Oxidative Stress in Health and Disease

Biomedicines, Journal Year: 2023, Volume and Issue: 11(11), P. 2925 - 2925

Published: Oct. 29, 2023

Oxidative stress, resulting from the excessive intracellular accumulation of reactive oxygen species (ROS), nitrogen (RNS), and other free radical species, contributes to onset progression various diseases, including diabetes, obesity, diabetic nephropathy, neuropathy, neurological such as Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), Parkinson’s (PD). stress is also implicated in cardiovascular cancer. Exacerbated oxidative leads accelerated formation advanced glycation end products (AGEs), a complex mixture crosslinked proteins protein modifications. Relatively high levels AGEs are generated AD, I diseases. Ne-carboxymethyllysine (CML) serve markers for progression. AGEs, through interaction with receptors (RAGE), initiate cascade deleterious signaling events form inflammatory cytokines, thereby further exacerbate vicious cycle. AGE inhibitors, breakers, RAGE inhibitors therefore potential therapeutic agents multiple diabetes AD. The complexity lack well-established mechanisms largely responsible effective therapeutics targeting AGE-related This review addresses role pathogenesis chronic disorders, recent progress development based on antioxidants, breakers inhibitors. Furthermore, this outlines strategies single-atom nanozymes that attenuate sequestering (ROS) (RNS).

Language: Английский

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Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Oct. 14, 2024

Iron, an essential mineral in the body, is involved numerous physiological processes, making maintenance of iron homeostasis crucial for overall health. Both overload and deficiency can cause various disorders human diseases. Ferroptosis, a form cell death dependent on iron, characterized by extensive peroxidation lipids. Unlike other kinds classical unprogrammed death, ferroptosis primarily linked to disruptions metabolism, lipid peroxidation, antioxidant system imbalance. Ferroptosis regulated through transcription, translation, post-translational modifications, which affect cellular sensitivity ferroptosis. Over past decade or so, diseases have been as part their etiology, including cancers, metabolic disorders, autoimmune diseases, central nervous cardiovascular musculoskeletal Ferroptosis-related proteins become attractive targets many major that are currently incurable, some regulators shown therapeutic effects clinical trials although further validation potential needed. Therefore, in-depth analysis its molecular mechanisms may offer additional strategies prevention treatment. In this review, we discuss significance contribution etiology development along with evidence supporting targeting approach. Importantly, evaluate recent promising interventions, providing guidance future targeted treatment therapies against

Language: Английский

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Photosynthetic ROS and retrograde signaling pathways

New Phytologist, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 17, 2024

Summary Sessile plants harness mitochondria and chloroplasts to sense adapt diverse environmental stimuli. These complex processes involve the generation of pivotal signaling molecules, including reactive oxygen species (ROS), phytohormones, volatiles, metabolites. Furthermore, specific modulation chloroplast proteins, through activation or deactivation, significantly enhances plant's capacity engage with its dynamic surroundings. While existing reviews have extensively covered role plastidial retrograde modules in developmental light signaling, our focus lies investigating how leverage photosynthetic ROS navigate fluctuations counteract oxidative stress, thereby sustaining primary metabolism. Unraveling nuanced interplay between plant stress responses holds promise for uncovering new insights that could reinforce resistance optimize net photosynthesis rates. This exploration aspires pave way innovative strategies enhance resilience agricultural productivity amidst changing conditions.

Language: Английский

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Nanoparticle-Mediated Multiple Modulation of Bone Microenvironment To Tackle Osteoarthritis

ACS Nano, Journal Year: 2024, Volume and Issue: 18(15), P. 10625 - 10641

Published: April 2, 2024

Development of nanomedicines that can collaboratively scavenge reactive oxygen species (ROS) and inhibit inflammatory cytokines, along with osteogenesis promotion, is essential for efficient osteoarthritis (OA) treatment. Herein, we report the design a ROS-responsive nanomedicine formulation based on fibronectin (FN)-coated polymer nanoparticles (NPs) loaded azabisdimethylphoaphonate-terminated phosphorus dendrimers (G4-TBP). The constructed G4-TBP NPs-FN size 268 nm are stable under physiological conditions, be specifically taken up by macrophages through FN-mediated targeting, dissociated in oxidative microenvironment. dendrimer having intrinsic anti-inflammatory property FN both antioxidative properties display integrated functions ROS scavenging, hypoxia attenuation, macrophage M2 polarization, thus protecting from apoptosis creating designed bone immune microenvironment stem cell osteogenic differentiation. These characteristics lead to their effective treatment an OA model vivo reduce pathological changes joints including synovitis inhibition cartilage matrix degradation simultaneously promote differentiation repair. developed combining advantages bioactive treat may immunomodulatory therapy different diseases.

Language: Английский

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Quercetin alleviates lipopolysaccharide‑induced acute lung injury by inhibiting ferroptosis via the Sirt1/Nrf2/Gpx4 pathway

International Journal of Molecular Medicine, Journal Year: 2023, Volume and Issue: 52(6)

Published: Oct. 20, 2023

Acute lung injury (ALI) causes high morbidity and mortality rates in critically ill patients, there are currently no effective therapeutic drugs. Ferroptosis is a newly discovered mode of regulated cell death that contributes to the progression ALI. Quercetin possesses anti‑inflammatory antioxidant properties. However, whether quercetin can protect against lipopolysaccharide (LPS)‑induced ALI by inhibiting ferroptosis its underlying mechanisms remains unclear. The present study evaluated protective effects molecular LPS‑induced establishing an mouse model alveolar epithelial via treatment mice or cells with LPS. Mouse was assessed evaluating histological score, bronchoalveolar lavage fluid count inflammatory cytokine levels; Cell counting kit‑8, lactate dehydrogenase EDU assays; detecting changes levels malondialdehyde, glutathione, iron, glutathione peroxidase 4 (Gpx4) 4‑hydroxynonenal in vivo vitro. indicated effectively ameliorated reducing histopathological changes, proinflammatory release reactive oxygen species generation ferroptosis. significantly decreased improved proliferative ability LPS‑treated cells. Additionally, it demonstrated markedly enhanced barrier, as evidenced upregulation tight junction protein expression both vitro. Mechanistically, activated sirtuin 1 (Sirt1)/nuclear factor erythroid 2‑related 2 (Nrf2)/Gpx4 signaling pathway, targeted inhibition vitro knockdown Sirt1 reduced anti‑ferroptotic functions quercetin. In conclusion, results exerts activation Sirt1/Nrf2/Gpx4 pathway.

Language: Английский

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Oxidative Metabolism as a Cause of Lipid Peroxidation in the Execution of Ferroptosis

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7544 - 7544

Published: July 9, 2024

Ferroptosis is a type of nonapoptotic cell death that characteristically caused by phospholipid peroxidation promoted radical reactions involving iron. Researchers have identified many the protein factors are encoded genes promote ferroptosis. Glutathione peroxidase 4 (GPX4) key enzyme protects phospholipids from and suppresses ferroptosis in glutathione-dependent manner. Thus, dysregulation involved cysteine and/or glutathione metabolism closely associated with From perspective dynamics, actively proliferating cells more prone to than quiescent cells, which suggests species generated during oxygen-involved responsible for lipid peroxidation. Herein, we discuss initial events dominantly occur process energy metabolism, association deficiency. Accordingly, tricarboxylic acid cycle coupled respiratory chain mitochondria main subjects here, this likely source both electrons free Since not only carbohydrates, but also amino acids, especially glutamate, major substrates central dealing nitrogen derived groups contributes subject discussion.

Language: Английский

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Artemisia herba-alba: antioxidant capacity and efficacy in preventing chronic arthritis in vivo

Inflammopharmacology, Journal Year: 2024, Volume and Issue: 32(3), P. 1855 - 1870

Published: April 12, 2024

Language: Английский

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Membrane Dynamics and Cation Handling in Ferroptosis

Physiology, Journal Year: 2024, Volume and Issue: 39(2), P. 73 - 87

Published: Jan. 9, 2024

Ferroptosis, a regulated cell death hallmarked by excessive lipid peroxidation, is implicated in various (patho)physiological contexts. During ferroptosis, peroxidation leads to diverse change membrane properties and the dysregulation of ion homeostasis via cation channels, ultimately resulting plasma rupture. This review illuminates cellular dynamics handling ferroptosis regulation.

Language: Английский

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HPB@LA@PDA nanoplatform ameliorates osteoarthritis by scavenging reactive oxygen species and remodelling the inflammatory microenvironment: An in vitro and in vivo study

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160592 - 160592

Published: Feb. 1, 2025

Language: Английский

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Structure optimizing of flavonoids against both MRSA and VRE

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 271, P. 116401 - 116401

Published: April 16, 2024

Language: Английский

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