ROS induced lipid peroxidation and their role in ferroptosis

Frontiers in Cell and Developmental Biology, Journal Year: 2023, Volume and Issue: 11

Published: Aug. 1, 2023

Reactive oxygen species (ROS) play a crucial part in the process of cell death, including apoptosis, autophagy, and ferroptosis. ROS involves oxidation lipids generate 4-hydroxynonenal other compounds associated with it. Ferroptosis may be facilitated by lipid peroxidation phospholipid bilayers. In order to offer novel ideas directions for investigation disorders connected these processes, we evaluate function which ultimately leads ferroptosis as well proposed crosstalk mechanisms between types programmed death.

Language: Английский

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A novel silkworm excrement-derived nanomedicine integrating ferroptosis and photodynamic therapy, well-suitable for PD-L1-mediated immune checkpoint blockade

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 505, P. 159676 - 159676

Published: Jan. 17, 2025

Language: Английский

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Ferroptosis: CD8+T cells’ blade to destroy tumor cells or poison for self-destruction

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: April 1, 2025

Abstract Ferroptosis represents an emerging, iron-dependent form of cell death driven by lipid peroxidation. In recent years, it has garnered significant attention in the realm cancer immunotherapy, particularly studies involving immune checkpoint inhibitors. This not only enhances our comprehension tumor microenvironment but is also considered a promising therapeutic strategy to address resistance, investigate activation mechanisms, and facilitate development vaccines. The combination immunotherapy with ferroptosis provides innovative targets fresh perspectives for advancing treatment. Nevertheless, cells appear possess wider array evasion strategies compared CD8 + T cells, which have been conclusively shown be more vulnerable ferroptosis. Furthermore, TME can create favorable environment survival invasion. Under this premise, both inducing inhibiting will impact antitumor immunity some extent, even make final result run counter purpose. paper systematically elucidates dual-edged sword role process briefly outlining complexity within TME. It explores potential side effects associated ferroptosis-inducing therapies critically considers combined application ferroptosis-based ICIs. highlights current challenges faced approach points out future directions development.

Language: Английский

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Ferroptosis: Promising approach for cancer and cancer immunotherapy

Cancer Letters, Journal Year: 2023, Volume and Issue: 561, P. 216152 - 216152

Published: April 4, 2023

Language: Английский

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Inhibition of spinal ferroptosis-like cell death alleviates hyperalgesia and spontaneous pain in a mouse model of bone cancer pain

Redox Biology, Journal Year: 2023, Volume and Issue: 62, P. 102700 - 102700

Published: April 12, 2023

Bone cancer pain (BCP) impairs patients' quality of life. However, the underlying mechanisms are still unclear. This study investigated role spinal interneuron death using a pharmacological inhibitor ferroptosis in mouse model BCP. Lewis lung carcinoma cells were inoculated into femur, resulting hyperalgesia and spontaneous pain. Biochemical analysis revealed that levels reactive oxygen species malondialdehyde increased, while those superoxide dismutase decreased. Histological showed loss GAD65+ interneurons provided ultrastructural evidence mitochondrial shrinkage. Pharmacologic inhibition ferrostatin-1 (FER-1, 10 mg/kg, intraperitoneal for 20 consecutive days) attenuated ferroptosis-associated iron accumulation lipid peroxidation alleviated Furthermore, FER-1 inhibited pain-associated activation ERK1/2 COX-2 expression prevented GABAergic interneurons. Moreover, improved analgesia by Parecoxib. Taken together, this shows ferroptosis-like cell alleviates BCP mice. The results suggest is potential therapeutic target patients suffering on possibly other types

Language: Английский

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DMT1 differentially regulates mitochondrial complex activities to reduce glutathione loss and mitigate ferroptosis

Free Radical Biology and Medicine, Journal Year: 2023, Volume and Issue: 207, P. 32 - 44

Published: July 5, 2023

Mitochondria are vital for energy production and redox homeostasis, yet knowledge of relevant mechanisms remains limited. Here, through a genome-wide CRISPR-Cas9 knockout screening, we have identified DMT1 as major regulator mitochondria membrane potential. Our findings demonstrate that deficiency increases the activity mitochondrial complex I reduces III. Enhanced leads to increased NAD+ production, which activates IDH2 by promoting its deacetylation via SIRT3. This results in higher levels NADPH GSH, improve antioxidant capacity during Erastin-induced ferroptosis. Meanwhile, loss III impairs biogenesis promotes mitophagy, contributing suppression Thus, differentially regulates activities cooperatly suppress Furthermore, NMN, an alternative method increasing NAD+, exhibits similar protective effects against ferroptosis boosting GSH manner deficiency, shedding light on potential therapeutic strategy ferroptosis-related pathologies.

Language: Английский

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Ferroptosis in gastrointestinal cancer: from mechanisms to implications

Cancer Letters, Journal Year: 2023, Volume and Issue: 561, P. 216147 - 216147

Published: March 24, 2023

Language: Английский

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Regulated cell death‐amplified sonodynamic anti‐tumor immune nanotherapeutics

BMEMat, Journal Year: 2024, Volume and Issue: unknown

Published: March 4, 2024

Abstract Nanomedicine‐assisted sonodynamic therapy (SDT) has emerged as one of the most promising cancer therapies due to its unique advantages high penetration, non‐radiation, and excellent oxidative stress effect, but always suffered from self‐protection mechanism apoptosis resistance characteristics evolutionarily mutated cells. Regulated cell death (RCD) received increasing attention in precision treatments because significant role synergistically sensitizing reversing immunosuppressive microenvironment during SDT nanomedicine‐triggered immunogenic death. Herein, paradigmatic research RCD‐augmented tumor immunotherapeutics are typically introduced, such autophagy blockade, ferroptosis targeting, pyroptosis induction, necroptosis initiation, cuproptosis actuation, PANoptosis trigger, coordinated anti‐tumor mechanisms discussed detail. Multiple analysis focusing on currently unsolved problems future development prospects RCD‐based nano‐oncology medicine also prospected further strengthen expand scope therapeutic applications.

Language: Английский

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Lipid peroxidation of immune cells in cancer

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 8, 2024

Growing evidence indicates that cellular metabolism is a critical determinant of immune cell viability and function in antitumor immunity lipid important for activation adaptation to the tumor microenvironment (TME). Lipid peroxidation process which oxidants attack lipid-containing carbon-carbon double bonds an part metabolism. In past decades, studies have shown participates signal transduction control proliferation, differentiation, death, essential execution human health. More importantly, recent affects modulate ability. this review, we briefly overview effect on adaptive innate TME discuss effectiveness sensitivity ability cells by regulating peroxidation.

Language: Английский

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Ferroptosis: Biology and Role in Gastrointestinal Disease

Gastroenterology, Journal Year: 2024, Volume and Issue: 167(2), P. 231 - 249

Published: March 1, 2024

Language: Английский

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