic dysfunction DOI
Fadi Khalaf, Dalia Barayan,

Sean Saldanha

et al.

Metabolism, Journal Year: 2025, Volume and Issue: 166, P. 156158 - 156158

Published: Feb. 11, 2025

Language: Английский

Citations

1