Rejuvenation Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 23, 2024
As
a
typical
E3
ligase,
tripartite
motif-containing
65
(TRIM65),
is
implicated
in
the
modulation
of
biological
processes,
such
as
metastasis,
proliferation,
and
apoptosis.
However,
function
TRIM65
prostate
cancer
(PCa)
its
potential
mechanism
have
not
yet
been
excavated.
In
this
work,
we
affirmed
Tripartite
protein
(TRIM65)
new
oncogene
PCa,
which
accelerated
PCa
cell
proliferation
impeded
ferroptosis.
vivo,
depletion
inhibited
tumorigenesis
metastasis.
Mechanically,
our
findings
uncovered
that
enhances
NKD
inhibitor
WNT
signaling
pathway
2
(NKD2)
degradation
via
ubiquitin-proteasome
signaling.
facilitated
restricted
ferroptosis
downregulating
NKD2
levels.
Moreover,
activated
wingless-integrated/β-catenin
cells
inhibiting
NKD2.
Taken
together,
these
data
controls
regulates
Wnt/β-catenin
directly
targeting
for
ubiquitination
degradation.
Our
study
provides
insights
into
multifaceted
regulatory
role
development
laying
foundation
exploring
therapeutic
approaches.
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
175, P. 116722 - 116722
Published: May 9, 2024
Ulcerative
colitis
(UC)
is
a
complex
immune-mediated
chronic
inflammatory
bowel
disease.
It
mainly
characterized
by
diffuse
inflammation
of
the
colonic
and
rectal
mucosa
with
barrier
function
impairment.
Identifying
new
biomarkers
for
development
more
effective
UC
therapies
remains
pressing
task
current
research.
Ferroptosis
newly
identified
form
regulated
cell
death
iron-dependent
lipid
peroxidation.
As
research
deepens,
ferroptosis
has
been
demonstrated
to
be
involved
in
pathological
processes
numerous
diseases.
A
growing
body
evidence
suggests
that
pathogenesis
associated
ferroptosis,
regulation
provides
opportunities
treatment.
However,
specific
mechanisms
which
participates
remain
fully
thoroughly
investigated.
Therefore,
this
review,
we
focus
on
advances
mechanism
recent
years
describe
potential
role
UC.
In
addition,
explore
underlying
crosslinked
pathway
between
other
such
as
macrophages,
neutrophils,
autophagy,
endoplasmic
reticulum
stress,
gut
microbiota
Finally,
also
summarize
compounds
may
act
inhibitors
future.
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
173, P. 116323 - 116323
Published: Feb. 23, 2024
Deubiquitination,
a
post-translational
modification
regulated
by
deubiquitinases,
is
essential
for
cancer
initiation
and
progression.
Ubiquitin-specific
proteases
(USPs)
are
elements
of
the
deubiquitinase
family,
overexpressed
in
gastric
(GC).
Through
regulation
several
signaling
pathways,
such
as
Wnt/β-Catenin
nuclear
factor-κB
signaling,
promotion
expression
deubiquitination-
stabilization-associated
proteins,
USPs
promote
proliferation,
metastasis,
invasion,
epithelial-mesenchymal
transition
GC.
In
addition,
closely
related
to
clinicopathological
features,
patient
prognosis,
chemotherapy
resistance.
therefore
could
be
used
prognostic
biomarkers.
USP
targeting
small
molecule
inhibitors
have
demonstrated
strong
anticancer
activity.
However,
they
not
yet
been
tested
clinic.
This
article
provides
an
overview
latest
fundamental
research
on
GC,
aiming
enhance
understanding
how
contribute
GC
progression,
identifying
possible
targets
treatment
improve
survival.
International Journal of Cancer,
Journal Year:
2024,
Volume and Issue:
155(1), P. 7 - 18
Published: March 27, 2024
Abstract
Immune
checkpoint
inhibitors
(ICIs)
have
been
extensively
used
in
immunological
therapy
primarily
due
to
their
ability
prolong
patient
survival.
Although
ICIs
achieved
success
cancer
treatment,
the
resistance
of
should
not
be
overlooked.
Ferroptosis
is
a
newly
found
cell
death
mode
characterized
by
accumulation
reactive
oxygen
species
(ROS),
glutathione
(GSH)
depletion,
and
peroxidase
4
(GPX4)
inactivation,
which
has
demonstrated
beneficial
immunotherapy
combining
ferroptosis
exploit
new
immunotherapies
may
reverse
resistance.
Exosomes
act
as
mediators
cell‐to‐cell
communication
that
regulate
influence
through
secretion
biological
molecules.
Thus,
utilizing
exosomes
target
opened
up
exciting
possibilities
for
reversing
In
this
review,
we
summarize
mechanisms
improving
how
adjusting
iron
metabolism,
blocking
ROS
accumulation,
controlling
defense
systems,
influencing
classic
signaling
pathways
engineered
improve
efficiency.
Theranostics,
Journal Year:
2024,
Volume and Issue:
14(15), P. 5826 - 5852
Published: Jan. 1, 2024
Ferroptosis,
an
iron-dependent
form
of
regulated
cell
death,
is
emerging
as
a
crucial
regulator
human
physiology
and
pathology.
Increasing
evidence
showcases
reciprocal
relationship
between
ferroptosis
dysregulated
metabolism,
propagating
pathogenic
vicious
cycle
that
exacerbates
pathology
diseases,
particularly
metabolic
disorders.
Consequently,
there
rapidly
growing
interest
in
developing
ferroptosis-based
therapeutics.
Therefore,
comprehensive
understanding
the
intricate
interplay
metabolism
could
provide
invaluable
resource
for
mechanistic
insight
therapeutic
development.
In
this
review,
we
summarize
important
substances
associated
pathways
initiation
progression,
outline
cascade
responses
disease
development,
overview
roles
mechanisms
introduce
methods
detection,
discuss
perspectives
ferroptosis,
which
collectively
aim
to
illustrate
view
basic,
translational,
clinical
science.
