A Systems Bioinformatics Analysis Indicates that Disruption of the lncRNA SFTA1P Network is Consistent with Impairing Surfactant Homeostasis and Respiratory Function Observed in Lung Adenocarcinoma

OMICS A Journal of Integrative Biology, Journal Year: 2025, Volume and Issue: unknown

Published: May 12, 2025

Lung adenocarcinoma (LUAD) is one of the leading global health challenges wherein novel therapeutic targets are much needed. In this systems bioinformatics study, we report that disruption long noncoding RNA (lncRNA) SFTA1P-centered network, respiratory gaseous exchange and surfactant-associated Biological Network (rgsBNet), consistent with impairing surfactant homeostasis function, thus warrants attention for future drug discovery development. We analyzed data from The Cancer Genome Atlas LUAD cohort to identify differentially expressed mRNAs, lncRNAs, microRNAs (miRNAs), followed by correlational analysis examine coexpression network lncRNA SFTA1P its potential role in pathogenesis. observed downregulation coexpressed LUAD. Intriguingly, appears be associated disrupting perturbing suggesting a progression. Additionally, identified key transcription factors correlate expression genes crucial homeostasis. attendant regulatory mechanisms suggested may act as "sponge" certain miRNAs, sequestering them away their mRNA targets. conclusion, work uncovers insights into molecular governing offers possible avenue interventions aimed at ameliorating lung function improving disease management. highlights regulators opens doors further investigation progression

Language: Английский

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Survival-based bioinformatics analysis to identify hub long non-coding RNAs along with lncRNA-miRNA-mRNA network for potential diagnosis/prognosis of thyroid cancer

Journal of Cell Communication and Signaling, Journal Year: 2022, Volume and Issue: 17(3), P. 639 - 655

Published: Sept. 23, 2022

Language: Английский

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DARS-AS1: A Vital Oncogenic LncRNA Regulator with Potential for Cancer Prognosis and Therapy

International Journal of Medical Sciences, Journal Year: 2024, Volume and Issue: 21(3), P. 571 - 582

Published: Jan. 1, 2024

DARS-AS1, short for Aspartyl-tRNA synthetase antisense RNA 1, has emerged as a pivotal player in cancers.Upregulation of this lncRNA is recurrent phenomenon observed across various cancer types, where it predominantly assumes oncogenic roles, exerting influence on multiple facets tumor cell biology.This aberrant expression DARS-AS1 triggered extensive research investigations, aiming to unravel its roles and clinical values cancer.In review, we elucidate the significant correlation between dysregulated adverse survival prognoses patients, drawing from existing literature pan-cancer analyses The Cancer Genome Atlas (TCGA).Additionally, provide comprehensive insights into diverse functions cancers.Our review encompasses elucidation molecular mechanisms, ceRNA networks, functional mediators, signaling pathways, well involvement therapy resistance, coupled with latest advancements DARS-AS1-related research.These recent updates enrich our comprehension role played by cancer, thereby paving way future applications DARS-AS1-targeted strategies prognosis evaluation therapeutic interventions.This furnishes valuable advance ongoing efforts combating effectively.

Language: Английский

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EZH2-interacting lncRNAs contribute to gastric tumorigenesis; a review on the mechanisms of action

Molecular Biology Reports, Journal Year: 2024, Volume and Issue: 51(1)

Published: Feb. 23, 2024

Language: Английский

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LINC02086 inhibits ferroptosis and promotes malignant phenotypes of pancreatic cancer via miR-342-3p/CA9 axis

Functional & Integrative Genomics, Journal Year: 2024, Volume and Issue: 24(2)

Published: March 5, 2024

Language: Английский

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