Tissue macrophages: origin, heterogenity, biological functions, diseases and therapeutic targets

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: March 7, 2025

Abstract Macrophages are immune cells belonging to the mononuclear phagocyte system. They play crucial roles in defense, surveillance, and homeostasis. This review systematically discusses types of hematopoietic progenitors that give rise macrophages, including primitive progenitors, erythro-myeloid stem cells. These have distinct genetic backgrounds developmental processes. Accordingly, macrophages exhibit complex diverse functions body, phagocytosis clearance cellular debris, antigen presentation, response, regulation inflammation cytokine production, tissue remodeling repair, multi-level regulatory signaling pathways/crosstalk involved homeostasis physiology. Besides, tumor-associated a key component TME, exhibiting both anti-tumor pro-tumor properties. Furthermore, functional status is closely linked development various diseases, cancer, autoimmune disorders, cardiovascular disease, neurodegenerative metabolic conditions, trauma. Targeting has emerged as promising therapeutic strategy these contexts. Clinical trials macrophage-based targeted drugs, immunotherapies, nanoparticle-based therapy were comprehensively summarized. Potential challenges future directions targeting also been discussed. Overall, our highlights significance this versatile cell human health which expected inform research clinical practice.

Language: Английский

---

Combined targeting of senescent cells and senescent macrophages: A new idea for integrated treatment of lung cancer

Seminars in Cancer Biology, Journal Year: 2024, Volume and Issue: 106-107, P. 43 - 57

Published: Aug. 29, 2024

Language: Английский

---

Integrated serum pharmacochemistry and network pharmacology to explore the mechanism of Yi-Shan-Hong formula in alleviating chronic liver injury

Phytomedicine, Journal Year: 2024, Volume and Issue: 128, P. 155439 - 155439

Published: Feb. 9, 2024

Language: Английский

---

Metabolic homeostasis of tissue macrophages across the lifespan

Trends in Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: 35(9), P. 793 - 808

Published: May 18, 2024

Language: Английский

---

Single cell analysis of short-term dry eye induced changes in cornea immune cell populations

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: March 15, 2024

Background Dry eye causes corneal inflammation, epitheliopathy and sensorineural changes. This study evaluates the hypothesis that dry alters percentages transcriptional profiles of immune cell populations in cornea. Methods Desiccating stress (DS) induced was created by pharmacologic suppression tear secretion exposure to drafty low humidity environment. Expression profiling cells performed single-cell RNA sequencing (scRNA-seq). Cell differentiation trajectories fate were modeled through velocity analysis. Confocal microscopy used immunodetect cells. Irritation response topical neurostimulants assessed. Results Twelve based on their identified at baseline consist monocytes, resident (rMP) MMP12/13 high macrophages, dendritic (cDC2), neutrophils, mast cells, pre T/B innate (γDT, ILC2, NK) conventional T B lymphocytes. macrophages largest normal cornea comprising 18.6 18.2 percent, respectively. rMP increased 55.2% after 5 days DS. Significant changes expression 1,365 genes (adj p < 0.0001) noted with increases cytokines chemokines ( Tnf, Cxcl1, Ccl12, Il1rn ), inflammatory markers Vcam, Adam17, Junb TAM receptor Mertk decreases complement MHCII genes. A trajectory from monocytes terminal state found. Phagocytosis, C-type lectin signaling, NF-kappa signaling Toll-like among pathways enhanced activity these The percentage MRC1 + rMPs they observed basal epithelium adjacent epithelial nerve plexus. Concentration chemokine CXCL1 it heightened irritation/pain responses topically applied hypertonic saline. Conclusion These findings indicate DS recruits differentiate inflammation associated proximity nerves neurosensitizers suggests contribute eye.

Language: Английский

---

Overnutrition and Lipotoxicity: Impaired Efferocytosis and Chronic Inflammation as Precursors to Multifaceted Disease Pathogenesis

Biology, Journal Year: 2024, Volume and Issue: 13(4), P. 241 - 241

Published: April 6, 2024

Overnutrition, driven by the consumption of high-fat, high-sugar diets, has reached epidemic proportions and poses a significant global health challenge. Prolonged overnutrition leads to deposition excessive lipids in adipose non-adipose tissues, condition known as lipotoxicity. The intricate interplay between overnutrition-induced lipotoxicity immune system plays pivotal role pathogenesis various diseases. This review aims elucidate consequences impaired efferocytosis, caused lipotoxicity-poisoned macrophages, leading chronic inflammation subsequent development severe infectious diseases, autoimmunity, cancer, well pulmonary cardiovascular Chronic promotes tissue expansion which induces cellular stress inflammatory responses, contributing insulin resistance, dyslipidemia, metabolic syndrome. Moreover, sustained exposure impairs efferocytic capacity compromising their ability efficiently engulf remove dead cells. unresolved perpetuates pro-inflammatory microenvironment, exacerbating damage promoting interaction overnutrition, lipotoxicity, efferocytosis highlights critical pathway through emerges, facilitating Understanding these connections sheds light on potential therapeutic avenues mitigate detrimental effects function homeostasis, thereby paving way for novel interventions aimed at reducing burden multifaceted diseases health.

Language: Английский

---

Release of damaged mitochondrial DNA: A novel factor in stimulating inflammatory response

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 258, P. 155330 - 155330

Published: April 26, 2024

Language: Английский

---

The dual function of cGAS-STING signaling axis in liver diseases

Acta Pharmacologica Sinica, Journal Year: 2024, Volume and Issue: 45(6), P. 1115 - 1129

Published: Jan. 17, 2024

Language: Английский

---

Calorie restriction mimetic, resveratrol, attenuates hepatic ischemia and reperfusion injury through enhancing efferocytosis of macrophages via AMPK/STAT3/S1PR1 pathway

The Journal of Nutritional Biochemistry, Journal Year: 2024, Volume and Issue: 126, P. 109587 - 109587

Published: Jan. 21, 2024

Language: Английский

---

Efferocytosis in liver disease

JHEP Reports, Journal Year: 2023, Volume and Issue: 6(1), P. 100960 - 100960

Published: Nov. 16, 2023

The process of dead cell clearance by phagocytic cells, called efferocytosis, prevents inflammatory necrosis and promotes resolution repair. Defective efferocytosis contributes to the progression numerous diseases in which death prominent, including liver disease. Many gaps remain our understanding how macrophages carry out this goes awry various types diseases. Studies thus far have suggested that, upon injury, resident Kupffer cells (KCs) infiltrating monocyte-derived (MoMϕs) clear limit inflammation, and, through macrophage reprogramming, repair damage. However, unusual settings, can promote In review, we will focus on acute chronic diseases, metabolic dysfunction-associated steatohepatitis. Understanding mechanisms consequences has potential shed new light disease pathophysiology suggest treatment strategies prevent progression.

Language: Английский

---