Biological Trace Element Research, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 30, 2024
Language: Английский
Toxics, Journal Year: 2024, Volume and Issue: 12(10), P. 719 - 719
Published: Sept. 30, 2024
Oxidative stress frequently contributes to intestinal barrier injury in animals and humans. It was reported that both Selenomethionine (SeMet) allicin exhibit protective effects against a range of diseases caused by oxidative stress. This study aimed investigate the synergistic antioxidant underlying mechanisms SeMet on H2O2-induced model using IPEC-J2 cells mice. The results showed H2O2 induced severe stress, including decrease cell viability, level, migration capacity, integrity. exhibited significant anti-oxidative epithelial cells. combined use increased SOD activity, GSH content, GSH/GSSG ratio while decreasing MDA, NO, ROS content levels. Furthermore, we found synergistically activated nuclear factor erythroid-related 2 (Nrf2)-NAD(P)H dehydrogenase [quinone] 1 (NQO1) signaling pathway down-regulated endoplasmic reticulum (ER stress)-related proteins. However, antioxidative were abolished Nrf2 inhibitor ML385 vitro vivo. In conclusion, attenuate excessively through activation inhibition ER These findings support could enhance properties alleviate further clinical practice.
Language: Английский
Citations
2
Cell Biochemistry and Function, Journal Year: 2024, Volume and Issue: 42(8)
Published: Oct. 25, 2024
ABSTRACT The endothelial semipermeable monolayers ensure tissue homeostasis, are subjected to a plethora of stimuli, and their function depends on cytoskeletal integrity remodeling. permeability those membranes can fluctuate maintain organ homeostasis. In cases severe injury, inflammation or disease, barrier hyperpermeability cause irreparable damage endothelium‐dependent issues, eventually death. Elucidation the signaling regulating structure promotes development targeted pharmacotherapies towards disorders related impaired endothelium (e.g., acute respiratory distress syndrome, sepsis). Recent reports investigate role unfolded protein response in function. Herein we review components, function; interrelations health disorder. Moreover, emphasize modulators, since they ameliorate illness leak.
Language: Английский
Citations
2
Advanced Science, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 21, 2024
Abstract Parkinson's disease (PD) is characterized by dopamine (DA) neuron loss and neuroinflammation. This study develops carrier‐free nanocapsules (NCs) for targeted delivery of DA catalase (CAT) to the PD brain, addressing both depletion neuroinflammation simultaneously. The NCs are engineered 4‐formylphenylboronic acid co‐loading with cRGD‐modified CAT (CAT‐cRGD) surface‐modifying Angiopep‐2 (Ang). Ang targets blood‐brain barrier (BBB), enhancing brain delivery, while cRGD upregulated integrin receptors in PD‐affected BBB. showed a 1.4‐fold increase parkinsonian targeting efficiency compared normal mice. In mice models, demonstrated stable learning memory, enhanced locomotor activity, improved motor coordination. supplementation significantly dopaminergic signaling, increasing levels 1.8‐ 3.5‐fold striatum substantia nigra, respectively. Additionally, delivered effectively reduced mitigating endoplasmic reticulum stress, slowing progression, protecting from oxidation. innovative approach using PD‐targeted represents synergistic strategy treatment, combining symptomatic relief progression intervention.
Language: Английский
Citations
2
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: March 17, 2024
Abstract Adult neural stem cells (NSC) are a potential source for the regeneration of damaged tissue during neuropathological conditions, but much remains unexplored. In an attempt to study influence neuroinflammation on NSCs, we generated transgenic reporter rat strain that expresses Discosoma sp . red (DsRed) fluorophore in NSCs and subjected it traumatic brain injury (TBI). Transcriptomic analysis isolated from TBI revealed enrichment stress response genes pertained endoplasmic reticulum (ER) integrated (ISR). Downstream NSC cultures pinpointed IL-1α as trigger ISR these cells. At concentration levels similar ones measured post-TBI rats, induced translation activating transcription factor 4 (ATF4), master regulator. Further, ATF4 was necessary -dependent induction senescent profile which included metabolic shift towards glycolysis, senescence-associated secretory phenotype, SASP, cell cycle arrest. summary, ISR/ATF4 pathway seems play major role function provides therapeutic tool protecting pool conditions.
Language: Английский
Citations
1
Biological Trace Element Research, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 30, 2024
Language: Английский
Citations
1