Microbiota in Irritable Bowel Syndrome and Endometriosis: Birds of a Feather Flock Together—A Review

Microorganisms, Journal Year: 2023, Volume and Issue: 11(8), P. 2089 - 2089

Published: Aug. 15, 2023

Endometriosis and irritable bowel syndrome (IBS) are chronic conditions affecting up to 10% of the global population, imposing significant burdens on healthcare systems patient quality life. Interestingly, around 20% endometriosis patients also present with symptoms indicative IBS. The pathogenesis both these multifactorial remains be fully elucidated, but connections gut microbiota becoming more apparent. Emerging research underscores differences in composition between healthy individuals those suffering from either or Intestinal dysbiosis appears pivotal conditions, exerting an influence via similar mechanisms. It impacts intestinal permeability, triggers inflammatory reactions, initiates immune responses. Furthermore, it is entwined a bidirectional relationship brain, as part gut–brain axis, whereby influences influenced by mental health pain perception. Recent years have witnessed development microbiota-focused therapies, such low FODMAP diets, prebiotics, probiotics, antibiotics, fecal transplantation, designed tackle relieve symptoms. While promising, treatments inconsistent data, highlighting need for further research. This review explores evidence IBS endometriosis, underscoring role conditions. A deeper understanding this common mechanism may enable enhanced diagnostics therapeutic advancements.

Language: Английский

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Alterations in gut and genital microbiota associated with gynecological diseases: a systematic review and meta-analysis

Reproductive Biology and Endocrinology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Jan. 18, 2024

Abstract Background Increasing number of studies have demonstrated certain patterns microbial changes in gynecological diseases; however, the interaction between them remains unclear. To evaluate consistency or specificity across multiple on different diseases and alterations at sites body (gut genital tract), we conducted a systematic review meta-analysis. Methods We searched PubMed, Embase, Web Science, Cochrane Library up to December 5, 2022(PROSPERO: CRD42023400205). Eligible focused adult women, applied next-generation sequencing microbiome, reported outcomes including alpha beta diversity relative abundance. The random-effects model standardized mean difference (SMD) was using inverse-variance method for indices. Results Of 3327 unique articles, 87 eligible were included. Significant decreases found gut microbiome patients versus controls (observed species SMD=-0.35; 95%CI, -0.62 -0.09; Shannon index SMD=-0.23; -0.40 -0.06), whereas significant increases observed vaginal (Chao1 SMD = 1.15; 0.74 1.56; 0.51; 0.16 0.86). Most diagnostic categories showed no differences diversity. Disease observed, but almost all only replicated three studies, except increased Aerococcus bacterial vaginosis (BV). Patients with major shared enrichment Prevotella depletion Lactobacillus , an overlap microbes implied BV, cervical intraepithelial neoplasia, cancer. Conclusions These findings association microbiota diseases. most results rather than disease-specific alterations. Therefore, further investigation is required identify specific biomarkers diagnosis treatment future.

Language: Английский

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Role of the gut microbiota in the pathogenesis of endometriosis: a review

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: March 5, 2024

Endometriosis is classically defined as a chronic inflammatory heterogeneous disorder occurring in any part of the body, characterized by estrogen-driven periodic bleeding, proliferation, and fibrosis ectopic endometrial glands stroma outside uterus. can take overwhelmingly serious damage to structure function multi-organ, even impair whole-body systems, resulting severe dysmenorrhea, pelvic pain, infertility, fatigue depression 5-10% women reproductive age. Precisely because huge deficiency cognition about underlying etiology complex pathogenesis debilitating disease, early diagnosis treatment modalities with relatively minor side effects become bottlenecks endometriosis. Thus, endometriosis warrants deeper exploration expanded investigation pathogenesis. The gut microbiota plays significant role diseases humans acting an important participant regulator metabolism immunity body. Increasingly, studies have shown that closely related inflammation, estrogen metabolism, development progression In this review, we discuss diverse mechanisms order provide new approaches for on prevention, treatment.

Language: Английский

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Effects of the gut microbiota and its metabolite short-chain fatty acids on endometriosis

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: June 13, 2024

In recent years, a growing body of research has confirmed that the gut microbiota plays major role in maintenance human health and disease. A imbalance can lead to development many diseases, such as pregnancy complications, adverse outcomes, polycystic ovary syndrome, endometriosis, cancer. Short-chain fatty acids are metabolites specific intestinal bacteria crucial for maintaining homeostasis regulating metabolism immunity. Endometriosis is result cell proliferation, escape from immune surveillance, invasive metastasis. There strong correlation between anti-proliferative anti-inflammatory effects short-chain produced by microbes endometriosis. Given mechanism action endometriosis remain unclear, this paper aims provide comprehensive review complex interactions flora, addition, we explored potential microbial-based treatment strategies providing new insights into future diagnostic tests prevention methods

Language: Английский

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The Current Applications of Metabolomics in Understanding Endometriosis: A Systematic Review

Metabolites, Journal Year: 2025, Volume and Issue: 15(1), P. 50 - 50

Published: Jan. 14, 2025

Endometriosis is a common gynecological disease that affects approximately 10–15% of reproductive-aged women worldwide. This debilitating has negative impact on the quality life those affected. Despite this condition being very common, pathogenesis not well understood. Metabolomics study array low-weight metabolites in given sample. emerging field omics-based science proved to be effective at furthering understanding endometriosis. In systematic review, we seek provide an overview application metabolomics We highlight use locating biomarkers for identification, treatment mechanisms and symptoms, relating external factors The literature search took place Web Science, Pubmed, Google Scholar based keywords “metabolomics” AND “endometriosis” or “metabolome” “endometriosis”. found 58 articles from 2012 2024 met our criteria. Significant alterations lipids, amino acids, as other compounds were present human animal models. Discrepancies among studies significantly altered make it difficult general conclusions metabolic signature However, several individual elevated multiple with endometriosis; these include 3-hydroxybutyrate, lactate, phosphatidic succinate, pyruvate, tetradecenoylcarnitine, hypoxanthine, xanthine. Accordingly, L-isoleucine citrate reduced Including larger cohorts, standardizing testing methods, studying phenotypes endometriosis may lead more separable results.

Language: Английский

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Omics-based novel strategies in the diagnosis of endometriosis

Critical Reviews in Clinical Laboratory Sciences, Journal Year: 2023, Volume and Issue: 61(3), P. 205 - 225

Published: Oct. 25, 2023

Endometriosis, an enigmatic and chronic disorder, is considered a debilitating condition despite being benign. Globally, this gynecologic disorder affects up to 10% of females reproductive age, impacting almost 190 million individuals. A variety genetic environmental factors are involved in endometriosis development, hence the pathophysiology etiology remain unclear. The uncertainty disease its complexity along with nonspecific symptoms have led misdiagnosis or lack diagnosis affected people. Biopsy laparoscopy referred as gold standard for diagnosis. However, invasiveness procedure, unnecessary operation disease-free women, dependence reliability on experience area most significant limitations. Therefore, continuous studies attempted offer noninvasive reliable approach. recent advances modern technologies generation large-scale biological data sets, known –omics data, resulting proceeding century biomedical sciences. Thereby, present study critically reviews novel biomarkers that based approaches from 2020 onward. findings reveal identified genomics, epigenomics, transcriptomics, proteomics, metabolomics potentially able diagnose endometriosis, predict prognosis, stage patients, potentially, near future, multi-panel these will generate clinical benefits.

Language: Английский

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How Do Microorganisms Influence the Development of Endometriosis? Participation of Genital, Intestinal and Oral Microbiota in Metabolic Regulation and Immunopathogenesis of Endometriosis

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(13), P. 10920 - 10920

Published: June 30, 2023

Microorganisms inhabiting the human body play an extremely key role in its proper functioning, as well development of immune system, which, by maintaining balance, allows you to enjoy health. Dysbiosis intestinal microbiota, or oral cavity reproductive tract, understood a change number and diversity all microorganisms them, may correlate with many diseases, including endometriosis, researchers have emphasized. Endometriosis is inflammatory, estrogen-dependent gynecological condition defined growth endometrial cells outside uterine cavity. Deregulation homeostasis resulting from microbiological disorders generate chronic inflammation, thus creating environment conducive increased adhesion angiogenesis involved endometriosis. In addition, research recent years has implicated bacterial contamination activation, reduced gastrointestinal function cytokines, altered estrogen metabolism signaling, abnormal progenitor stem cell homeostasis, pathogenesis The aim this review was present influence intestinal, genital microbiota dysbiosis metabolic regulation immunopathogenesis

Language: Английский

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The Role of Selected Dietary Factors in the Development and Course of Endometriosis

Nutrients, Journal Year: 2023, Volume and Issue: 15(12), P. 2773 - 2773

Published: June 16, 2023

Endometriosis is a chronic disease with complex, heterogeneous pathogenesis that affects about 10% of women reproductive age, causing pain and leading to infertility. Treatment consists administering pharmacological agents (resulting in reduction estrogen levels inflammation), as well the surgical removal endometriotic lesions. Unfortunately, despite wide range available therapies, there still high recurrence rate after surgery. Consequently, it necessary improve outcome patients endometriosis. In this context, growing interest possible dietary modification support or complement classic treatment options even serve potential alternative hormone therapy. addition, number studies indicate positive effects selected factors on development course This review article focuses potentially beneficial compounds from polyphenol group (curcumin, epigallocatechin gallate, quercetin, resveratrol), vitamins, micronutrients The results ingredients fighting disease. However, most have been performed experimental animal models, smaller proportion looking at actual use among women. Therefore, well-designed are needed assess importance well-chosen diet specific health suffering

Language: Английский

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Surge in endometriosis research after decades of underfunding could herald new era for women’s health

Nature Medicine, Journal Year: 2024, Volume and Issue: 30(2), P. 315 - 318

Published: Feb. 1, 2024

Language: Английский

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Gut microbiota and female health

World Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: 30(12), P. 1655 - 1662

Published: March 28, 2024

The gut microbiota is recognized as an endocrine organ with the capacity to influence distant organs and associated biological pathways. Recent advancements underscore critical role of microbial homeostasis in female health; dysbiosis potentially leading diseases among women such polycystic ovarian syndrome, endometriosis, breast cancer, cervical cancer etc. Despite this, there has been limited discussion on underlying mechanisms. This editorial explores three potential mechanisms through which may impact development women, namely, immune system, microbiota-estrogen axis, metabolite pathway. We focused approaches for treating by addressing imbalances probiotics, prebiotics supplementation, fecal transplantation (FMT). Future studies should focus determining molecular associations between realize precision medicine, FMT emerging a promising intervention.

Language: Английский

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